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Conserved domains on  [gi|70608131|ref|NP_083949|]
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MICOS complex subunit Mic60 isoform 1 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-745 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 569.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKtecpntnegkstsetteeafsssvrerppeeva 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAK--------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   203 arlAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKe 282
Cdd:pfam09731 117 ---AQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   283 rrkavdeaadallkakeelEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 362
Cdd:pfam09731 193 -------------------EKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   363 QARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKR 442
Cdd:pfam09731 254 SERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELD 326

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   443 TFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 518
Cdd:pfam09731 327 KLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEE 406

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   519 QElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAI 598
Cdd:pfam09731 407 ER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKAL 475

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   599 RVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAE 678
Cdd:pfam09731 476 KELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GE 551

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70608131   679 LYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 745
Cdd:pfam09731 552 ADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-745 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 569.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKtecpntnegkstsetteeafsssvrerppeeva 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAK--------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   203 arlAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKe 282
Cdd:pfam09731 117 ---AQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   283 rrkavdeaadallkakeelEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 362
Cdd:pfam09731 193 -------------------EKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   363 QARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKR 442
Cdd:pfam09731 254 SERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELD 326

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   443 TFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 518
Cdd:pfam09731 327 KLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEE 406

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   519 QElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAI 598
Cdd:pfam09731 407 ER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKAL 475

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   599 RVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAE 678
Cdd:pfam09731 476 KELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GE 551

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70608131   679 LYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 745
Cdd:pfam09731 552 ADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 271-568 7.56e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 7.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 350
Cdd:COG1196 232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 351 AKVVSQYHELVVQARDDFRKELDSITpditpgwkgMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 430
Cdd:COG1196 304 IARLEERRRELEERLEELEEELAELE---------EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 431 LALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 510
Cdd:COG1196 375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70608131 511 GLSEKLSEQELEFRRRS----QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
Cdd:COG1196 455 EEEEEALLELLAELLEEaallEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
PTZ00121 PTZ00121
MAEBL; Provisional
 159-568 4.66e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   159 APAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQvemESLAKSLEDALNRTSSVTLQTI 238
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA---EAAADEAEAAEEKAEAAEKKKE 1374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   239 TAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQwrTVEGALKERRKAvDEA---ADALLKAKEelekMKTIIEDAKKRE 315
Cdd:PTZ00121 1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD--ELKKAAAAKKKA-DEAkkkAEEKKKADE----AKKKAEEAKKAD 1447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   316 IAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQArDDFRKELDSITPDITPGWKGMSISDLAGKL 395
Cdd:PTZ00121 1448 EAKK----KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA-EEAKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   396 STDDLNSliAHAHRRIDQLNRELAQQKATE---KQHIELALEKHKLEEKRTFD---------SAVAKALEHHRSE----- 458
Cdd:PTZ00121 1523 KADEAKK--AEEAKKADEAKKAEEKKKADElkkAEELKKAEEKKKAEEAKKAEedknmalrkAEEAKKAEEARIEevmkl 1600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   459 ------IQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGL--SEKLSEQELEFRRRSQEQ 530
Cdd:PTZ00121 1601 yeeekkMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikAAEEAKKAEEDKKKAEEA 1680

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 70608131   531 MDSFTLDINTAYARLRGIEQAVQSHAV---AEEEARKAHQL 568
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAEELkkkEAEEKKKAEEL 1721
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 220-554 2.30e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    220 AKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAVDE 289
Cdd:TIGR02168  628 VDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKALAE 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    290 AADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 369
Cdd:TIGR02168  703 LRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    370 KELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK-----------HKL 438
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsedieslaAEI 861

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    439 EEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELKYEFE 509
Cdd:TIGR02168  862 EELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLEVRID 939

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 70608131    510 QgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 554
Cdd:TIGR02168  940 N-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-745 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 569.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKtecpntnegkstsetteeafsssvrerppeeva 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAK--------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   203 arlAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKe 282
Cdd:pfam09731 117 ---AQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   283 rrkavdeaadallkakeelEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 362
Cdd:pfam09731 193 -------------------EKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   363 QARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKR 442
Cdd:pfam09731 254 SERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELD 326

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   443 TFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 518
Cdd:pfam09731 327 KLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEE 406

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   519 QElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAI 598
Cdd:pfam09731 407 ER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKAL 475

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   599 RVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAE 678
Cdd:pfam09731 476 KELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GE 551

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70608131   679 LYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 745
Cdd:pfam09731 552 ADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 271-568 7.56e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 7.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 350
Cdd:COG1196 232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 351 AKVVSQYHELVVQARDDFRKELDSITpditpgwkgMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 430
Cdd:COG1196 304 IARLEERRRELEERLEELEEELAELE---------EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 431 LALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 510
Cdd:COG1196 375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70608131 511 GLSEKLSEQELEFRRRS----QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
Cdd:COG1196 455 EEEEEALLELLAELLEEaallEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
271-499 3.38e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 3.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 346
Cdd:COG4913  692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  347 ------AQSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG-----------WKGMSIS 389
Cdd:COG4913  770 nleeriDALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerfkellneNSIEFVA 849

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  390 DLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEE 469
Cdd:COG4913  850 DLLSKLRRA-----IREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAA 924

                        250       260       270
                 ....*....|....*....|....*....|.
gi 70608131  470 VRDAMEnemrtQLRRQAAAHTDH-LRDVLKV 499
Cdd:COG4913  925 LKRLIE-----RLRSEEEESDRRwRARVLDV 950
PTZ00121 PTZ00121
MAEBL; Provisional
 159-568 4.66e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   159 APAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQvemESLAKSLEDALNRTSSVTLQTI 238
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA---EAAADEAEAAEEKAEAAEKKKE 1374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   239 TAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQwrTVEGALKERRKAvDEA---ADALLKAKEelekMKTIIEDAKKRE 315
Cdd:PTZ00121 1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD--ELKKAAAAKKKA-DEAkkkAEEKKKADE----AKKKAEEAKKAD 1447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   316 IAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQArDDFRKELDSITPDITPGWKGMSISDLAGKL 395
Cdd:PTZ00121 1448 EAKK----KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA-EEAKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   396 STDDLNSliAHAHRRIDQLNRELAQQKATE---KQHIELALEKHKLEEKRTFD---------SAVAKALEHHRSE----- 458
Cdd:PTZ00121 1523 KADEAKK--AEEAKKADEAKKAEEKKKADElkkAEELKKAEEKKKAEEAKKAEedknmalrkAEEAKKAEEARIEevmkl 1600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   459 ------IQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGL--SEKLSEQELEFRRRSQEQ 530
Cdd:PTZ00121 1601 yeeekkMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikAAEEAKKAEEDKKKAEEA 1680

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 70608131   531 MDSFTLDINTAYARLRGIEQAVQSHAV---AEEEARKAHQL 568
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAEELkkkEAEEKKKAEEL 1721
PTZ00121 PTZ00121
MAEBL; Provisional
 199-568 1.04e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   199 EEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEG 278
Cdd:PTZ00121 1408 DELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKAD 1486

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   279 ALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSE-AKVV 354
Cdd:PTZ00121 1487 EAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEeKKKA 1566

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   355 SQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLiAHAHRRIDQLNRELAQQKATEKQHIELALE 434
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEE 1645

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   435 KHKLEE--KRTFDSAVAKALEHHRSEiqaEQDRKVEEVRDAMENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGL 512
Cdd:PTZ00121 1646 KKKAEElkKAEEENKIKAAEEAKKAE---EDKKKAEEAKKAEEDEK-------------------KAAEALKKEAEEAKK 1703

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 70608131   513 SEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQAVQShavAEEEARKAHQL 568
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKA-------EEENKIKAEEAKKE---AEEDKKKAEEA 1749
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 220-554 2.30e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    220 AKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAVDE 289
Cdd:TIGR02168  628 VDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKALAE 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    290 AADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 369
Cdd:TIGR02168  703 LRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    370 KELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK-----------HKL 438
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsedieslaAEI 861

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    439 EEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELKYEFE 509
Cdd:TIGR02168  862 EELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLEVRID 939

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 70608131    510 QgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 554
Cdd:TIGR02168  940 N-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 199-519 3.91e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 3.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    199 EEVAARLAQQEKQEQ----VEMESLAKSLEDALN---RTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSA 271
Cdd:pfam12128  641 ETFARTALKNARLDLrrlfDEKQSEKDKKNKALAerkDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQA 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    272 QWRTVEGALKERRKAVDEAADAL-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQS 349
Cdd:pfam12128  719 YWQVVEGALDAQLALLKAAIAARrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVR 790

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    350 EAKVVSQ---YHELVVQARDDFRKELDSITpditpgwkgMSISDLagklsTDDLNSLIAHAHRRIDQLNRELaqqKATEK 426
Cdd:pfam12128  791 RQEVLRYfdwYQETWLQRRPRLATQLSNIE---------RAISEL-----QQQLARLIADTKLRRAKLEMER---KASEK 853

