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Conserved domains on  [gi|47059145|ref|NP_081678|]
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fibronectin type III domain-containing protein 5 preproprotein [Mus musculus]

Protein Classification

FN3 and DUF4808 domain-containing protein( domain architecture ID 10812976)

FN3 and DUF4808 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-121 3.07e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 3.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145  31 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 108
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|...
gi 47059145 109 GQSPASEPVLFKT 121
Cdd:cd00063  81 GESPPSESVTVTT 93
DUF4808 super family cl24589
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 148-181 2.77e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


The actual alignment was detected with superfamily member pfam16066:

Pssm-ID: 374343  Cd Length: 121  Bit Score: 39.39  E-value: 2.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 47059145   148 RTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEP 181
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALFFNRWGKIRMLEP 36
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-121 3.07e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 3.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145  31 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 108
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|...
gi 47059145 109 GQSPASEPVLFKT 121
Cdd:cd00063  81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 31-111 3.31e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.94  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145     31 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAIS--QQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 108
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 47059145    109 GQS 111
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
32-114 1.71e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 1.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145    32 SAPVNVTVRHLKANSAVVSWDVLED--EVVIGFAIsqQKKDVRMLRFIQEVNT--TTRSCALWDLEEDTEYIVHVQAISI 107
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEV--EYRPKNSGEPWNEITVpgTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 47059145   108 QGQSPAS 114
Cdd:pfam00041  79 GGEGPPS 85
DUF4808 pfam16066
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 148-181 2.77e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


Pssm-ID: 374343  Cd Length: 121  Bit Score: 39.39  E-value: 2.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 47059145   148 RTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEP 181
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALFFNRWGKIRMLEP 36
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
31-117 1.36e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145  31 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTT----TrscalwDLEEDTEYIVHVQAIS 106
Cdd:COG3401 233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306

                        90
                ....*....|..
gi 47059145 107 IQG-QSPASEPV 117
Cdd:COG3401 307 AAGnESAPSNVV 318
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-121 3.07e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 3.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145  31 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 108
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                        90
                ....*....|...
gi 47059145 109 GQSPASEPVLFKT 121
Cdd:cd00063  81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 31-111 3.31e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.94  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145     31 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAIS--QQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 108
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 47059145    109 GQS 111
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
32-114 1.71e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 1.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145    32 SAPVNVTVRHLKANSAVVSWDVLED--EVVIGFAIsqQKKDVRMLRFIQEVNT--TTRSCALWDLEEDTEYIVHVQAISI 107
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEV--EYRPKNSGEPWNEITVpgTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 47059145   108 QGQSPAS 114
Cdd:pfam00041  79 GGEGPPS 85
DUF4808 pfam16066
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 148-181 2.77e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


Pssm-ID: 374343  Cd Length: 121  Bit Score: 39.39  E-value: 2.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 47059145   148 RTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEP 181
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALFFNRWGKIRMLEP 36
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
31-117 1.36e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059145  31 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTT----TrscalwDLEEDTEYIVHVQAIS 106
Cdd:COG3401 233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306

                        90
                ....*....|..
gi 47059145 107 IQG-QSPASEPV 117
Cdd:COG3401 307 AAGnESAPSNVV 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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