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Conserved domains on  [gi|13775226|ref|NP_112592|]
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glycosyltransferase 8 domain-containing protein 2 isoform 1 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 51-336 1.07e-68

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06429:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 257  Bit Score: 215.72  E-value: 1.07e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  51 IPVVIcAAAGRMGATMAAINSIYSNTD-ANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDS--- 126
Cdd:cd06429   1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmq 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 127 ------------SRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdin 194
Cdd:cd06429  80 leseadtsnlkqRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 195 rlvglqntymgyldyrkkaikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPML 274
Cdd:cd06429 149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13775226 275 IVFHGKYSTINPLWHIRHLGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 336
Cdd:cd06429 196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 51-336 1.07e-68

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 215.72  E-value: 1.07e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  51 IPVVIcAAAGRMGATMAAINSIYSNTD-ANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDS--- 126
Cdd:cd06429   1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmq 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 127 ------------SRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdin 194
Cdd:cd06429  80 leseadtsnlkqRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 195 rlvglqntymgyldyrkkaikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPML 274
Cdd:cd06429 149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13775226 275 IVFHGKYSTINPLWHIRHLGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 336
Cdd:cd06429 196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 52-321 2.84e-43

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 150.16  E-value: 2.84e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226    52 PVVICAAAGRMGATMAAINSIYSNT-DANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDSSRPE 130
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226   131 LLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdinrlvglqnTYMGYLDYR 210
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226   211 KKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHI 290
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 13775226   291 RHLGWNPDARYSEHFLQEAKLLHWNGRHKPW 321
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPW 248
PLN02659 PLN02659
Probable galacturonosyltransferase
 101-334 3.47e-25

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 106.27  E-value: 3.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  101 SKLREINFKIVEFN---PMVLKGKIRPDSsrPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGH 177
Cdd:PLN02659 295 SQFRGGSSAIVANNtekPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  178 AAAFSDDCdlpSAQDinRLVgLQNTYMGYLDYRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEE 257
Cdd:PLN02659 372 VNGAVETC---RGED--KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKS 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  258 NLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW---DFPSVHnDLWESW 334
Cdd:PLN02659 445 DLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPWldiAFPQLR-PLWAKY 518
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 51-331 2.26e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 95.43  E-value: 2.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  51 IPVVICAAAGRMGATMAAINSIY-SNTDANILFYVV--GLRN-TLTRIRKWIE--HSKLREINFKIVEFNPMVLKGKIRP 124
Cdd:COG1442   6 INIVFAIDDNYLPGLGVSIASLLeNNPDRPYDFHILtdGLSDeNKERLEALAAkyNVSIEFIDVDDELLKDLPVSKHISK 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 125 DSsrpellqplnFVRFYLP-LLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdinrlvglqnty 203
Cdd:COG1442  86 AT----------YYRLLIPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------- 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 204 mgyldYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHG 279
Cdd:COG1442 141 -----SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGG 204

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13775226 280 KYSTINPLW-----HIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHN--DLW 331
Cdd:COG1442 205 KVKFLPPRYnyqysLYYELKDKSNKKELLEARKNPVIIHYTGPTKPWHKWCTHPyaDLY 263
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 51-336 1.07e-68

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 215.72  E-value: 1.07e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  51 IPVVIcAAAGRMGATMAAINSIYSNTD-ANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDS--- 126
Cdd:cd06429   1 IHVVI-FSDNRLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmq 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 127 ------------SRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdin 194
Cdd:cd06429  80 leseadtsnlkqRKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 195 rlvglqntymgyldyrkkaikdlgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPML 274
Cdd:cd06429 149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGL 195

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13775226 275 IVFHGKYSTINPLWHIRHLGWNPDARysEHFLQEAKLLHWNGRHKPWDFPSVHN--DLWESWFV 336
Cdd:cd06429 196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAIPSykELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 52-321 2.84e-43

