NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8923536|ref|NP_060355|]
View 

host cell factor C1 regulator 1 isoform 1 [Homo sapiens]

Protein Classification

HPIP domain-containing protein( domain architecture ID 10633591)

HPIP domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HPIP pfam15226
HCF-1 beta-propeller-interacting protein family; HPIP is a small cellular polypeptide that ...
 2-134 4.64e-78

HCF-1 beta-propeller-interacting protein family; HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localization. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.


:

Pssm-ID: 373659  Cd Length: 133  Bit Score: 226.79  E-value: 4.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923536      2 ILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSQLSLHNDHPYCS 81
Cdd:pfam15226   1 ILQQPLERGPQGRAQRDPRAASGVTRGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSRLSLHNDHPYCS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 8923536     82 PPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPAGD 134
Cdd:pfam15226  81 PPMAFPPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPTPPYPATPAGD 133
 
Name Accession Description Interval E-value
HPIP pfam15226
HCF-1 beta-propeller-interacting protein family; HPIP is a small cellular polypeptide that ...
 2-134 4.64e-78

HCF-1 beta-propeller-interacting protein family; HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localization. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.


Pssm-ID: 373659  Cd Length: 133  Bit Score: 226.79  E-value: 4.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923536      2 ILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSQLSLHNDHPYCS 81
Cdd:pfam15226   1 ILQQPLERGPQGRAQRDPRAASGVTRGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSRLSLHNDHPYCS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 8923536     82 PPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPAGD 134
Cdd:pfam15226  81 PPMAFPPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPTPPYPATPAGD 133
 
Name Accession Description Interval E-value
HPIP pfam15226
HCF-1 beta-propeller-interacting protein family; HPIP is a small cellular polypeptide that ...
 2-134 4.64e-78

HCF-1 beta-propeller-interacting protein family; HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localization. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.


Pssm-ID: 373659  Cd Length: 133  Bit Score: 226.79  E-value: 4.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923536      2 ILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSQLSLHNDHPYCS 81
Cdd:pfam15226   1 ILQQPLERGPQGRAQRDPRAASGVTRGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSRLSLHNDHPYCS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 8923536     82 PPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPAGD 134
Cdd:pfam15226  81 PPMAFPPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPTPPYPATPAGD 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH