NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|168229161|ref|NP_078811|]
View 

coronin-7 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 471-880 1.68e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 1.68e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 471 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 546
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 626
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 627 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 707 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 786
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 787 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 858
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 168229161 859 PPDMSPVSQAPREAPARRAPSS 880
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-428 3.69e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 187.79  E-value: 3.69e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161   6 VSKFRHTEARPPRRESWISDIRAGTAP-SCRNHIKSSCSLIAfnsdrpgvlgiVPLQGQG-------EDKRRVAH----- 72
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIA-----------VPWQQLGstavlkhTDYGKLASnppil 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  73 LGCHSDLVtDLDFSPFDDFLLATGSADRTVKLWRLPGPG-QALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSA-AGTTV 150
Cdd:PTZ00421  72 LGQEGPII-DVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 151 KVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVST 230
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 231 GFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLR 310
Cdd:PTZ00421 230 GCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHK 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 311 GAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPA 388
Cdd:PTZ00421 308 GLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAV 387

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 168229161 389 CRPH-PSFTSCLVPPAEPLPdtaQPAVMETPVGDADASEGF 428
Cdd:PTZ00421 388 FDGTsPELMGASALSPSGKP---RHSGVSVPASTSAMTHSF 425
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 471-880 1.68e-69

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 1.68e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 471 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 546
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 626
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 627 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 707 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 786
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 787 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 858
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 168229161 859 PPDMSPVSQAPREAPARRAPSS 880
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 6-428 3.69e-51

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 187.79  E-value: 3.69e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161   6 VSKFRHTEARPPRRESWISDIRAGTAP-SCRNHIKSSCSLIAfnsdrpgvlgiVPLQGQG-------EDKRRVAH----- 72
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIA-----------VPWQQLGstavlkhTDYGKLASnppil 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  73 LGCHSDLVtDLDFSPFDDFLLATGSADRTVKLWRLPGPG-QALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSA-AGTTV 150
Cdd:PTZ00421  72 LGQEGPII-DVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 151 KVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVST 230
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 231 GFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLR 310
Cdd:PTZ00421 230 GCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHK 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 311 GAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPA 388
Cdd:PTZ00421 308 GLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAV 387

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 168229161 389 CRPH-PSFTSCLVPPAEPLPdtaQPAVMETPVGDADASEGF 428
Cdd:PTZ00421 388 FDGTsPELMGASALSPSGKP---RHSGVSVPASTSAMTHSF 425
WD40 COG2319
WD40 repeat [General function prediction only];
545-760 2.05e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 2.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 545 AAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDL 624
Cdd:COG2319  163 GAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 625 QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsq 704
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNS-VAFSPDGKLLASGSDD-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 168229161 705 seRQLLLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 760
Cdd:COG2319  310 --GTVRLWDLA--TGKLLRTLTGHTGAVRSV-AFSPD-GKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 546-704 1.44e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.72  E-value: 1.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 546 AVTDLAWDPFDpHRLAVAGEDARIRLWRVPAEgleEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 625
Cdd:cd00200   53 PVRDVAASADG-TYLASGSSDKTIRLWDLETG---ECVRT----LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 626 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRCLLVSGFD 702
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGE----VNSVAfspDGEKLLSSSSD 198


                 ..
gi 168229161 703 SQ 704
Cdd:cd00200  199 GT 200
WD40 COG2319
WD40 repeat [General function prediction only];
65-246 1.60e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 1.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPTSDGILVS 144
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-GKLLRTLTG-----HTGAVRSVAFSPDGKLLASG 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 145 AAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRasQSTQAHENSRDSRLAW--MG 222
Cdd:COG2319  223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFspDG 300

                        170       180
                 ....*....|....*....|....
gi 168229161 223 TWehLVSTGFNQMrereVKLWDTR 246
Cdd:COG2319  301 KL--LASGSDDGT----VRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-246 1.32e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPgPGQALpsapGVVLGPEDlPVEVLQFHPTSDGILVS 144
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE-TGKCL----TTLRGHTD-WVNSVAFSPDGTFVASS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 145 AAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKpRASQSTQAHENSRDSrLAWMGTW 224
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNS-VAFSPDG 231

                        170       180
                 ....*....|....*....|..
gi 168229161 225 EHLVSTGFNqmreREVKLWDTR 246
Cdd:cd00200  232 YLLASGSED----GTIRVWDLR 249
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 808-852 5.43e-15