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    427 QHIELALEKHKLeekRTFDSAVAKALEHHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQ 502
Cdd:pfam12128  854 QQVRLSENLRGL---RCEMSKLATLKEDANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSG 925

                          330
                   ....*....|....*..
gi 70608131    503 ELKYEFEQGLSEKLSEQ 519
Cdd:pfam12128  926 SGLAETWESLREEDHYQ 942
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 199-522 7.86e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 7.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 199 EEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGE-----KKSAQW 273
Cdd:COG1196 441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEgvkaaLLLAGL 519

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 274 RTVEGAL-------KERRKAVDEAADALLKAK--EELEKMKTIIEDAKKREIAGAT--PHITAAEGRLHNMIVDLDNVVK 342
Cdd:COG1196 520 RGLAGAVavligveAAYEAALEAALAAALQNIvvEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGA 599

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 343 KVQAAQSEAkvvsQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQK 422
Cdd:COG1196 600 AVDLVASDL----READARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 423 ATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEvrdamENEMRTQLRRQAAAHTDHLRDVLKVQEQ 502
Cdd:COG1196 676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELE-----EEALEEQLEAEREELLEELLEEEELLEE 750

                       330       340
                ....*....|....*....|
gi 70608131 503 ELKYEFEQGLSEKLSEQELE 522
Cdd:COG1196 751 EALEELPEPPDLEELERELE 770
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 448-567 1.00e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 43.12  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   448 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 527
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 70608131   528 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 567
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
279-544 1.13e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.68  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  279 ALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAgatpHITAAE--------GRLHNMIVDLDNVVKKVQAAQSE 350
Cdd:COG4913  611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREA----LQRLAEyswdeidvASAEREIAELEAELERLDASSDD 686

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  351 AKVVSQYHELVVQARDDFRKELDSItpditpgwkgmsiSDLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIE 430
Cdd:COG4913  687 LAALEEQLEELEAELEELEEELDEL-------------KGEIGRLEKE-----LEQAEEELDELQDRLEAAEDLARLELR 748

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  431 LALEKHKLEE-KRTFDSAVAKALEHHRSEIQAEQDRKveevRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFE 509
Cdd:COG4913  749 ALLEERFAAAlGDAVERELRENLEERIDALRARLNRA----EEELERAMRAFNREWPAETADLDADLESLPEYLALLDRL 824

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 70608131  510 QglSEKLSEQELEFRRRSQEQMDSFTLDINTAYAR 544
Cdd:COG4913  825 E--EDGLPEYEERFKELLNENSIEFVADLLSKLRR 857
PTZ00121 PTZ00121
MAEBL; Provisional
 186-534 1.28e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   186 EEAFSSSVRERPPEEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIA 265
Cdd:PTZ00121 1434 DEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   266 GEKKSAQWRTVEGALK-ERRKAVDEA--------ADALLKAkEELEKMKTI--IEDAKKREIAGATPHITA-----AEGR 329
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKaEEAKKADEAkkaeekkkADELKKA-EELKKAEEKkkAEEAKKAEEDKNMALRKAeeakkAEEA 1592

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   330 LHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKG---MSISDLAGKLSTDDLNSLIAH 406
Cdd:PTZ00121 1593 RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKaeeLKKAEEENKIKAAEEAKKAEE 1672

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   407 AHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEiQAEQDRKVEEVRDAMENEMRT--QLRR 484
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-EEENKIKAEEAKKEAEEDKKKaeEAKK 1751

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 70608131   485 QAAAHTD--HLRDVLKVQEQELKYE----FEQGLSEKLSEQELEFRRRSQEQMDSF 534
Cdd:PTZ00121 1752 DEEEKKKiaHLKKEEEKKAEEIRKEkeavIEEELDEEDEKRRMEVDKKIKDIFDNF 1807
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 398-566 5.07e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 5.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    398 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 463
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    464 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 531
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 70608131    532 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 566
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
144-554 8.02e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 8.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  144 AAQIISAAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPP------EEVAARLAQQEKqEQVEME 217
Cdd:PRK02224 232 ARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRErleeleEERDDLLAEAGL-DDADAE 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  218 SLAKSLEDALNRTSSVTlQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEgalkerrKAVDEAADALLKA 297
Cdd:PRK02224 311 AVEARREELEDRDEELR-DRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELE-------SELEEAREAVEDR 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  298 KEELEKMKTIIEDAKKR------EIAGATPH---ITAAEGRLHNMIVDL-------DNVVKKVQAAQSEAK--------- 352
Cdd:PRK02224 383 REEIEELEEEIEELRERfgdapvDLGNAEDFleeLREERDELREREAELeatlrtaRERVEEAEALLEAGKcpecgqpve 462

