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Conserved domains on  [gi|27229061|ref|NP_080740|]
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WD repeat-containing protein 55 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
40-333 5.00e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 5.00e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  40 APASGLAFHPTRDLLAAGDVDGDVFVFAYScqegETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQL 119
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 120 ERRIsKAHSAPINSVLLV-DENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNI 198
Cdd:COG2319 155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 199 KRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCIV--PvTENLLCTGSTDGI 276
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27229061 277 IRAVNILPNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWDMTQLRTVVV 333
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
40-333 5.00e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 5.00e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  40 APASGLAFHPTRDLLAAGDVDGDVFVFAYScqegETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQL 119
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 120 ERRIsKAHSAPINSVLLV-DENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNI 198
Cdd:COG2319 155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 199 KRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCIV--PvTENLLCTGSTDGI 276
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27229061 277 IRAVNILPNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWDMTQLRTVVV 333
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-331 3.75e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 3.75e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  84 HLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRIsKAHSAPINSVLLV-DENALVTGDDTGGIRLWDQRKEGPL 162
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 163 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNG 242
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 243 FGaTSDRFALRAESIDCIVPV-TENLLCTGSTDGIIRAVNILPNRVVGTVGQHaGEPVEALALSHCGHFLASSGHDQRLK 321
Cdd:cd00200 167 GK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIR 244

                       250
                ....*....|
gi 27229061 322 FWDMTQLRTV 331
Cdd:cd00200 245 VWDLRTGECV 254
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 45-134 9.77e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061    45 LAFHPTRDLLAAGDVDGDVFVFAYSCQEgetkeLWS-SGHHLKSC-RAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERR 122
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-----VWTlSPDKEDLEvTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|..
gi 27229061   123 ISkAHSAPINSV 134
Cdd:pfam12894  76 FS-AGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 284-324 8.46e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 8.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27229061    284 PNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWD 324
Cdd:smart00320   1 SGELLKTLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
40-333 5.00e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 5.00e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  40 APASGLAFHPTRDLLAAGDVDGDVFVFAYScqegETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQL 119
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 120 ERRIsKAHSAPINSVLLV-DENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNI 198
Cdd:COG2319 155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 199 KRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCIV--PvTENLLCTGSTDGI 276
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27229061 277 IRAVNILPNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWDMTQLRTVVV 333
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
39-326 3.59e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 3.59e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  39 EAPASGLAFHPTRDLLAAGDVDGDVFVFayscQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQ 118
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 119 LERRIsKAHSAPINSV-LLVDENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFN 197
Cdd:COG2319 196 LLRTL-TGHTGAVRSVaFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 198 IKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCIV--PvTENLLCTGSTDG 275
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAfsP-DGKTLASGSDDG 352

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 27229061 276 IIRAVNILPNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWDMT 326
Cdd:COG2319 353 TVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-331 3.75e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 3.75e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  84 HLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRIsKAHSAPINSVLLV-DENALVTGDDTGGIRLWDQRKEGPL 162
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 163 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNG 242
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 243 FGaTSDRFALRAESIDCIVPV-TENLLCTGSTDGIIRAVNILPNRVVGTVGQHaGEPVEALALSHCGHFLASSGHDQRLK 321
Cdd:cd00200 167 GK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIR 244

                       250
                ....*....|
gi 27229061 322 FWDMTQLRTV 331
Cdd:cd00200 245 VWDLRTGECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-324 7.03e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 7.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  39 EAPASGLAFHPTRDLLAAGDVDGDVFVFAYSCQEGETKElwsSGHHLKScRAVVFSEDGQKLVTVSKDKAIHILDVEQGQ 118
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPV-RDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 119 LERRIsKAHSAPINSVLLVDENALVTG---DDTggIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGV 195
Cdd:cd00200  85 CVRTL-TGHTSYVSSVAFSPDGRILSSssrDKT--IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 196 FNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLfnWN-GFGATSDRFALRAESIDCIVP-VTENLLCTGST 273
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL--WDlSTGKCLGTLRGHENGVNSVAFsPDGYLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 27229061 274 DGIIRAVNILPNRVVGTVGQHAgEPVEALALSHCGHFLASSGHDQRLKFWD 324
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-331 5.44e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 5.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  40 APASGLAFHPTRDLLAAGDVDGDVFVFAyscqEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQL 119
Cdd:COG2319  37 AAVASLAASPDGARLAAGAGDLTLLLLD----AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 120 eRRISKAHSAPINSVLL-VDENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNI 198
Cdd:COG2319 113 -LRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 199 KRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCIV--PvTENLLCTGSTDGI 276
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAfsP-DGRLLASGSADGT 269

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27229061 277 IRAVNILPNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWDMTQLRTV 331
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
39-242 2.07e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 2.07e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  39 EAPASGLAFHPTRDLLAAGDVDGDVFVfaYSCQEGetKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQ 118
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRL--WDLATG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 119 LERRIsKAHSAPINSVLLV-DENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFN 197
Cdd:COG2319 280 LLRTL-TGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 27229061 198 IKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNG 242
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
77-357 7.72e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 7.72e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061  77 ELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQ 156
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 157 RKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIY 236
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 237 LFNWNGfGATSDRFALRAESIDCIV--PvTENLLCTGSTDGIIRAVNILPNRVVGTVGQHAGePVEALALSHCGHFLASS 314
Cdd:COG2319 188 LWDLAT-GKLLRTLTGHTGAVRSVAfsP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASG 264

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 27229061 315 GHDQRLKFWDmtqlrtvvVDDYRRRKKKGGPLRALSSKAWSTD 357
Cdd:COG2319 265 SADGTVRLWD--------LATGELLRTLTGHSGGVNSVAFSPD 299
WD40 COG2319
WD40 repeat [General function prediction only];
134-357 4.37e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 4.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 134 VLLVDENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGD 213
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061 214 LTSVALMKYGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCIV--PVTENLLcTGSTDGIIRAVNILPNRVVGTV 291
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAfsPDGKTLA-SGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27229061 292 GQHAGePVEALALSHCGHFLASSGHDQRLKFWDmtqlrtvvVDDYRRRKKKGGPLRALSSKAWSTD 357
Cdd:COG2319 159 TGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWD--------LATGKLLRTLTGHTGAVRSVAFSPD 215
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 45-134 9.77e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27229061    45 LAFHPTRDLLAAGDVDGDVFVFAYSCQEgetkeLWS-SGHHLKSC-RAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERR 122
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-----VWTlSPDKEDLEvTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|..
gi 27229061   123 ISkAHSAPINSV 134
Cdd:pfam12894  76 FS-AGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 284-324 8.46e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 8.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27229061    284 PNRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWD 324
Cdd:smart00320   1 SGELLKTLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-324 5.37e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 27229061   285 NRVVGTVGQHAGePVEALALSHCGHFLASSGHDQRLKFWD 324
Cdd:pfam00400   1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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