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Conserved domains on  [gi|7706529|ref|NP_057466|]
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natural killer cell receptor 2B4 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 22-127 9.66e-59

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


:

Pssm-ID: 288342  Cd Length: 108  Bit Score: 185.55  E-value: 9.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529     22 CQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNT--SNDRFSFIVKNLSLLIKAAQQ 99
Cdd:pfam11465   1 CQDSSEEVVGVSGKPVQLRPSNIQTKVVSIAWKKLLPSHNGFHHILKWENGSLPSNNmcSSDIYGFIVKNFALSIKSAKL 80

                          90       100
                  ....*....|....*....|....*...
gi 7706529    100 QDSGLYCLEVTSISGKVQTATFQVFVFD 127
Cdd:pfam11465  81 QDSGHYLLEITNISGKVCTKNFQVLIFD 108
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 131-210 1.77e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 39.69  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529    131 KPRLQGQGKILDRGrCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGthTYTCNVSNPVSWE-SHTLNL 209
Cdd:pfam13895   1 KPVLTPSPTVVTEG-EPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSG--TYTCVARNGRGGKvSNPVEL 77


                  .
gi 7706529    210 T 210
Cdd:pfam13895  78 T 78
 
Name Accession Description Interval E-value
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 22-127 9.66e-59

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 185.55  E-value: 9.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529     22 CQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNT--SNDRFSFIVKNLSLLIKAAQQ 99
Cdd:pfam11465   1 CQDSSEEVVGVSGKPVQLRPSNIQTKVVSIAWKKLLPSHNGFHHILKWENGSLPSNNmcSSDIYGFIVKNFALSIKSAKL 80

                          90       100
                  ....*....|....*....|....*...
gi 7706529    100 QDSGLYCLEVTSISGKVQTATFQVFVFD 127
Cdd:pfam11465  81 QDSGHYLLEITNISGKVCTKNFQVLIFD 108
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 25-125 3.52e-12

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 62.15  E-value: 3.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529   25 SADHVVSISGVPLQLQPNSIQTKVDSIAWKKLlPSQNGFHHILKWENGS---LPSNTSNDRFsFIVKNLSLLIKAAQQQD 101
Cdd:cd05741   1 SSEQFYGAEGKNVLLLVPNLQTPLKSVSWYKG-KQVSRNDEIAEYENSSdefRAGSAFSGRE-YIYTNGSLLIQNITLSD 78

                        90       100
                ....*....|....*....|....
gi 7706529  102 SGLYCLEVTSISGKVQTATFQVFV 125
Cdd:cd05741  79 TGFYTLESTNIGGKTESATFQLHV 102
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 131-210 1.77e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 39.69  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529    131 KPRLQGQGKILDRGrCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGthTYTCNVSNPVSWE-SHTLNL 209
Cdd:pfam13895   1 KPVLTPSPTVVTEG-EPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSG--TYTCVARNGRGGKvSNPVEL 77


                  .
gi 7706529    210 T 210
Cdd:pfam13895  78 T 78
 
Name Accession Description Interval E-value
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 22-127 9.66e-59

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 185.55  E-value: 9.66e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529     22 CQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNT--SNDRFSFIVKNLSLLIKAAQQ 99
Cdd:pfam11465   1 CQDSSEEVVGVSGKPVQLRPSNIQTKVVSIAWKKLLPSHNGFHHILKWENGSLPSNNmcSSDIYGFIVKNFALSIKSAKL 80

                          90       100
                  ....*....|....*....|....*...
gi 7706529    100 QDSGLYCLEVTSISGKVQTATFQVFVFD 127
Cdd:pfam11465  81 QDSGHYLLEITNISGKVCTKNFQVLIFD 108
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 25-125 3.52e-12

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 62.15  E-value: 3.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529   25 SADHVVSISGVPLQLQPNSIQTKVDSIAWKKLlPSQNGFHHILKWENGS---LPSNTSNDRFsFIVKNLSLLIKAAQQQD 101
Cdd:cd05741   1 SSEQFYGAEGKNVLLLVPNLQTPLKSVSWYKG-KQVSRNDEIAEYENSSdefRAGSAFSGRE-YIYTNGSLLIQNITLSD 78

                        90       100
                ....*....|....*....|....
gi 7706529  102 SGLYCLEVTSISGKVQTATFQVFV 125
Cdd:cd05741  79 TGFYTLESTNIGGKTESATFQLHV 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 29-125 1.87e-11

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 60.05  E-value: 1.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529   29 VVSISGVPLQLQPNSIQTKVDSIAWKKllpsqNGFHhILKWENGSLP--SNTSNDRFSFIVKNLSLLIKAAQQQDSGLYC 106
Cdd:cd05775   5 VYGALGGNVTLTISSLQDDIDEIKWKK-----TKDK-IVEWENNIGPtyFGSFKDRVLLDKESGSLTIKNLTKEDSGTYE 78

                        90
                ....*....|....*....
gi 7706529  107 LEVTSISGKVQTATFQVFV 125
Cdd:cd05775  79 LEITSTNGKVLSSKFTLEV 97
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 131-210 1.77e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 39.69  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706529    131 KPRLQGQGKILDRGrCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGthTYTCNVSNPVSWE-SHTLNL 209
Cdd:pfam13895   1 KPVLTPSPTVVTEG-EPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSG--TYTCVARNGRGGKvSNPVEL 77


                  .
gi 7706529    210 T 210
Cdd:pfam13895  78 T 78
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 67-121 6.79e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.00  E-value: 6.79e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 7706529   67 LKWE-NGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATF 121
Cdd:cd00096  15 ITWYkNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSASASV 70
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 86-125 9.56e-03

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 35.32  E-value: 9.56e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7706529   86 IVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFV 125
Cdd:cd05774  66 IYPNGSLLIQNVTQKDTGFYTLQTITADLQTEQASVHLQV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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