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 150.16  E-value: 2.84e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226    52 PVVICAAAGRMGATMAAINSIYSNT-DANILFYVVGLRNTLTRIRKWIEHSKLREINFKIVEFNPMVLKGKIRPDSSRPE 130
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226   131 LLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdinrlvglqnTYMGYLDYR 210
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226   211 KKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHI 290
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|.
gi 13775226   291 RHLGWNPDARYSEHFLQEAKLLHWNGRHKPW 321
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPW 248
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 53-322 8.21e-35

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 127.56  E-value: 8.21e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  53 VVICAAAGRMGATMAAINSIYSNTDANILFYVVGLrNTLTRIRKWIEHskLREINFKIVEFNPMVLKGKIRPDS-SRPEL 131
Cdd:cd00505   4 VIVATGDEYLRGAIVLMKSVLRHRTKPLRFHVLTN-PLSDTFKAALDN--LRKLYNFNYELIPVDILDSVDSEHlKRPIK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 132 lqPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDlpsaqdinrlvglqnTYMGYLDYRK 211
Cdd:cd00505  81 --IVTLTKLHLPNLVPDYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGD---------------RREGKYYRQK 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 212 KAIKDLgispsTCSFNPGVIVANMTEW-KHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHgkystINPLWHI 290
Cdd:cd00505 144 RSHLAG-----PDYFNSGVFVVNLSKErRNQLLKVALEKWLQSLSSLSGGDQDLLNTFFKQVPFIVKS-----LPCIWNV 213

                       250       260       270
                ....*....|....*....|....*....|..
gi 13775226 291 RHLGWNPDARYSEHFLQEAKLLHWNGRHKPWD 322
Cdd:cd00505 214 RLTGCYRSLNCFKAFVKNAKVIHFNGPTKPWN 245
PLN02659 PLN02659
Probable galacturonosyltransferase
 101-334 3.47e-25

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 106.27  E-value: 3.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  101 SKLREINFKIVEFN---PMVLKGKIRPDSsrPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGH 177
Cdd:PLN02659 295 SQFRGGSSAIVANNtekPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GK 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  178 AAAFSDDCdlpSAQDinRLVgLQNTYMGYLDYRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEE 257
Cdd:PLN02659 372 VNGAVETC---RGED--KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKS 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  258 NLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW---DFPSVHnDLWESW 334
Cdd:PLN02659 445 DLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQENTSLAD--AESAGVVHFNGRAKPWldiAFPQLR-PLWAKY 518
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 51-331 2.26e-22

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 95.43  E-value: 2.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  51 IPVVICAAAGRMGATMAAINSIY-SNTDANILFYVV--GLRN-TLTRIRKWIE--HSKLREINFKIVEFNPMVLKGKIRP 124
Cdd:COG1442   6 INIVFAIDDNYLPGLGVSIASLLeNNPDRPYDFHILtdGLSDeNKERLEALAAkyNVSIEFIDVDDELLKDLPVSKHISK 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 125 DSsrpellqplnFVRFYLP-LLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdinrlvglqnty 203
Cdd:COG1442  86 AT----------YYRLLIPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------- 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 204 mgyldYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHG 279
Cdd:COG1442 141 -----SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGG 204

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13775226 280 KYSTINPLW-----HIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHN--DLW 331
Cdd:COG1442 205 KVKFLPPRYnyqysLYYELKDKSNKKELLEARKNPVIIHYTGPTKPWHKWCTHPyaDLY 263
PLN02870 PLN02870
Probable galacturonosyltransferase
 112-321 2.84e-21

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 94.62  E-value: 2.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  112 EFNPMVLKGKIRPDSsrPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSAQ 191
Cdd:PLN02870 308 ETTPRTFASKLQARS--PKYISLLNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDLG-GKVNGAVETCRGEDEW 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  192 DINRlvglqnTYMGYLDYRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATS 271
Cdd:PLN02870 385 VMSK------RFRNYFNFSHPLIAK-NLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNLTMWKLG---TLP 454

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 13775226  272 PMLIVFHGKYSTINPLWHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 321
Cdd:PLN02870 455 PALIAFKGHVHPIDPSWHMLGLGYQSKTNIES--VKKAAVIHYNGQSKPW 502
PLN02742 PLN02742
Probable galacturonosyltransferase
 129-321 6.80e-21

