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Conserved domains on  [gi|47523382|ref|NP_082249|]
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centromere protein U isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 139-312 3.83e-66

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


:

Pssm-ID: 463785  Cd Length: 180  Bit Score: 208.41  E-value: 3.83e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   139 DDVRRRVASAEGPRSQQRQAAPAAPSPPERPAE----PVTPRRTRLHSAQLSPVDETPA-TQSQLKTQKKVRPSPGRRKR 213
Cdd:pfam13097   2 SDVRRKVQSAEKISTQQREAVPATASASSELSEkpaeSVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   214 PRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKA 293
Cdd:pfam13097  82 SRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLKN 161

                         170
                  ....*....|....*....
gi 47523382   294 LKMKNTKIIANMEKKRQRL 312
Cdd:pfam13097 162 LKRKNAKVISDIEKKRQRL 180
GAS super family cl25894
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 280-365 6.39e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


The actual alignment was detected with superfamily member pfam13851:

Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   280 ELIRMLKE--AQMlKALKMKNTKIIANMEKKRQRLIE----VQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNL 353
Cdd:pfam13851  26 ELIKSLKEeiAEL-KKKEERNEKLMSEIQQENKRLTEplqkAQEEVEELRKQLENYEKDKQSLKNLKARLKVLEKELKDL 104

                          90
                  ....*....|....*.
gi 47523382   354 KQ----LCQDYSNVQE 365
Cdd:pfam13851 105 KWehevLEQRFEKVER 120
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 139-312 3.83e-66

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 208.41  E-value: 3.83e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   139 DDVRRRVASAEGPRSQQRQAAPAAPSPPERPAE----PVTPRRTRLHSAQLSPVDETPA-TQSQLKTQKKVRPSPGRRKR 213
Cdd:pfam13097   2 SDVRRKVQSAEKISTQQREAVPATASASSELSEkpaeSVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   214 PRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKA 293
Cdd:pfam13097  82 SRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLKN 161

                         170
                  ....*....|....*....
gi 47523382   294 LKMKNTKIIANMEKKRQRL 312
Cdd:pfam13097 162 LKRKNAKVISDIEKKRQRL 180
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 280-365 6.39e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   280 ELIRMLKE--AQMlKALKMKNTKIIANMEKKRQRLIE----VQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNL 353
Cdd:pfam13851  26 ELIKSLKEeiAEL-KKKEERNEKLMSEIQQENKRLTEplqkAQEEVEELRKQLENYEKDKQSLKNLKARLKVLEKELKDL 104

                          90
                  ....*....|....*.
gi 47523382   354 KQ----LCQDYSNVQE 365
Cdd:pfam13851 105 KWehevLEQRFEKVER 120
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 276-355 7.07e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   276 KMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQR----LIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLS 351
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 47523382   352 NLKQ 355
Cdd:TIGR04523 180 KEKL 183
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 139-312 3.83e-66

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 208.41  E-value: 3.83e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   139 DDVRRRVASAEGPRSQQRQAAPAAPSPPERPAE----PVTPRRTRLHSAQLSPVDETPA-TQSQLKTQKKVRPSPGRRKR 213
Cdd:pfam13097   2 SDVRRKVQSAEKISTQQREAVPATASASSELSEkpaeSVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   214 PRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKA 293
Cdd:pfam13097  82 SRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLKN 161

                         170
                  ....*....|....*....
gi 47523382   294 LKMKNTKIIANMEKKRQRL 312
Cdd:pfam13097 162 LKRKNAKVISDIEKKRQRL 180
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 280-365 6.39e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   280 ELIRMLKE--AQMlKALKMKNTKIIANMEKKRQRLIE----VQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNL 353
Cdd:pfam13851  26 ELIKSLKEeiAEL-KKKEERNEKLMSEIQQENKRLTEplqkAQEEVEELRKQLENYEKDKQSLKNLKARLKVLEKELKDL 104

                          90
                  ....*....|....*.
gi 47523382   354 KQ----LCQDYSNVQE 365
Cdd:pfam13851 105 KWehevLEQRFEKVER 120
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 276-355 7.07e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523382   276 KMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQR----LIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLS 351
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 47523382   352 NLKQ 355
Cdd:TIGR04523 180 KEKL 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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