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Conserved domains on  [gi|226437676|ref|NP_081789|]
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nuclear pore complex protein Nup205 [Mus musculus]

Protein Classification

nuclear pore complex Nup192/Nup205 family protein( domain architecture ID 10571003)

nuclear pore complex Nup192/Nup205 family protein; similar to Homo sapiens Nup205 and Saccharomyces cerevisiae Nup192, which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC) that can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 165-1684 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


:

Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1087.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   165 ELVSMTTRFTDELME-QGLTYKVLTLLSQIDVNNEfekLQRERGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLPK 243
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   244 DDTLLLIGHLERVtveanGSLDAVNLCLLMALLYCFDtsfidqSTEERddmihhLPLLTERQYVSTIHSRLQDSqpWKLP 323
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFG------SLEDL------SVLQDVRELHSKITKSLDSE--WPLY 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   324 --GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFLseAVVLAEN------------------ 381
Cdd:pfam11894  138 tdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFL--LSIAADTsnkdwedplrydfrsllq 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   382 --------------FYQEEFYIRRIHSLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLLIG 447
Cdd:pfam11894  216 rhiprltpeklllsDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLIIA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   448 ELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCA 527
Cdd:pfam11894  289 YLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENA 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   528 HYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQL 603
Cdd:pfam11894  343 RAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRL 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   604 TSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVR 677
Cdd:pfam11894  419 ISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVP 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   678 VPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLR 746
Cdd:pfam11894  499 RTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   747 fRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELAL 820
Cdd:pfam11894  579 -STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALF 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   821 SLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQGIN 887
Cdd:pfam11894  658 SIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   888 prtkkadNVVNIARYLYHGnnNPELAFESAKILCCISCNSNI----------QVKMVGDFTHDQSvSQKLMAGFVECLDY 957
Cdd:pfam11894  735 -------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEA 804

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   958 EDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERNP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCLHA 1035
Cdd:pfam11894  805 PIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHS 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1036 ILNILEKGTEGRDGPVAVREYP-QLADLCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEHE-------- 1106
Cdd:pfam11894  874 LLLLLLSSLDLISEGDYIDYAPaRLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfd 952

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1107 -------------ISMLSQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKpysdgeggmedenrsvsgflhfD 1173
Cdd:pfam11894  953 gvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLLLGNNILD----------------------G 1010

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1174 TATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGMAA 1248
Cdd:pfam11894 1011 GEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGESK 1090

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1249 IGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDLLQDVHDKV-----L 1323
Cdd:pfam11894 1091 AGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveL 1167

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1324 DDEAAQELMPVVAGAVFTLTAHLSQAVRTEQRQplvsgpgeaqyafmldssltsspaaesrpvgFASIGDSSLHIILKKL 1403
Cdd:pfam11894 1168 DIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFKTC 1216

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1404 LDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVVCR 1483
Cdd:pfam11894 1217 IDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVICN 1275

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1484 DACDGHEIGRMLALALLDRIVSVD--KQHQWLLYLSNSGYLKVLVDSLVDDDRTLQSLLTPQPPLLKALY--TYESKMAF 1559
Cdd:pfam11894 1276 DAIGGEGTCRITALLLLDSLVHLDsnKSNFILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLAL 1355

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1560 LTRVAKEQQGSAELLRSGVIVRLAQCQVYDMRPEMdshGMFgmRDPPVFIPTPVDRYRQILLPALQLCQVILTSSMSQHL 1639
Cdd:pfam11894 1356 LIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL---GLS--LDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNK 1430

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226437676  1640 QAAGQVLQFLVSHSDTIQAILR---------CQDVSTGSLQELALLTGIISKAA 1684
Cdd:pfam11894 1431 SAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 165-1684 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1087.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   165 ELVSMTTRFTDELME-QGLTYKVLTLLSQIDVNNEfekLQRERGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLPK 243
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   244 DDTLLLIGHLERVtveanGSLDAVNLCLLMALLYCFDtsfidqSTEERddmihhLPLLTERQYVSTIHSRLQDSqpWKLP 323
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFG------SLEDL------SVLQDVRELHSKITKSLDSE--WPLY 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   324 --GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFLseAVVLAEN------------------ 381
Cdd:pfam11894  138 tdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFL--LSIAADTsnkdwedplrydfrsllq 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   382 --------------FYQEEFYIRRIHSLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLLIG 447
Cdd:pfam11894  216 rhiprltpeklllsDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLIIA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   448 ELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCA 527
Cdd:pfam11894  289 YLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENA 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   528 HYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQL 603
Cdd:pfam11894  343 RAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRL 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   604 TSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVR 677
Cdd:pfam11894  419 ISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVP 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   678 VPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLR 746
Cdd:pfam11894  499 RTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   747 fRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELAL 820
Cdd:pfam11894  579 -STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALF 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   821 SLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQGIN 887
Cdd:pfam11894  658 SIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   888 prtkkadNVVNIARYLYHGnnNPELAFESAKILCCISCNSNI----------QVKMVGDFTHDQSvSQKLMAGFVECLDY 957
Cdd:pfam11894  735 -------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEA 804

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   958 EDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERNP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCLHA 1035
Cdd:pfam11894  805 PIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHS 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1036 ILNILEKGTEGRDGPVAVREYP-QLADLCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEHE-------- 1106
Cdd:pfam11894  874 LLLLLLSSLDLISEGDYIDYAPaRLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfd 952

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1107 -------------ISMLSQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKpysdgeggmedenrsvsgflhfD 1173
Cdd:pfam11894  953 gvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLLLGNNILD----------------------G 1010

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1174 TATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGMAA 1248
Cdd:pfam11894 1011 GEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGESK 1090

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1249 IGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDLLQDVHDKV-----L 1323
Cdd:pfam11894 1091 AGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveL 1167

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1324 DDEAAQELMPVVAGAVFTLTAHLSQAVRTEQRQplvsgpgeaqyafmldssltsspaaesrpvgFASIGDSSLHIILKKL 1403
Cdd:pfam11894 1168 DIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFKTC 1216

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1404 LDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVVCR 1483
Cdd:pfam11894 1217 IDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVICN 1275

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1484 DACDGHEIGRMLALALLDRIVSVD--KQHQWLLYLSNSGYLKVLVDSLVDDDRTLQSLLTPQPPLLKALY--TYESKMAF 1559
Cdd:pfam11894 1276 DAIGGEGTCRITALLLLDSLVHLDsnKSNFILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLAL 1355

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1560 LTRVAKEQQGSAELLRSGVIVRLAQCQVYDMRPEMdshGMFgmRDPPVFIPTPVDRYRQILLPALQLCQVILTSSMSQHL 1639
Cdd:pfam11894 1356 LIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL---GLS--LDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNK 1430

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226437676  1640 QAAGQVLQFLVSHSDTIQAILR---------CQDVSTGSLQELALLTGIISKAA 1684
Cdd:pfam11894 1431 SAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 165-1684 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1087.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   165 ELVSMTTRFTDELME-QGLTYKVLTLLSQIDVNNEfekLQRERGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLPK 243
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   244 DDTLLLIGHLERVtveanGSLDAVNLCLLMALLYCFDtsfidqSTEERddmihhLPLLTERQYVSTIHSRLQDSqpWKLP 323
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFG------SLEDL------SVLQDVRELHSKITKSLDSE--WPLY 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   324 --GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFLseAVVLAEN------------------ 381
Cdd:pfam11894  138 tdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFL--LSIAADTsnkdwedplrydfrsllq 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   382 --------------FYQEEFYIRRIHSLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLLIG 447
Cdd:pfam11894  216 rhiprltpeklllsDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLIIA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   448 ELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCA 527
Cdd:pfam11894  289 YLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENA 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   528 HYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQL 603
Cdd:pfam11894  343 RAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRL 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   604 TSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVR 677
Cdd:pfam11894  419 ISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVP 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   678 VPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLR 746
Cdd:pfam11894  499 RTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   747 fRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELAL 820
Cdd:pfam11894  579 -STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALF 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   821 SLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQGIN 887
Cdd:pfam11894  658 SIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   888 prtkkadNVVNIARYLYHGnnNPELAFESAKILCCISCNSNI----------QVKMVGDFTHDQSvSQKLMAGFVECLDY 957
Cdd:pfam11894  735 -------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEA 804

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676   958 EDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERNP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCLHA 1035
Cdd:pfam11894  805 PIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHS 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1036 ILNILEKGTEGRDGPVAVREYP-QLADLCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEHE-------- 1106
Cdd:pfam11894  874 LLLLLLSSLDLISEGDYIDYAPaRLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfd 952

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1107 -------------ISMLSQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKpysdgeggmedenrsvsgflhfD 1173
Cdd:pfam11894  953 gvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLLLGNNILD----------------------G 1010

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1174 TATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGMAA 1248
Cdd:pfam11894 1011 GEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGESK 1090

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1249 IGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDLLQDVHDKV-----L 1323
Cdd:pfam11894 1091 AGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveL 1167

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1324 DDEAAQELMPVVAGAVFTLTAHLSQAVRTEQRQplvsgpgeaqyafmldssltsspaaesrpvgFASIGDSSLHIILKKL 1403
Cdd:pfam11894 1168 DIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFKTC 1216

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1404 LDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVVCR 1483
Cdd:pfam11894 1217 IDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVICN 1275

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1484 DACDGHEIGRMLALALLDRIVSVD--KQHQWLLYLSNSGYLKVLVDSLVDDDRTLQSLLTPQPPLLKALY--TYESKMAF 1559
Cdd:pfam11894 1276 DAIGGEGTCRITALLLLDSLVHLDsnKSNFILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLAL 1355

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226437676  1560 LTRVAKEQQGSAELLRSGVIVRLAQCQVYDMRPEMdshGMFgmRDPPVFIPTPVDRYRQILLPALQLCQVILTSSMSQHL 1639
Cdd:pfam11894 1356 LIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL---GLS--LDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNK 1430

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226437676  1640 QAAGQVLQFLVSHSDTIQAILR---------CQDVSTGSLQELALLTGIISKAA 1684
Cdd:pfam11894 1431 SAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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