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Conserved domains on  [gi|20070349|ref|NP_112200|]
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vacuole membrane protein 1 isoform 1 [Homo sapiens]

Protein Classification

SNARE-associated domain-containing protein( domain architecture ID 727)

SNARE-associated domain-containing protein similar to human vacuole membrane protein 1, which is a phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNARE_assoc super family cl00429
SNARE associated Golgi protein; This is a family of SNARE associated Golgi proteins. The yeast ...
 247-298 1.74e-06

SNARE associated Golgi protein; This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.


The actual alignment was detected with superfamily member pfam09335:

Pssm-ID: 469768  Cd Length: 120  Bit Score: 46.49  E-value: 1.74e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20070349   247 AVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAI 298
Cdd:pfam09335  58 KVERLLEKYGFLALLLLRLIPGVPRDLVNYAAGATRVPFRRFFLATLLGSIP 109
 
Name Accession Description Interval E-value
SNARE_assoc pfam09335
SNARE associated Golgi protein; This is a family of SNARE associated Golgi proteins. The yeast ...
 247-298 1.74e-06

SNARE associated Golgi protein; This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.


Pssm-ID: 430535  Cd Length: 120  Bit Score: 46.49  E-value: 1.74e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20070349   247 AVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAI 298
Cdd:pfam09335  58 KVERLLEKYGFLALLLLRLIPGVPRDLVNYAAGATRVPFRRFFLATLLGSIP 109
YqaA COG1238
Uncharacterized membrane protein YqaA, VTT domain [Function unknown];
196-298 3.82e-03

Uncharacterized membrane protein YqaA, VTT domain [Function unknown];


Pssm-ID: 440851  Cd Length: 162  Bit Score: 37.88  E-value: 3.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070349 196 IGTAIGELPPYFMARAARLSGAEPDDEEYqEFEEMLEHAesaqdfasraklavQKLVQKVGFFGILACASIPNPlFDLAG 275
Cdd:COG1238  60 LGSVLGGLVGYAIGRFLFEAVGRPLLERY-GKEEKLERA--------------QAWFRRYGFWALLLAGWTPIP-GDVLT 123

                        90       100
                ....*....|....*....|...
gi 20070349 276 ITCGHFLVPFWTFFGATLIGKAI 298
Cdd:COG1238 124 IAAGVLRLPLWPFLLASLIGRGA 146
 
Name Accession Description Interval E-value
SNARE_assoc pfam09335
SNARE associated Golgi protein; This is a family of SNARE associated Golgi proteins. The yeast ...
 247-298 1.74e-06

SNARE associated Golgi protein; This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.


Pssm-ID: 430535  Cd Length: 120  Bit Score: 46.49  E-value: 1.74e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20070349   247 AVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAI 298
Cdd:pfam09335  58 KVERLLEKYGFLALLLLRLIPGVPRDLVNYAAGATRVPFRRFFLATLLGSIP 109
YqaA COG1238
Uncharacterized membrane protein YqaA, VTT domain [Function unknown];
196-298 3.82e-03

Uncharacterized membrane protein YqaA, VTT domain [Function unknown];


Pssm-ID: 440851  Cd Length: 162  Bit Score: 37.88  E-value: 3.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070349 196 IGTAIGELPPYFMARAARLSGAEPDDEEYqEFEEMLEHAesaqdfasraklavQKLVQKVGFFGILACASIPNPlFDLAG 275
Cdd:COG1238  60 LGSVLGGLVGYAIGRFLFEAVGRPLLERY-GKEEKLERA--------------QAWFRRYGFWALLLAGWTPIP-GDVLT 123

                        90       100
                ....*....|....*....|...
gi 20070349 276 ITCGHFLVPFWTFFGATLIGKAI 298
Cdd:COG1238 124 IAAGVLRLPLWPFLLASLIGRGA 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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