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Conserved domains on  [gi|9790109|ref|NP_062804|]
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protein arginine N-methyltransferase 1 isoform 1 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10116212)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
63-236 1.34e-46

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.34e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   63 HEEMLKDEVRtltyrNSMFH---NRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS-SISDYAVKIVKANKLDHV 138
Cdd:COG4076  12 HHPMLNDVER-----NDAFKaaiERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109  139 VTIIKGKVEEVELPvEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWweN 218
Cdd:COG4076  87 ITVINADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--Q 163

                       170
                ....*....|....*...
gi 9790109  219 VYGFDMSCIKDVAIKEPL 236
Cdd:COG4076 164 FDGFDFRLFGFLLYAEPL 181
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
63-236 1.34e-46

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.34e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   63 HEEMLKDEVRtltyrNSMFH---NRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS-SISDYAVKIVKANKLDHV 138
Cdd:COG4076  12 HHPMLNDVER-----NDAFKaaiERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109  139 VTIIKGKVEEVELPvEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWweN 218
Cdd:COG4076  87 ITVINADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--Q 163

                       170
                ....*....|....*...
gi 9790109  219 VYGFDMSCIKDVAIKEPL 236
Cdd:COG4076 164 FDGFDFRLFGFLLYAEPL 181
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 92-189 1.70e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     92 VLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN--KLDHVVTIIKGKVEEVELPVEKVDIIISeWMGYCLF 169
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVD---LSPEMLERARERaaEAGLNVEFVQGDAEDLPFPDGSFDLVVS-SGVLHHL 76

                          90       100
                  ....*....|....*....|..
gi 9790109    170 YESMLNTVLH--ARdkWLAPDG 189
Cdd:pfam13649  77 PDPDLEAALReiAR--VLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 92-192 4.39e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.37  E-value: 4.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   92 VLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVK---ANKLDHVVTIIKGKVEE-VELPVEKVDIIISeWMGYC 167
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVD---ISPVALELARkaaAALLADNVEVLKGDAEElPPEADESFDVIIS-DPPLH 77

                        90       100
                ....*....|....*....|....*
gi 9790109  168 LFYESMLNTVLHARDKwLAPDGLIF 192
Cdd:cd02440  78 HLVEDLARFLEEARRL-LKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
84-160 3.25e-08

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 54.00  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109    84 RHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN-KLDHVvtiikgkVEEVELP--VEKVDIII 160
Cdd:PRK00517 115 KLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAARENaELNGV-------ELNVYLPqgDLKADVIV 184
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
63-236 1.34e-46

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.34e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   63 HEEMLKDEVRtltyrNSMFH---NRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS-SISDYAVKIVKANKLDHV 138
Cdd:COG4076  12 HHPMLNDVER-----NDAFKaaiERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109  139 VTIIKGKVEEVELPvEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWweN 218
Cdd:COG4076  87 ITVINADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDW--Q 163

                       170
                ....*....|....*...
gi 9790109  219 VYGFDMSCIKDVAIKEPL 236
Cdd:COG4076 164 FDGFDFRLFGFLLYAEPL 181
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 83-192 4.37e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 68.12  E-value: 4.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   83 NRHLFKDKVVLDVGSGTGILCMFAAKAGARkVIGIEcssISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISe 162
Cdd:COG2227  19 ARLLPAGGRVLDVGCGTGRLALALARRGAD-VTGVD---ISPEALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVIC- 93

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 9790109  163 wmgyclfyesmLNTVLHARD---------KWLAPDGLIF 192
Cdd:COG2227  94 -----------SEVLEHLPDpaallrelaRLLKPGGLLL 121
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
84-160 1.88e-12

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 67.12  E-value: 1.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   84 RHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKI----VKANKLDHVVTIIKGKVeeveLPVEKVDII 159
Cdd:COG2264 144 KLLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD---IDPVAVEAarenAELNGVEDRIEVVLGDL----LEDGPYDLV 216


                .
gi 9790109  160 I 160
Cdd:COG2264 217 V 217
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 92-189 1.70e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.88  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     92 VLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN--KLDHVVTIIKGKVEEVELPVEKVDIIISeWMGYCLF 169
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVD---LSPEMLERARERaaEAGLNVEFVQGDAEDLPFPDGSFDLVVS-SGVLHHL 76

                          90       100
                  ....*....|....*....|..
gi 9790109    170 YESMLNTVLH--ARdkWLAPDG 189
Cdd:pfam13649  77 PDPDLEAALReiAR--VLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 92-192 4.39e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.37  E-value: 4.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   92 VLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVK---ANKLDHVVTIIKGKVEE-VELPVEKVDIIISeWMGYC 167
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVD---ISPVALELARkaaAALLADNVEVLKGDAEElPPEADESFDVIIS-DPPLH 77

                        90       100
                ....*....|....*....|....*
gi 9790109  168 LFYESMLNTVLHARDKwLAPDGLIF 192
Cdd:cd02440  78 HLVEDLARFLEEARRL-LKPGGVLV 101
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
87-161 2.55e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 59.53  E-value: 2.55e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9790109   87 FKDKVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN--KLDHVVTIIKGKVEEVELpVEKVDIIIS 161
Cdd:COG2263  44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD---IDPEALEIARENaeRLGVRVDFIRADVTRIPL-GGSVDTVVM 116
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 93-192 1.69e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 54.21  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     93 LDVGSGTGILCMFAAKAGARkVIGIEcssISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMgycLFYES 172
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVD---ISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEV---LHHVE 73

                          90       100
                  ....*....|....*....|
gi 9790109    173 MLNTVLHARDKWLAPDGLIF 192
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 84-160 2.01e-09

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 58.05  E-value: 2.01e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9790109     84 RHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN-KLDHVVTIIKGKVEEvELPVEKVDIII 160
Cdd:pfam06325 157 RLVKPGESVLDVGCGSGILAIAALKLGAKKVVGVD---IDPVAVRAAKENaELNGVEARLEVYLPG-DLPKEKADVVV 230
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
84-160 3.25e-08

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 54.00  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109    84 RHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN-KLDHVvtiikgkVEEVELP--VEKVDIII 160
Cdd:PRK00517 115 KLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAARENaELNGV-------ELNVYLPqgDLKADVIV 184
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 92-192 4.11e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 52.24  E-value: 4.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   92 VLDVGSGTGILCMFAAKAGARKVIGIecsSIS----DYAVKIVKANKLDHVVTIIKGKVEEVELPvEKVDIIIS----EW 163
Cdd:COG2230  55 VLDIGCGWGGLALYLARRYGVRVTGV---TLSpeqlEYARERAAEAGLADRVEVRLADYRDLPAD-GQFDAIVSigmfEH 130

                        90       100
                ....*....|....*....|....*....
gi 9790109  164 MGYcLFYESMLNTVlharDKWLAPDGLIF 192
Cdd:COG2230 131 VGP-ENYPAYFAKV----ARLLKPGGRLL 154
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 92-161 6.08e-08

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 52.84  E-value: 6.08e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9790109   92 VLDVGSGTGILC-MFAAKAGARKVIGIECSSIS-DYAVKIVKANKLDHVVTIIKGKVEEV--ELPVEKVDIIIS 161
Cdd:COG4123  41 VLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAaELARRNVALNGLEDRITVIHGDLKEFaaELPPGSFDLVVS 114
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 88-161 1.70e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.99  E-value: 1.70e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9790109   88 KDKVVLDVGSGTGILCMFAAKAGARkVIGIEcssISDYAVKIV--KANKLDHVVTIIKGKVEEVELPVEKVDIIIS 161
Cdd:COG2226  22 PGARVLDLGCGTGRLALALAERGAR-VTGVD---ISPEMLELAreRAAEAGLNVEFVVGDAEDLPFPDGSFDLVIS 93
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
47-192 2.43e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 50.38  E-value: 2.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   47 MTSKDY---YFDSYAHfgIHEEMLkdeVRTLTYRN------SMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARkVIGI 117
Cdd:COG4976   1 MALDAYveaLFDQYAD--SYDAAL---VEDLGYEApallaeELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR-LTGV 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9790109  118 EcssISDYAVKIVKANKLDhvVTIIKGKVEEVELPVEKVDIIISeWMGYClfYESMLNTVLHARDKWLAPDG-LIF 192
Cdd:COG4976  75 D---LSEEMLAKAREKGVY--DRLLVADLADLAEPDGRFDLIVA-ADVLT--YLGDLAAVFAGVARALKPGGlFIF 142
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 92-192 4.45e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.91  E-value: 4.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   92 VLDVGSGTGILCMFAAKAGARKVIGIECSSIS-DYAVKIVKANKLDHvVTIIKGKVEE-VELPVEKVDIIISeWMGYCLF 169
Cdd:COG0500  30 VLDLGCGTGRNLLALAARFGGRVIGIDLSPEAiALARARAAKAGLGN-VEFLVADLAElDPLPAESFDLVVA-FGVLHHL 107

                        90       100
                ....*....|....*....|...
gi 9790109  170 YESMLNTVLHARDKWLAPDGLIF 192
Cdd:COG0500 108 PPEEREALLRELARALKPGGVLL 130
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 77-217 3.31e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 47.00  E-value: 3.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   77 RNSMFhNR--HLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN----KLDHVVTIIKGKVEEV- 149
Cdd:COG0742  29 REALF-NIlgPDIEGARVLDLFAGSGALGLEALSRGAASVVFVE---KDRKAAAVIRKNleklGLEDRARVIRGDALRFl 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109  150 -ELPVEKVDIIIsewmgycL---FYESMLNTVLHA--RDKWLAPDGLI---------FPDRATLYvTAIEDRQYKDYKIH 214
Cdd:COG0742 105 kRLAGEPFDLVF-------LdppYAKGLLEKALELlaENGLLAPGGLIvvehskreeLPELPAGL-ELLKERKYGDTRLS 176


                ...
gi 9790109  215 WWE 217
Cdd:COG0742 177 FYR 179
arsM PRK11873
arsenite methyltransferase;
91-161 4.31e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 47.64  E-value: 4.31e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9790109    91 VVLDVGSGTGILCMFAAKA-GAR-KVIGIEcssISDYAVKIVKAN--KLDHV-VTIIKGKVEEVELPVEKVDIIIS 161
Cdd:PRK11873  80 TVLDLGSGGGFDCFLAARRvGPTgKVIGVD---MTPEMLAKARANarKAGYTnVEFRLGEIEALPVADNSVDVIIS 152
PRK14968 PRK14968
putative methyltransferase; Provisional
 88-138 8.38e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 46.05  E-value: 8.38e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 9790109    88 KDKVVLDVGSGTGILCMFAAKAGArKVIGIEcssISDYAVKIVKAN-KLDHV 138
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNGK-KVVGVD---INPYAVECAKCNaKLNNI 70
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 86-160 5.09e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 44.78  E-value: 5.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   86 LFKDKVVLDVGSGTGILCMFAAKAgARKVIGIECS--SISDyAVKIVKANKLDHvVTIIKGKVEEV---ELPVEKVDIII 160
Cdd:COG2265 231 LTGGERVLDLYCGVGTFALPLARR-AKKVIGVEIVpeAVED-ARENARLNGLKN-VEFVAGDLEEVlpeLLWGGRPDVVV 307
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 86-192 1.97e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 41.64  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     86 LFKDKVVLDVGSGTGILCMFAAKAGArKVIGIEcssISDYAVKIVKANKLDHVVTIIKGKVEEvelpvEKVDIIISeWMG 165
Cdd:pfam13489  20 LPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVD---PSPIAIERALLNVRFDQFDEQEAAVPA-----GKFDVIVA-REV 89

                          90       100
                  ....*....|....*....|....*..
gi 9790109    166 YCLFyESMLNTVLHARdKWLAPDGLIF 192
Cdd:pfam13489  90 LEHV-PDPPALLRQIA-ALLKPGGLLL 114
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 88-161 5.71e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.27  E-value: 5.71e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9790109     88 KDKVVLDVGSGTGILCMFAAKAGARkvIGIECSSISDYAVKIVKANKLDH---VVTIIKGKVEEvELPVEKVDIIIS 161
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPD--AELTMVDINARALESARENLAANgleNGEVVASDVYS-GVEDGKFDLIIS 104
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 86-161 6.12e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 39.71  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     86 LFKDKVVLDVGSGTGILCMFAA-KAGAR-KVIGIEcssISDYAVKIVKANKLDH---VVTIIKGKVEEVELPVE--KVDI 158
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAeELGPNaEVVGID---ISEEAIEKARENAQKLgfdNVEFEQGDIEELPELLEddKFDV 77


                  ...
gi 9790109    159 IIS 161
Cdd:pfam13847  78 VIS 80
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
92-192 9.23e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 38.27  E-value: 9.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   92 VLDVGSGTGILC-MFAAKAGARKVIGIEcssISDYAVKIVKANkLDHvVTIIKGKVEEVELPvEKVDIIISewmGYCLFY 170
Cdd:COG4106   5 VLDLGCGTGRLTaLLAERFPGARVTGVD---LSPEMLARARAR-LPN-VRFVVADLRDLDPP-EPFDLVVS---NAALHW 75

                        90       100
                ....*....|....*....|...
gi 9790109  171 ESMLNTVLHARDKWLAPDG-LIF 192
Cdd:COG4106  76 LPDHAALLARLAAALAPGGvLAV 98
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 88-161 1.49e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.76  E-value: 1.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9790109    88 KDKVVLDVGSGTG-ILCMFAAKAGARKVIGIEcssISDYAVKIVKANKLDHV---VTIIKGKVEEvELPVEKVDIIIS 161
Cdd:PRK09328 108 EPLRVLDLGTGSGaIALALAKERPDAEVTAVD---ISPEALAVARRNAKHGLgarVEFLQGDWFE-PLPGGRFDLIVS 181
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
86-161 2.12e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 39.50  E-value: 2.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9790109    86 LFKDKVVLDVGSGTGILCMFAAKAgARKVIGIEC-SSISDYAVKIVKANKLdhvVTIIKGKVEEVELPveKVDIIIS 161
Cdd:PRK14896  27 DTDGDPVLEIGPGKGALTDELAKR-AKKVYAIELdPRLAEFLRDDEIAAGN---VEIIEGDALKVDLP--EFNKVVS 97
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 55-152 2.31e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 39.76  E-value: 2.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109   55 DSYAHFGIHeeMLKDEVRTLTYRNSmfhnrHLFKDKVVLDVGSGTG---ILCMFAAKAGarKVIGIECSSIsdyAVKIVK 131
Cdd:COG2242 221 EAFERDKGP--ITKREVRALTLAKL-----ALRPGDVLWDIGAGSGsvsIEAARLAPGG--RVYAIERDPE---RAALIR 288

                        90       100
                ....*....|....*....|....*.
gi 9790109  132 ANKLDH-V--VTIIKGKVEEV--ELP 152
Cdd:COG2242 289 ANARRFgVpnVEVVEGEAPEAlaDLP 314
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 91-165 2.45e-03

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 38.34  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     91 VVLDVGSGTGIL--CMF--AAKAGAR-KVIGIEcssISDYAV----KIVKANKLDHVVTIIKGKVEEVELPvEKVDIIIS 161
Cdd:pfam05185  66 VILVVGAGRGPLvdRALraAEETGTKvKIYAVE---KNPNAYvtlqKRINFEKWGDKVTIISSDMREWQGP-EKADILVS 141


                  ....
gi 9790109    162 EWMG 165
Cdd:pfam05185 142 ELLG 145
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
90-160 3.44e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 38.74  E-value: 3.44e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9790109   90 KVVLDVGSGTGILCMFAAKAGARKVIGIEcssISDYAVKIVKAN----KL-DHVVTIIKGKVEEV--ELPVEKVDIII 160
Cdd:COG2521 134 DRVLDTCTGLGYTAIEALKRGAREVITVE---KDPNVLELAELNpwsrELaNERIKIILGDASEVikTFPDESFDAII 208
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
85-118 4.18e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 38.69  E-value: 4.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 9790109    85 HLF--KDKVVLDVGSGTGILCMFAAKAGARKVIGIE 118
Cdd:PRK15068 117 HLSplKGRTVLDVGCGNGYHMWRMLGAGAKLVVGID 152
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 93-191 4.43e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.19  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     93 LDVGSGTGILCMFAAKAGAR-KVIGIEcssISDYAVKI----VKANKLDHVVTIIKGKVEEVELPVEKVDIIIsewMGYC 167
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGlEYTGLD---ISPAALEAarerLAALGLLNAVRVELFQLDLGELDPGSFDVVV---ASNV 74

                          90       100
                  ....*....|....*....|....
gi 9790109    168 LFYESMLNTVLHARDKWLAPDGLI 191
Cdd:pfam08242  75 LHHLADPRAVLRNIRRLLKPGGVL 98
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 84-161 5.03e-03

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 37.57  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790109     84 RHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGI------ECSSISDYAVKIVKANkldhvVTIIKGKVEEVELPVEKVD 157
Cdd:pfam01728  17 GLLKPGKTVLDLGAAPGGWSQVALQRGAGKVVGVdlgpmqLWKPRNDPGVTFIQGD-----IRDPETLDLLEELLGRKVD 91


                  ....
gi 9790109    158 IIIS 161
Cdd:pfam01728  92 LVLS 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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