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Conserved domains on  [gi|7657212|ref|NP_055290|]
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trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [Homo sapiens]

Protein Classification

-; -; Gfo/Idh/MocA family oxidoreductase; Gfo/Idh/MocA family oxidoreductase( domain architecture ID 11430574)

-; -; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to biliverdin reductase A (BLVRA)

CATH:  3.40.50.720
Gene Ontology:  GO:0016491|GO:0016651
PubMed:  26749496

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-247 5.59e-65

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 207.08  E-value: 5.59e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    1 MALRWGIVSVGLISSDFTAVLQTLPRSEhqVVAVAARDLSRAKEFAQKHDIpKAYGSYEELAKDPSVEVAYIGTQHPQHK 80
Cdd:COG0673   2 DKLRVGIIGAGGIGRAHAPALAALPGVE--LVAVADRDPERAEAFAEEYGV-RVYTDYEELLADPDIDAVVIATPNHLHA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   81 AAVMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIH 160
Cdd:COG0673  79 ELAIAALEAGKHVLCEKPLALTLEEARELVAAAEEAGVVLMVGFNRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212  161 VP---RAVDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVGRR---HETGVDDTVTVLLQYPGEVHGSFTCSITVQ- 233
Cdd:COG0673 159 GPadwRFDPELAGGGALLDLGIHDIDLARWLL-GSEPESVSATGGRlvpDRVEVDDTAAATLRFANGAVATLEASWVAPg 237

                       250
                ....*....|....*.
gi 7657212  234 --LSNTASVSGTKGMV 247
Cdd:COG0673 238 geRDERLEVYGTKGTL 253
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-247 5.59e-65

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 207.08  E-value: 5.59e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    1 MALRWGIVSVGLISSDFTAVLQTLPRSEhqVVAVAARDLSRAKEFAQKHDIpKAYGSYEELAKDPSVEVAYIGTQHPQHK 80
Cdd:COG0673   2 DKLRVGIIGAGGIGRAHAPALAALPGVE--LVAVADRDPERAEAFAEEYGV-RVYTDYEELLADPDIDAVVIATPNHLHA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   81 AAVMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIH 160
Cdd:COG0673  79 ELAIAALEAGKHVLCEKPLALTLEEARELVAAAEEAGVVLMVGFNRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212  161 VP---RAVDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVGRR---HETGVDDTVTVLLQYPGEVHGSFTCSITVQ- 233
Cdd:COG0673 159 GPadwRFDPELAGGGALLDLGIHDIDLARWLL-GSEPESVSATGGRlvpDRVEVDDTAAATLRFANGAVATLEASWVAPg 237

                       250
                ....*....|....*.
gi 7657212  234 --LSNTASVSGTKGMV 247
Cdd:COG0673 238 geRDERLEVYGTKGTL 253
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
 3-116 7.29e-23

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 91.89  E-value: 7.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212      3 LRWGIVSVGLISSDFTAVLQTlPRSEHQVVAVAARDLSRAKEFAQKHDIPkAYGSYEELAKDPSVEVAYIGTQHPQHKAA 82
Cdd:pfam01408   1 IRVGIIGAGKIGSKHARALNA-SQPGAELVAILDPNSERAEAVAESFGVE-VYSDLEELLNDPEIDAVIVATPNGLHYDL 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 7657212     83 VMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSR 116
Cdd:pfam01408  79 AIAALEAGKHVLCEKPLATTVEEAKELVELAKKK 112
XylDh_Gfo6_Halo NF041392
D-xylose 1-dehydrogenase Gfo6;
22-249 3.20e-08

D-xylose 1-dehydrogenase Gfo6;


