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Conserved domains on  [gi|23618922|ref|NP_112340|]
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dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [Rattus norvegicus]

Protein Classification

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1( domain architecture ID 10763433)

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 (PDE1) is a cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
287-515 5.99e-112

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 339.53  E-value: 5.99e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   287 YHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAY 366
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   367 RLLQeDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQ-------PEAIEKPKAL-SLMLHTADIS 438
Cdd:pfam00233  81 QILQ-DEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktldflENEEDRRLLLlSMLIKAADIS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23618922   439 HPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKiVSPLID 515
Cdd:pfam00233 160 NPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPE-LQPLLD 236
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 142-202 5.15e-35

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


:

Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 126.69  E-value: 5.15e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23618922   142 RLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER 202
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
PTZ00121 super family cl31754
MAEBL; Provisional
 603-695 1.59e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtsKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKAdKKDHSNTG 682
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAK--KKAEEAKKAAEAAKAEAEAAADEAEAAEEKA-EAAEKKKE 1374

                          90
                  ....*....|...
gi 23618922   683 NESKKADGTKKRS 695
Cdd:PTZ00121 1375 EAKKKADAAKKKA 1387
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
287-515 5.99e-112

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 339.53  E-value: 5.99e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   287 YHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAY 366
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   367 RLLQeDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQ-------PEAIEKPKAL-SLMLHTADIS 438
Cdd:pfam00233  81 QILQ-DEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktldflENEEDRRLLLlSMLIKAADIS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23618922   439 HPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKiVSPLID 515
Cdd:pfam00233 160 NPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPE-LQPLLD 236
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 142-202 5.15e-35

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 126.69  E-value: 5.15e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23618922   142 RLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER 202
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 287-459 2.40e-14

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 70.83  E-value: 2.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922 287 YHNLMHAADVTQTVHYLLYKTGvanwLTELEIFAIIFSAAIHDYEHTGTTNNFhiqtrsdpailYNDRSVLENHHLSAAY 366
Cdd:cd00077   1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922 367 RLLQEDEemnilvnlskddWREFRTLVIEMVMATDmSCHFQQIKAMKTALQqpEAIEKPKALSLMLHTADISHPAKA--W 444
Cdd:cd00077  66 EILRELL------------LEEVIKLIDELILAVD-ASHHERLDGLGYPDG--LKGEEITLEARIVKLADRLDALRRdsR 130

                       170
                ....*....|....*
gi 23618922 445 DLHHRWTMSLLEEFF 459
Cdd:cd00077 131 EKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 285-450 1.03e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 62.70  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922    285 NPYHNLMHAADVTQTVHYLLYKTGvanwltELEIFAIIFSAAIHDYEHTGTTNNFHIQTrsdpailyndrSVLENHHLSA 364
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922    365 AYRLLQEDEEmNILVNLSKddwrefrtlviemvmaTDMSCHFQQIKAMKTALQQPEAiekpkalsLMLHTADISHPAKAW 444
Cdd:smart00471  64 AEILLEEEEP-RILEEILR----------------TAILSHHERPDGLRGEPITLEA--------RIVKVADRLDALRAD 118


                   ....*.
gi 23618922    445 DLHHRW 450
Cdd:smart00471 119 RRYRRV 124
PTZ00121 PTZ00121
MAEBL; Provisional
 603-695 1.59e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtsKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKAdKKDHSNTG 682
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAK--KKAEEAKKAAEAAKAEAEAAADEAEAAEEKA-EAAEKKKE 1374

                          90
                  ....*....|...
gi 23618922   683 NESKKADGTKKRS 695
Cdd:PTZ00121 1375 EAKKKADAAKKKA 1387
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
287-515 5.99e-112

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 339.53  E-value: 5.99e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   287 YHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAY 366
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   367 RLLQeDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQ-------PEAIEKPKAL-SLMLHTADIS 438
Cdd:pfam00233  81 QILQ-DEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktldflENEEDRRLLLlSMLIKAADIS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23618922   439 HPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR-KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKiVSPLID 515
Cdd:pfam00233 160 NPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPE-LQPLLD 236
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 142-202 5.15e-35

