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Conserved domains on  [gi|150170704|ref|NP_055574|]
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phytanoyl-CoA hydroxylase-interacting protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHYHIP_C super family cl44715
Phytanoyl-CoA hydroxylase-interacting protein C-terminus; This entry includes PHYHIP and ...
111-330 1.44e-140

Phytanoyl-CoA hydroxylase-interacting protein C-terminus; This entry includes PHYHIP and PHYHIPL from humans. PHYHIP interacts with DYRK1A and may contribute to new cellular functions of DYRK1A.


The actual alignment was detected with superfamily member pfam19281:

Pssm-ID: 437113  Cd Length: 221  Bit Score: 396.55  E-value: 1.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704  111 CTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEF 190
Cdd:pfam19281   1 CTADYSPVQLKQLLQKAEVIAGRMLPFSVFYRNQHNEYFQCFRDANGNRMLPSVKDNSGSHGSPISGKLEGIFFSCNTEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704  191 NTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCS-V 269
Cdd:pfam19281  81 NTGKPPQDSPYGRYRFQVPAERLFNPNTNLYFGDFYCMYTAYHYVILVLAPVGSKGDLFCKGRLPALDRSNNKFLTCGeE 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 150170704  270 EDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR 330
Cdd:pfam19281 161 EDGSLVFHHAQDVILEVIYTEPVDLSLGTVSQISGHQLMSLSTANAKKDPSCKTCNISVGR 221
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
5-112 7.37e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704   5 STPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVakavplpmTVRGhwfLSPRTEY 84
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSY--------TLTG---LKPGTEY 70
                         90       100
                 ....*....|....*....|....*...
gi 150170704  85 SVAVQTAVKQSDGEylvsgWSETVEFCT 112
Cdd:cd00063   71 EFRVRAVNGGGESP-----PSESVTVTT 93
 
Name Accession Description Interval E-value
PHYHIP_C pfam19281
Phytanoyl-CoA hydroxylase-interacting protein C-terminus; This entry includes PHYHIP and ...
111-330 1.44e-140

Phytanoyl-CoA hydroxylase-interacting protein C-terminus; This entry includes PHYHIP and PHYHIPL from humans. PHYHIP interacts with DYRK1A and may contribute to new cellular functions of DYRK1A.


Pssm-ID: 437113  Cd Length: 221  Bit Score: 396.55  E-value: 1.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704  111 CTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEF 190
Cdd:pfam19281   1 CTADYSPVQLKQLLQKAEVIAGRMLPFSVFYRNQHNEYFQCFRDANGNRMLPSVKDNSGSHGSPISGKLEGIFFSCNTEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704  191 NTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCS-V 269
Cdd:pfam19281  81 NTGKPPQDSPYGRYRFQVPAERLFNPNTNLYFGDFYCMYTAYHYVILVLAPVGSKGDLFCKGRLPALDRSNNKFLTCGeE 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 150170704  270 EDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR 330
Cdd:pfam19281 161 EDGSLVFHHAQDVILEVIYTEPVDLSLGTVSQISGHQLMSLSTANAKKDPSCKTCNISVGR 221
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
5-112 7.37e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704   5 STPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVakavplpmTVRGhwfLSPRTEY 84
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSY--------TLTG---LKPGTEY 70
                         90       100
                 ....*....|....*....|....*...
gi 150170704  85 SVAVQTAVKQSDGEylvsgWSETVEFCT 112
Cdd:cd00063   71 EFRVRAVNGGGESP-----PSESVTVTT 93
 
Name Accession Description Interval E-value
PHYHIP_C pfam19281
Phytanoyl-CoA hydroxylase-interacting protein C-terminus; This entry includes PHYHIP and ...
111-330 1.44e-140

Phytanoyl-CoA hydroxylase-interacting protein C-terminus; This entry includes PHYHIP and PHYHIPL from humans. PHYHIP interacts with DYRK1A and may contribute to new cellular functions of DYRK1A.


Pssm-ID: 437113  Cd Length: 221  Bit Score: 396.55  E-value: 1.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704  111 CTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEF 190
Cdd:pfam19281   1 CTADYSPVQLKQLLQKAEVIAGRMLPFSVFYRNQHNEYFQCFRDANGNRMLPSVKDNSGSHGSPISGKLEGIFFSCNTEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704  191 NTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCS-V 269
Cdd:pfam19281  81 NTGKPPQDSPYGRYRFQVPAERLFNPNTNLYFGDFYCMYTAYHYVILVLAPVGSKGDLFCKGRLPALDRSNNKFLTCGeE 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 150170704  270 EDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR 330
Cdd:pfam19281 161 EDGSLVFHHAQDVILEVIYTEPVDLSLGTVSQISGHQLMSLSTANAKKDPSCKTCNISVGR 221
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
5-112 7.37e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150170704   5 STPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVakavplpmTVRGhwfLSPRTEY 84
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSY--------TLTG---LKPGTEY 70
                         90       100
                 ....*....|....*....|....*...
gi 150170704  85 SVAVQTAVKQSDGEylvsgWSETVEFCT 112
Cdd:cd00063   71 EFRVRAVNGGGESP-----PSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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