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Conserved domains on  [gi|47059478|ref|NP_075974|]
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syncoilin [Mus musculus]

Protein Classification

intermediate filament family protein( domain architecture ID 705869)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Filament super family cl25641
Intermediate filament protein;
159-445 1.47e-12

Intermediate filament protein;


The actual alignment was detected with superfamily member pfam00038:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 68.41  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQ-----------DILAAYKLHAQAELERDGLREE 227
Cdd:pfam00038   4 EQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSlyekeiedlrrQLDTLTVERARLQLELDNLRLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   228 IRTVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRD---------ACQKQKEQLQQQLEAP 298
Cdd:pfam00038  84 AEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKnheeevrelQAQVSDTQVNVEMDAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   299 PTQSDGHFLQESRRlstQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQN 378
Cdd:pfam00038 164 RKLDLTSALAEIRA---QYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47059478   379 RNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAML 445
Cdd:pfam00038 241 ASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLL 307
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
159-445 1.47e-12

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 68.41  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQ-----------DILAAYKLHAQAELERDGLREE 227
Cdd:pfam00038   4 EQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSlyekeiedlrrQLDTLTVERARLQLELDNLRLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   228 IRTVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRD---------ACQKQKEQLQQQLEAP 298
Cdd:pfam00038  84 AEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKnheeevrelQAQVSDTQVNVEMDAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   299 PTQSDGHFLQESRRlstQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQN 378
Cdd:pfam00038 164 RKLDLTSALAEIRA---QYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47059478   379 RNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAML 445
Cdd:pfam00038 241 ASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLL 307
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 159-436 3.09e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.77  E-value: 3.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLRepalQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKV 238
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLR----KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    239 TKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRdacqkqkeqlqqqleapptqsdghflQESRRLSTQFE 318
Cdd:TIGR02168  760 EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR--------------------------EALDELRAELT 813

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    319 NLMAESRQGLEEeyepqLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQ 398
Cdd:TIGR02168  814 LLNEEAANLRER-----LESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA 888

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 47059478    399 YREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAE 436
Cdd:TIGR02168  889 LALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 198-446 1.41e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 1.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 198 QEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTKECVAYQYQLECRQQDVAQfadcreaLTTRAAQLSEEL 277
Cdd:COG4942  27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE-------LEKEIAELRAEL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 278 TQLRDACQKQKEQLQQQLEAPPTQ---SDGHFLQESRRLStqfenlmaesrqgLEEEYEPQLLRLLERKEAGTKALQDTQ 354
Cdd:COG4942 100 EAQKEELAELLRALYRLGRQPPLAlllSPEDFLDAVRRLQ-------------YLKYLAPARREQAEELRADLAELAALR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 355 AEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSgvQVQQQKNKEMERLRMSL 434
Cdd:COG4942 167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA--LIARLEAEAAAAAERTP 244

                       250
                ....*....|..
gi 47059478 435 AEELSTYKAMLP 446
Cdd:COG4942 245 AAGFAALKGKLP 256
mukB PRK04863
chromosome partition protein MukB;
159-437 5.17e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.64  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQeVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKV 238
Cdd:PRK04863  376 EQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQ-YQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQEA 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   239 TKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQ--LRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQ 316
Cdd:PRK04863  455 TEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQR 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   317 FENLMAE--SRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRpleAEARQLQLQNRNLEdQITLVRQKRDE 394
Cdd:PRK04863  535 AERLLAEfcKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALR---QQLEQLQARIQRLA-ARAPAWLAAQD 610

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 47059478   395 EVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEE 437
Cdd:PRK04863  611 ALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAAR 653
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
159-445 1.47e-12