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 126.69  E-value: 5.15e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23618922   142 RLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVER 202
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 287-459 2.40e-14

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 70.83  E-value: 2.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922 287 YHNLMHAADVTQTVHYLLYKTGvanwLTELEIFAIIFSAAIHDYEHTGTTNNFhiqtrsdpailYNDRSVLENHHLSAAY 366
Cdd:cd00077   1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922 367 RLLQEDEemnilvnlskddWREFRTLVIEMVMATDmSCHFQQIKAMKTALQqpEAIEKPKALSLMLHTADISHPAKA--W 444
Cdd:cd00077  66 EILRELL------------LEEVIKLIDELILAVD-ASHHERLDGLGYPDG--LKGEEITLEARIVKLADRLDALRRdsR 130

                       170
                ....*....|....*
gi 23618922 445 DLHHRWTMSLLEEFF 459
Cdd:cd00077 131 EKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 285-450 1.03e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 62.70  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922    285 NPYHNLMHAADVTQTVHYLLYKTGvanwltELEIFAIIFSAAIHDYEHTGTTNNFHIQTrsdpailyndrSVLENHHLSA 364
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922    365 AYRLLQEDEEmNILVNLSKddwrefrtlviemvmaTDMSCHFQQIKAMKTALQQPEAiekpkalsLMLHTADISHPAKAW 444
Cdd:smart00471  64 AEILLEEEEP-RILEEILR----------------TAILSHHERPDGLRGEPITLEA--------RIVKVADRLDALRAD 118


                   ....*.
gi 23618922    445 DLHHRW 450
Cdd:smart00471 119 RRYRRV 124
PTZ00121 PTZ00121
MAEBL; Provisional
 603-695 1.59e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtsKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKAdKKDHSNTG 682
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAK--KKAEEAKKAAEAAKAEAEAAADEAEAAEEKA-EAAEKKKE 1374

                          90
                  ....*....|...
gi 23618922   683 NESKKADGTKKRS 695
Cdd:PTZ00121 1375 EAKKKADAAKKKA 1387
PTZ00121 PTZ00121
MAEBL; Provisional
 603-693 3.61e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtsKGDNPRGKNSKGDKAGEKQQNGDLKDGKnKADKKDHSNTG 682
Cdd:PTZ00121 1466 AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAK--KAAEAKKKADEAKKAEEAKKADEAKKAE-EAKKADEAKKA 1542

                          90
                  ....*....|.
gi 23618922   683 NESKKADGTKK 693
Cdd:PTZ00121 1543 EEKKKADELKK 1553
PTZ00121 PTZ00121
MAEBL; Provisional
 603-695 3.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtsKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKdhsntG 682
Cdd:PTZ00121 1427 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKK--KAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKK-----A 1499

                          90
                  ....*....|...
gi 23618922   683 NESKKADGTKKRS 695
Cdd:PTZ00121 1500 DEAKKAAEAKKKA 1512
PTZ00121 PTZ00121
MAEBL; Provisional
 600-695 3.61e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   600 RLAAEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRTS-----KGDNPRGKNSKGDKAGEKQQNGDLKDGKNKAD 674
Cdd:PTZ00121 1391 KKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAdeakkKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAK 1470

                          90       100
                  ....*....|....*....|..
gi 23618922   675 KKDHSNT-GNESKKADGTKKRS 695
Cdd:PTZ00121 1471 KADEAKKkAEEAKKADEAKKKA 1492
PTZ00121 PTZ00121
MAEBL; Provisional
 603-695 4.50e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtSKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSN-T 681
Cdd:PTZ00121 1387 AEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAK-KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKkK 1465

                          90
                  ....*....|....
gi 23618922   682 GNESKKADGTKKRS 695
Cdd:PTZ00121 1466 AEEAKKADEAKKKA 1479
PTZ00121 PTZ00121
MAEBL; Provisional
 603-693 5.16e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618922   603 AEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRtsKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSNTG 682
Cdd:PTZ00121 1453 AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK--KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKA 1530

                          90
                  ....*....|.
gi 23618922   683 NESKKADGTKK 693
Cdd:PTZ00121 1531 EEAKKADEAKK 1541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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