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Conserved domains on  [gi|148612821|ref|NP_114162|]
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tetratricopeptide repeat protein 29 isoform 2 [Homo sapiens]

Protein Classification

lipopolysaccharide assembly protein LapB( domain architecture ID 11459274)

lipopolysaccharide assembly protein LapB is a tetratricopeptide repeat (TPR) protein that modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-382 1.48e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 171 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLENKEY 250
Cdd:COG2956   33 EALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 251 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEM 330
Cdd:COG2956   93 DRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQGDY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148612821 331 TEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:COG2956  161 DEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-382 1.48e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 171 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLENKEY 250
Cdd:COG2956   33 EALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 251 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEM 330
Cdd:COG2956   93 DRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQGDY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148612821 331 TEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:COG2956  161 DEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 198-394 1.93e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 46.73  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 198 LLEAAEhyEAFHQLTQGRIWKDEtgrslnllACESLLRTYRllsdkmlENKEYKQAIKIlikASEIAKEGsDKKMEAEas 277
Cdd:PRK11788 122 LLDRAE--ELFLQLVDEGDFAEG--------ALQQLLEIYQ-------QEKDWQKAIDV---AERLEKLG-GDSLRVE-- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 278 yylgLAHLaaeeyetaltvldtYCKISTdldddlslgrgyEAIAkvlqsQGEMTEAIKYLKKFVKIARNNfqsldlVRAS 357
Cdd:PRK11788 179 ----IAHF--------------YCELAQ------------QALA-----RGDLDAARALLKKALAADPQC------VRAS 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 148612821 358 TMLGDIYNEKGYYNKASECFQQAFDTTVELMSM---PLMD 394
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDPEYLSEvlpKLME 257
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 210-380 4.99e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 4.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821  210 QLTQGRIWKDET--GRSLNLLACESLLRTyrLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEaeasyyLGLAHLAA 287
Cdd:TIGR02917 339 QLRLGRVDEAIAtlSPALGLDPDDPAALS--LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQ------LGISKLSQ 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821  288 EEYETALTVLDTYCKISTDLDD-DLSLGRGYeaiakvLQSqGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNE 366
Cdd:TIGR02917 411 GDPSEAIADLETAAQLDPELGRaDLLLILSY------LRS-GQFDKALAAAKKLEKKQPDNASLHNL------LGAIYLG 477

                         170
                  ....*....|....
gi 148612821  367 KGYYNKASECFQQA 380
Cdd:TIGR02917 478 KGDLAKAREAFEKA 491
TPR_12 pfam13424
Tetratricopeptide repeat;
317-382 1.02e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148612821  317 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNNF--QSLDLVRASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-382 1.48e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 171 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLENKEY 250
Cdd:COG2956   33 EALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 251 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEM 330
Cdd:COG2956   93 DRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQGDY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148612821 331 TEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:COG2956  161 DEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-384 1.09e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 171 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwkdetgRSLNLLACESLLRTYrllsdkmLENKEY 250
Cdd:COG2956   67 KLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-----------DPDDAEALRLLAEIY-------EQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 251 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQGEM 330
Cdd:COG2956  127 EKAIEVLERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEKA------LKLDPDCARALLLLAELYLEQGDY 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148612821 331 TEAIKYLKKFVKIARNNFQSLDlvrastMLGDIYNEKGYYNKASECFQQAFDTT 384
Cdd:COG2956  195 EEAIAALERALEQDPDYLPALP------RLAELYEKLGDPEEALELLRKALELD 242
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 181-382 9.22e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.78  E-value: 9.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 181 EAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLsdkmlENKEYKQAIKILIKA 260
Cdd:COG3914   30 AELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQ-----ALGRYEEALALYRRA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 261 SEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLdddlslGRGYEAIAKVLQSQGEMTEAIKYLKKF 340
Cdd:COG3914  105 LALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGRLEEAIAALRRA 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 148612821 341 VKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:COG3914  173 LELDPDN------AEALNNLGNALQDLGRLEEAIAAYRRALE 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
180-380 1.18e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.78  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 180 KEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwKDETGRSLNLLAcesllRTYRLLsdkmlenKEYKQAIKILIK 259
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL------DPDDAEALYNLG-----LAYLRL-------GRYEEALADYEQ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 260 ASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLdddlslGRGYEAIAKVLQSQGEMTEAIKYLKK 339
Cdd:COG0457   68 ALELDPD------DAEALNNLGLALQALGRYEEALEDYDKALELDPDD------AEALYNLGLALLELGRYDEAIEAYER 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148612821 340 FVKIARNNFQSLDLvrastmLGDIYNEKGYYNKASECFQQA 380
Cdd:COG0457  136 ALELDPDDADALYN------LGIALEKLGRYEEALELLEKL 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-380 1.84e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 171 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIwkdetgrslnllacesllRTYRLLSDKMLENKEY 250
Cdd:COG2956  101 KLLELD--PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA------------------HAYCELAELYLEQGDY 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 251 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQGEM 330
Cdd:COG2956  161 DEAIEALEKALKLDPD------CARALLLLAELYLEQGDYEEAIAALERA------LEQDPDYLPALPRLAELYEKLGDP 228

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 148612821 331 TEAIKYLKKFVKIARNNFQSLdlvrastMLGDIYNEKGYYNKASECFQQA 380
Cdd:COG2956  229 EEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 245-380 6.66e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 6.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 245 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVL 324
Cdd:COG2956   19 LLNGQPDKAIDLLEEALELDPE------TVEAHLALGNLYRRRGEYDRAIRIHQKL------LERDPDRAEALLELAQDY 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148612821 325 QSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 380
Cdd:COG2956   87 LKAGLLDRAEELLEKLLELDPDDAEAL------RLLAEIYEQEGDWEKAIEVLERL 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 274-382 1.06e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.18  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 274 AEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQsldl 353
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKA------LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE---- 73

                         90       100
                 ....*....|....*....|....*....
gi 148612821 354 vrASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:COG4783   74 --ARLNLGLALLKAGDYDEALALLEKALK 100
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 198-394 1.93e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 46.73  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 198 LLEAAEhyEAFHQLTQGRIWKDEtgrslnllACESLLRTYRllsdkmlENKEYKQAIKIlikASEIAKEGsDKKMEAEas 277
Cdd:PRK11788 122 LLDRAE--ELFLQLVDEGDFAEG--------ALQQLLEIYQ-------QEKDWQKAIDV---AERLEKLG-GDSLRVE-- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 278 yylgLAHLaaeeyetaltvldtYCKISTdldddlslgrgyEAIAkvlqsQGEMTEAIKYLKKFVKIARNNfqsldlVRAS 357
Cdd:PRK11788 179 ----IAHF--------------YCELAQ------------QALA-----RGDLDAARALLKKALAADPQC------VRAS 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 148612821 358 TMLGDIYNEKGYYNKASECFQQAFDTTVELMSM---PLMD 394
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDPEYLSEvlpKLME 257
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 278-383 4.19e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 278 YYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQsldlvrAS 357
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVE------AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE------AL 79

                         90       100
                 ....*....|....*....|....*.
gi 148612821 358 TMLGDIYNEKGYYNKASECFQQAFDT 383
Cdd:COG2956   80 LELAQDYLKAGLLDRAEELLEKLLEL 105
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 210-380 4.99e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 4.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821  210 QLTQGRIWKDET--GRSLNLLACESLLRTyrLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEaeasyyLGLAHLAA 287
Cdd:TIGR02917 339 QLRLGRVDEAIAtlSPALGLDPDDPAALS--LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQ------LGISKLSQ 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821  288 EEYETALTVLDTYCKISTDLDD-DLSLGRGYeaiakvLQSqGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNE 366
Cdd:TIGR02917 411 GDPSEAIADLETAAQLDPELGRaDLLLILSY------LRS-GQFDKALAAAKKLEKKQPDNASLHNL------LGAIYLG 477