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 68.41  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQ-----------DILAAYKLHAQAELERDGLREE 227
Cdd:pfam00038   4 EQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSlyekeiedlrrQLDTLTVERARLQLELDNLRLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   228 IRTVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRD---------ACQKQKEQLQQQLEAP 298
Cdd:pfam00038  84 AEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKnheeevrelQAQVSDTQVNVEMDAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   299 PTQSDGHFLQESRRlstQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQN 378
Cdd:pfam00038 164 RKLDLTSALAEIRA---QYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47059478   379 RNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAML 445
Cdd:pfam00038 241 ASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLL 307
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 159-436 3.09e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.77  E-value: 3.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLRepalQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKV 238
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLR----KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    239 TKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRdacqkqkeqlqqqleapptqsdghflQESRRLSTQFE 318
Cdd:TIGR02168  760 EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR--------------------------EALDELRAELT 813

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    319 NLMAESRQGLEEeyepqLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQ 398
Cdd:TIGR02168  814 LLNEEAANLRER-----LESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA 888

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 47059478    399 YREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAE 436
Cdd:TIGR02168  889 LALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 198-446 1.41e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 1.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 198 QEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTKECVAYQYQLECRQQDVAQfadcreaLTTRAAQLSEEL 277
Cdd:COG4942  27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE-------LEKEIAELRAEL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 278 TQLRDACQKQKEQLQQQLEAPPTQ---SDGHFLQESRRLStqfenlmaesrqgLEEEYEPQLLRLLERKEAGTKALQDTQ 354
Cdd:COG4942 100 EAQKEELAELLRALYRLGRQPPLAlllSPEDFLDAVRRLQ-------------YLKYLAPARREQAEELRADLAELAALR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 355 AEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSgvQVQQQKNKEMERLRMSL 434
Cdd:COG4942 167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA--LIARLEAEAAAAAERTP 244

                       250
                ....*....|..
gi 47059478 435 AEELSTYKAMLP 446
Cdd:COG4942 245 AAGFAALKGKLP 256
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 212-454 5.16e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.28  E-value: 5.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    212 KLHAQAELERD--GLREEIRTVKQKLFkvTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKE 289
Cdd:TIGR02168  204 SLERQAEKAERykELKAELRELELALL--VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEE 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    290 QLQQQL----EAPPTQSDghFLQESRRLSTQFENLMAESRQGLE--EEYEPQLLRLLERKEAGTKALQDTQAEIQEMREA 363
Cdd:TIGR02168  282 EIEELQkelyALANEISR--LEQQKQILRERLANLERQLEELEAqlEELESKLDELAEELAELEEKLEELKEELESLEAE 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    364 LRPLEAEARQLQLQNRNLEDQITLVRQKRDE----------EVQQYREQLEEMEERQRQLRsgvQVQQQKNKEMERLRMS 433
Cdd:TIGR02168  360 LEELEAELEELESRLEELEEQLETLRSKVAQlelqiaslnnEIERLEARLERLEDRRERLQ---QEIEELLKKLEEAELK 436

                          250       260
                   ....*....|....*....|..
gi 47059478    434 -LAEELSTYKAMLPKSLEQADA 454
Cdd:TIGR02168  437 eLQAELEELEEELEELQEELER 458
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 163-450 2.21e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.98  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    163 RLEARFQQCVQAVSQLEEERDQLIHELVLLRepalQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVtkec 242
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIE----NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEEL---- 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    243 vayQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQFENLMA 322
Cdd:TIGR02169  743 ---EEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQ 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    323 E-SRQGLEEEYEPQLLRLLERKEAGTKA-LQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYR 400
Cdd:TIGR02169  820 KlNRLTLEKEYLEKEIQELQEQRIDLKEqIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR 899

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 47059478    401 eqleEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLE 450
Cdd:TIGR02169  900 ----ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEE 945
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 212-440 3.06e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.47  E-value: 3.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 212 KLHAQAE--LERDGLREEIRTVKQKLfkvtkecvaYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKe 289
Cdd:COG1196 204 PLERQAEkaERYRELKEELKELEAEL---------LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR- 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 290 qlqqqleapptqsdghflQESRRLSTQFENLMAESRQGLEE--EYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPL 367
Cdd:COG1196 274 ------------------LELEELELELEEAQAEEYELLAElaRLEQDIARLEERRRELEERLEELEEELAELEEELEEL 335

