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Conserved domains on  [gi|269973927|ref|NP_082176|]
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R3H domain-containing protein 2 isoform 2 [Mus musculus]

Protein Classification

R3H_encore_like and Med15 domain-containing protein( domain architecture ID 11552550)

R3H_encore_like and Med15 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 168-229 3.11e-27

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


:

Pssm-ID: 100071  Cd Length: 63  Bit Score: 104.99  E-value: 3.11e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973927 168 DRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG-KAVIINKT 229
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 424-755 1.44e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 68.50  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  424 QHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAEDLSNPFGQmslsrQGSTEAADPSSALFQP-PLISQHPQQASFIM 502
Cdd:pfam09606 148 RMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGG-----QQGPMGGQMPPQMGVPgMPGPADAGAQMGQQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  503 ASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQppQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQASQQ--P 580
Cdd:pfam09606 223 AQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQ--SQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVmsI 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  581 GLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQ---GLVVQYTPLPSYQVPVGSDSQNVVQP---SFQQPML 654
Cdd:pfam09606 301 GDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVValgGLNHLETWNPGNFGGLGANPMQRGQPgmmSSPSPVP 380

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  655 VPASQSVQG--GLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMSQQYSGVSPSG-PGVVVM 731
Cdd:pfam09606 381 GQQVRQVTPnqFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGGSLNtPGQSAV 460

                         330       340
                  ....*....|....*....|....
gi 269973927  732 qlNVPNGPQAPQNPSMVQWSHCKY 755
Cdd:pfam09606 461 --NSPLNPQEEQLYREKYRQLTKY 482
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 168-229 3.11e-27

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 104.99  E-value: 3.11e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973927 168 DRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG-KAVIINKT 229
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
152-229 1.37e-14

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 69.64  E-value: 1.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927   152 IDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINdNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKA--VIINKT 229
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGPKrrVVISKK 79
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 424-755 1.44e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 68.50  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  424 QHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAEDLSNPFGQmslsrQGSTEAADPSSALFQP-PLISQHPQQASFIM 502
Cdd:pfam09606 148 RMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGG-----QQGPMGGQMPPQMGVPgMPGPADAGAQMGQQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  503 ASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQppQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQASQQ--P 580
Cdd:pfam09606 223 AQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQ--SQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVmsI 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  581 GLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQ---GLVVQYTPLPSYQVPVGSDSQNVVQP---SFQQPML 654
Cdd:pfam09606 301 GDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVValgGLNHLETWNPGNFGGLGANPMQRGQPgmmSSPSPVP 380

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  655 VPASQSVQG--GLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMSQQYSGVSPSG-PGVVVM 731
Cdd:pfam09606 381 GQQVRQVTPnqFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGGSLNtPGQSAV 460

                         330       340
                  ....*....|....*....|....
gi 269973927  732 qlNVPNGPQAPQNPSMVQWSHCKY 755
Cdd:pfam09606 461 --NSPLNPQEEQLYREKYRQLTKY 482
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 170-228 1.35e-10

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 57.50  E-value: 1.35e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269973927  170 MMLLKLEQEILDFINDNNNQFKkFPQMTSYHRMLLHRVAAYFGMDHNV--DQTGKAVIINK 228
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 417-584 1.03e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.70  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  417 PALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAEDlsnpFGQMSLSRQGSTEAADPSSALFQPPLISQHPQ 496
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEG----YPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPA 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  497 QASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQiqvsyyPPGQYPNSNQQYRPLSHPVAYSPQRgQQLPQA 576
Cdd:PRK10263  412 AEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQ------STFAPQSTYQTEQTYQQPAAQEPLY-QQPQPV 484


                  ....*...
gi 269973927  577 SQQPGLQP 584
Cdd:PRK10263  485 EQQPVVEP 492
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 461-630 1.45e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.57  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  461 LSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASfimasAGQPLptsNYstsshaPPTQQVLPPQGYMQPPQQIQ 540
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQF-----NGQPL---GW------PRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  541 VSYYPPGQYPNSNQQYRPLSHPVA---YSPQ-RGQQLPQASQQPGLQPMMSNQQQTAYQgMLGVQQPQnqgllsNQRSSM 616
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQpvmYPPNyQSLPLSQDLPQPQSTASQGGQNKKLAQ-VLASATPQ------MQKQVL 509

                         170
                  ....*....|....
gi 269973927  617 GGQMQGLVVQYTPL 630
Cdd:TIGR01628 510 GERLFPLVEAIEPA 523
Amelin smart00817
Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin ...
 472-607 3.97e-03

Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.


Pssm-ID: 214832 [Multi-domain]  Cd Length: 411  Bit Score: 40.64  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927   472 RQGSTEAADPSSALFQPPLISQHPQQAsfimasagqPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPN 551
Cdd:smart00817  82 REHETQQYEYSLPVHPPPLPSQPSLQP---------QQPGLKPFLQPTALPTNQATPQKNGPQPPMHLGQPPLQQAELPM 152

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973927   552 SNQQYRPLSHP-------VAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQG 607
Cdd:smart00817 153 IPPQVAPSDKPpqtelplYDFADPQNPLLFQIAHLMSRGPMPQNKQQHLYPGLFYMSYGANQL 215
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 168-229 3.11e-27

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 104.99  E-value: 3.11e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973927 168 DRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG-KAVIINKT 229
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
152-229 1.37e-14

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 69.64  E-value: 1.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927   152 IDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINdNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKA--VIINKT 229
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGPKrrVVISKK 79
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 424-755 1.44e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 68.50  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  424 QHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAEDLSNPFGQmslsrQGSTEAADPSSALFQP-PLISQHPQQASFIM 502
Cdd:pfam09606 148 RMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGG-----QQGPMGGQMPPQMGVPgMPGPADAGAQMGQQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  503 ASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQppQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQASQQ--P 580
Cdd:pfam09606 223 AQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQ--SQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVmsI 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  581 GLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQ---GLVVQYTPLPSYQVPVGSDSQNVVQP---SFQQPML 654
Cdd:pfam09606 301 GDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVValgGLNHLETWNPGNFGGLGANPMQRGQPgmmSSPSPVP 380

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  655 VPASQSVQG--GLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMSQQYSGVSPSG-PGVVVM 731
Cdd:pfam09606 381 GQQVRQVTPnqFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGGSLNtPGQSAV 460

                         330       340
                  ....*....|....*....|....
gi 269973927  732 qlNVPNGPQAPQNPSMVQWSHCKY 755
Cdd:pfam09606 461 --NSPLNPQEEQLYREKYRQLTKY 482
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 172-228 3.69e-11

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 59.16  E-value: 3.69e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 269973927 172 LLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG--KAVIINK 228
Cdd:cd02325    1 REEREEELEAFAKDAAGKSLELPPMNSYERKLIHDLAEYYGLKSESEGEGpnRRVVITK 59
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 170-228 1.35e-10

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 57.50  E-value: 1.35e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269973927  170 MMLLKLEQEILDFINDNNNQFKkFPQMTSYHRMLLHRVAAYFGMDHNV--DQTGKAVIINK 228
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 417-654 7.66e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.12  E-value: 7.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  417 PALPPTPQHQPPL----NNHMISQPVPALQPS------PQPVQFSPSSCPQAEDLSNPFGQ-----MSLSRqgsTEAAdp 481
Cdd:pfam09770 128 YASQQSQQPSKPVrtgyEKYKEPEPIPDLQVDaslwgvAPKKAAAPAPAPQPAAQPASLPApsrkmMSLEE---VEAA-- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  482 ssALFQPPLISQHPQQASfimasAGQPlptsnystssHAPPTQQVLPPQGYMQPPQQIQvsyyPPGQYPNSNQQYRPLSH 561
Cdd:pfam09770 203 --MRAQAKKPAQQPAPAP-----AQPP----------AAPPAQQAQQQQQFPPQIQQQQ----QPQQQPQQPQQHPGQGH 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  562 PVAYspqrgQQLPQASQQPGLQPMMSNQQQTAYQGMLGV-QQP----QNQGLLSNQRSSMGGQMQGlVVQYTPLPSYQVP 636
Cdd:pfam09770 262 PVTI-----LQRPQSPQPDPAQPSIQPQAQQFHQQPPPVpVQPtqilQNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQ 335

