second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 254 RGDLGELPFPCPDGfSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaASGDPPVVTLHDISPDIFIHV 333
Cdd:cd18296    1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172088123 334 LYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLE 377
Cdd:cd18296   78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

Ankyrin repeat [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123   6 LFASCRKGDVGRVRYLLEqRDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCLYGALSDPIRRAL 85
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         90       100       110
                 ....*....|....*....|....*....|...
gi 172088123  86 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 118
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 254 RGDLGELPFPCPDGfSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaASGDPPVVTLHDISPDIFIHV 333
Cdd:cd18296    1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172088123 334 LYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLE 377
Cdd:cd18296   78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123  105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGveh 184
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISE--- 77

                          90       100
                  ....*....|....*....|....*...
gi 172088123  185 vsdcERLAKQCQLWDLL--DDLEAKCEK 210
Cdd:pfam00651  78 ----ENVDDLLAAADKLqiPSLVDKCEE 101

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123   116 DVVFVVHGKPFRAHRCILGARSTYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 193
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 172088123   194 QCQLWDLLDDLEAKCEK 210
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95

Ankyrin repeat [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123   6 LFASCRKGDVGRVRYLLEqRDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCLYGALSDPIRRAL 85
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         90       100       110
                 ....*....|....*....|....*....|...
gi 172088123  86 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 118
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 269 SSCPD-ICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEepaasgdppvVTL-HDIspDIFIHVLYYVYSDHTELPP 346
Cdd:PHA03098   8 KFCDEsIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE----------INLnIDY--DSFNEVIKYIYTGKINITS 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 172088123 347 ELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDF 417
Cdd:PHA03098  76 NNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDF 146

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.

                           10        20
                   ....*....|....*....|....*....
gi 172088123    36 DSTPLYYACLCGHEELVRYLLANGARCEA 64
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 254 RGDLGELPFPCPDGfSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaASGDPPVVTLHDISPDIFIHV 333
Cdd:cd18296    1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 172088123 334 LYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLE 377
Cdd:cd18296   78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 114 HSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 193
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                 ..
gi 172088123 194 QC 195
Cdd:cd18186   81 KL 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 269 SSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaasgdpPVVTLHDISPDIFIHVLYYVYSDHTELPPEL 348
Cdd:cd18286   15 GEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNS-------SEITLTGVSHAAVSFVLLFIYGGVLDLPDDV 87

                         90       100
                 ....*....|....*....|
gi 172088123 349 -AYDVLSVADMYLLPGLKRL 367
Cdd:cd18286   88 nLGELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 273 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPaasgdppVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 352
Cdd:cd18186    3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSS-------EIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                 ....*..
gi 172088123 353 LSVADMY 359
Cdd:cd18186   76 LAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 103 DFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDI 180
Cdd:cd18287   11 EDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMResQQSEIELKD--TNAEAFKALLKYIYTGRLTL 88

                         90
                 ....*....|....*..
gi 172088123 181 G---VEHVSDCERLAKQ 194
Cdd:cd18287   89 TdlkEDVLLDVLGLAHQ 105

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123   116 DVVFVVHGKPFRAHRCILGARSTYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYTGRLDIGVEHVSDCERLAK 193
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 172088123   194 QCQLWDLLDDLEAKCEK 210
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 172088123 102 DDFLQrLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI 180
Cdd:cd18286    6 KDLLQ-LFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDL 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 273 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQEseepaasGDPPVVTLHDISPDIFIHVLYYVYSDHTE---LPPELA 349
Cdd:cd18297   14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTE-------AQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 172088123 350 YDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 380
Cdd:cd18297   87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 115 SDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQ 194
Cdd:cd18297   13 SDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALELLRA 92

                         90
                 ....*....|....*
gi 172088123 195 CQLWdLLDDLEAKCE 209
Cdd:cd18297   93 ASFF-QLDGLKRHCE 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 114 HSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLD------IGVEHVSD 187
Cdd:cd18298   12 TSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDlppedaIGLLDLAN 91

                         90
                 ....*....|..
gi 172088123 188 C---ERLAKQCQ 196
Cdd:cd18298   92 SyceERLKKLCE 103

Ankyrin repeat [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123   6 LFASCRKGDVGRVRYLLEqRDVEVNVRDKWDSTPLYYACLCGHEELVRYLLANGARCEANTFDGERCLYGALSDPIRRAL 85
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         90       100       110
                 ....*....|....*....|....*....|...
gi 172088123  86 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 118
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKG---KSVVVLRHPLINPVAFGALLQYLYTGRLDIG 181
Cdd:cd18292    8 IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSeskQSEIELVEDPECAAVFEKFLRYLYTGQISVN 87

                         90
                 ....*....|....*....
gi 172088123 182 VEHVSDCERLAKQCQLWDL 200
Cdd:cd18292   88 LETALPLLMLADKYNVTDL 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 105 LQRLLEQGIHSDVVFVV-HGKPFRAHRCILGARSTYFANMLDTKwkgksVVVLRHPLINPVAFGALLQYLYTGRLDIgve 183
Cdd:cd18299    3 LRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFLMM-----TVVTLDSDITPEAFRRVLEFLYTGVLDE--- 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 172088123 184 hvsDCERLAKQCQLWDLLD--DLEAKCEKV 211
Cdd:cd18299   75 ---NEDDLKELKDAAELLElfDLVMMCTNV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 273 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaasgdpPVVTLHDISPDIFIHVLYYVYSDH---TELPPELA 349
Cdd:cd18287   24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQ-------SEIELKDTNAEAFKALLKYIYTGRltlTDLKEDVL 96

                         90
                 ....*....|....*.
gi 172088123 350 YDVLSVADMYLLPGLK 365
Cdd:cd18287   97 LDVLGLAHQYGFEELE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEH 184
Cdd:cd18256   11 LNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSN 90

                         90
                 ....*....|....*...
gi 172088123 185 VSDCERLAKQCQLWDLLD 202
Cdd:cd18256   91 VQELLVAADMLQLTEVVE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 246 DCALPSELrGDLGElpfpcpdgFSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPAasgdppvVTLHDI 325
Cdd:cd18279    2 ECRLAEDL-GNLWE--------NSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR-------VEINDV 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 172088123 326 SPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 380
Cdd:cd18279   66 DPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANML--DTKWKGKSVVVLRHplINPVAFGALLQYLYTGRLDIGV 182
Cdd:cd18242   12 MNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsEMSEKGKSEVELQG--LTASTMEILLDFVYTETVHVTV 89

                 ....*
gi 172088123 183 EHVSD 187
Cdd:cd18242   90 ENVQE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLdtKWKGKSVVVLRHpLINPVAFGALLQYLYTGRLDIGVEH 184
Cdd:cd18210   12 LNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQV--LLKNMSSISLPG-VMDPGAFESVLASAYTGKLTMLADE 88

                         90       100
                 ....*....|....*....|....
gi 172088123 185 VSDCERLAKQCQLWDLLDdleaKC 208
Cdd:cd18210   89 IVNYLTVGSVLQMWHIVD----KC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 172088123 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI 180
Cdd:cd18331   15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNL 90

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 273 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaasgdpPVVTLHDISPDIFIHVLYYVYSDHTELPPEL-AYD 351
Cdd:cd18300   11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-------KEVELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                         90
                 ....*....|....*..
gi 172088123 352 VLSVADMYLLPGLKRLC 368
Cdd:cd18300   84 LIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 172088123 105 LQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEH 184
Cdd:cd18306    9 LNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADL 88

                         90
                 ....*....|
gi 172088123 185 VSDCERLAKQ 194
Cdd:cd18306   89 VKSVYSAAKK 98