                         170
                  ....*....|....
gi 148612821  367 KGYYNKASECFQQA 380
Cdd:TIGR02917 478 KGDLAKAREAFEKA 491
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 182-347 7.19e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 7.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 182 AEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGriwkdetgrslNLLACESLLRTYrllsdkmLENKEYKQAIKILIKAS 261
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPD-----------NPEAFALLGEIL-------LQLGDLDEAIVLLHEAL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 262 EIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEMTEAIKYLKKFV 341
Cdd:COG4783   66 ELDPD------EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRPDEAIAALEKAL 133


                 ....*.
gi 148612821 342 KIARNN 347
Cdd:COG4783  134 ELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 245-380 8.96e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.49  E-value: 8.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 245 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKIStdlDDDLSLgrgYEAIAKVL 324
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPD------NPEAFALLGEILLQLGDLDEAIVLLHEALELD---PDEPEA---RLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148612821 325 QSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEKGYYNKASECFQQA 380
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLR------LARAYRALGRPDEAIAALEKA 132
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 84-313 2.52e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 2.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821  84 LFALMERWDALREAARVRSLFWLQKPLEEQPDKLDYLYHYLTRAEDAERKESFEDVHNNLYALACYFNNSEDKWvrnHFY 163
Cdd:COG3914   25 ELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEAL---ALY 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 164 ERcfkiaqLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwKDETGRSLNLLAcESLLRTYRllsdk 243
Cdd:COG3914  102 RR------ALALN--PDNAEALFNLGNLLLALGRLEEALAALRRALAL------NPDFAEAYLNLG-EALRRLGR----- 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 244 mlenkeYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSL 313
Cdd:COG3914  162 ------LEEAIAALRRALELDPD------NAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 274-383 5.18e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.99  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 274 AEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSlgrgyeAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDL 353
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALL------DLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 148612821 354 vrastmLGDIYNEKGYYNKASECFQQAFDT 383
Cdd:COG4235   91 ------LGLAAFQQGDYAEAIAAWQKLLAL 114
TPR_12 pfam13424
Tetratricopeptide repeat;
317-382 1.02e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148612821  317 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNNF--QSLDLVRASTMLGDIYNEKGYYNKASECFQQAFD 382
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
TPR_12 pfam13424
Tetratricopeptide repeat;
232-297 1.59e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 1.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148612821  232 SLLRTYRLLSDKMLENKEYKQAIKILIKASEIAKE--GSDKKMEAEASYYLGLAHLAAEEYETALTVL 297
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRllGPDHPLTATTLLNLGRLYLELGRYEEALELL 68
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
307-380 2.49e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 2.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148612821 307 LDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 380
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEAL------YNLGLAYLRLGRYEEALADYEQA 68
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 245-380 7.87e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821  245 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLgrgyeaIAKVL 324
Cdd:TIGR02917 272 FQKKNYEDARETLQDALKSAPE------YLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRL------LASIQ 339

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148612821  325 QSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 380
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAAL------SLLGEAYLALGDFEKAAEYLAKA 389
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
182-375 8.85e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.68  E-value: 8.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 182 AEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwkdetgRSLNLLACESLLRTYRLLsdkmlenKEYKQAIKILIKAS 261
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALEL-----------DPDDAEALYNLGLALLEL-------GRYDEAIEAYERAL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 262 EIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFV 341
Cdd:COG0457  138 ELDPD------DADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211

                        170       180       190
                 ....*....|....*....|....*....|....
gi 148612821 342 KIARNNFQSLDLVRASTMLGDIYNEKGYYNKASE 375
Cdd:COG0457  212 AILTLAALAELLLLALALLLALRLAALALYQYRA 245
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 282-379 9.58e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.12  E-value: 9.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148612821 282 LAHLAAEEYETALTVLDtycKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDlvrASTMLG 361
Cdd:COG1729    1 KALLKAGDYDEAIAAFK---AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPD---ALLKLG 74

                         90
                 ....*....|....*...
gi 148612821 362 DIYNEKGYYNKASECFQQ 379
Cdd:COG1729   75 LSYLELGDYDKARATLEE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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