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Conserved domains on  [gi|301069322|ref|NP_060150|]
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asporin isoform 1 preproprotein [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-323 2.40e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 183
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 184 KIQKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGLP--PTLLELHLDYNKISTVELEdFK 261
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301069322 262 RYKELQRLGLGNNKITDIENgSLANIPRVREIHLENNKLKKIPSgLPELKYLQIIFLHSNSI 323
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
73-103 3.37e-08

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.37e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 301069322    73 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 103
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-323 2.40e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 183
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 184 KIQKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGLP--PTLLELHLDYNKISTVELEdFK 261
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301069322 262 RYKELQRLGLGNNKITDIENgSLANIPRVREIHLENNKLKKIPSgLPELKYLQIIFLHSNSI 323
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-326 8.62e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 8.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  90 LGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFLTT-------------------KK 150
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 151 LRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSanpldnngiepgafegvtvfhiriaeak 230
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNS---------------------------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 231 LTSVPKGLPPTLLELHLDYNKISTVElEDFKryKELQRLGLGNNKITDIENgSLAniPRVREIHLENNKLKKIPSGLP-E 309
Cdd:PRK15370 316 LTALPETLPPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLPaA 389

                        250
                 ....*....|....*..
gi 301069322 310 LKYLQIIFlhsNSIARV 326
Cdd:PRK15370 390 LQIMQASR---NNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
104-161 1.16e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 301069322  104 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQL 161
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-324 8.09e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 8.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  85 VHCSDLGLTSVPTNIPF-DTRMLDLQNNKIKEIKENDF-KGLTSLYgliLNNNKLTKIHPKAFLttKKLRRLYLSHNQLS 162
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLENL--VNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 163 EIP-LNLPKSLAELRIhenkvkkiqkdtfkgmnalhvlemsanplDNNGIEPG---AFEGVTVFHIRiaeakltsvpkgl 238
Cdd:cd21340   82 VVEgLENLTNLEELHI-----------------------------ENQRLPPGeklTFDPRSLAALS------------- 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 239 pPTLLELHLDYNKISTveLEDFKRYKELQRLGLGNNKITDIEN--GSLANIPRVREIHLENNKLKKIPsglpelKYLQII 316
Cdd:cd21340  120 -NSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP------KYRDKI 190


                 ....*...
gi 301069322 317 FLHSNSIA 324
Cdd:cd21340  191 ILASKSLE 198
LRRNT smart00013
Leucine rich repeat N-terminal domain;
73-103 3.37e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.37e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 301069322    73 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 103
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 73-100 4.33e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.70  E-value: 4.33e-07
                          10        20
                  ....*....|....*....|....*...
gi 301069322   73 MCPFGCQCYSRVVHCSDLGLTSVPTNIP 100
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-323 2.40e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 183
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 184 KIQKDtFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGLP--PTLLELHLDYNKISTVELEdFK 261
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNN-------------------------QLTDLPEELGnlTNLKELDLSNNQITDLPEP-LG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301069322 262 RYKELQRLGLGNNKITDIENgSLANIPRVREIHLENNKLKKIPSgLPELKYLQIIFLHSNSI 323
Cdd:COG4886  203 NLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-303 4.76e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  83 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKENdFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 160
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 161 LSEIPLNLP--KSLAELRIHENKVKKIqkDTFKGMNALHVLEMSANpldnngiepgafegvtvfhiriaeaKLTSVPKGL 238
Cdd:COG4886  217 LTDLPEPLAnlTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNN-------------------------QLTDLPPLA 269

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301069322 239 P-PTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKI 303
Cdd:COG4886  270 NlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-326 8.62e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 8.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  90 LGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFLTT-------------------KK 150
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 151 LRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSanpldnngiepgafegvtvfhiriaeak 230
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNS---------------------------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 231 LTSVPKGLPPTLLELHLDYNKISTVElEDFKryKELQRLGLGNNKITDIENgSLAniPRVREIHLENNKLKKIPSGLP-E 309
Cdd:PRK15370 316 LTALPETLPPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLPaA 389

                        250
                 ....*....|....*..
gi 301069322 310 LKYLQIIFlhsNSIARV 326
Cdd:PRK15370 390 LQIMQASR---NNLVRL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-295 2.91e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 2.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  83 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKEnDFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 160
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 161 LSEIP--LNLPKsLAELRIHENKVKKIqkDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGL 238
Cdd:COG4886  240 LTDLPelGNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 301069322 239 PPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHL 295
Cdd:COG4886  317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR_8 pfam13855
Leucine rich repeat;
104-161 1.16e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 301069322  104 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQL 161
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-324 8.09e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 8.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  85 VHCSDLGLTSVPTNIPF-DTRMLDLQNNKIKEIKENDF-KGLTSLYgliLNNNKLTKIHPKAFLttKKLRRLYLSHNQLS 162
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLENL--VNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 163 EIP-LNLPKSLAELRIhenkvkkiqkdtfkgmnalhvlemsanplDNNGIEPG---AFEGVTVFHIRiaeakltsvpkgl 238
Cdd:cd21340   82 VVEgLENLTNLEELHI-----------------------------ENQRLPPGeklTFDPRSLAALS------------- 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 239 pPTLLELHLDYNKISTveLEDFKRYKELQRLGLGNNKITDIEN--GSLANIPRVREIHLENNKLKKIPsglpelKYLQII 316
Cdd:cd21340  120 -NSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP------KYRDKI 190


                 ....*...
gi 301069322 317 FLHSNSIA 324
Cdd:cd21340  191 ILASKSLE 198
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 245-326 2.25e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 245 LHLDYNKIStvELEDFKRYKELQRLGLGNNKITDIENgsLANIPRVREIHLENNKLKKIPsGLPELKYLQIIFLHSNSIA 324
Cdd:cd21340    7 LYLNDKNIT--KIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIS 81


                 ..
gi 301069322 325 RV 326
Cdd:cd21340   82 VV 83
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 104-320 3.10e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 104 RMLDLQNNKI-----KEIKENdFKGLTSLYGLILNNNKLTK----IHPKAFLTTKKLRRLYLSHNQLSEiplNLPKSLAE 174
Cdd:COG5238  211 TTLWLKRNPIgdegaEILAEA-LKGNKSLTTLDLSNNQIGDegviALAEALKNNTTVETLYLSGNQIGA---EGAIALAK 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 175 lrihenkvkkiqkdTFKGMNALHVLEMSANPLDnngiEPGAfegvtvfhirIAEAKLTSVPKglppTLLELHLDYNKIST 254
Cdd:COG5238  287 --------------ALQGNTTLTSLDLSVNRIG----DEGA----------IALAEGLQGNK----TLHTLNLAYNGIGA 334

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301069322 255 VE----LEDFKRYKELQRLGLGNNKITDIENGSLA----NIPRVREIHLENNKLKKipSGLPEL-KYLQIIFLHS 320
Cdd:COG5238  335 QGaialAKALQENTTLHSLDLSDNQIGDEGAIALAkyleGNTTLRELNLGKNNIGK--QGAEALiDALQTNRLHT 407
LRRNT smart00013
Leucine rich repeat N-terminal domain;
73-103 3.37e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 3.37e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 301069322    73 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 103
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRR_8 pfam13855
Leucine rich repeat;
240-300 3.73e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.73e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301069322  240 PTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKL 300
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 73-100 4.33e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.70  E-value: 4.33e-07
                          10        20
                  ....*....|....*....|....*...
gi 301069322   73 MCPFGCQCYSRVVHCSDLGLTSVPTNIP 100
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 149-357 5.51e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 5.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 149 KKLRRLYLSHNQLSEIP-LNLPKSLAELRIHENKVKKIQK-DTFKGMNALHvlemsanpLDNNGIEpgafegvtvfhiRI 226
Cdd:cd21340    2 KRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIENlEFLTNLTHLY--------LQNNQIE------------KI 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 227 AEakLTSVPKglpptLLELHLDYNKISTVE-LEDFKRYKEL----QRLGLGnNKITdIENGSLANI-PRVREIHLENNKL 300
Cdd:cd21340   62 EN--LENLVN-----LKKLYLGGNRISVVEgLENLTNLEELhienQRLPPG-EKLT-FDPRSLAALsNSLRVLNISGNNI 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301069322 301 KKIpSGLPELKYLQIIFLHSNSIARvgVNDFCPTVPKMkKSLYSaISLFNNPV----KYWE 357
Cdd:cd21340  133 DSL-EPLAPLRNLEQLDASNNQISD--LEELLDLLSSW-PSLRE-LDLTGNPVckkpKYRD 188
LRR_8 pfam13855
Leucine rich repeat;
125-206 7.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 7.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  125 TSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPlnlpkslaelrihenkvkkiqKDTFKGMNALHVLEMSAN 204
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS---------------------PGAFSGLPSLRYLDLSGN 59


                  ..
gi 301069322  205 PL 206
Cdd:pfam13855  60 RL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 142-339 1.09e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 142 PKAFLTTKKLRRLYLSHNQLSE------IPLNLPKSLAELRIHENKV-----KKIQKDTFKGMNALHVLEMSANPLDNNG 210
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPdgcgvlESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGAS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 211 IEPgafegvtvfhirIAEAkLTSVPKglpptLLELHLDYNKIS----TVELEDFKRYKELQRLGLGNNKITDIENGSLAN 286
Cdd:cd00116  154 CEA------------LAKA-LRANRD-----LKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDEGASALAE 215

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301069322 287 IPR----VREIHLENNKLK-----KIPSGLPEL-KYLQIIFLHSNSIARVGVNDFCPTVPKMK 339
Cdd:cd00116  216 TLAslksLEVLNLGDNNLTdagaaALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-288 3.20e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  83 RVVHCSDLGLTSVPTNIPFDTRM--LDLQNNKIKEIKEndFKGLTSLYGLILNNNKLTKIHPKAFLTtkKLRRLYLSHNQ 160
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQ 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 161 LSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPP 240
Cdd:COG4886  284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 301069322 241 TLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIP 288
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
153-323 1.21e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 153 RLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDtfkgmnaLH--VLEMSANpldnngiepgafegvtvfhiriaEAK 230
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN-------LQgnIKTLYAN-----------------------SNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 231 LTSVPKGLPPTLLELHLDYNKIstVELEDfKRYKELQRLGLGNNKITDIENgslaNIPR-VREIHLENNKLKKIPSGLPE 309
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRI--TELPE-RLPSALQSLDLFHNKISCLPE----NLPEeLRYLSVYDNSIRTLPAHLPS 304

                        170
                 ....*....|....
gi 301069322 310 lkYLQIIFLHSNSI 323
Cdd:PRK15370 305 --GITHLNVQSNSL 316
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-332 1.48e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 105 MLDLQNNKIK-EIKEndfkGLTS---LYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLS-EIPLNLPKS--LAELRI 177
Cdd:PLN00113 360 VLDLSTNNLTgEIPE----GLCSsgnLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLplVYFLDI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 178 HENKVKKIQKDTFKGMNALHVLEMSANPLdnNGIEPGAFEGVTVFHIRIAEAKLT-SVPKGLP--PTLLELHLDYNKIST 254
Cdd:PLN00113 436 SNNNLQGRINSRKWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGslSELMQLKLSENKLSG 513

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 255 VELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK-KIPSGLPELKYLQII----------------F 317
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVnishnhlhgslpstgaF 593

                        250
                 ....*....|....*
gi 301069322 318 LHSNSIARVGVNDFC 332
Cdd:PLN00113 594 LAINASAVAGNIDLC 608
LRR_8 pfam13855
Leucine rich repeat;
265-323 3.51e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301069322  265 ELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIP----SGLPELKYLqiiFLHSNSI 323
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLPSLRYL---DLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
84-315 9.86e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 9.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  84 VVHCSDLGLTSVPTNIPFDTRMLDLQNNKikeikendfkgLTSLYGLilnnnkltkihpkafltTKKLRRLYLSHNQLSE 163
Cdd:PRK15387 205 VLNVGESGLTTLPDCLPAHITTLVIPDNN-----------LTSLPAL-----------------PPELRTLEVSGNQLTS 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 164 IPLnLPKSLAELRIHENKVKKIQKDTfkgmNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEA-------------- 229
Cdd:PRK15387 257 LPV-LPPGLLELSIFSNPLTHLPALP----SGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLpalpselcklwayn 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 230 -KLTSVPKgLPPTLLELHLDYNKISTVELEDfkryKELQRLGLGNNKITdiengSLANIPR-VREIHLENNKLKKIPSGL 307
Cdd:PRK15387 332 nQLTSLPT-LPSGLQELSVSDNQLASLPTLP----SELYKLWAYNNRLT-----SLPALPSgLKELIVSGNRLTSLPVLP 401


                 ....*...
gi 301069322 308 PELKYLQI 315
Cdd:PRK15387 402 SELKELMV 409
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-174 1.55e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  83 RVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFltTKKLRRLYLSHNQLS 162
Cdd:PRK15370 328 KTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTNL-PENL--PAALQIMQASRNNLV 401

                         90
                 ....*....|..
gi 301069322 163 EIPLNLPKSLAE 174
Cdd:PRK15370 402 RLPESLPHFRGE 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-262 1.74e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  83 RVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSlygLILNNNKLTKIhPKAFltTKKLRRLYLSHNQLS 162
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKT---LEAGENALTSL-PASL--PPELQVLDVSKNQIT 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 163 EIPLNLPKSLAELRIHENKVKKIQKDTfkgMNALHVLEMSANPLdnngiepgafegvtvfhIRIAEAKLTSVPKGLPPTl 242
Cdd:PRK15370 360 VLPETLPPTITTLDVSRNALTNLPENL---PAALQIMQASRNNL-----------------VRLPESLPHFRGEGPQPT- 418

                        170       180
                 ....*....|....*....|
gi 301069322 243 lELHLDYNKISTVELEDFKR 262
Cdd:PRK15370 419 -RIIVEYNPFSERTIQNMQR 437
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 94-323 4.92e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 4.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322  94 SVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLS-EIPLNLP--K 170
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgQIPRELGqmK 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 171 SLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLdnNGIEPGAFEGVTVFH-IRIAEAKLT-SVPKGL--PPTLLELH 246
Cdd:PLN00113 213 SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL--TGPIPSSLGNLKNLQyLFLYQNKLSgPIPPSIfsLQKLISLD 290

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 301069322 247 LDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK-KIPSGLPELKYLQIIFLHSNSI 323
Cdd:PLN00113 291 LSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
241-323 6.75e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 241 TLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKitdiengSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHS 320
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSN 145


                 ...
gi 301069322 321 NSI 323
Cdd:COG4886  146 NQL 148
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 233-324 3.06e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069322 233 SVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKL-KKIPSGLPELK 311
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMK 212

                         90
                 ....*....|...
gi 301069322 312 YLQIIFLHSNSIA 324
Cdd:PLN00113 213 SLKWIYLGYNNLS 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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