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Conserved domains on  [gi|31981132|ref|NP_080181|]
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tetratricopeptide repeat protein 23 isoform 1 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-255 1.23e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457  14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457  79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 31981132 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRDR 255
Cdd:COG0457 135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLE 171
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-255 1.23e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457  14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457  79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 31981132 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRDR 255
Cdd:COG0457 135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLE 171
TPR_12 pfam13424
Tetratricopeptide repeat;
187-253 1.08e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.53  E-value: 1.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31981132   187 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-255 1.23e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.62  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457  14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457  79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 31981132 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRDR 255
Cdd:COG0457 135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLE 171
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 52-253 6.45e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 6.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  52 AKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKglslqakqHAEKAKEILANSIESPCHNktd 131
Cdd:COG2956  49 GNLYRRRGEYDRAIRIHQKLLERDP--------DRAEALLELAQDYLKAG--------LLDRAEELLEKLLELDPDD--- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 132 ifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQK 211
Cdd:COG2956 110 -----AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE---------------NAHAYCELAELYLEQGDYDEAIEALEK 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 31981132 212 ALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:COG2956 170 ALKLDP--------DCARALLLLAELYLEQGDYEEAIAALER 203
TPR_12 pfam13424
Tetratricopeptide repeat;
187-253 1.08e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.53  E-value: 1.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31981132   187 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-253 3.60e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.38  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  85 KLAEAYVNLAQGYLQLkGLSLQAKQHAEKAKEILANSIESpchnktdifkcslelFYTLGRALLSLQKFKDASENLIKAE 164
Cdd:COG0457   6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDAEA---------------LYNLGLAYLRLGRYEEALADYEQAL 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 165 RLSKEMLQCgnivkeeWIEIqsriklsfAQLYQGQKRSKEAFPFYQKALEYteitkdekSLECVQVLRELAGVEQALGLY 244
Cdd:COG0457  70 ELDPDDAEA-------LNNL--------GLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126


                ....*....
gi 31981132 245 AAAISHFSR 253
Cdd:COG0457 127 DEAIEAYER 135
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 52-248 4.02e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 4.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  52 AKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktd 131
Cdd:COG2956 117 AEIYEQEGDWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYD-EAIEALEKALKLDPDCARA------- 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 132 ifkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQK 211
Cdd:COG2956 181 --------LLLLAELYLEQGDYEEAIAALERALEQDPDYLP---------------ALPRLAELYEKLGDPEEALELLRK 237

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 31981132 212 ALEytEITKDEKSLECVQVLRELAGVEQALGLYAAAI 248
Cdd:COG2956 238 ALE--LDPSDDLLLALADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-253 1.83e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 1.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  31 KLLQTALfQPPREKLHLCEERAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQH 110
Cdd:COG2956  63 RIHQKLL-ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDP--------DDAEALRLLAEIYEQEGDWE-KAIEV 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 111 AEKAKEILANSIEspchnktdifkcsleLFYTLGRALLSLQKFKDASENLIKAERLSKEMLqcgnivkeewieiqsRIKL 190
Cdd:COG2956 133 LERLLKLGPENAH---------------AYCELAELYLEQGDYDEAIEALEKALKLDPDCA---------------RALL 182

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31981132 191 SFAQLYQGQKRSKEAFPFYQKALeyteitkdEKSLECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:COG2956 183 LLAELYLEQGDYEEAIAALERAL--------EQDPDYLPALPRLAELYEKLGDPEEALELLRK 237
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-247 3.67e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 3.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLkGLSLQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457  48 LGLAYLRLGRYEEALADYEQALELDP--------DDAEALNNLGLALQAL-GRYEEALEDYDKALELDPDDAEA------ 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEMLQCGNivkeewieiqsriklSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457 113 ---------LYNLGLALLELGRYDEAIEAYERALELDPDDADALY---------------NLGIALEKLGRYEEALELLE 168

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 31981132 211 KALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAA 247
Cdd:COG0457 169 KLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 50-214 1.60e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 1.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  50 ERAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSiespchnk 129
Cdd:COG4783   9 ALAQALLLAGDYDEAEALLEKALELDP--------DNPEAFALLGEILLQLGDLD-EAIVLLHEALELDPDE-------- 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 130 tdifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEMlqcgnivkeewIEIQSRIklsfAQLYQGQKRSKEAFPFY 209
Cdd:COG4783  72 -------PEARLNLGLALLKAGDYDEALALLEKALKLDPEH-----------PEAYLRL----ARAYRALGRPDEAIAAL 129


                ....*
gi 31981132 210 QKALE 214
Cdd:COG4783 130 EKALE 134
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 136-253 2.03e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.45  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 136 SLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEy 215
Cdd:COG4235  16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA- 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 31981132 216 teitKDEKSlecVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:COG4235  80 ----LDPDN---PEALYLLGLAAFQQGDYAEAIAAWQK 110
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 31-214 2.12e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  31 KLLQTALFQPPREKLHLCEERAKSYSSSREYKQAIQELVRCVALtricygdwHWKLAEAYVNLAQGYLQLkGLSLQAKQH 110
Cdd:COG3914  64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--------NPDNAEALFNLGNLLLAL-GRLEEALAA 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132 111 AEKAKEIlansieSPCHnktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEMlqcgnivkeewIEIQSRIkl 190
Cdd:COG3914 135 LRRALAL------NPDF---------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDN-----------AEALNNL-- 186

                       170       180
                ....*....|....*....|....
gi 31981132 191 sfAQLYQGQKRSKEAFPFYQKALE 214
Cdd:COG3914 187 --GNALQDLGRLEEAIAAYRRALE 208
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-253 4.11e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 4.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981132  97 YLQLKGLSLQAKQHAEKAKEILANSIEspchnktdIFKCSLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgni 176
Cdd:COG4783   6 ALYALAQALLLAGDYDEAEALLEKALE--------LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31981132 177 vkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSR 253
Cdd:COG4783  71 --------EPEARLNLGLALLKAGDYDEALALLEKALKLDP--------EHPEAYLRLARAYRALGRPDEAIAALEK 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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