Pssm-ID: 469283 [Multi-domain]  Cd Length: 350  Bit Score: 54.54  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    22 QTLP---RSEHQVVAVA-ARDLSRAKEFAQKHDIPKAYGSYEEL----AKDpSVEVAYIGTQHPQHKAAVMLCLAAGKAV 93
Cdd:NF041392  31 VAIPaieSSDLCETTVLvSSSTEKAERVADEADTVEHGITYDEFhdgaAAD-AYDAVYVCTPNALHLEYVETAAELGKAV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    94 LCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIHV----------Pr 163
Cdd:NF041392 110 LCEKPMEATVERAERMVEACEDADVPLMVAYRMHTEPAVRRARELIRDGFIGDPVQVHGNNSQPLLEMipdpdqwrldP- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   164 avDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVGRRHETGVDDT----VTVLLQYPGEVHGSFTCSITVQLSNTAS 239
Cdd:NF041392 189 --DLSGYGTSVMDLGIYPLNTARFLL-DADPVAVQASMRSEHEAFADVpderASFTLEFEDGVQAVCTASQNAHEDTHLR 265

                        250
                 ....*....|
gi 7657212   240 VSGTKGMVQL 249
Cdd:NF041392 266 ITGTEGEIEL 275
PRK10206 PRK10206
putative oxidoreductase; Provisional
 59-219 1.15e-07

putative oxidoreductase; Provisional


Pssm-ID: 182305 [Multi-domain]  Cd Length: 344  Bit Score: 52.52  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    59 EELAKDPSVEVAYIGTQHPQHKAAVMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSV 138
Cdd:PRK10206  57 DEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLVEKPFTPTLAEAKELFALAKSKGLTVTPYQNRRFDSCFLTAKKA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   139 LAQGTLGDLRVARAEFGKNlihvpRAVDRAQAG----GALLDIGIYCVQFTSMVFGgqKPEKISVVGR--RHETGVDDTV 212
Cdd:PRK10206 137 IESGKLGEIVEVESHFDYY-----RPVAETKPGlpqdGAFYGLGVHTMDQIISLFG--RPDHVAYDIRslRNKANPDDTF 209


                 ....*..
gi 7657212   213 TVLLQYP 219
Cdd:PRK10206 210 EAQLFYG 216
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
1-247 5.59e-65

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 207.08  E-value: 5.59e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    1 MALRWGIVSVGLISSDFTAVLQTLPRSEhqVVAVAARDLSRAKEFAQKHDIpKAYGSYEELAKDPSVEVAYIGTQHPQHK 80
Cdd:COG0673   2 DKLRVGIIGAGGIGRAHAPALAALPGVE--LVAVADRDPERAEAFAEEYGV-RVYTDYEELLADPDIDAVVIATPNHLHA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   81 AAVMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIH 160
Cdd:COG0673  79 ELAIAALEAGKHVLCEKPLALTLEEARELVAAAEEAGVVLMVGFNRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212  161 VP---RAVDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVGRR---HETGVDDTVTVLLQYPGEVHGSFTCSITVQ- 233
Cdd:COG0673 159 GPadwRFDPELAGGGALLDLGIHDIDLARWLL-GSEPESVSATGGRlvpDRVEVDDTAAATLRFANGAVATLEASWVAPg 237

                       250
                ....*....|....*.
gi 7657212  234 --LSNTASVSGTKGMV 247
Cdd:COG0673 238 geRDERLEVYGTKGTL 253
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
 3-116 7.29e-23

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 91.89  E-value: 7.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212      3 LRWGIVSVGLISSDFTAVLQTlPRSEHQVVAVAARDLSRAKEFAQKHDIPkAYGSYEELAKDPSVEVAYIGTQHPQHKAA 82
Cdd:pfam01408   1 IRVGIIGAGKIGSKHARALNA-SQPGAELVAILDPNSERAEAVAESFGVE-VYSDLEELLNDPEIDAVIVATPNGLHYDL 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 7657212     83 VMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSR 116
Cdd:pfam01408  79 AIAALEAGKHVLCEKPLATTVEEAKELVELAKKK 112
XylDh_Gfo6_Halo NF041392
D-xylose 1-dehydrogenase Gfo6;
22-249 3.20e-08

D-xylose 1-dehydrogenase Gfo6;


