putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 31543417   31 PGPGQAPVPAQVPAPAPGFALFPSPGPVALGSAAPFLPLPG 71
Cdd:PRK05641  53 PTPAPAPAPAVPSAPTPVAPAAPAPAPASAGENVVTAPMPG 93

Putative phospholipid scramblase YxjI, Tubby2 superfamily [Lipid transport and metabolism];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543417  83 DQILIHQKaervetFLGWEtcNRYELRSGAGQPLGQAAEesnccaRLccgARRPLRVRLADPGDREVLRLLRPLhcgcsc 162
Cdd:COG4894   2 RTLYIKQK------IFSLG--DDFTIYDENGQPVYLVKG------KF---FSLGDTLSIYDADGNELATIKQKL------ 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543417 163 cPCGLQEMEVQAPpGTTIGHVLQTWHPFLPKFSIqDADRQTvLRVVGPCWtcgcgtDTNFEVktRDESRSVGRISKQWgg 242
Cdd:COG4894  59 -FSLLPTFEIYDD-GEPVATIKKKFTFFKDRFTI-EADGLD-LEIEGDFW------DHDFEI--TRGGKVVASVSKKW-- 124

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 31543417 243 lvreaLTDADDFGLQFPldlDVRVKAVLLGATFLIDYMFFEKRGGAG 289
Cdd:COG4894 125 -----FSWRDTYELDID---DEEDRPLVIALAIAIDAVLHKERRAAS 163

N-terminal domain of transcription factor Specificity Protein (SP) 7; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP7, also called Osterix (Osx) in humans, is highly conserved among bone-forming vertebrates. It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. SP7 also plays a regulatory role by inhibiting chondrocyte differentiation, maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. SP7 is thought to play a role in diseases such as Osteogenesis imperfecta. SP7 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP7.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31543417  26 EPALHPGPGQAPVPAQVPAPAPGFAL-FPSPGPVALGSAAPFLP 68
Cdd:cd22542 184 QASLQPVPAQTPLNPQLPSYTEFTTLnPAPYPAVGISSSSHLLP 227

Putative phospholipid scramblase YxjI, Tubby2 superfamily [Lipid transport and metabolism];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543417  83 DQILIHQKaervetFLGWEtcNRYELRSGAGQPLGQAAEesnccaRLccgARRPLRVRLADPGDREVLRLLRPLhcgcsc 162
Cdd:COG4894   2 RTLYIKQK------IFSLG--DDFTIYDENGQPVYLVKG------KF---FSLGDTLSIYDADGNELATIKQKL------ 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543417 163 cPCGLQEMEVQAPpGTTIGHVLQTWHPFLPKFSIqDADRQTvLRVVGPCWtcgcgtDTNFEVktRDESRSVGRISKQWgg 242
Cdd:COG4894  59 -FSLLPTFEIYDD-GEPVATIKKKFTFFKDRFTI-EADGLD-LEIEGDFW------DHDFEI--TRGGKVVASVSKKW-- 124

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 31543417 243 lvreaLTDADDFGLQFPldlDVRVKAVLLGATFLIDYMFFEKRGGAG 289
Cdd:COG4894 125 -----FSWRDTYELDID---DEEDRPLVIALAIAIDAVLHKERRAAS 163

N-terminal domain of transcription factor Specificity Protein (SP) 7; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP7, also called Osterix (Osx) in humans, is highly conserved among bone-forming vertebrates. It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. SP7 also plays a regulatory role by inhibiting chondrocyte differentiation, maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. SP7 is thought to play a role in diseases such as Osteogenesis imperfecta. SP7 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP7.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31543417  26 EPALHPGPGQAPVPAQVPAPAPGFAL-FPSPGPVALGSAAPFLP 68
Cdd:cd22542 184 QASLQPVPAQTPLNPQLPSYTEFTTLnPAPYPAVGISSSSHLLP 227