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Conserved domains on  [gi|110625730|ref|NP_081258|]
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transmembrane protein 256 precursor [Mus musculus]

Protein Classification

DUF423 domain-containing protein( domain architecture ID 10515198)

DUF423 domain-containing protein, possibly an integral membrane protein similar to human transmembrane protein 256 and Bacillus subtilis membrane protein YwdK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 22-101 5.68e-15

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


:

Pssm-ID: 461234  Cd Length: 86  Bit Score: 64.46  E-value: 5.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625730   22 LASYGAHGAQfPDAYGKELFDKANKHHFLHSLALLGVPSC-------RKPVWAGLLLASGTTLFCTSFYYQALSGDTSIQ 94
Cdd:pfam04241   1 LGAFGAHGLK-ARPEQLAVFETAVQYQMYHALALLAVALLargapraRLLNLAGWLFLAGIVLFSGSLYALALTGIKWLG 79


                  ....*..
gi 110625730   95 TLGPVGG 101
Cdd:pfam04241  80 PITPIGG 86
 
Name Accession Description Interval E-value
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 22-101 5.68e-15

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


Pssm-ID: 461234  Cd Length: 86  Bit Score: 64.46  E-value: 5.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625730   22 LASYGAHGAQfPDAYGKELFDKANKHHFLHSLALLGVPSC-------RKPVWAGLLLASGTTLFCTSFYYQALSGDTSIQ 94
Cdd:pfam04241   1 LGAFGAHGLK-ARPEQLAVFETAVQYQMYHALALLAVALLargapraRLLNLAGWLFLAGIVLFSGSLYALALTGIKWLG 79


                  ....*..
gi 110625730   95 TLGPVGG 101
Cdd:pfam04241  80 PITPIGG 86
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
11-113 5.08e-14

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


Pssm-ID: 441930  Cd Length: 126  Bit Score: 62.88  E-value: 5.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625730  11 LGALSGAGALGLASYGAHG-AQFPDAYGKELFDKANKHHFLHSLALLGV------PSCRKPVWAGLLLASGTTLFCTSFY 83
Cdd:COG2363    9 LGALLGALAVALGAFGAHGlKGRLSPEALATFETAVRYQMYHALALLALgllaqrLPSRLLRLAGWLFLLGILLFSGSLY 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 110625730  84 YQALSGDTSIQTLGPVGGSLLILGWLALAF 113
Cdd:COG2363   89 ALALTGIKLLGAITPIGGLLFILGWLLLAI 118
PRK10873 PRK10873
hypothetical protein; Provisional
 50-109 1.23e-03

hypothetical protein; Provisional


Pssm-ID: 182798  Cd Length: 131  Bit Score: 35.83  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110625730  50 LHSLALLG--VPSCRKPV----WAGLLLASGTTLFCTSFYYQALSGDTSIQTLGPVGGSLLILGWL 109
Cdd:PRK10873  49 FHTLAILGlaVAMQRRISiwfyWSSVFLALGTVLFSGSLYCLALSHLRLWAYITPVGGVSFLAGWA 114
 
Name Accession Description Interval E-value
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 22-101 5.68e-15

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


Pssm-ID: 461234  Cd Length: 86  Bit Score: 64.46  E-value: 5.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625730   22 LASYGAHGAQfPDAYGKELFDKANKHHFLHSLALLGVPSC-------RKPVWAGLLLASGTTLFCTSFYYQALSGDTSIQ 94
Cdd:pfam04241   1 LGAFGAHGLK-ARPEQLAVFETAVQYQMYHALALLAVALLargapraRLLNLAGWLFLAGIVLFSGSLYALALTGIKWLG 79


                  ....*..
gi 110625730   95 TLGPVGG 101
Cdd:pfam04241  80 PITPIGG 86
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
11-113 5.08e-14

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


Pssm-ID: 441930  Cd Length: 126  Bit Score: 62.88  E-value: 5.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625730  11 LGALSGAGALGLASYGAHG-AQFPDAYGKELFDKANKHHFLHSLALLGV------PSCRKPVWAGLLLASGTTLFCTSFY 83
Cdd:COG2363    9 LGALLGALAVALGAFGAHGlKGRLSPEALATFETAVRYQMYHALALLALgllaqrLPSRLLRLAGWLFLLGILLFSGSLY 88

                         90       100       110
                 ....*....|....*....|....*....|
gi 110625730  84 YQALSGDTSIQTLGPVGGSLLILGWLALAF 113
Cdd:COG2363   89 ALALTGIKLLGAITPIGGLLFILGWLLLAI 118
PRK10873 PRK10873
hypothetical protein; Provisional
 50-109 1.23e-03

hypothetical protein; Provisional


Pssm-ID: 182798  Cd Length: 131  Bit Score: 35.83  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110625730  50 LHSLALLG--VPSCRKPV----WAGLLLASGTTLFCTSFYYQALSGDTSIQTLGPVGGSLLILGWL 109
Cdd:PRK10873  49 FHTLAILGlaVAMQRRISiwfyWSSVFLALGTVLFSGSLYCLALSHLRLWAYITPVGGVSFLAGWA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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