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Conserved domains on  [gi|9789935|ref|NP_062765|]
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melanoma-associated antigen D1 [Mus musculus]

Protein Classification

MAGE domain-containing protein( domain architecture ID 13453538)

MAGE (Melanoma-associated antigen) domain-containing protein similar to human melanoma-associated antigen F1 and non-structural maintenance of chromosomes element 3 homolog

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 475-635 3.72e-18

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 83.47  E-value: 3.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    475 LVKYLMLKDYTKVPIKRSEMLRDIIREY-TDVYPEIIERACFVLEKKFGIQLKEIDKEEHL------------------- 534
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    535 -YILIST--PESLAGILGTTKDTPKLGLLLVILGII----------FMNGNRATEAVLWEALRKMGLR---PGVRHPLLG 598
Cdd:pfam01454  81 sYILVSTlpPEYRVPAIIWPSKAPSFVLDQDEATYTgiltvilsliLLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 9789935    599 DLRKLLTyEFVKQKYLDYRRVPNSNP--PEYEFLWGLRS 635
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
271-462 6.54e-07

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 6.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   271 RSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAArqSPPARQTPSAWQNPVAWQNPVIWPNPViwqnP 350
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA--AAPARRSPAPEALAAARQASARGPGGA----P 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   351 VIWPNPIVWPGPIVwPNPMAWQSTPgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsFPSDWPFPPDWIPADW 430
Cdd:PRK12323 449 APAPAPAAAPAAAA-RPAAAGPRPV----AAAAAAAPARAAPAAAPAPADDDPPPWEELPPE--FASPAPAQPDAAPAGW 521

                        170       180       190
                 ....*....|....*....|....*....|..
gi 9789935   431 PippdwQNLRPSPNLRSSSNSRASQNQGPPQP 462
Cdd:PRK12323 522 V-----AESIPDPATADPDDAFETLAPAPAAA 548
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 36-477 4.80e-06

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 4.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    36 ISEAPPTSQATAAASGPNASPQSSQPPTAnekADTEVSAAAARPktgfkaqnATTKGPNDYSQARNAKEMPknqskAAFK 115
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPA---AAAPAAAAAPAP--------AAAPQPAPAPAPAPAPPSP-----AGNA 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   116 SQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANE--MTNNQPKTakAWNDT-TKVPGA 192
Cdd:PRK07764 449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaDDAATLRE--RWPEIlAAVPKR 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   193 daqtqnvNQAKMADVGTSAGISEADG----------AAAQTSADGSQTQNVesRTIIR---GKRTRKVNNLNVEENNSGD 259
Cdd:PRK07764 527 -------SRKTWAILLPEATVLGVRGdtlvlgfstgGLARRFASPGNAEVL--VTALAeelGGDWQVEAVVGPAPGAAGG 597

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   260 QRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQN 337
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   338 PVIWPNPVIWQNPviwPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDwsMPPDWSFPS 417
Cdd:PRK07764 678 PAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--EPDDPPDPA 752

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   418 DWPFPPDwiPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVK 477
Cdd:PRK07764 753 GAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLE 810
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 475-635 3.72e-18

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 83.47  E-value: 3.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    475 LVKYLMLKDYTKVPIKRSEMLRDIIREY-TDVYPEIIERACFVLEKKFGIQLKEIDKEEHL------------------- 534
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    535 -YILIST--PESLAGILGTTKDTPKLGLLLVILGII----------FMNGNRATEAVLWEALRKMGLR---PGVRHPLLG 598
Cdd:pfam01454  81 sYILVSTlpPEYRVPAIIWPSKAPSFVLDQDEATYTgiltvilsliLLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 9789935    599 DLRKLLTyEFVKQKYLDYRRVPNSNP--PEYEFLWGLRS 635
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
271-462 6.54e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 6.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   271 RSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAArqSPPARQTPSAWQNPVAWQNPVIWPNPViwqnP 350
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA--AAPARRSPAPEALAAARQASARGPGGA----P 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   351 VIWPNPIVWPGPIVwPNPMAWQSTPgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsFPSDWPFPPDWIPADW 430
Cdd:PRK12323 449 APAPAPAAAPAAAA-RPAAAGPRPV----AAAAAAAPARAAPAAAPAPADDDPPPWEELPPE--FASPAPAQPDAAPAGW 521

                        170       180       190
                 ....*....|....*....|....*....|..
gi 9789935   431 PippdwQNLRPSPNLRSSSNSRASQNQGPPQP 462
Cdd:PRK12323 522 V-----AESIPDPATADPDDAFETLAPAPAAA 548
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 36-477 4.80e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 4.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    36 ISEAPPTSQATAAASGPNASPQSSQPPTAnekADTEVSAAAARPktgfkaqnATTKGPNDYSQARNAKEMPknqskAAFK 115
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPA---AAAPAAAAAPAP--------AAAPQPAPAPAPAPAPPSP-----AGNA 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   116 SQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANE--MTNNQPKTakAWNDT-TKVPGA 192
Cdd:PRK07764 449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaDDAATLRE--RWPEIlAAVPKR 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   193 daqtqnvNQAKMADVGTSAGISEADG----------AAAQTSADGSQTQNVesRTIIR---GKRTRKVNNLNVEENNSGD 259
Cdd:PRK07764 527 -------SRKTWAILLPEATVLGVRGdtlvlgfstgGLARRFASPGNAEVL--VTALAeelGGDWQVEAVVGPAPGAAGG 597

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   260 QRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQN 337
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   338 PVIWPNPVIWQNPviwPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDwsMPPDWSFPS 417
Cdd:PRK07764 678 PAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--EPDDPPDPA 752

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   418 DWPFPPDwiPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVK 477
Cdd:PRK07764 753 GAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLE 810
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 276-467 1.92e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    276 PVTTQQNPPGAPPnvvwqtplawQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIwPNPVIWQNPVIWPN 355
Cdd:pfam03154 172 PVLQAQSGAASPP----------SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PHTLIQQTPTLHPQ 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    356 PIVWPGPIVWPNPmawQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsfPSDWPFPPDWIPADWPIPPD 435
Cdd:pfam03154 241 RLPSPHPPLQPMT---QPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP---PQPFPLTPQSSQSQVPPGPS 314

                         170       180       190
                  ....*....|....*....|....*....|....
gi 9789935    436 WQNLRPSpnlRSSSNSRASQNQGPPQ--PRDVAL 467
Cdd:pfam03154 315 PAAPGQS---QQRIHTPPSQSQLQSQqpPREQPL 345
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 475-635 3.72e-18

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 83.47  E-value: 3.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    475 LVKYLMLKDYTKVPIKRSEMLRDIIREY-TDVYPEIIERACFVLEKKFGIQLKEIDKEEHL------------------- 534
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    535 -YILIST--PESLAGILGTTKDTPKLGLLLVILGII----------FMNGNRATEAVLWEALRKMGLR---PGVRHPLLG 598
Cdd:pfam01454  81 sYILVSTlpPEYRVPAIIWPSKAPSFVLDQDEATYTgiltvilsliLLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 9789935    599 DLRKLLTyEFVKQKYLDYRRVPNSNP--PEYEFLWGLRS 635
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
271-462 6.54e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 6.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   271 RSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAArqSPPARQTPSAWQNPVAWQNPVIWPNPViwqnP 350
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA--AAPARRSPAPEALAAARQASARGPGGA----P 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   351 VIWPNPIVWPGPIVwPNPMAWQSTPgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsFPSDWPFPPDWIPADW 430
Cdd:PRK12323 449 APAPAPAAAPAAAA-RPAAAGPRPV----AAAAAAAPARAAPAAAPAPADDDPPPWEELPPE--FASPAPAQPDAAPAGW 521

                        170       180       190
                 ....*....|....*....|....*....|..
gi 9789935   431 PippdwQNLRPSPNLRSSSNSRASQNQGPPQP 462
Cdd:PRK12323 522 V-----AESIPDPATADPDDAFETLAPAPAAA 548
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 36-477 4.80e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 4.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    36 ISEAPPTSQATAAASGPNASPQSSQPPTAnekADTEVSAAAARPktgfkaqnATTKGPNDYSQARNAKEMPknqskAAFK 115
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPA---AAAPAAAAAPAP--------AAAPQPAPAPAPAPAPPSP-----AGNA 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   116 SQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANE--MTNNQPKTakAWNDT-TKVPGA 192
Cdd:PRK07764 449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaDDAATLRE--RWPEIlAAVPKR 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   193 daqtqnvNQAKMADVGTSAGISEADG----------AAAQTSADGSQTQNVesRTIIR---GKRTRKVNNLNVEENNSGD 259
Cdd:PRK07764 527 -------SRKTWAILLPEATVLGVRGdtlvlgfstgGLARRFASPGNAEVL--VTALAeelGGDWQVEAVVGPAPGAAGG 597

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   260 QRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQN 337
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   338 PVIWPNPVIWQNPviwPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDwsMPPDWSFPS 417
Cdd:PRK07764 678 PAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--EPDDPPDPA 752

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   418 DWPFPPDwiPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVK 477
Cdd:PRK07764 753 GAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLE 810
PHA03247 PHA03247
large tegument protein UL36; Provisional
 38-462 1.27e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935     38 EAPPTSQATAAASGPNASPQSSQPPTANEKADTEV-------SAAAARPKTGFKAQNATTKGPNDYSQARNAKEMPKNQS 110
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPdppppspSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARR 2669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    111 KAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEmafKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKT-----AKAWND 185
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP---PPPTPEPAPHALVSATPLPPGPAAARQASPALpaapaPPAVPA 2746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    186 TTKVPGADAQTQNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQnvESRTIIRGKRTRKVNNLNVEENNSGDQRRASL 265
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS--ESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    266 ASGnwrSAPVPVTTQQNPPGAPPNVVWQTPL-AWQNPSG--WQNQTARQTP--PAARQSPPARQTPSawqnpvawqnpvi 340
Cdd:PHA03247 2825 AGP---LPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGdvRRRPPSRSPAakPAAPARPPVRRLAR------------- 2888

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    341 wpnpviwqnpviwpnPIVWPGPIVWPNPmawqstpgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWP 420
Cdd:PHA03247 2889 ---------------PAVSRSTESFALP-----------PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 9789935    421 FPPDWIPADWPIP----PDWQNLRPSPNLRSSSNSRASQNQgPPQP 462
Cdd:PHA03247 2943 LAPTTDPAGAGEPsgavPQPWLGALVPGRVAVPRFRVPQPA-PSRE 2987
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 263-416 3.25e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    263 ASLASGNWrSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN------QTARQTPPAARQSPPARQTPSAWQNPVAWQ 336
Cdd:PRK10263  326 ATTATQSW-AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTgepviaPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQ 404

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    337 NPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPG--WQSPPS---WQAPPSWQSPQDWQGP---PDWQVPPDWS 408
Cdd:PRK10263  405 QPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGnaWQAEEQqstFAPQSTYQTEQTYQQPaaqEPLYQQPQPV 484


                  ....*...
gi 9789935    409 MPPDWSFP 416
Cdd:PRK10263  485 EQQPVVEP 492
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 276-467 1.92e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    276 PVTTQQNPPGAPPnvvwqtplawQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIwPNPVIWQNPVIWPN 355
Cdd:pfam03154 172 PVLQAQSGAASPP----------SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PHTLIQQTPTLHPQ 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    356 PIVWPGPIVWPNPmawQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsfPSDWPFPPDWIPADWPIPPD 435
Cdd:pfam03154 241 RLPSPHPPLQPMT---QPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP---PQPFPLTPQSSQSQVPPGPS 314

                         170       180       190
                  ....*....|....*....|....*....|....
gi 9789935    436 WQNLRPSpnlRSSSNSRASQNQGPPQ--PRDVAL 467
Cdd:pfam03154 315 PAAPGQS---QQRIHTPPSQSQLQSQqpPREQPL 345
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 272-447 3.99e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    272 SAPVPVTTQQNPPGAPPnvVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQN 349
Cdd:pfam03154 197 AGPTPSAPSVPPQGSPA--TSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQ 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    350 PVIWPNPIvWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPAD 429
Cdd:pfam03154 275 MPPMPHSL-QTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP 353

                         170
                  ....*....|....*...
gi 9789935    430 WPIPPDWQNLRPSPNLRS 447
Cdd:pfam03154 354 HIKPPPTTPIPQLPNPQS 371
PHA03247 PHA03247
large tegument protein UL36; Provisional
 39-471 4.67e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935     39 APPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKT--GFKAQNATTKGPNDYSQARNAKEMPKNQSKAAFKS 116
Cdd:PHA03247 2558 AAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRApvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANE 2637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    117 QNGTPKGPHAASDFSQAAPTGKSAKKSEMAfkGQNSTKAGPGTTYNFPQSPSAnemtnnqPKTAKAWNDTTKVPGADAQT 196
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRA--RRLGRAAQASSPPQRPRRRAA-------RPTVGSLTSLADPPPPPPTP 2708

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    197 QNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRKvnnlnveennsgdqrRASLASGNWRSAPVP 276
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA---------------RPPTTAGPPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    277 VTTQQNPPGAP-PNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPN 355
Cdd:PHA03247 2774 APAAGPPRRLTrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    356 PIVWPGPIVWPNPMAWQSTPGWQSPP-----SWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPsdwpfPPDWIPADW 430
Cdd:PHA03247 2854 GSVAPGGDVRRRPPSRSPAAKPAAPArppvrRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQ 2928

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 9789935    431 PIPPDWQNLRPSPNLRSSSNSRASQNQGP--PQPRDVALLQER 471
Cdd:PHA03247 2929 PQPPPPPPPRPQPPLAPTTDPAGAGEPSGavPQPWLGALVPGR 2971
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 260-400 9.68e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   260 QRRASLASGNWRSAPVPVTTQQNPPGAPPnvvwqTPLAWQNPSGWQNQTArQTPPAARQSPPARQTPSAWQNPVAWQNPV 339
Cdd:PRK07764 376 ARLERLERRLGVAGGAGAPAAAAPSAAAA-----APAAAPAPAAAAPAAA-AAPAPAAAPQPAPAPAPAPAPPSPAGNAP 449

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9789935   340 IWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQdwQGPPD 400
Cdd:PRK07764 450 AGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP--AGADD 508
PRK13808 PRK13808
adenylate kinase; Provisional
 30-156 1.72e-03

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 41.41  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    30 LMEAIQISEAPPTSQATAAASGPNASpqSSQPPTANEKADTEVSAAAARP------------KTGFKAQNATTKGPNDyS 97
Cdd:PRK13808 190 VLAAVGAANAKKAAKTPAAKSGAKKA--SAKAKSAAKKVSKKKAAKTAVSakkaaktaakaaKKAKKTAKKALKKAAK-A 266

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 9789935    98 QARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAG 156
Cdd:PRK13808 267 VKKAAKKAAKAAAKAAKGAAKATKGKAKAKKKAGKKAAAGSKAKATAKAPKRGAKGKKA 325
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 217-460 1.86e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    217 DGAAAQTSADGSQTQNVESRtIIRGKRTRKVNNLNVEENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAPPNVVW---- 292
Cdd:PRK10263  219 DDEEYEDENHGKQHESRRAR-ILRGALARRKRLAEKFINPMGRQTDAALFSGKRMDDDEEITYTARGVAADPDDVLfsgn 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    293 -QTPLAWQNPSGWQNQTARQTP-PAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIW---PNPIVwPGPIVWPN 367
Cdd:PRK10263  298 rATQPEYDEYDPLLNGAPITEPvAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWqpvPGPQT-GEPVIAPA 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    368 PMAWQSTPGWQSPPS-----WQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPAD---WPIPPDWQNL 439
Cdd:PRK10263  377 PEGYPQQSQYAQPAVqynepLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAgnaWQAEEQQSTF 456

                         250       260
                  ....*....|....*....|.
gi 9789935    440 RPSPNLRSSSNSRASQNQGPP 460
Cdd:PRK10263  457 APQSTYQTEQTYQQPAAQEPL 477
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
39-321 2.54e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935    39 APPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPNDYS---QARNAKEMPKNQSKAAFK 115
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPappATADRGDDAADGDAPVPA 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   116 SQNgTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKTAKAWNDTTKVPGADAQ 195
Cdd:PRK07003 452 KAN-ARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAP 530

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   196 tqnvnQAKMADVGTSAGISEADGAAAqtsadgsqtqnveSRTIIRGKRTRkvnnlnveenNSGDQRRASLASGNWRSAPV 275
Cdd:PRK07003 531 -----EARPPTPAAAAPAARAGGAAA-------------ALDVLRNAGMR----------VSSDRGARAAAAAKPAAAPA 582

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 9789935   276 PVTTqqnPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAA--RQSPP 321
Cdd:PRK07003 583 AAPK---PAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAesRGAPP 627
dnaA PRK14086
chromosomal replication initiator protein DnaA;
275-471 7.56e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   275 VPVTTQQNPPGAPPnvvwQTPLAWQNPsgwqnqtarQTPPAARQSPPARQTPSAWQNPVAW----QNPVIWPNPVIWQNP 350
Cdd:PRK14086  86 ITVDPSAGEPAPPP----PHARRTSEP---------ELPRPGRRPYEGYGGPRADDRPPGLprqdQLPTARPAYPAYQQR 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935   351 viwPNPIVWPGPivwPNPMAWQSTPGWQSPPSWQAPPSwqspQDWQGPPDWQVPPDWSMPpdwSFPSDWPfPPDWIPADW 430
Cdd:PRK14086 153 ---PEPGAWPRA---ADDYGWQQQRLGFPPRAPYASPA----SYAPEQERDREPYDAGRP---EYDQRRR-DYDHPRPDW 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 9789935   431 PIPPDWQNLRPSPNLRSSSNSRASqnQGPPQPRDVALLQER 471
Cdd:PRK14086 219 DRPRRDRTDRPEPPPGAGHVHRGG--PGPPERDDAPVVPIR 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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