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 93.68  E-value: 6.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  129 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDINRlvglqntYMGYLD 208
Cdd:PLN02742 333 PKYLSMLNHLRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETC----LETFHR-------YHKYLN 400

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  209 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 288
Cdd:PLN02742 401 FSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVDRTLW--KLG---TLPPGLLTFYGLTEPLDRRW 474

                        170       180       190
                 ....*....|....*....|....*....|...
gi 13775226  289 HIRHLGWNPDArySEHFLQEAKLLHWNGRHKPW 321
Cdd:PLN02742 475 HVLGLGYDTNI--DPRLIESAAVLHFNGNMKPW 505
PLN02523 PLN02523
galacturonosyltransferase
 129-321 1.20e-19

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 89.93  E-value: 1.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  129 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsaqdinrlVGLQNTYMGYLD 208
Cdd:PLN02523 357 PKYLSMLNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGLWKIDMD-GKVNGAVETC-----------FGSFHRYAQYLN 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  209 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFhgkYSTINPL- 287
Cdd:PLN02523 425 FSHPLIKE-KFNPKACAWAYGMNIFDLDAWRREKCTEQYHYWQNLNENRTLW--KLG---TLPPGLITF---YSTTKPLd 495

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 13775226  288 --WHIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 321
Cdd:PLN02523 496 ksWHVLGLGYNPSISMDE--IRNAAVIHFNGNMKPW 529
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 51-323 2.71e-19

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 85.73  E-value: 2.71e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  51 IPVVICAAAGRMGATMAAINSIYSNTDA-NILFYVV--GL-RNTLTRIRKWIE--HSKLREINFKIVEFNPMVLKGKIRP 124
Cdd:cd04194   1 MNIVFAIDDNYAPYLAVTIKSILANNSKrDYDFYILndDIsEENKKKLKELLKkyNSSIEFIKIDNDDFKFFPATTDHIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 125 DSSrpellqplnFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsaqdinrlvglqntym 204
Cdd:cd04194  81 YAT---------YYRLLIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP------------------- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226 205 gYLDYRKKAIKDLGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssslgggvatsP----MLIVFHGK 280
Cdd:cd04194 132 -FIEQEKKRKRRLGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIY-----------PdqdiLNAVLKDK 199

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13775226 281 YSTINPLW--HIRHLGWNPDARYSEHFLQEA----KLLHWNGRHKPWDF 323
Cdd:cd04194 200 ILYLPPRYnfQTGFYYLLKKKSKEEQELEEArknpVIIHYTGSDKPWNK 248
PLN02867 PLN02867
Probable galacturonosyltransferase
 129-331 6.01e-19

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 87.65  E-value: 6.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  129 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpSAQDINRLVGLQntYMGYLD 208
Cdd:PLN02867 325 PSCLSLLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDLNGKVVGAVVD-----SWCGDNCCPGRK--YKDYLN 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  209 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLW 288
Cdd:PLN02867 398 FSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLKLSLNSGLQLWQPG---ALPPALLAFKGHVHPIDPSW 473

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 13775226  289 HIRHLGWNPdARYSEHFLQEAKLLHWNGRHKPW---DFPSVHNdLW 331
Cdd:PLN02867 474 HVAGLGSRP-PEVPREILESAAVLHFSGPAKPWleiGFPEVRS-LW 517
PLN02829 PLN02829
Probable galacturonosyltransferase
 129-321 2.85e-18

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 86.06  E-value: 2.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  129 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDINRlvglqntYMGYLD 208
Cdd:PLN02829 437 PKYLSILNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDLK-GNVNGAVETC----GESFHR-------FDRYLN 504

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  209 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 288
Cdd:PLN02829 505 FSNPLISK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLNHDRQLW--KLG---TLPPGLITFWKRTYPLDRSW 578

                        170       180       190
                 ....*....|....*....|....*....|...
gi 13775226  289 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 321
Cdd:PLN02829 579 HVLGLGYNPNVNQRD--IERAAVIHYNGNMKPW 609
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 129-321 1.06e-17