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059478 368 EAEARQLQLQNRNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELST 440
Cdd:COG1196 336 EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA 408
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 159-445 3.45e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.60  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKV 238
Cdd:TIGR02169  184 ENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISEL 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    239 TKECVAYQYQLECRQQDVAQFADCRE-ALTTRAAQLSEELTQLRDACQKQKEQLQ--QQLEAPPTQSDGHFLQESRRLST 315
Cdd:TIGR02169  264 EKRLEEIEQLLEELNKKIKDLGEEEQlRVKEKIGELEAEIASLERSIAEKERELEdaEERLAKLEAEIDKLLAEIEELER 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    316 QFENLMAESRQgLEEEY---EPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQitlvRQKR 392
Cdd:TIGR02169  344 EIEEERKRRDK-LTEEYaelKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEE----LQRL 418

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 47059478    393 DEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAML 445
Cdd:TIGR02169  419 SEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQEL 471
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 323-443 9.70e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 9.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 323 ESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYREQ 402
Cdd:COG1196 235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL 314

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47059478 403 LEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKA 443
Cdd:COG1196 315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE 355
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
161-405 1.27e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  161 LERLEARFQQCVQAVSQLEEERDQLIHELvllrePALQEVQQVHQDILAayklHAQAELERDGLREEIRTVKQKLFKVTK 240
Cdd:COG4913  612 LAALEAELAELEEELAEAEERLEALEAEL-----DALQERREALQRLAE----YSWDEIDVASAEREIAELEAELERLDA 682

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  241 ---ECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQS----DGHFLQES--- 310
Cdd:COG4913  683 ssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELrallEERFAAALgda 762

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  311 --RRLSTQFENLMA---ESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEA------EARQLQLQNR 379
Cdd:COG4913  763 veRELRENLEERIDalrARLNRAEEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLEEdglpeyEERFKELLNE 842

                        250       260
                 ....*....|....*....|....*.
gi 47059478  380 NLEDQITLVRQKRDEEVQQYREQLEE 405
Cdd:COG4913  843 NSIEFVADLLSKLRRAIREIKERIDP 868
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 160-431 1.95e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    160 DLERLEARFQQCVQAVSQLEEERDQLIHELVLLREpalqEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVT 239
Cdd:TIGR02168  226 ELALLVLRLEELREELEELQEELKEAEEELEELTA----ELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    240 KECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHFLQESRR--LSTQF 317
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLeeLEEQL 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    318 ENLMAESRQGLEEEY--EPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQ--NRNLEDQITLVRQKRd 393
Cdd:TIGR02168  382 ETLRSKVAQLELQIAslNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEelEEELEELQEELERLE- 460

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 47059478    394 EEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLR 431
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSLERLQ 498
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 159-418 4.41e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 4.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    159 EDLERLEARFQQCVQAVSQLEEERDQL----------IHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEI 228
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELeaeieeleerLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL 812

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    229 RTVKQKLFKVT--------------KECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKeqlqqq 294
Cdd:TIGR02168  813 TLLNEEAANLRerleslerriaateRRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE------ 886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    295 leapptqsdghflQESRRLSTQFENLMAESRQGLEE--EYEPQLLRLLERKEAGTKALQDTQAEIQEMREALR------- 365
Cdd:TIGR02168  887 -------------EALALLRSELEELSEELRELESKrsELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeeysltl 953

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47059478    366 -PLEAEARQLQLQNRNLEDQITLVRQKRD----------EEVQQYREQLEEMEERQRQLRSGVQ 418
Cdd:TIGR02168  954 eEAEALENKIEDDEEEARRRLKRLENKIKelgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKE 1017
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 177-452 4.49e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 4.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 177 QLEEERDQLIHELVLLR-EPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTKECVAYQYQLECRQQD 255
Cdd:COG1196 217 ELKEELKELEAELLLLKlRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 256 VAQFADCREALTTRAAQLSEELTQLrdacqkqkeqlqqqleapptqsdghflQESRRLSTQFENLMAESRQGLEEEYEPQ 335
Cdd:COG1196 297 LARLEQDIARLEERRRELEERLEEL---------------------------EEELAELEEELEELEEELEELEEELEEA 349

