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Conserved domains on  [gi|10863995|ref|NP_067011|]
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zinc finger protein 410 isoform b [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11779705)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Bos taurus zinc finger protein 22 that binds DNA through the consensus sequence 5'-CAATG-3'

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.23e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.23e-05
                          10        20
                  ....*....|....*....|....*.
gi 10863995   325 SLRKHLVVHSGEKPHQCQVCGKTFSQ 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 189-300 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 189 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 265
Cdd:COG5189 320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                        90       100       110
                ....*....|....*....|....*....|....*
gi 10863995 266 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 300
Cdd:COG5189 395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.23e-05
                          10        20
                  ....*....|....*....|....*.
gi 10863995   325 SLRKHLVVHSGEKPHQCQVCGKTFSQ 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 189-300 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 189 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 265
Cdd:COG5189 320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                        90       100       110
                ....*....|....*....|....*....|....*
gi 10863995 266 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 300
Cdd:COG5189 395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 275-363 6.85e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 6.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 275 GEKPFMCHESGCGKQFTTAGNLKNHRRihtgekpflceaQG-CGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGS 353
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML------------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413

                        90
                ....*....|
gi 10863995 354 RNVHMRKHHL 363
Cdd:COG5189 414 LKYHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 279-303 1.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....*
gi 10863995   279 FMCHEsgCGKQFTTAGNLKNHRRIH 303
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
339-361 8.94e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 8.94e-03
                           10        20
                   ....*....|....*....|...
gi 10863995    339 HQCQVCGKTFSQSGSRNVHMRKH 361
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.23e-05
                          10        20
                  ....*....|....*....|....*.
gi 10863995   325 SLRKHLVVHSGEKPHQCQVCGKTFSQ 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 189-300 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 189 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 265
Cdd:COG5189 320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                        90       100       110
                ....*....|....*....|....*....|....*
gi 10863995 266 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 300
Cdd:COG5189 395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-367 2.64e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 228 RTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNH-----RRI 302
Cdd:COG5048 301 RSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPqslqqYKD 380

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 10863995 303 HTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCqvcgKTFSQSGSRNVHMRKHHLQLGA 367
Cdd:COG5048 381 LKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHYNLIPHKKIH 441
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 339-361 3.94e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.94e-04
                          10        20
                  ....*....|....*....|...
gi 10863995   339 HQCQVCGKTFSQSGSRNVHMRKH 361
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 275-363 6.85e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 6.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 275 GEKPFMCHESGCGKQFTTAGNLKNHRRihtgekpflceaQG-CGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGS 353
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHML------------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413

                        90
                ....*....|
gi 10863995 354 RNVHMRKHHL 363
Cdd:COG5189 414 LKYHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
245-326 9.32e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 9.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995 245 NDRSFICPaeGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYS 324
Cdd:COG5048  30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107


                ..
gi 10863995 325 SL 326
Cdd:COG5048 108 SS 109
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 279-303 1.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....*
gi 10863995   279 FMCHEsgCGKQFTTAGNLKNHRRIH 303
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 251-332 4.18e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.63  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10863995   251 CPAEGCGKSFYVLQRLKVHMRTHNGE------KPFMCHESGCGKQFTTAGNLKNHRRIH-TGEKPFLCEaqGCGRSFAEY 323
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKCE--NCLLRFRTH 79


                  ....*....
gi 10863995   324 SSLRKHLVV 332
Cdd:pfam15909  80 RSLFKHLHV 88
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 339-362 7.60e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.16  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|....
gi 10863995   339 HQCQVCGKTFSQSGSRNVHMRKHH 362
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTHH 24
ZnF_C2H2 smart00355
zinc finger;
339-361 8.94e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 8.94e-03
                           10        20
                   ....*....|....*....|...
gi 10863995    339 HQCQVCGKTFSQSGSRNVHMRKH 361
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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