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Conserved domains on  [gi|544346209|ref|NP_057311|]
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SUN domain-containing ossification factor isoform 2 [Homo sapiens]

Protein Classification

Sad1_UNC and OmpH domain-containing protein( domain architecture ID 12082773)

Sad1_UNC and OmpH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 481-603 2.39e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 162.46  E-value: 2.39e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209   481 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQLDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 554
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 544346209   555 TFH-GRDERNVQSFPLDEQMY--AKYVKVELLSHFGSEHFCPLSLIRVFGTS 603
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDiwVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1087-1142 3.82e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


:

Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 42.18  E-value: 3.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 544346209  1087 LEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQ 1142
Cdd:pfam03938   24 LEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQ 79
GumC super family cl34566
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1028-1164 2.69e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3206:

Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209 1028 LRGLQRTATDFYAELQNSTDLGYANGNLVHGSnqkeSVFMRLNNRIKALEVNMS-LSGRYLEELS--QRYRKQMEEMQKA 1104
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS----PVIQQLRAQLAELEAELAeLSARYTPNHPdvIALRAQIAALRAQ 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544346209 1105 FNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREV-SDRQSY 1164
Cdd:COG3206   307 LQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVeVARELY 367
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 481-603 2.39e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 162.46  E-value: 2.39e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209   481 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQLDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 554
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 544346209   555 TFH-GRDERNVQSFPLDEQMY--AKYVKVELLSHFGSEHFCPLSLIRVFGTS 603
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDiwVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1087-1142 3.82e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 42.18  E-value: 3.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 544346209  1087 LEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQ 1142
Cdd:pfam03938   24 LEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQ 79
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1028-1164 2.69e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209 1028 LRGLQRTATDFYAELQNSTDLGYANGNLVHGSnqkeSVFMRLNNRIKALEVNMS-LSGRYLEELS--QRYRKQMEEMQKA 1104
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS----PVIQQLRAQLAELEAELAeLSARYTPNHPdvIALRAQIAALRAQ 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544346209 1105 FNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREV-SDRQSY 1164
Cdd:COG3206   307 LQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVeVARELY 367
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1083-1165 6.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209 1083 SGRYLEELSQRYRKQMEEMQKafnkTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQ 1162
Cdd:COG4942   137 RLQYLKYLAPARREQAEELRA----DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELA 212


                  ...
gi 544346209 1163 SYL 1165
Cdd:COG4942   213 AEL 215
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 481-603 2.39e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 162.46  E-value: 2.39e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209   481 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQLDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 554
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 544346209   555 TFH-GRDERNVQSFPLDEQMY--AKYVKVELLSHFGSEHFCPLSLIRVFGTS 603
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDiwVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 1087-1142 3.82e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 42.18  E-value: 3.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 544346209  1087 LEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQ 1142
Cdd:pfam03938   24 LEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQ 79
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1028-1164 2.69e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209 1028 LRGLQRTATDFYAELQNSTDLGYANGNLVHGSnqkeSVFMRLNNRIKALEVNMS-LSGRYLEELS--QRYRKQMEEMQKA 1104
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS----PVIQQLRAQLAELEAELAeLSARYTPNHPdvIALRAQIAALRAQ 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544346209 1105 FNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREV-SDRQSY 1164
Cdd:COG3206   307 LQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVeVARELY 367
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1083-1165 6.32e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209 1083 SGRYLEELSQRYRKQMEEMQKafnkTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQ 1162
Cdd:COG4942   137 RLQYLKYLAPARREQAEELRA----DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELA 212


                  ...
gi 544346209 1163 SYL 1165
Cdd:COG4942   213 AEL 215
MbeD_MobD pfam04899
MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the ...
 1087-1156 8.18e-03

MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilization and transfer in the presence of conjugative plasmids.


Pssm-ID: 113664  Cd Length: 70  Bit Score: 36.38  E-value: 8.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346209  1087 LEELSQRYRKQMEEMQKAFnktiVKLQNTSriaeEQDQRQTEAiqlLQAQLTNMTQLVSNLSATVAELKR 1156
Cdd:pfam04899   12 LEQLQQDYEQRLQEWESAF----AELQRMF----GLTQRENAA---LSEQVTGLSQQVQSLSEQVRRLSR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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