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Conserved domains on  [gi|190358526|ref|NP_060092|]
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BLOC-1-related complex subunit 6 [Homo sapiens]

Protein Classification

BORCS6 domain-containing protein( domain architecture ID 10562704)

BORCS6 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORCS6 pfam10157
BLOC-1-related complex sub-unit 6 C-terminal helix; This is a family of conserved proteins ...
 256-353 5.21e-38

BLOC-1-related complex sub-unit 6 C-terminal helix; This is a family of conserved proteins found from nematodes to humans. Family members include BORCS6 (BLOC-1-related complex sub-unit 6) also known as Lyspersin (lysosome-dispersing protein) or C17orf59. It constitutes sub-unit 6 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery. this entry represents a C-terminal alpha helix according to structure predictions.


:

Pssm-ID: 462969  Cd Length: 101  Bit Score: 131.54  E-value: 5.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358526  256 IDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPV 335
Cdd:pfam10157   4 IDPNLLNDLEKEARAIAENLDDLLRNLQSSLHEMSALTVESVETYKDSVDSTCDAVDASIKSMYALIAKCEELNKSMKPV 83

                          90
                  ....*....|....*...
gi 190358526  336 QGLARQVRDIRRTLEVLE 353
Cdd:pfam10157  84 YKLAQQIKEIKRLLDLLE 101
 
Name Accession Description Interval E-value
BORCS6 pfam10157
BLOC-1-related complex sub-unit 6 C-terminal helix; This is a family of conserved proteins ...
 256-353 5.21e-38

BLOC-1-related complex sub-unit 6 C-terminal helix; This is a family of conserved proteins found from nematodes to humans. Family members include BORCS6 (BLOC-1-related complex sub-unit 6) also known as Lyspersin (lysosome-dispersing protein) or C17orf59. It constitutes sub-unit 6 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery. this entry represents a C-terminal alpha helix according to structure predictions.


Pssm-ID: 462969  Cd Length: 101  Bit Score: 131.54  E-value: 5.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358526  256 IDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPV 335
Cdd:pfam10157   4 IDPNLLNDLEKEARAIAENLDDLLRNLQSSLHEMSALTVESVETYKDSVDSTCDAVDASIKSMYALIAKCEELNKSMKPV 83

                          90
                  ....*....|....*...
gi 190358526  336 QGLARQVRDIRRTLEVLE 353
Cdd:pfam10157  84 YKLAQQIKEIKRLLDLLE 101
 
Name Accession Description Interval E-value
BORCS6 pfam10157
BLOC-1-related complex sub-unit 6 C-terminal helix; This is a family of conserved proteins ...
 256-353 5.21e-38

BLOC-1-related complex sub-unit 6 C-terminal helix; This is a family of conserved proteins found from nematodes to humans. Family members include BORCS6 (BLOC-1-related complex sub-unit 6) also known as Lyspersin (lysosome-dispersing protein) or C17orf59. It constitutes sub-unit 6 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery. this entry represents a C-terminal alpha helix according to structure predictions.


Pssm-ID: 462969  Cd Length: 101  Bit Score: 131.54  E-value: 5.21e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358526  256 IDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPV 335
Cdd:pfam10157   4 IDPNLLNDLEKEARAIAENLDDLLRNLQSSLHEMSALTVESVETYKDSVDSTCDAVDASIKSMYALIAKCEELNKSMKPV 83

                          90
                  ....*....|....*...
gi 190358526  336 QGLARQVRDIRRTLEVLE 353
Cdd:pfam10157  84 YKLAQQIKEIKRLLDLLE 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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