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Conserved domains on  [gi|269973856|ref|NP_082627|]
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R-spondin-3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 2.36e-51

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


:

Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 163.76  E-value: 2.36e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973856   42 QGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKV-DCDTCFNKNFCTKCKSGFYL 120
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAeNCESCFSKDFCTKCKEGFYL 80

                          90       100
                  ....*....|....*....|..
gi 269973856  121 HLGKCLDSCPEGLEANNHTMEC 142
Cdd:pfam15913  81 HKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.61e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.36  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 269973856  148 CEASEWSPWSPCmkkGKTCGfkRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQR 203
Cdd:pfam19028   1 CVVSEWSEWSEC---SVTCG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 2.36e-51

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 163.76  E-value: 2.36e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973856   42 QGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKV-DCDTCFNKNFCTKCKSGFYL 120
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAeNCESCFSKDFCTKCKEGFYL 80

                          90       100
                  ....*....|....*....|..
gi 269973856  121 HLGKCLDSCPEGLEANNHTMEC 142
Cdd:pfam15913  81 HKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.61e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.36  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 269973856  148 CEASEWSPWSPCmkkGKTCGfkRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQR 203
Cdd:pfam19028   1 CVVSEWSEWSEC---SVTCG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 97-143 3.41e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 40.58  E-value: 3.41e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 269973856  97 KCKVDCDTCFNK--NFCTKCKSGFYLHLGKCLDSCPEGLEANNHTMECV 143
Cdd:cd00064    1 PCHPSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
FU smart00261
Furin-like repeats;
93-132 2.51e-04

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 37.87  E-value: 2.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 269973856    93 NKCTKCKVDCDTCFNK--NFCTKCKSGFYLHLGKCLDSCPEG 132
Cdd:smart00261   2 GECKPCHPECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPG 43
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 151-202 2.30e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 269973856   151 SEWSPWSPCmkkGKTCGfkRGTETRVRD-ILQHPSAKGNLCP-PTSETRTCIVQ 202
Cdd:smart00209   2 SEWSEWSPC---SVTCG--GGVQTRTRScCSPPPQNGGGPCTgEDVETRACNEQ 50
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 2.36e-51

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 163.76  E-value: 2.36e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973856   42 QGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKV-DCDTCFNKNFCTKCKSGFYL 120
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAeNCESCFSKDFCTKCKEGFYL 80

                          90       100
                  ....*....|....*....|..
gi 269973856  121 HLGKCLDSCPEGLEANNHTMEC 142
Cdd:pfam15913  81 HKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.61e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.36  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 269973856  148 CEASEWSPWSPCmkkGKTCGfkRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQR 203
Cdd:pfam19028   1 CVVSEWSEWSEC---SVTCG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 97-143 3.41e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 40.58  E-value: 3.41e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 269973856  97 KCKVDCDTCFNK--NFCTKCKSGFYLHLGKCLDSCPEGLEANNHTMECV 143
Cdd:cd00064    1 PCHPSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
FU smart00261
Furin-like repeats;
93-132 2.51e-04

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 37.87  E-value: 2.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 269973856    93 NKCTKCKVDCDTCFNK--NFCTKCKSGFYLHLGKCLDSCPEG 132
Cdd:smart00261   2 GECKPCHPECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPG 43
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 151-202 2.30e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 2.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 269973856   151 SEWSPWSPCmkkGKTCGfkRGTETRVRD-ILQHPSAKGNLCP-PTSETRTCIVQ 202
Cdd:smart00209   2 SEWSEWSPC---SVTCG--GGVQTRTRScCSPPPQNGGGPCTgEDVETRACNEQ 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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