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 84.23  E-value: 1.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  129 PELLQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDlpsaQDINRlvglqntYMGYLD 208
Cdd:PLN02910 455 PKYLSMLNHLRFYLPEVYPKLEKILFLDDDIVVQKDLTPLWSIDMQ-GMVNGAVETCK----ESFHR-------FDKYLN 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  209 YRKKAIKDlGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 288
Cdd:PLN02910 523 FSNPKISE-NFDPNACGWAFGMNMFDLKEWRKRNITGIYHYWQDLNEDRTLW--KLG---SLPPGLITFYNLTYPLDRSW 596

                        170       180       190
                 ....*....|....*....|....*....|...
gi 13775226  289 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 321
Cdd:PLN02910 597 HVLGLGYDPALNQTE--IENAAVVHYNGNYKPW 627
PLN02718 PLN02718
Probable galacturonosyltransferase
 64-321 5.19e-14

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 73.00  E-value: 5.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226   64 ATMAAINSIYSNTD--ANILFYVVGLRNTLTRIRKW----------IEHSKLREINFKIVEFNPMVLKgkirPDSSRPEL 131
Cdd:PLN02718 325 ACSVVVNSTISSSKepEKIVFHVVTDSLNYPAISMWfllnppgkatIQILNIDDMNVLPADYNSLLMK----QNSHDPRY 400

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  132 LQPLNFVRFYLPLLIHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDC--DLPSAQDINRLVGLQNTYMGyldy 209
Cdd:PLN02718 401 ISALNHARFYLPDIFPGLNKIVLFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCleGEPSFRSMDTFINFSDPWVA---- 475

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  210 rKKaikdlgISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSS-SLGGGVATspmlivFHGKYSTINPLW 288
Cdd:PLN02718 476 -KK------FDPKACTWAFGMNLFDLEEWRRQKLTSVYHKYLQLGVKRPLWKAgSLPIGWLT------FYNQTVALDKRW 542

                        250       260       270
                 ....*....|....*....|....*....|...
gi 13775226  289 HIRHLGWNPDARYSEhfLQEAKLLHWNGRHKPW 321
Cdd:PLN02718 543 HVLGLGHESGVGASD--IEQAAVIHYDGVMKPW 573
PLN02769 PLN02769
Probable galacturonosyltransferase
 140-321 2.41e-09

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 58.55  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  140 FYLPLLIHQHEKVIYLDDDVIVQGDIQELYDttLALGH----AAAFsddCDLpsaqdinRLVGLQNtYMGyldyrkkaik 215
Cdd:PLN02769 443 FLLPEIFKKLKKVVVLDDDVVVQRDLSFLWN--LDMGGkvngAVQF---CGV-------RLGQLKN-YLG---------- 499

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  216 DLGISPSTCSFNPGVIVANMTEWKHQRITK---QLEKWMQKNVEENLyssslgGGVATSPMLIVFHgkySTINPL---WH 289
Cdd:PLN02769 500 DTNFDTNSCAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESL------RAAALPASLLTFQ---DLIYPLddrWV 570

                        170       180       190
                 ....*....|....*....|....*....|..
gi 13775226  290 IRHLGWnpDARYSEHFLQEAKLLHWNGRHKPW 321
Cdd:PLN02769 571 LSGLGH--DYGIDEQAIKKAAVLHYNGNMKPW 600
PRK15171 PRK15171
lipopolysaccharide 3-alpha-galactosyltransferase;
146-246 4.58e-07

lipopolysaccharide 3-alpha-galactosyltransferase;


Pssm-ID: 185093 [Multi-domain]  Cd Length: 334  Bit Score: 50.91  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13775226  146 IHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLPSAQdiNRLVGLQNTYM--GYldyrkkaikdlgispst 223
Cdd:PRK15171 118 IDKTDKVLYLDADIACKGSIKELIDLDFAENEIAAVVAEGDAEWWS--KRAQSLQTPGLasGY----------------- 178

                         90       100
                 ....*....|....*....|...
gi 13775226  224 csFNPGVIVANMTEWKHQRITKQ 246
Cdd:PRK15171 179 --FNSGFLLINIPAWAQENISAK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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