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 336 LLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQL------QLQNRNLEDQITLVRQKRDEEVQQYREQLEEMEER 409
Cdd:COG1196 350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELlealraAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47059478 410 QRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLEQA 452
Cdd:COG1196 430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 306-458 4.68e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    306 FLQESRRLSTQFENLMAESRQGLE--EEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLED 383
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEklEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47059478    384 QITLVRQKRD---EEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLEQADAPTSQ 458
Cdd:TIGR02168  324 QLEELESKLDelaEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNE 401
mukB PRK04863
chromosome partition protein MukB;
159-437 5.17e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.64  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQeVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKV 238
Cdd:PRK04863  376 EQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQ-YQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQEA 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   239 TKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQ--LRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQ 316
Cdd:PRK04863  455 TEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQR 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   317 FENLMAE--SRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRpleAEARQLQLQNRNLEdQITLVRQKRDE 394
Cdd:PRK04863  535 AERLLAEfcKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALR---QQLEQLQARIQRLA-ARAPAWLAAQD 610

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 47059478   395 EVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEE 437
Cdd:PRK04863  611 ALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAAR 653
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
153-405 6.95e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 6.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  153 EDPLSVEDLERLEARFQQCVQAVSQLEEERDQLIHelvllrepaLQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVK 232
Cdd:COG4913  219 EEPDTFEAADALVEHFDDLERAHEALEDAREQIEL---------LEPIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  233 QKLfkvtkecvaYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHfLQESRR 312
Cdd:COG4913  290 LEL---------LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERE-LEERER 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  313 LSTQFENLMA-------ESRQGLEEEYEpQLLRLLERKEAGTKALQDTQAE----IQEMREALRPLEAEARQLQLQNRNL 381
Cdd:COG4913  360 RRARLEALLAalglplpASAEEFAALRA-EAAALLEALEEELEALEEALAEaeaaLRDLRRELRELEAEIASLERRKSNI 438

                        250       260
                 ....*....|....*....|....
gi 47059478  382 edqitlvrqkrDEEVQQYREQLEE 405
Cdd:COG4913  439 -----------PARLLALRDALAE 451
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 251-465 1.15e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    251 CRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSdghflQESRRLSTQFENLMAESRQgLEE 330
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELS-----RQISALRKDLARLEAEVEQ-LEE 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    331 EYEPQLLRLLERKEAGTKALQdtqaEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDE----------EVQQYR 400
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEE----RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDElraeltllneEAANLR 823

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47059478    401 EQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLEQADAPTSQAGGVEAQ 465
Cdd:TIGR02168  824 ERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA 888
PTZ00121 PTZ00121
MAEBL; Provisional
 84-437 1.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    84 DESRQPDEALGLEEPVRPEEMLSVEESVTPDEVQISE--QPVEPAKSPT-----ACEGEMVATEGSLPAQPIPNTEEDPL 156
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEakKKADAAKKKAeekkkADEAKKKAEEDKKKADELKKAAAAKK 1418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   157 SVEDLERLEARFQQCVQAVSQLEEERDQliHELVLLREPA--LQEVQQVHQDILAAYKLHAQAELER--DGLREEIRTVK 232
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKKA--DEAKKKAEEAkkAEEAKKKAEEAKKADEAKKKAEEAKkaDEAKKKAEEAK 1496

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   233 QKLFKVTKECVAYQYQLECRQQDVAQFAD-------CREALTTRAAQLSEELTQLRDA--CQKQKEQLQQQLEAPPTQSD 303
Cdd:PTZ00121 1497 KKADEAKKAAEAKKKADEAKKAEEAKKADeakkaeeAKKADEAKKAEEKKKADELKKAeeLKKAEEKKKAEEAKKAEEDK 1576

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478   304 GHFLQESRRLSTQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAE-IQEMREALRPLEAEARQLQLQNRNLE 382
Cdd:PTZ00121 1577 NMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEeEKKKVEQLKKKEAEEKKKAEELKKAE 1656

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 47059478   383 DQITLVRQ---KRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEE 437
Cdd:PTZ00121 1657 EENKIKAAeeaKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
248-443 2.56e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  248 QLECRQQDVAQFADCREALTTRAAQLSEE---LTQLRDACQKQKEQLQQQLEAPPTQsdghflQESRRLSTQFENLMAES 324
Cdd:COG4913  611 KLAALEAELAELEEELAEAEERLEALEAEldaLQERREALQRLAEYSWDEIDVASAE------REIAELEAELERLDASS 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  325 rqgleeeyePQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQitlVRQKRDEEVQQYREQLE 404
Cdd:COG4913  685 ---------DDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDR---LEAAEDLARLELRALLE 752

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 47059478  405 EM------EERQRQLRSGVQVQQQK-NKEMERLRMSLAEELSTYKA 443
Cdd:COG4913  753 ERfaaalgDAVERELRENLEERIDAlRARLNRAEEELERAMRAFNR 798
PRK12704 PRK12704
phosphodiesterase; Provisional
 339-451 3.21e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.76  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  339 LLERKEAGTKALQDTQAEIQEMREALRPLEaeaRQLQLQNRNLEDQITLVRQKRDE---EVQQYREQLEEMEERQRQLRs 415
Cdd:PRK12704  59 LLEAKEEIHKLRNEFEKELRERRNELQKLE---KRLLQKEENLDRKLELLEKREEElekKEKELEQKQQELEKKEEELE- 134

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 47059478  416 gvQVQQQKNKEMERLrMSL-AEELstyKAMLPKSLEQ 451
Cdd:PRK12704 135 --ELIEEQLQELERI-SGLtAEEA---KEILLEKVEE 165
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 345-438 3.53e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.75  E-value: 3.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 345 AGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKN 424
Cdd:COG4942  17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                        90
                ....*....|....
gi 47059478 425 KEMERLRMSLAEEL 438
Cdd:COG4942  97 AELEAQKEELAELL 110
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 159-415 3.64e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQ-QVH---------QDILAAYKLHAQ-AELERDGLREE 227
Cdd:TIGR02169  251 EELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKeKIGeleaeiaslERSIAEKERELEdAEERLAKLEAE 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    228 IRTVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDacqkqkeqlqqqleapptqsdghfl 307
Cdd:TIGR02169  331 IDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRD------------------------- 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    308 qESRRLSTQFENLMAEsrqglEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITL 387
Cdd:TIGR02169  386 -ELKDYREKLEKLKRE-----INELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQ 459

                          250       260       270
                   ....*....|....*....|....*....|.
gi 47059478    388 VRQKRDEEVQQY---REQLEEMEERQRQLRS 415
Cdd:TIGR02169  460 LAADLSKYEQELydlKEEYDRVEKELSKLQR 490
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
330-436 3.94e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 39.12  E-value: 3.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 330 EEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDE---EVQQYREQLEEM 406
Cdd:COG1340   4 DELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDElneKVKELKEERDEL 83

                        90       100       110
                ....*....|....*....|....*....|
gi 47059478 407 EERQRQLRSGVQVQQQKNKEMERLRMSLAE 436
Cdd:COG1340  84 NEKLNELREELDELRKELAELNKAGGSIDK 113
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 157-384 5.22e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    157 SVEDLERLEARFQQCVQAVSQLE---EERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQ 233
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRlevSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    234 KLFKVTKECVAYQYQLECRQQDVAQ-------FADCREALTTRAAQLSEELTQLRDACQKQKEQLQ------QQLEAPPT 300
Cdd:TIGR02168  331 KLDELAEELAELEEKLEELKEELESleaeleeLEAELEELESRLEELEEQLETLRSKVAQLELQIAslnneiERLEARLE 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    301 QSDGH---FLQESRRLSTQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQ 377
Cdd:TIGR02168  411 RLEDRrerLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQAR 490


                   ....*..
gi 47059478    378 NRNLEDQ 384
Cdd:TIGR02168  491 LDSLERL 497
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 102-283 5.83e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.28  E-value: 5.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    102 EEMLSVEESVTPDEVQISEQPVEPAKSPTACEGEMVATEgSLPAQPIPNTEEDPLSVEDLERLEARFQQCVQAVSQLEEE 181
Cdd:TIGR02169  315 RELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRD-KLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREK 393

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478    182 RDQLIHE----------LVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTKECVAYQYQLEC 251
Cdd:TIGR02169  394 LEKLKREinelkreldrLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYD 473

                          170       180       190
                   ....*....|....*....|....*....|..
gi 47059478    252 RQQDVAQFADCREALTTRAAQLSEELTQLRDA 283
Cdd:TIGR02169  474 LKEEYDRVEKELSKLQRELAEAEAQARASEER 505
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
215-421 6.29e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 39.23  E-value: 6.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 215 AQAELERDGLREEIRTVKQKLFKVTKECVAYQyqlecRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQK------ 288
Cdd:COG3206 171 EEARKALEFLEEQLPELRKELEEAEAALEEFR-----QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEarlaal 245

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 289 -EQLQQQLEAPPTQSDGHFLQESRRLSTQFENLMAESRQGLEEEYePQLLRLLERKEA--------GTKALQDTQAEIQE 359
Cdd:COG3206 246 rAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNH-PDVIALRAQIAAlraqlqqeAQRILASLEAELEA 324

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47059478 360 MREALRPLEAEARQLQLQNRNL-EDQITLVRQKRDeeVQQYREQLEEMEERQRQLRSGVQVQQ 421
Cdd:COG3206 325 LQAREASLQAQLAQLEARLAELpELEAELRRLERE--VEVARELYESLLQRLEEARLAEALTV 385
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
330-437 6.33e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.07  E-value: 6.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 330 EEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQlQNRNLEDQITLVRQKRDEEVQQYREQLEEMEER 409
Cdd:COG2433 409 TEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEAR-SEERREIRKDREISRLDREIERLERELEEERER 487

                        90       100
                ....*....|....*....|....*...
gi 47059478 410 QRQLRSgvqvqqqKNKEMERLRMSLAEE 437
Cdd:COG2433 488 IEELKR-------KLERLKELWKLEHSG 508
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 320-437 8.25e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 8.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478 320 LMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVrQKRDEEVQQY 399
Cdd:COG4942  13 LAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL-EAELAELEKE 91

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47059478 400 REQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEE 437
Cdd:COG4942  92 IAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPE 129
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
159-418 9.53e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 38.48  E-value: 9.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  159 EDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREpalqEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLfKV 238
Cdd:PRK02224 363 EEAAELESELEEAREAVEDRREEIEELEEEIEELRE----RFGDAPVDLGNAEDFLEELREERDELREREAELEATL-RT 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  239 TKECVAYQYQL-------ECRQQ-----DVAQFADCREalttRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHF 306
Cdd:PRK02224 438 ARERVEEAEALleagkcpECGQPvegspHVETIEEDRE----RVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIER 513

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059478  307 LQESRRLSTQfenLMAESRQGLEEEYEpQLLRLLERKEA------------------------GTKALQDTQAEIQEMRE 362
Cdd:PRK02224 514 LEERREDLEE---LIAERRETIEEKRE-RAEELRERAAEleaeaeekreaaaeaeeeaeeareEVAELNSKLAELKERIE 589

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 47059478  363 ALRPLEAEARQLQlqnrNLEDQITLVRQKRD---EEVQQYREQLEEMEERQRQLRSGVQ 418
Cdd:PRK02224 590 SLERIRTLLAAIA----DAEDEIERLREKREalaELNDERRERLAEKRERKRELEAEFD 644
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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