                         250
                  ....*....|....*...
gi 269973927  637 VGSDSQNVVQPSFQQPML 654
Cdd:pfam09770 336 QGSFGRQAPIITHPQQLA 353
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 417-584 1.03e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.70  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  417 PALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAEDlsnpFGQMSLSRQGSTEAADPSSALFQPPLISQHPQ 496
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEG----YPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPA 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  497 QASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQiqvsyyPPGQYPNSNQQYRPLSHPVAYSPQRgQQLPQA 576
Cdd:PRK10263  412 AEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQ------STFAPQSTYQTEQTYQQPAAQEPLY-QQPQPV 484


                  ....*...
gi 269973927  577 SQQPGLQP 584
Cdd:PRK10263  485 EQQPVVEP 492
PHA03379 PHA03379
EBNA-3A; Provisional
 376-803 1.26e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 49.29  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 376 PGMALGAPEVCNQVTSPQSVRGLLPCTAQQQQQqqqqqqqLPALPPTPQHQP-PLNNHMISQPVPALQPSPQPVQfspsS 454
Cdd:PHA03379 409 SEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQ-------VPEPPPVHDLEPgPLHDQHSMAPCPVAQLPPGPLQ----D 477

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 455 CPQAEDLSNPFgqmSLSRQGSTEAADPSSALFQP--PLISQHPQQASFI-----MASAGQPLPTSNYSTSSHAPPTQQVL 527
Cdd:PHA03379 478 LEPGDQLPGVV---QDGRPACAPVPAPAGPIVRPweASLSQVPGVAFAPvmpqpMPVEPVPVPTVALERPVCPAPPLIAM 554

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 528 PPQGYMQPPQQIQVSYYPPGQYPNSNQQYRPLshPVAYSPQRGQQLPQASQQP-GLQPMMSNQQQTayqgmlgvQQPQNQ 606
Cdd:PHA03379 555 QGPGETSGIVRVRERWRPAPWTPNPPRSPSQM--SVRDRLARLRAEAQPYQASvEVQPPQLTQVSP--------QQPMEY 624

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 607 GLLSNQRSSMGGQMQGL--VVQYTPLPSYQVPvgSDSQNVVQPSFQQPMLVPASQSVQGGLPTGGVPVYYSMIPPAQQ-- 682
Cdd:PHA03379 625 PLEPEQQMFPGSPFSQVadVMRAGGVPAMQPQ--YFDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPin 702

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 683 NGTSPSVGFLQPPGS-------EQYQMPQSPSPCSPPQMSQQYSGVSPSGPgvvvMQLNVPNGPQAPQNPSMVQWshcky 755
Cdd:PHA03379 703 QGASAAHFLPQQPMEgplvperWMFQGATLSQSVRPGVAQSQYFDLPLTQP----INHGAPAAHFLHQPPMEGPW----- 773

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 269973927 756 ysVEQRGQKPGDLYSPdGSPQANAQMGSSPVTSPTQSPAPSPVTSLSN 803
Cdd:PHA03379 774 --VPEQWMFQGAPPSQ-GTDVVQHQLDALGYVLHVLNHPGVPVSPAVN 818
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 410-697 3.93e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  410 QQQQQQLPALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAEDLSNPFGQMSLSRQGST-------EAADPS 482
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTlhpqrlpSPHPPL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  483 SALFQPPLISQHPQQA--SFIMASAGQPLPTSNYSTSSHAPptqQVLPPQGYMQPPQ--QIQVSYYPPGQYPNSNQQ--Y 556
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPlpQPSLHGQMPPMPHSLQTGPSHMQ---HPVPPQPFPLTPQssQSQVPPGPSPAAPGQSQQriH 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  557 RPLSHPVAYSPQ--RGQQLPQASQQ------------PGLQPMMSNQQQTAYQGMLGVQQPQN----------QGLLSNQ 612
Cdd:pfam03154 327 TPPSQSQLQSQQppREQPLPPAPLSmphikpppttpiPQLPNPQSHKHPPHLSGPSPFQMNSNlppppalkplSSLSTHH 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  613 RSSMGGQMQGLVVQYTPLPS--YQVPVGSDSQNVVQPSFQQPmlvPASQSVQGG----------LPTGGVPVYYSMIPPA 680
Cdd:pfam03154 407 PPSAHPPPLQLMPQSQQLPPppAQPPVLTQSQSLPPPAASHP---PTSGLHQVPsqspfpqhpfVPGGPPPITPPSGPPT 483

                         330
                  ....*....|....*..
gi 269973927  681 QqngTSPSVGFLQPPGS 697
Cdd:pfam03154 484 S---TSSAMPGIQPPSS 497
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 481-632 6.55e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 6.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  481 PSSALFQPPLI-SQHPQQasfimasagQPLPTSNYSTSSH-APPTQQVLPPQGYMQPPQQiqvsYYPPGQYPNSNQQYRP 558
Cdd:PRK10263  740 PHEPLFTPIVEpVQQPQQ---------PVAPQQQYQQPQQpVAPQPQYQQPQQPVAPQPQ----YQQPQQPVAPQPQYQQ 806

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 269973927  559 LSHPVAYSPQRGQ-QLPQASQQPGLQPmmsnQQQTAyqgmlgvqqPQNQGLLSNQRSSMGGQMQGLVVQYTPLPS 632
Cdd:PRK10263  807 PQQPVAPQPQYQQpQQPVAPQPQYQQP----QQPVA---------PQPQDTLLHPLLMRNGDSRPLHKPTTPLPS 868
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 461-630 1.45e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.57  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  461 LSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASfimasAGQPLptsNYstsshaPPTQQVLPPQGYMQPPQQIQ 540
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQF-----NGQPL---GW------PRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  541 VSYYPPGQYPNSNQQYRPLSHPVA---YSPQ-RGQQLPQASQQPGLQPMMSNQQQTAYQgMLGVQQPQnqgllsNQRSSM 616
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQpvmYPPNyQSLPLSQDLPQPQSTASQGGQNKKLAQ-VLASATPQ------MQKQVL 509

                         170
                  ....*....|....
gi 269973927  617 GGQMQGLVVQYTPL 630
Cdd:TIGR01628 510 GERLFPLVEAIEPA 523
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 420-674 1.90e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.46  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  420 PPTPQHQPPLNNHMISQPVPALQPSPQPVQfspsscpqaedlsnpfgqmslSRQGSTEAADPSSALFQPPLISQHPQqas 499
Cdd:PRK10263  302 PEYDEYDPLLNGAPITEPVAVAAAATTATQ---------------------SWAAPVEPVTQTPPVASVDVPPAQPT--- 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  500 fimaSAGQPLPTSNYSTSSHAPPtqqvlpPQGYMQPPQ--QIQVSYYPPGQYPNSNQQyrPLSHPVAYSPQRGQQLPQAS 577
Cdd:PRK10263  358 ----VAWQPVPGPQTGEPVIAPA------PEGYPQQSQyaQPAVQYNEPLQQPVQPQQ--PYYAPAAEQPAQQPYYAPAP 425

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  578 QQPGLQPMMSNQQQTAYQGMLGVQQPQNQgLLSNQRSsmggqmqglvvqYTPLPSYQVPVGSDSQNVVQPSFQQPMLVPA 657
Cdd:PRK10263  426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQS-TFAPQST------------YQTEQTYQQPAAQEPLYQQPQPVEQQPVVEP 492

                         250
                  ....*....|....*..
gi 269973927  658 SQSVQGGLPTGGvPVYY 674
Cdd:PRK10263  493 EPVVEETKPARP-PLYY 508
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 421-586 1.79e-03

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 41.44  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  421 PTPQHQPPLNnhMISQPVPALQPSPQPVQFSPSSCPQAEDLSNPFgqmslsrQGSTeAADPSSALFQPPLISQHPQQASF 500
Cdd:pfam15991 108 AAQVFLPQLS--MQGQPHHQQHPGPQVGVLKRTRSPSPPVQQQAY-------YKQP-AFSPGYAEHGQQKHDDGRRGYDV 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  501 IMASAGQPLPTSNYSTSSHAPPTQQVLPP-QGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAY---SPQRGQQLPQA 576
Cdd:pfam15991 178 ARFGSWNKSTAQYPPSGQLFYPTHQYLPPpQTQGQADARLQTIYPQPGYALPLQQQYEHANQPSPFvssSPLKQMQSPKA 257

                         170
                  ....*....|..
gi 269973927  577 --SQQPGLQPMM 586
Cdd:pfam15991 258 gpGPQPMQLSVL 269
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 457-698 2.16e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  457 QAEDLSNPFGQMSLSRQGST-------EAADPSSALfQPPLISQ--HPQQASFimaSAGQPLPTSNYSTSSHAPPTQQVL 527
Cdd:PRK10263  660 QQDELARQFAQTQQQRYGEQyqhdvpvNAEDADAAA-EAELARQfaQTQQQRY---SGEQPAGANPFSLDDFEFSPMKAL 735

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  528 PPQGYMQPpqqiqvsYYPPGQYPNSNQQYRPLSHPVAYSPQRgqqlPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQG 607
Cdd:PRK10263  736 LDDGPHEP-------LFTPIVEPVQQPQQPVAPQQQYQQPQQ----PVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQY 804

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  608 LLSNQrssmggqmqglvvQYTPLPSYQVPvgsDSQNVVQPSFQQPMLVPASQSVQgglptggvpvyySMIPP-AQQNGTS 686
Cdd:PRK10263  805 QQPQQ-------------PVAPQPQYQQP---QQPVAPQPQYQQPQQPVAPQPQD------------TLLHPlLMRNGDS 856

                         250       260
                  ....*....|....*....|..
gi 269973927  687 ----------PSVGFLQPPGSE 698
Cdd:PRK10263  857 rplhkpttplPSLDLLTPPPSE 878
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 568-698 3.63e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.95  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  568 QRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQ----PQNQGLLSNQRSSMGGQMQGLVVQYTPLPSYQVPvGSDSQN 643
Cdd:TIGR01628 374 QFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQfngqPLGWPRMSMMPTPMGPGGPLRPNGLAPMNAVRAP-SRNAQN 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269973927  644 VVQPSFQQPMlvPASQSVQGGLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSE 698
Cdd:TIGR01628 453 AAQKPPMQPV--MYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQ 505
Amelin smart00817
Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin ...
 472-607 3.97e-03

Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.


Pssm-ID: 214832 [Multi-domain]  Cd Length: 411  Bit Score: 40.64  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927   472 RQGSTEAADPSSALFQPPLISQHPQQAsfimasagqPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPN 551
Cdd:smart00817  82 REHETQQYEYSLPVHPPPLPSQPSLQP---------QQPGLKPFLQPTALPTNQATPQKNGPQPPMHLGQPPLQQAELPM 152

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973927   552 SNQQYRPLSHP-------VAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQG 607
Cdd:smart00817 153 IPPQVAPSDKPpqtelplYDFADPQNPLLFQIAHLMSRGPMPQNKQQHLYPGLFYMSYGANQL 215
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 453-823 4.70e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  453 SSCPQAEDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASFIMASAGQPLPTSNYSTSSHAP-PTQQVLPPQG 531
Cdd:pfam03154 131 SSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPtPSAPSVPPQG 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  532 Y---MQPPQQIQVSYYPPG---QYPNSNQQYRPLSHP----VAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQ 601
Cdd:pfam03154 211 SpatSQPPNQTQSTAAPHTliqQTPTLHPQRLPSPHPplqpMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  602 QP-QNQGLLSNQRSSMGgqmqglvvQYTPLPSYQVPVGSDSQNVVQPSfqQPMLVPASQSVQGGLPTGGVPVYYSMIPPa 680
Cdd:pfam03154 291 HPvPPQPFPLTPQSSQS--------QVPPGPSPAAPGQSQQRIHTPPS--QSQLQSQQPPREQPLPPAPLSMPHIKPPP- 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  681 qqngTSPsVGFLQPPGSEQYQMPQspspcsppqmsqqysgvspSGPGVVVMQLNVPNGPQapqnpsmvqwshCKYYSVEQ 760
Cdd:pfam03154 360 ----TTP-IPQLPNPQSHKHPPHL-------------------SGPSPFQMNSNLPPPPA------------LKPLSSLS 403

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269973927  761 RGQKPGDLYSPDGSPQANAQMGSSPVTSP--TQSPAPSPVTSLSNVCTGLSPLPVLTPFPR----PGGP 823
Cdd:pfam03154 404 THHPPSAHPPPLQLMPQSQQLPPPPAQPPvlTQSQSLPPPAASHPPTSGLHQVPSQSPFPQhpfvPGGP 472
PHA03377 PHA03377
EBNA-3C; Provisional
 417-691 4.72e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 40.81  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  417 PALPPTPQHQPPLNNHMISQPVPALQPSP-QPVQFSPSSCPQAedlsnpfgqMSLSRQGSTEAADPSSALFQPPLISQHP 495
Cdd:PHA03377  672 PATQSTPPRPSWLPSVFVLPSVDAGRAQPsEESHLSSMSPTQP---------ISHEEQPRYEDPDDPLDLSLHPDQAPPP 742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  496 QQASFIMASAGQPLPTSNYSTSSHAPPTQqvLPPQGYMQPP-QQIQVSYYPPGQYP-NSNQQYRPLSHPVAYSPQR---- 569
Cdd:PHA03377  743 SHQAPYSGHEEPQAQQAPYPGYWEPRPPQ--APYLGYQEPQaQGVQVSSYPGYAGPwGLRAQHPRYRHSWAYWSQYpghg 820

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  570 GQQLPQASQQPGLQPmmsnqqqtAYQGMLGVQQPQNQGLLSNQRSSMGGQMQGLVVQYTPLPsyQVPVGSDSQNVVQPSF 649
Cdd:PHA03377  821 HPQGPWAPRPPHLPP--------QWDGSAGHGQDQVSQFPHLQSETGPPRLQLSQVPQLPYS--QTLVSSSAPSWSSPQP 890

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 269973927  650 QQPMlvpasQSVQGGLPTGGVPVYYSMIPPAQQNGTS-PSVGF 691
Cdd:PHA03377  891 RAPI-----RPIPTRFPPPPMPLQDSMAVGCDSSGTAcPSMPF 928
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 467-695 6.03e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.40  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  467 QMSLSRQGSTEAADPSSALfQPPLISQHPQQASFIMASAGQPLPTS--NYSTSSHAPPTQ--QVL---PPQGYMQPPQQI 539
Cdd:pfam09770  99 QVRFNRQQPAARAAQSSAQ-PPASSLPQYQYASQQSQQPSKPVRTGyeKYKEPEPIPDLQvdASLwgvAPKKAAAPAPAP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  540 QVSYYPPGQYPNSNQ---------QYRplshpvAYSPQRGQQLPQASQQP--GLQPMMSNQQQTAYQGMLGVQQPQNQGL 608
Cdd:pfam09770 178 QPAAQPASLPAPSRKmmsleeveaAMR------AQAKKPAQQPAPAPAQPpaAPPAQQAQQQQQFPPQIQQQQQPQQQPQ 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  609 LSNQRSSMGGQMQGL---------VVQYTPLPSYQVPVGSDSQNVVQPS--FQQPMLVPASQSVQGGLPTGGVPVyysmi 677
Cdd:pfam09770 252 QPQQHPGQGHPVTILqrpqspqpdPAQPSIQPQAQQFHQQPPPVPVQPTqiLQNPNRLSAARVGYPQNPQPGVQP----- 326

                         250
                  ....*....|....*...
gi 269973927  678 PPAQQNGTSPSVGFLQPP 695
Cdd:pfam09770 327 APAHQAHRQQGSFGRQAP 344
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
380-580 6.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 40.33  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 380 LGAPEVCNQVTSPQSVRGLLPCTAQQQQQQQQQQQQlPALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQAE 459
Cdd:PRK14948 360 LPSAFISEIANASAPANPTPAPNPSPPPAPIQPSAP-KTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANAANAPPS 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927 460 D---------LSN---PFGQMSLSRQGSTEAADPSSALFQ------------PPLIS-------QHPQQASFIMASAGQP 508
Cdd:PRK14948 439 LnleelwqqiLAKlelPSTRMLLSQQAELVSLDSNRAVIAvspnwlgmvqsrKPLLEqafakvlGRSIKLNLESQSGSAS 518

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 269973927 509 lptsnySTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQASQQP 580
Cdd:PRK14948 519 ------NTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEP 584
PHA03247 PHA03247
large tegument protein UL36; Provisional
 416-528 7.50e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973927  416 LPALPPTPQHQPPLnnhmisqPVPALQPSPQPVQFSPSSCPQAEDLSNPFGQMSLSRQGSTEaadPSSALFQPPLISQHP 495
Cdd:PHA03247 2900 LPPDQPERPPQPQA-------PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE---PSGAVPQPWLGALVP 2969

                          90       100       110
                  ....*....|....*....|....*....|...
gi 269973927  496 QQASFIMASAGQPLPTSNYSTSSHAPPTQQVLP 528
Cdd:PHA03247 2970 GRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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