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  353 ------VVSQYHELVVQ---ARDDFRKELDSITPDITPGWKGMSISDLAGKLST--DDLNSLIAHAHRRIDQlNRELAQQ 421
Cdd:PRK02224 463 gsphveTIEEDRERVEEleaELEDLEEEVEEVEERLERAEDLVEAEDRIERLEErrEDLEELIAERRETIEE-KRERAEE 541

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  422 KATEKQHIELALEKHKLEEKRTFDSA-----VAKALEHHRSEIQAEQDR--KVEEVRDAMEN-----EMRTQLRRQAAAH 489
Cdd:PRK02224 542 LRERAAELEAEAEEKREAAAEAEEEAeeareEVAELNSKLAELKERIESleRIRTLLAAIADaedeiERLREKREALAEL 621

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70608131  490 TDHLRDVLKVqeqelKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQS 554
Cdd:PRK02224 622 NDERRERLAE-----KRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQA 681
PTZ00121 PTZ00121
MAEBL; Provisional
 409-585 1.16e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   409 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 487
Cdd:PTZ00121 1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   488 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 567
Cdd:PTZ00121 1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                         170
                  ....*....|....*...
gi 70608131   568 LWLSVEALKYSMKTSSAE 585
Cdd:PTZ00121 1371 KKKEEAKKKADAAKKKAE 1388
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
405-548 1.40e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  405 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 479
Cdd:COG4913  647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131  480 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 548
Cdd:COG4913  723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
512-746 2.42e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 40.42  E-value: 2.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 512 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 591
Cdd:COG4223  39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 592 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 671
Cdd:COG4223 110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70608131 672 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 746
Cdd:COG4223 180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 417-589 3.40e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.88  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   417 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 496
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131   497 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 570
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 70608131   571 SVEALK--YSMKTSSAEMPTI 589
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 416-565 3.47e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 3.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 416 RELaQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRdamenEMRTQLRRQAAAHTDHLRD 495
Cdd:COG1196 216 REL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELE-----ELRLELEELELELEEAQAE 289

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 496 VLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 565
Cdd:COG1196 290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 412-530 5.14e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131    412 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 491
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 70608131    492 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 530
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 290-527 5.19e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.75  E-value: 5.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 290 AADALLKAKEELEKMKTIIEdAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 369
Cdd:COG4942  18 QADAAAEAEAELEQLQQEIA-ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 370 KELDSITPDITP----GWKGMSISDLAGKLSTDDLNSLIAHAhRRIDQLNRELAQQ-KATEKQHIELALEKHKLEEKRTF 444
Cdd:COG4942  97 AELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRL-QYLKYLAPARREQaEELRADLAELAALRAELEAERAE 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 445 DSAVAKALEHHRSEIQAEQDRKveevrdameNEMRTQLRRQAAAHTDHLRDvLKVQEQELkyefeQGLSEKLSEQELEFR 524
Cdd:COG4942 176 LEALLAELEEERAALEALKAER---------QKLLARLEKELAELAAELAE-LQQEAEEL-----EALIARLEAEAAAAA 240


                ...
gi 70608131 525 RRS 527
Cdd:COG4942 241 ERT 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 199-568 7.60e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 7.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 199 EEVAARLAQQEKQEQVEMESLAKSLEDALnrtssvtlQTITAQNAAVQAVKAHSNILKtamdnSEIAGEKKSAQwrtveg 278
Cdd:COG1196 245 EAELEELEAELEELEAELAELEAELEELR--------LELEELELELEEAQAEEYELL-----AELARLEQDIA------ 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 279 ALKERRKAVDEAADALLKAKEELEKmktiiedakkreiagatpHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 358
Cdd:COG1196 306 RLEERRRELEERLEELEEELAELEE------------------ELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 359 ELVVQARDDFRKELDsitpditpgwkgmsisdlagklstDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKL 438
Cdd:COG1196 368 LEAEAELAEAEEELE------------------------ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL 423

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70608131 439 EEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 518
Cdd:COG1196 424 EELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADY 503

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 70608131 519 QELEFRRRSQEQMDSFTLdINTAYARLRGIEQAVQSHAVAEEEARKAHQL 568
Cdd:COG1196 504 EGFLEGVKAALLLAGLRG-LAGAVAVLIGVEAAYEAALEAALAAALQNIV 552
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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