Pssm-ID: 469283 [Multi-domain]  Cd Length: 350  Bit Score: 54.54  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    22 QTLP---RSEHQVVAVA-ARDLSRAKEFAQKHDIPKAYGSYEEL----AKDpSVEVAYIGTQHPQHKAAVMLCLAAGKAV 93
Cdd:NF041392  31 VAIPaieSSDLCETTVLvSSSTEKAERVADEADTVEHGITYDEFhdgaAAD-AYDAVYVCTPNALHLEYVETAAELGKAV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    94 LCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIHV----------Pr 163
Cdd:NF041392 110 LCEKPMEATVERAERMVEACEDADVPLMVAYRMHTEPAVRRARELIRDGFIGDPVQVHGNNSQPLLEMipdpdqwrldP- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   164 avDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVGRRHETGVDDT----VTVLLQYPGEVHGSFTCSITVQLSNTAS 239
Cdd:NF041392 189 --DLSGYGTSVMDLGIYPLNTARFLL-DADPVAVQASMRSEHEAFADVpderASFTLEFEDGVQAVCTASQNAHEDTHLR 265

                        250
                 ....*....|
gi 7657212   240 VSGTKGMVQL 249
Cdd:NF041392 266 ITGTEGEIEL 275
PRK10206 PRK10206
putative oxidoreductase; Provisional
 59-219 1.15e-07

putative oxidoreductase; Provisional


Pssm-ID: 182305 [Multi-domain]  Cd Length: 344  Bit Score: 52.52  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    59 EELAKDPSVEVAYIGTQHPQHKAAVMLCLAAGKAVLCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSV 138
Cdd:PRK10206  57 DEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLVEKPFTPTLAEAKELFALAKSKGLTVTPYQNRRFDSCFLTAKKA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212   139 LAQGTLGDLRVARAEFGKNlihvpRAVDRAQAG----GALLDIGIYCVQFTSMVFGgqKPEKISVVGR--RHETGVDDTV 212
Cdd:PRK10206 137 IESGKLGEIVEVESHFDYY-----RPVAETKPGlpqdGAFYGLGVHTMDQIISLFG--RPDHVAYDIRslRNKANPDDTF 209


                 ....*..
gi 7657212   213 TVLLQYP 219
Cdd:PRK10206 210 EAQLFYG 216
PRK11579 PRK11579
putative oxidoreductase; Provisional
 2-199 8.76e-06

putative oxidoreductase; Provisional


Pssm-ID: 183212 [Multi-domain]  Cd Length: 346  Bit Score: 47.02  E-value: 8.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212     2 ALRWGIVSVGLISSDFTAVLqTLPRSEHQVVAVAARDLSRAKEfaqkhDIP--KAYGSYEELAKDPSVEVAYIGTQHPQH 79
Cdd:PRK11579   4 KIRVGLIGYGYASKTFHAPL-IAGTPGLELAAVSSSDATKVKA-----DWPtvTVVSEPQHLFNDPNIDLIVIPTPNDTH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    80 ----KAAvmlcLAAGKAVLCEKPTGVNAAEVREMVAEARSRALFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFG 155
Cdd:PRK11579  78 fplaKAA----LEAGKHVVVDKPFTVTLSQARELDALAKSAGRVLSVFHNRRWDSDFLTLKALLAEGVLGEVAYFESHFD 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 7657212   156 KNLIHVpRAVDRAQAG---GALLDIGIYCVQFTSMVFGgqKPEKISV 199
Cdd:PRK11579 154 RFRPQV-RQRWREQGGpgsGIWYDLAPHLLDQAIQLFG--LPVSITV 197
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 136-245 5.51e-04

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 40.48  E-value: 5.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657212    136 RSVLAQGTLGDLRVARAefgkNLIHVPRA--------VDRAQAGGALLDIGIY---CVQFtsmVFGgqkPEKISVVGRRH 204
Cdd:pfam02894   1 KELIENGVLGEVVMVTV----HTRDPFRPpqefkrwrVDPEKSGGALYDLGIHtidLLIY---LFG---EPPSVVAVYAS 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 7657212    205 EtgvdDTVTVLLQYPGEVHGSF---TCSITVQLSNTASVSGTKG 245
Cdd:pfam02894  71 E----DTAFATLEFKNGAVGTLetsGGSIVEANGHRISIHGTKG 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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