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 69.46  E-value: 5.43e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 168229161  808 LEPVAFRLPRVRKEFFQDDVFPDTAViWEPVLSAEAWLQGANGQP 852
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAG-TEPALTAEEWLSGKNAEP 44
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 338-380 4.70e-13

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 64.07  E-value: 4.70e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 168229161  338 IVPIGYHVPRKAVE-FHEDLFPDTAGCVPATDPHSWWAGDNQQV 380
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 633-664 3.13e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 3.13e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 168229161   633 LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 5.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 5.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 168229161    66 DKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLW 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 471-880 1.68e-69

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 1.68e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 471 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 546
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 547 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 626
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 627 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 707 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 786
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 787 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 858
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 168229161 859 PPDMSPVSQAPREAPARRAPSS 880
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 6-428 3.69e-51

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 187.79  E-value: 3.69e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161   6 VSKFRHTEARPPRRESWISDIRAGTAP-SCRNHIKSSCSLIAfnsdrpgvlgiVPLQGQG-------EDKRRVAH----- 72
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIA-----------VPWQQLGstavlkhTDYGKLASnppil 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  73 LGCHSDLVtDLDFSPFDDFLLATGSADRTVKLWRLPGPG-QALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSA-AGTTV 150
Cdd:PTZ00421  72 LGQEGPII-DVAFNPFDPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 151 KVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVST 230
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 231 GFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLR 310
Cdd:PTZ00421 230 GCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHK 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 311 GAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPA 388
Cdd:PTZ00421 308 GLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAV 387

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 168229161 389 CRPH-PSFTSCLVPPAEPLPdtaQPAVMETPVGDADASEGF 428
Cdd:PTZ00421 388 FDGTsPELMGASALSPSGKP---RHSGVSVPASTSAMTHSF 425
PTZ00420 PTZ00420
coronin; Provisional
 53-385 2.06e-37

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 148.94  E-value: 2.06e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  53 GVLGIVPLQGQGEdKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSA--PGVVLGPEDLPVE 130
Cdd:PTZ00420  51 GLIGAIRLENQMR-KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIkdPQCILKGHKKKIS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 131 VLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLvQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQA 209
Cdd:PTZ00420 130 IIDWNPMNYYIMCSSGfDSFVNIWDIENEKRAFQINMPKKL-SSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIAS-SFHI 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 210 HENSRDSRLAWM----GTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQL 285
Cdd:PTZ00420 208 HDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNC 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 286 YCYEVvpQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQ-LSDTAIVPIGYHVPRK-AVEFHEDLFPDTAGC 363
Cdd:PTZ00420 288 RYYQH--SLGSIRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMH 365

                        330       340
                 ....*....|....*....|..
gi 168229161 364 VPATDPHSWWAGDNQQVQKVSL 385
Cdd:PTZ00420 366 DPERSSRNWIDGKDNKMKRINI 387
PTZ00420 PTZ00420
coronin; Provisional
 500-849 5.68e-37

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 147.40  E-value: 5.68e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 500 ESDGFCANKLRVAVPL-LSSGGQVAVLELRKPGRLPdtalPTLQ---NGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVP 575
Cdd:PTZ00420  30 DSCGIACSSGFVAVPWeVEGGGLIGAIRLENQMRKP----PVIKlkgHTSSILDLQFNPCFSEILASGSEDLTIRVWEIP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 576 A--EGLEEVlTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQgHQDQIFSLAWSPDGQQLA 653
Cdd:PTZ00420 106 HndESVKEI-KDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 654 TVCKDGRVRVYRPRSgPEPLQEGPGPKGGRGARIVWV----CDGRCLLVSGFDSQSERQLLLYEAEALAgGPLAVLGLDV 729
Cdd:PTZ00420 184 GTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLKNTT-SALVTMSIDN 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 730 APSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESpfFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLR-LRQSSL 808
Cdd:PTZ00420 262 ASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSI 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 168229161 809 EPVAFRLPRVRKEFFQDDVFPDTaVIWEPVLSAEAWLQGAN 849
Cdd:PTZ00420 340 RPISFYVPRKNPTKFQEDLYPPI-LMHDPERSSRNWIDGKD 379
WD40 COG2319
WD40 repeat [General function prediction only];
545-760 2.05e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 2.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 545 AAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDL 624
Cdd:COG2319  163 GAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 625 QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsq 704
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNS-VAFSPDGKLLASGSDD-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 168229161 705 seRQLLLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 760
Cdd:COG2319  310 --GTVRLWDLA--TGKLLRTLTGHTGAVRSV-AFSPD-GKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
476-760 9.55e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 9.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 476 AQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT------LQNGAAVTD 549
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGallatlLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 550 LAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQAGAD 629
Cdd:COG2319   84 VAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 630 RLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsqseRQL 709
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRS-VAFSPDGKLLASGSAD----GTV 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 168229161 710 LLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 760
Cdd:COG2319  229 RLWDLA--TGKLLRTLTGHSGSVRSV-AFSPD-GRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
544-702 9.22e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 9.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 544 GAAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 623
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT-------GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 168229161 624 LQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFD 702
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
544-668 4.15e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 4.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 544 GAAVTDLAWDPfDPHRLAVAGEDARIRLWRVpaeGLEEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 623
Cdd:COG2319  288 SGGVNSVAFSP-DGKLLASGSDDGTVRLWDL---ATGKLLRT----LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD 358

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 168229161 624 LQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 668
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 546-704 1.44e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.72  E-value: 1.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 546 AVTDLAWDPFDpHRLAVAGEDARIRLWRVPAEgleEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 625
Cdd:cd00200   53 PVRDVAASADG-TYLASGSSDKTIRLWDLETG---ECVRT----LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 626 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRCLLVSGFD 702
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGE----VNSVAfspDGEKLLSSSSD 198


                 ..
gi 168229161 703 SQ 704
Cdd:cd00200  199 GT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 547-665 6.81e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.72  E-value: 6.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 547 VTDLAWDPfDPHRLAVAGEDARIRLWRVPAEgleevltTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQA 626
Cdd:cd00200  180 VNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-------KCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRT 250

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 168229161 627 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 665
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
65-246 1.60e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 1.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPTSDGILVS 144
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-GKLLRTLTG-----HTGAVRSVAFSPDGKLLASG 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 145 AAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRasQSTQAHENSRDSRLAW--MG 222
Cdd:COG2319  223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFspDG 300

                        170       180
                 ....*....|....*....|....
gi 168229161 223 TWehLVSTGFNQMrereVKLWDTR 246
Cdd:COG2319  301 KL--LASGSDDGT----VRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 546-755 2.48e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 546 AVTDLAWDPfDPHRLAVAGEDARIRLWRVPAEgleevltTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 625
Cdd:cd00200   95 YVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 626 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGgrGARIVWVCDGRCLLVSG----- 700
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHEN--GVNSVAFSPDGYLLASGsedgt 242

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 168229161 701 ---FDSQSERQLllyeaEALAGGPLAVLGLDVAPstllpsydpdTGLVLLTGKGDTRV 755
Cdd:cd00200  243 irvWDLRTGECV-----QTLSGHTNSVTSLAWSP----------DGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
65-246 7.27e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 7.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPGPgqalpsAPGVVLGPEDLPVEVLQFHPtsDG-ILV 143
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG------KLLRTLTGHSGSVRSVAFSP--DGrLLA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 144 SA-AGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWM- 221
Cdd:COG2319  263 SGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSp 340

                        170       180
                 ....*....|....*....|....*.
gi 168229161 222 -GTWehLVSTGfnqmREREVKLWDTR 246
Cdd:COG2319  341 dGKT--LASGS----DDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-246 1.32e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPgPGQALpsapGVVLGPEDlPVEVLQFHPTSDGILVS 144
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE-TGKCL----TTLRGHTD-WVNSVAFSPDGTFVASS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 145 AAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKpRASQSTQAHENSRDSrLAWMGTW 224
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNS-VAFSPDG 231

                        170       180
                 ....*....|....*....|..
gi 168229161 225 EHLVSTGFNqmreREVKLWDTR 246
Cdd:cd00200  232 YLLASGSED----GTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-295 1.35e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  76 HSDLVTDLDFSPFDDFLlATGSADRTVKLWRLPGPgqalpsAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDA 155
Cdd:cd00200   50 HTGPVRDVAASADGTYL-ASGSSDKTIRLWDLETG------ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 156 AKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRdSRLAWMGTWEHLVSTGFNqm 235
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSD-- 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 168229161 236 reREVKLWDTRFFSSaLASLT--LDTSLGCLVpllDPDsGLLVLAGKGERQLYCYEVVPQQP 295
Cdd:cd00200  199 --GTIKLWDLSTGKC-LGTLRghENGVNSVAF---SPD-GYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
14-246 1.18e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  14 ARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPfDDFLL 93
Cdd:COG2319   15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  94 ATGSADRTVKLWRLPGpgqalpSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQS 173
Cdd:COG2319   94 ASASADGTVRLWDLAT------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229161 174 AVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWMGTWEHLVSTGFNqmreREVKLWDTR 246
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSPDGKLLASGSAD----GTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
65-199 1.74e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPTSDGILVS 144
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAT-GKLLRTLTG-----HTGAVRSVAFSPDGKTLASG 348

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 168229161 145 AAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRT 199
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 589-669 1.61e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 589 VLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 668
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82


                 .
gi 168229161 669 G 669
Cdd:cd00200   83 G 83
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-196 7.80e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 7.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  76 HSDLVTDLDFSPfDDFLLATGSADRTVKLWRLPGpGQALpsapgVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDA 155
Cdd:cd00200  176 HTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST-GKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 168229161 156 AKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFD 196
Cdd:cd00200  249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 808-852 5.43e-15

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 69.46  E-value: 5.43e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 168229161  808 LEPVAFRLPRVRKEFFQDDVFPDTAViWEPVLSAEAWLQGANGQP 852
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAG-TEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 470-532 1.36e-13

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 66.37  E-value: 1.36e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168229161  470 SSKFRHAQGTVLHRDSHITNLKglNLTTPGESDGFCANKLRVAVPLLSSG-GQVAVLELRKPGR 532
Cdd:pfam08953   5 ASKFRHVYGKPAKKELCYDNIK--VTKNAWDSNFIAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 338-380 4.70e-13

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 64.07  E-value: 4.70e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 168229161  338 IVPIGYHVPRKAVE-FHEDLFPDTAGCVPATDPHSWWAGDNQQV 380
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-60 3.22e-12

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 62.52  E-value: 3.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161    3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFN--SDRPGVLGIVPL 60
Cdd:pfam08953   2 FVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNweSSGGGAFAVLPL 61
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-246 1.44e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 128 PVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRAsqST 207
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV--RT 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 168229161 208 QAHENSRDSRLAWMGTwEHLVSTGfnqMREREVKLWDTR 246
Cdd:cd00200   89 LTGHTSYVSSVAFSPD-GRILSSS---SRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
559-760 4.65e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 4.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 559 RLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAAnVLASSSYDLTVRIWDLQAGADRLKLQGHQD 638
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161 639 QIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGarIVWVCDGRCLLVSGFDsqseRQLLLYEAEalA 718
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS--VAFSPDGKTLASGSAD----GTVRLWDLA--T 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 168229161 719 GGPLAVL-GLDVAPSTLlpSYDPDtGLVLLTGKGDTRVFLYEL 760
Cdd:COG2319  152 GKLLRTLtGHSGAVTSV--AFSPD-GKLLASGSDDGTVRLWDL 191
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 633-664 3.13e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 3.13e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 168229161   633 LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 5.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 5.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 168229161    66 DKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLW 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 585-623 6.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 168229161   585 TPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 623
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
632-664 1.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.05e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 168229161  632 KLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 664
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
67-105 1.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 168229161   67 KRRVAHLGCHSDLVTDLDFSPFDDFLlATGSADRTVKLW 105
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
585-623 4.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 168229161  585 TPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 623
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 620-664 2.99e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 2.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 168229161  620 RIWDLQAGADRLKlqghqdqIFSLAWSPDGQQLATVCKDGRVRVY 664
Cdd:pfam12894  28 RVWTLSPDKEDLE-------VTSLAWRPDGKLLAVGYSDGTVRLL 65
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-106 1.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 168229161  65 EDKRRVAHLGCHSDLVTDLDFSPfDDFLLATGSADRTVKLWR 106
Cdd:cd00200  249 RTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 516-669 2.79e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.56  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  516 LSSGGQVAVLELR--------KPG---RLPDTAlptlqnGAAVTDLAWDPfDPHRLAVA----GEDArirLWRVPAEGLE 580
Cdd:COG4946   309 LSPDGKRVAFEARgevftvpaEKGptrNLTNTP------GVRERLPAWSP-DGKSIAYFsdasGEYE---LYIAPADGSG 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229161  581 EV--LTTPETvltghtekicSLRFHPLAANV---LASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWSPDGQQLAT 654
Cdd:COG4946   379 EPkqLTLGDL----------GRVFNPVWSPDgkkIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAY 448

                         170
                  ....*....|....*....
gi 168229161  655 VCKDG----RVRVYRPRSG 669
Cdd:COG4946   449 SKPGPnqlsQIFLYDVETG 467
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 640-715 9.97e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 9.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168229161  640 IFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAE 715
Cdd:COG4946   391 VFNPVWSPDGKKIAFTDNRGRLWVVDLASG-KVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPNQLSQIFLYDVE 465
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH