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Conserved domains on  [gi|124249226|ref|NP_082852|]
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calmodulin-lysine N-methyltransferase isoform 1 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 113-278 4.58e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 74.68  E-value: 4.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226  113 EDVLTSFDNTGNVC---IWPSEEVLAHYCLK------HSHIFRDLAVCELGGGmTCLAGLMVAISADVKEVLLTDgNEKA 183
Cdd:pfam10294   4 NPGLRIEEDTGNGIgghVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSG-TGLVGIAVALLLPGASVTITD-LEEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226  184 IRNVDSIIACNKKTGvfktpKISSRVLRWDNETDVSQLEGH-FDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAP 262
Cdd:pfam10294  82 LELLKKNIELNALSS-----KVVVKVLDWGENLPPDLFDGHpVDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYK 156

                         170
                  ....*....|....*.
gi 124249226  263 RRGNTFNQFCNLAEKA 278
Cdd:pfam10294 157 KRREAEKKFFKLLERF 172
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 113-278 4.58e-16

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 74.68  E-value: 4.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226  113 EDVLTSFDNTGNVC---IWPSEEVLAHYCLK------HSHIFRDLAVCELGGGmTCLAGLMVAISADVKEVLLTDgNEKA 183
Cdd:pfam10294   4 NPGLRIEEDTGNGIgghVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSG-TGLVGIAVALLLPGASVTITD-LEEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226  184 IRNVDSIIACNKKTGvfktpKISSRVLRWDNETDVSQLEGH-FDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAP 262
Cdd:pfam10294  82 LELLKKNIELNALSS-----KVVVKVLDWGENLPPDLFDGHpVDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYK 156

                         170
                  ....*....|....*.
gi 124249226  263 RRGNTFNQFCNLAEKA 278
Cdd:pfam10294 157 KRREAEKKFFKLLERF 172
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 150-259 2.54e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.02  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226 150 VCELGGGMTCLAglMVAISADVKEVLLTDGNEKAIRNVDSIIACNKKTGVfktpkissRVLRWDNETDVSQLEGHFDIVM 229
Cdd:cd02440    2 VLDLGCGTGALA--LALASGPGARVTGVDISPVALELARKAAAALLADNV--------EVLKGDAEELPPEADESFDVII 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 124249226 230 CADCL-FLDQYRASLVDAIKRLLQPTGKAVV 259
Cdd:cd02440   72 SDPPLhHLVEDLARFLEEARRLLKPGGVLVL 102
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 217-281 7.09e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.51  E-value: 7.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124249226 217 DVSQL---EGHFDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAPRRGNTFnQFCNLAEKAGFS 281
Cdd:COG2226   77 DAEDLpfpDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLA-ELEELLAEAGFE 143
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 113-278 4.58e-16

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 74.68  E-value: 4.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226  113 EDVLTSFDNTGNVC---IWPSEEVLAHYCLK------HSHIFRDLAVCELGGGmTCLAGLMVAISADVKEVLLTDgNEKA 183
Cdd:pfam10294   4 NPGLRIEEDTGNGIgghVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSG-TGLVGIAVALLLPGASVTITD-LEEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226  184 IRNVDSIIACNKKTGvfktpKISSRVLRWDNETDVSQLEGH-FDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAP 262
Cdd:pfam10294  82 LELLKKNIELNALSS-----KVVVKVLDWGENLPPDLFDGHpVDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYK 156

                         170
                  ....*....|....*.
gi 124249226  263 RRGNTFNQFCNLAEKA 278
Cdd:pfam10294 157 KRREAEKKFFKLLERF 172
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 150-259 2.54e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.02  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249226 150 VCELGGGMTCLAglMVAISADVKEVLLTDGNEKAIRNVDSIIACNKKTGVfktpkissRVLRWDNETDVSQLEGHFDIVM 229
Cdd:cd02440    2 VLDLGCGTGALA--LALASGPGARVTGVDISPVALELARKAAAALLADNV--------EVLKGDAEELPPEADESFDVII 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 124249226 230 CADCL-FLDQYRASLVDAIKRLLQPTGKAVV 259
Cdd:cd02440   72 SDPPLhHLVEDLARFLEEARRLLKPGGVLVL 102
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 217-281 7.09e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.51  E-value: 7.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124249226 217 DVSQL---EGHFDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAPRRGNTFnQFCNLAEKAGFS 281
Cdd:COG2226   77 DAEDLpfpDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLA-ELEELLAEAGFE 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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