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Conserved domains on  [gi|34222121|ref|NP_076962|]
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nucleoporin Nup37 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 1.51e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  16 EDYVHVVEFNPfengdSGNLIAYGG-NNYVVIGtctfqeeeaDVEGiqYKTLRTF-HHGVRVDGIAWSPETRLdslppvi 93
Cdd:COG2319 204 TGAVRSVAFSP-----DGKLLASGSaDGTVRLW---------DLAT--GKLLRTLtGHSGSVRSVAFSPDGRL------- 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  94 kFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSV 171
Cdd:COG2319 261 -LASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSV 336

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 34222121 172 CWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319 337 AFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 1.51e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  16 EDYVHVVEFNPfengdSGNLIAYGG-NNYVVIGtctfqeeeaDVEGiqYKTLRTF-HHGVRVDGIAWSPETRLdslppvi 93
Cdd:COG2319 204 TGAVRSVAFSP-----DGKLLASGSaDGTVRLW---------DLAT--GKLLRTLtGHSGSVRSVAFSPDGRL------- 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  94 kFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSV 171
Cdd:COG2319 261 -LASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSV 336

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 34222121 172 CWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319 337 AFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-194 2.90e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 2.90e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  64 KTLRTFH-HGVRVDGIAWSPETRldslppviKFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIAS 142
Cdd:cd00200 168 KCVATLTgHTGEVNSVAFSPDGE--------KLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-GYLLAS 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 34222121 143 VSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYD 194
Cdd:cd00200 237 GSEDGTIRVWDLRtGECVQTLSGHTNSvTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-153 5.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 34222121    113 DKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
118-153 2.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 34222121   118 KVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 1.51e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  16 EDYVHVVEFNPfengdSGNLIAYGG-NNYVVIGtctfqeeeaDVEGiqYKTLRTF-HHGVRVDGIAWSPETRLdslppvi 93
Cdd:COG2319 204 TGAVRSVAFSP-----DGKLLASGSaDGTVRLW---------DLAT--GKLLRTLtGHSGSVRSVAFSPDGRL------- 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  94 kFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSV 171
Cdd:COG2319 261 -LASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSV 336

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 34222121 172 CWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319 337 AFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
64-216 2.13e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 2.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  64 KTLRTF-HHGVRVDGIAWSPETRLdslppVIkfcTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIAS 142
Cdd:COG2319 153 KLLRTLtGHSGAVTSVAFSPDGKL-----LA---SGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSP-DGKLLAS 221

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 34222121 143 VSDDHTCRIWNLEGVQTAHFVLHSPGM--SVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSPDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-194 2.90e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 2.90e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  64 KTLRTFH-HGVRVDGIAWSPETRldslppviKFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIAS 142
Cdd:cd00200 168 KCVATLTgHTGEVNSVAFSPDGE--------KLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-GYLLAS 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 34222121 143 VSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYD 194
Cdd:cd00200 237 GSEDGTIRVWDLRtGECVQTLSGHTNSvTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
64-195 2.31e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 2.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  64 KTLRTF-HHGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIAS 142
Cdd:COG2319 279 ELLRTLtGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPD-GKTLAS 347

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 34222121 143 VSDDHTCRIWNLEGVQTAH-FVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYDL 195
Cdd:COG2319 348 GSDDGTVRLWDLATGELLRtLTGHTGAvTSVAFSPDGRT-LASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-216 1.87e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  59 EGIQYKTLRTFH-HGVRVDGIAWSPETRLDSlppvikfcTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeG 137
Cdd:cd00200 121 DVETGKCLTTLRgHTDWVNSVAFSPDGTFVA--------SSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPD-G 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121 138 QEIASVSDDHTCRIWNL-EGVQTAHFVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAH 215
Cdd:cd00200 190 EKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGvNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268


                .
gi 34222121 216 W 216
Cdd:cd00200 269 W 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-271 1.89e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  71 HGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCR 150
Cdd:cd00200   8 HTGGVTCVAFSPDGKL--------LATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121 151 IWNLEGVQTAH-FVLH-SPGMSVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVA 228
Cdd:cd00200  77 LWDLETGECVRtLTGHtSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 34222121 229 GNDWLIWDItRSSYPQNKRPVHMDRACLFRWSTISENLFATTG 271
Cdd:cd00200 156 DGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 COG2319
WD40 repeat [General function prediction only];
71-238 2.94e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 2.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  71 HGVRVDGIAWSPETRLDSlppvikfcTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCR 150
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLA--------SASADGTVRLW--DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVR 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121 151 IWNLE-GVQTAHFVLHSPGM-SVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVA 228
Cdd:COG2319 146 LWDLAtGKLLRTLTGHSGAVtSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                       170
                ....*....|
gi 34222121 229 GNDWLIWDIT 238
Cdd:COG2319 225 DGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
64-156 3.55e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 3.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  64 KTLRTF-HHGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIAS 142
Cdd:COG2319 321 KLLRTLtGHTGAVRSVAFSPDGKT--------LASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSP-DGRTLAS 389

                        90
                ....*....|....
gi 34222121 143 VSDDHTCRIWNLEG 156
Cdd:COG2319 390 GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-153 1.89e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 1.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121  59 EGIQYKTLRTfhHGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQ 138
Cdd:cd00200 208 TGKCLGTLRG--HENGVNSVAFSPDGYL--------LASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSP-DGK 274

                        90
                ....*....|....*
gi 34222121 139 EIASVSDDHTCRIWN 153
Cdd:cd00200 275 RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-238 1.90e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222121 116 EYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEGVQTAH-FVLHSPGMSVC-WHPEETFkLMVAEKNGTIRFY 193
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVaASADGTY-LASGSSDKTIRLW 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 34222121 194 DLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDIT 238
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-153 5.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 34222121    113 DKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
118-153 2.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 34222121   118 KVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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