NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|74315969|ref|NP_082814|]
View 

zinc finger protein 974 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-500 2.89e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 2.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 125 KPYECEECGKAFRLPQQLTRHQKFHSGEKPFECN--ECGKAFHLPDLLKYHKTIHTGEKPFEC-----------RECGLY 191
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskaSSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 192 RIIHADVKPYKCSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQ----------------------LTRHQN 249
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 250 IHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLV 329
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 330 EHRLIHADV-------KPHKCNECGKAFKRNKSLMQHQ--KIHSGE--RPFQC--QECGKAFIVLAHLTRHQTIHTGEKS 396
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 397 FECK--ECGKKFRTATH-----LVQHQSIHTGEKPFECNV--CGKAFRLQIYLSEHQKTHM--EAKHFECNICGKVFRLQ 465
Cdd:COG5048 352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....*
gi 74315969 466 VYLSEHQKTHTEEKPFKCKLCGSAFRSKyQLSKHH 500
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-707 3.67e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 337 DVKPHKCNECGKAFKRNKSLMQHQKIHSGERPFQC--QECGKAFIVLAHLTRHQTIHTGEKSFECK-------------- 400
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassss 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 401 --ECGKKFRTATHLVQHQSIHTGEKPFECNVCGKAFRLQIYLSEHQKTHMEAK-----HFECNICGKVFRLQVYLSE--H 471
Cdd:COG5048 110 lsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslHPPLPANSLSKDPSSNLSLliS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 472 QKTHTEEKPFKCKLCGSAFRSKYQLSKHHTVHTDEKPYQCKECGKCFRQRSNftdHQSIHTGKKPFQCKECGKFYRLNTL 551
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL---SQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 552 LIRHQKSHSSER----------PYECKECGKAFHLPSELNNHQ--IVHTS--NRPFECKV--CGKSFKRESTLIQHMAIH 615
Cdd:COG5048 267 TASSQSSSPNESdsssekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 616 SGVKSYECKECGKGFIHRSSL-------LHHRKIHSDEKPFKC--QECGKAFVVLAYLTRH--QSIHTGEKSFECQHCGS 684
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSK 426

                       410       420
                ....*....|....*....|...
gi 74315969 685 AFRYKSQLSKHQRIHTDVRLFQC 707
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLC 449
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-500 2.89e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 2.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 125 KPYECEECGKAFRLPQQLTRHQKFHSGEKPFECN--ECGKAFHLPDLLKYHKTIHTGEKPFEC-----------RECGLY 191
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskaSSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 192 RIIHADVKPYKCSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQ----------------------LTRHQN 249
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 250 IHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLV 329
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 330 EHRLIHADV-------KPHKCNECGKAFKRNKSLMQHQ--KIHSGE--RPFQC--QECGKAFIVLAHLTRHQTIHTGEKS 396
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 397 FECK--ECGKKFRTATH-----LVQHQSIHTGEKPFECNV--CGKAFRLQIYLSEHQKTHM--EAKHFECNICGKVFRLQ 465
Cdd:COG5048 352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....*
gi 74315969 466 VYLSEHQKTHTEEKPFKCKLCGSAFRSKyQLSKHH 500
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-707 3.67e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 337 DVKPHKCNECGKAFKRNKSLMQHQKIHSGERPFQC--QECGKAFIVLAHLTRHQTIHTGEKSFECK-------------- 400
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassss 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 401 --ECGKKFRTATHLVQHQSIHTGEKPFECNVCGKAFRLQIYLSEHQKTHMEAK-----HFECNICGKVFRLQVYLSE--H 471
Cdd:COG5048 110 lsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslHPPLPANSLSKDPSSNLSLliS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 472 QKTHTEEKPFKCKLCGSAFRSKYQLSKHHTVHTDEKPYQCKECGKCFRQRSNftdHQSIHTGKKPFQCKECGKFYRLNTL 551
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL---SQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 552 LIRHQKSHSSER----------PYECKECGKAFHLPSELNNHQ--IVHTS--NRPFECKV--CGKSFKRESTLIQHMAIH 615
Cdd:COG5048 267 TASSQSSSPNESdsssekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 616 SGVKSYECKECGKGFIHRSSL-------LHHRKIHSDEKPFKC--QECGKAFVVLAYLTRH--QSIHTGEKSFECQHCGS 684
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSK 426

                       410       420
                ....*....|....*....|...
gi 74315969 685 AFRYKSQLSKHQRIHTDVRLFQC 707
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-294 5.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.33e-03
                          10        20
                  ....*....|....*....|...
gi 74315969   272 LTRHQKSHSGEKPFKCNECGKAF 294
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-500 2.89e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 2.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 125 KPYECEECGKAFRLPQQLTRHQKFHSGEKPFECN--ECGKAFHLPDLLKYHKTIHTGEKPFEC-----------RECGLY 191
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskaSSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 192 RIIHADVKPYKCSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQ----------------------LTRHQN 249
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 250 IHTGEKSFECHECGKAFRLPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLV 329
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 330 EHRLIHADV-------KPHKCNECGKAFKRNKSLMQHQ--KIHSGE--RPFQC--QECGKAFIVLAHLTRHQTIHTGEKS 396
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 397 FECK--ECGKKFRTATH-----LVQHQSIHTGEKPFECNV--CGKAFRLQIYLSEHQKTHM--EAKHFECNICGKVFRLQ 465
Cdd:COG5048 352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....*
gi 74315969 466 VYLSEHQKTHTEEKPFKCKLCGSAFRSKyQLSKHH 500
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-643 2.83e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 224 SDERPFQCKDCGKGFIVLAQLTRHQNIHTGEKSFECH--ECGKAFRLPQQLTRHQKSHSGEKPFKCN-ECGKAFHLPDLL 300
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSS 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 301 KYHKTIHTSTKPFECRECGKSFHRISNLVEHRLIH---ADVKPHKCNECGKAFK-RNKSLMQHQKIHSGERPFQCQecgk 376
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL---- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 377 afivlaHLTRHQTIHTGEKSFECKECGKKFRTATHLVQHQSIHTGEKPFECNVCGKAFRLQIYLSEHQKTHMEAKHFECN 456
Cdd:COG5048 185 ------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 457 ICGKVFRLQVYLSEHQKTHTEE-------KPFKCKLCGSAFRSKYQLSKH--HTVHTDE--KPYQCKE--CGKCFRQRSN 523
Cdd:COG5048 259 ESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDA 338

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 524 FTDHQSIHTGKKPFQCKEC-------GKFYRLNTLLIRHQKSHSSERPYEC--KECGKAFHLPSELNNHQIVHTSNRP-- 592
Cdd:COG5048 339 LKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPyn 418

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 74315969 593 FECKVCGKSFKRESTLIQHMAIHSGVKSYECkeCGKGFIHRSSLLHHRKIH 643
Cdd:COG5048 419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-659 1.17e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 283 KPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECR--ECGKSFHRISNLVEHRLIH----------------ADVKPHKCN 344
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHhnnpsdlnskslplsnSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 345 ECGKAFKRNKSLMQHQKIHSGERPFQCQECGKAFIVLAHLTRHQTIHTGEKSFECK-------ECGKKFRTATHLVQHQS 417
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 418 IHTGEKPFECNVCGKAFRLQIYLSEHQKTHMEAKHFECNICGKVFRLQVYLSEHQKTHTEEKPFKCKLCGSAFRSKYQLS 497
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 498 KHHTVHTDE-------KPYQCKECGKCFRQRSNFTDHQ--SIHTGK--KPFQCKE--CGKFYRLNTLLIRHQKSHSSERP 564
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 565 YECK--ECGKAFHLPSELNNHQIVHTS-----NRPFECKV--CGKSFKRESTLIQHMAIHSGVKSYECK--ECGKGFIHR 633
Cdd:COG5048 352 AKEKllNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                       410       420
                ....*....|....*....|....*.
gi 74315969 634 SSLLHHRKIHSDEKPFKCQECGKAFV 659
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-707 3.67e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 337 DVKPHKCNECGKAFKRNKSLMQHQKIHSGERPFQC--QECGKAFIVLAHLTRHQTIHTGEKSFECK-------------- 400
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassss 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 401 --ECGKKFRTATHLVQHQSIHTGEKPFECNVCGKAFRLQIYLSEHQKTHMEAK-----HFECNICGKVFRLQVYLSE--H 471
Cdd:COG5048 110 lsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslHPPLPANSLSKDPSSNLSLliS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 472 QKTHTEEKPFKCKLCGSAFRSKYQLSKHHTVHTDEKPYQCKECGKCFRQRSNftdHQSIHTGKKPFQCKECGKFYRLNTL 551
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL---SQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 552 LIRHQKSHSSER----------PYECKECGKAFHLPSELNNHQ--IVHTS--NRPFECKV--CGKSFKRESTLIQHMAIH 615
Cdd:COG5048 267 TASSQSSSPNESdsssekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 616 SGVKSYECKECGKGFIHRSSL-------LHHRKIHSDEKPFKC--QECGKAFVVLAYLTRH--QSIHTGEKSFECQHCGS 684
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSK 426

                       410       420
                ....*....|....*....|...
gi 74315969 685 AFRYKSQLSKHQRIHTDVRLFQC 707
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
367-739 8.09e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 8.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 367 RPFQCQECGKAFIVLAHLTRHQTIHTGEKSFEC--KECGKKFRTATHLVQHQSIHTGEKPFECNvcgKAFRLQIYLSEHQ 444
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 445 KTHMEAKHF--ECNICGKVFRLQVYLSEHQKTHTEEKPFKCKL--CGSAFRSKYQ-LSKHHTVHTDEKpyqckeCGKCFR 519
Cdd:COG5048 109 SLSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgNNSSSVNTPQsNSLHPPLPANSL------SKDPSS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 520 QRSNFTDHQSIHTGKKPFQCKECGKFYRLNTLLIRHQKSHSSErPYECKECGKAFHLPSELNNHQIVHTSNRPFECKVCG 599
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 600 KSFKRESTLIQHMAIHSGV-------KSYECKECGKGFIHRSSLLHHR--KIHSDE--KPFKC--QECGKAFVVLAYLTR 666
Cdd:COG5048 262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 667 HQSIHTGEKSFEC--QHCGSAFR-----YKSQLSKHQRIHTDVRLFQCM------------------------EGRND-- 713
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLsnscirnfkrdsnlslhiithlsfRPYNCkn 421

                       410       420       430
                ....*....|....*....|....*....|..
gi 74315969 714 ------FVHGLDLRIHQGIHTSETPFQCNEYG 739
Cdd:COG5048 422 ppcsksFNRHYNLIPHKKIHTNHAPLLCSILK 453
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 281-364 4.28e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 4.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74315969 281 GEKPFKCN--ECGKAFHLPDLLKYHKtIHTstkpfecrECGKSFHRISNLVEHRLIHADVKPHKCNECGKAFKRNKSLMQ 358
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 74315969 359 HQKiHS 364
Cdd:COG5189 417 HRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 151-224 5.17e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74315969 151 GEKPFECN--ECGKAFHLPDLLKYHKTI-HTGEKPFECRECGLYRIIHADVKPYKCSECGKAFKRRSNLVQHqKTHS 224
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-294 5.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.33e-03
                          10        20
                  ....*....|....*....|...
gi 74315969   272 LTRHQKSHSGEKPFKCNECGKAF 294
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-378 5.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.77e-03
                          10        20
                  ....*....|....*....|....
gi 74315969   355 SLMQHQKIHSGERPFQCQECGKAF 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 201-223 8.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.75e-03
                          10        20
                  ....*....|....*....|...
gi 74315969   201 YKCSECGKAFKRRSNLVQHQKTH 223
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
142-164 9.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.81e-03
                          10        20
                  ....*....|....*....|...
gi 74315969   142 LTRHQKFHSGEKPFECNECGKAF 164
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH