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Conserved domains on  [gi|155722994|ref|NP_055932|]
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zinc finger CCCH domain-containing protein 3 [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 708395)

zinc finger CCCH domain-containing protein similar to cleavage and polyadenylation specificity factor (CPSF) subunit 4, which is part of the complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YTH1 super family cl25862
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 672-777 1.60e-10

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


The actual alignment was detected with superfamily member COG5084:

Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 62.97  E-value: 1.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722994 672 YCMYYNRFGRCNRGERCPYIHDPEKVA---VCTRFVRGTCKKTDGtCPFSHHVS--KEKMPVCSYF-LKGICSNSN-CPY 744
Cdd:COG5084   76 ACISRNFNSIRGSRLSTPNNHVNPVLSssvVCKFFLRGLCKSGFS-CEFLHEYDlrSSQGPPCRSFsLKGSCSSGPsCGY 154

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 155722994 745 SHVYVSRKAEVC---SDFLKGYCPLGAKCKKKHTLL 777
Cdd:COG5084  155 SHIDPDSFAGNCdqySGATYGFCPLGASCKFSHTLK 190
 
Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 672-777 1.60e-10

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 62.97  E-value: 1.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722994 672 YCMYYNRFGRCNRGERCPYIHDPEKVA---VCTRFVRGTCKKTDGtCPFSHHVS--KEKMPVCSYF-LKGICSNSN-CPY 744
Cdd:COG5084   76 ACISRNFNSIRGSRLSTPNNHVNPVLSssvVCKFFLRGLCKSGFS-CEFLHEYDlrSSQGPPCRSFsLKGSCSSGPsCGY 154

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 155722994 745 SHVYVSRKAEVC---SDFLKGYCPLGAKCKKKHTLL 777
Cdd:COG5084  155 SHIDPDSFAGNCdqySGATYGFCPLGASCKFSHTLK 190
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
668-694 2.94e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 41.41  E-value: 2.94e-05
                          10        20
                  ....*....|....*....|....*..
gi 155722994  668 KRKEYCMYYNRFGRCNRGERCPYIHDP 694
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
750-776 5.39e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.99  E-value: 5.39e-04
                           10        20
                   ....*....|....*....|....*..
gi 155722994   750 SRKAEVCSDFLKGYCPLGAKCKKKHTL 776
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 672-777 1.60e-10

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 62.97  E-value: 1.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722994 672 YCMYYNRFGRCNRGERCPYIHDPEKVA---VCTRFVRGTCKKTDGtCPFSHHVS--KEKMPVCSYF-LKGICSNSN-CPY 744
Cdd:COG5084   76 ACISRNFNSIRGSRLSTPNNHVNPVLSssvVCKFFLRGLCKSGFS-CEFLHEYDlrSSQGPPCRSFsLKGSCSSGPsCGY 154

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 155722994 745 SHVYVSRKAEVC---SDFLKGYCPLGAKCKKKHTLL 777
Cdd:COG5084  155 SHIDPDSFAGNCdqySGATYGFCPLGASCKFSHTLK 190
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
668-694 2.94e-05

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 41.41  E-value: 2.94e-05
                          10        20
                  ....*....|....*....|....*..
gi 155722994  668 KRKEYCMYYNRFGRCNRGERCPYIHDP 694
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
750-776 5.39e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.99  E-value: 5.39e-04
                           10        20
                   ....*....|....*....|....*..
gi 155722994   750 SRKAEVCSDFLKGYCPLGAKCKKKHTL 776
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAHPL 27
ZnF_C3H1 smart00356
zinc finger;
669-694 2.13e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.45  E-value: 2.13e-03
                           10        20
                   ....*....|....*....|....*.
gi 155722994   669 RKEYCMYYnRFGRCNRGERCPYIHDP 694
Cdd:smart00356   3 KTELCKFF-KRGYCPRGDRCKFAHPL 27
ZnF_C3H1 smart00356
zinc finger;
723-748 6.54e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.91  E-value: 6.54e-03
                           10        20
                   ....*....|....*....|....*..
gi 155722994   723 KEKMPVCSYFLKGICS-NSNCPYSHVY 748
Cdd:smart00356   1 KYKTELCKFFKRGYCPrGDRCKFAHPL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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