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Conserved domains on  [gi|110625609|ref|NP_062681|]
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cadherin-13 preproprotein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-111 5.95e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 130.52  E-value: 5.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   26 ECTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGR--TLFVHARTPHA 103
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHG 80


                  ....*...
gi 110625609  104 EDMAELVI 111
Cdd:pfam08758  81 EKMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-581 2.59e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 2.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 488 ENISVGSVLLTVNATDPDSLQHQTIRYSIYK-DPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPAT 566
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 110625609 567 GTGTLLITLEDINDN 581
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-359 3.79e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 249 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 328
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 110625609 329 LIIEAQDMAGLdvGLTGTATATIVIDDKNDH 359
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-243 5.44e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 5.44e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   161 KVVDSDRPEGSKFRLTGkgVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGKTLEGPVPLEVIVIDQND 240
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 110625609   241 NRP 243
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
368-469 5.74e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  368 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 445
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 110625609  446 NEDPlvpdvsYGPSSTATVHITVL 469
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
589-680 3.03e-09

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  589 VAEVCDDAR-NLSVVILGASDKDLHPNTDPFKFEIhkQTVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 664
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 110625609  665 GKPPMTNITDLRVQVC 680
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-111 5.95e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 130.52  E-value: 5.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   26 ECTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGR--TLFVHARTPHA 103
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHG 80


                  ....*...
gi 110625609  104 EDMAELVI 111
Cdd:pfam08758  81 EKMASVKV 88
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 2.48e-23

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 94.27  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609    27 CTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVG--RTLFVHARTPHAE 104
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 110625609   105 DMAELVI 111
Cdd:smart01055  81 EKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-581 2.59e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 2.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 488 ENISVGSVLLTVNATDPDSLQHQTIRYSIYK-DPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPAT 566
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 110625609 567 GTGTLLITLEDINDN 581
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-359 3.79e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 249 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 328
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 110625609 329 LIIEAQDMAGLdvGLTGTATATIVIDDKNDH 359
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
250-353 7.93e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 7.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  250 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 329
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|....
gi 110625609  330 IIEAQDMAGldVGLTGTATATIVI 353
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
488-576 1.41e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  488 ENISVGSVLLTVNATDPDSLQHQTIRYSI-YKDPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPAT 566
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 110625609  567 GTGTLLITLE 576
Cdd:pfam00028  83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 500-583 1.79e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.79e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   500 NATDPDSLQHQTIRYSI-YKDPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPATGTGTLLITLEDI 578
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 110625609   579 NDNAP 583
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-243 5.44e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 5.44e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   161 KVVDSDRPEGSKFRLTGkgVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGKTLEGPVPLEVIVIDQND 240
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 110625609   241 NRP 243
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 145-241 8.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 8.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 145 ILIPENQRQPFPrdVGKV--VDSDRPEGSK--FRLtgkgVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDA 220
Cdd:cd11304    4 VSVPENAPPGTV--VLTVsaTDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 110625609 221 SGKTLEGPVPLEVIVIDQNDN 241
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
368-469 5.74e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  368 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 445
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 110625609  446 NEDPlvpdvsYGPSSTATVHITVL 469
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-473 1.44e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 367 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 444
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 110625609 445 enEDPLVPdvsyGPSSTATVHITVLDVNE 473
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-361 3.68e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 3.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   268 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 347
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 110625609   348 TATIVIDDKNDHSP 361
Cdd:smart00112  68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
144-236 4.50e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 4.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  144 PILIPENQR-QPFPRDVGkVVDSDRPEGSK--FRLTGkgvdQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDA 220
Cdd:pfam00028   2 SASVPENAPvGTEVLTVT-ATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 110625609  221 SGKTLEGPVPLEVIVI 236
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-475 4.13e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   384 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 463
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 110625609   464 VHITVLDVNEGP 475
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
589-680 3.03e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  589 VAEVCDDAR-NLSVVILGASDKDLHPNTDPFKFEIhkQTVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 664
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 110625609  665 GKPPMTNITDLRVQVC 680
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-680 2.57e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.15  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 589 VAEVCDDARNLSVVI-LGASDKDLHPNtDPFKFEIHKQTVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 664
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 110625609 665 GKPPMTNITDLRVQVC 680
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 606-680 1.04e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 1.04e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110625609   606 ASDKDLHPNTDpFKFEIHKQTVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 680
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-111 5.95e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 130.52  E-value: 5.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   26 ECTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGR--TLFVHARTPHA 103
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHG 80


                  ....*...
gi 110625609  104 EDMAELVI 111
Cdd:pfam08758  81 EKMASVKV 88
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 2.48e-23

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 94.27  E-value: 2.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609    27 CTPGFQRKVLHIHQPAEFIEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVG--RTLFVHARTPHAE 104
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 110625609   105 DMAELVI 111
Cdd:smart01055  81 EKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-581 2.59e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 2.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 488 ENISVGSVLLTVNATDPDSLQHQTIRYSIYK-DPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPAT 566
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 110625609 567 GTGTLLITLEDINDN 581
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-359 3.79e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 249 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 328
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 110625609 329 LIIEAQDMAGLdvGLTGTATATIVIDDKNDH 359
Cdd:cd11304   70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
250-353 7.93e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 7.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  250 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 329
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|....
gi 110625609  330 IIEAQDMAGldVGLTGTATATIVI 353
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
488-576 1.41e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  488 ENISVGSVLLTVNATDPDSLQHQTIRYSI-YKDPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPAT 566
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 110625609  567 GTGTLLITLE 576
Cdd:pfam00028  83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 500-583 1.79e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.79e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   500 NATDPDSLQHQTIRYSI-YKDPAGWLSINPINGTVDTTAVLDRESpfvhNSVYTALFLAIDSGNPPATGTGTLLITLEDI 578
Cdd:smart00112   1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 110625609   579 NDNAP 583
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-243 5.44e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 5.44e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   161 KVVDSDRPEGSKFRLTGkgVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGKTLEGPVPLEVIVIDQND 240
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 110625609   241 NRP 243
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 145-241 8.90e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 8.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 145 ILIPENQRQPFPrdVGKV--VDSDRPEGSK--FRLtgkgVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDA 220
Cdd:cd11304    4 VSVPENAPPGTV--VLTVsaTDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 110625609 221 SGKTLEGPVPLEVIVIDQNDN 241
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
368-469 5.74e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 5.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  368 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 445
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 110625609  446 NEDPlvpdvsYGPSSTATVHITVL 469
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-473 1.44e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 367 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 444
Cdd:cd11304    1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*....
gi 110625609 445 enEDPLVPdvsyGPSSTATVHITVLDVNE 473
Cdd:cd11304   75 --TDGGGP----PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-361 3.68e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 3.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   268 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 347
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 110625609   348 TATIVIDDKNDHSP 361
Cdd:smart00112  68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
144-236 4.50e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 4.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  144 PILIPENQR-QPFPRDVGkVVDSDRPEGSK--FRLTGkgvdQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDA 220
Cdd:pfam00028   2 SASVPENAPvGTEVLTVT-ATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 110625609  221 SGKTLEGPVPLEVIVI 236
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-475 4.13e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609   384 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 463
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 110625609   464 VHITVLDVNEGP 475
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
589-680 3.03e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  589 VAEVCDDAR-NLSVVILGASDKDLHPNTDPFKFEIhkQTVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 664
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 110625609  665 GKPPMTNITDLRVQVC 680
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-241 2.56e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.57  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 144 PILIPENQRQPFPRdVGKVVDSDRPEGSKFRLTGKGVDQdPKGTFRINENTGSVSVTRTLDRETIATYQLYVETTDASGK 223
Cdd:cd00031    3 DGSAVEGRSRGSFR-VSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                         90
                 ....*....|....*...
gi 110625609 224 TLEGPVPLEVIVIDQNDN 241
Cdd:cd00031   81 VPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-680 2.57e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.15  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609 589 VAEVCDDARNLSVVI-LGASDKDLHPNtDPFKFEIHKQTVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDS 664
Cdd:cd11304    3 EVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTATDG 77

                         90
                 ....*....|....*.
gi 110625609 665 GKPPMTNITDLRVQVC 680
Cdd:cd11304   78 GGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 606-680 1.04e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.48  E-value: 1.04e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110625609   606 ASDKDLHPNTDpFKFEIHKQTVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 680
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 462-533 5.65e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 36.01  E-value: 5.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110625609  462 ATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLtVNATDPDSlqhQTIRYSIYKDPA--GWLSINPiNGTV 533
Cdd:pfam17803   1 ATVTITVTGVNDAPVAVDDTATVDEDTPVTITGNVL-ANDTDVDG---DTLTVTSVTGAPayGTLTLNA-DGSF 69
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 461-537 6.03e-03

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 36.55  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625609  461 TATVHITVLDVNEGPVFYPDpmmvtkqeNISVGSVLLTVNATDP--DSLQHQTIRYSIYKDPA-GWLSINPiNGTVDTTA 537
Cdd:pfam17963   1 TATVTVTVTPVNDAPVAVDD--------SVTVTEDTVLANDSDPdgDPLTITSLTVTIVTAPAnGTVTVNA-DGTLTYTP 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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