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Conserved domains on  [gi|222080092|ref|NP_054868|]
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WD repeat-containing protein 91 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-739 1.92e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 485
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 486 LCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAI 565
Cdd:COG2319  155 LRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDLAT--GKLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 566 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSL 645
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 646 PSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKV 700
Cdd:COG2319  287 HSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLASGSDDGTVrLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 222080092 701 LEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 739
Cdd:COG2319  366 RT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-739 1.92e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 485
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 486 LCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAI 565
Cdd:COG2319  155 LRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDLAT--GKLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 566 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSL 645
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 646 PSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKV 700
Cdd:COG2319  287 HSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLASGSDDGTVrLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 222080092 701 LEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 739
Cdd:COG2319  366 RT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-739 3.73e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 3.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 486
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 487 CEININDNMprILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpGRLLLWDTKTMKQQlqFSLDPEPIAIN 566
Cdd:cd00200   87 RTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDVETGKCL--TTLRGHTDWVN 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 567 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLP 646
Cdd:cd00200  140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGH 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 647 SDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDC 725
Cdd:cd00200  219 EN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGECVQT----LSGHTNSVTSLAWSP--DG 273

                        330
                 ....*....|....
gi 222080092 726 GTCLTASMDGKIKL 739
Cdd:cd00200  274 KRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 564-590 7.95e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 7.95e-05
                           10        20
                   ....*....|....*....|....*..
gi 222080092   564 AINCTAFNHNGNLLVTGAADGVIRLFD 590
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 555-615 4.69e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222080092  555 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 615
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
407-739 1.92e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWAtkRD-RLLLLGSGVGTVRLYDTEAKKN 485
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS--PDgKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 486 LCEININDNmpRILSLACSPNGASFVcsaaapsltsqvdfsapdIGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAI 565
Cdd:COG2319  155 LRTLTGHSG--AVTSVAFSPDGKLLA------------------SGSDD-----GTVRLWDLAT--GKLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 566 NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSL 645
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 646 PSDA--------TGPFVLSGySGYKQVQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKV 700
Cdd:COG2319  287 HSGGvnsvafspDGKLLASG-SDDGTVRLwdlATGKLLrtltghtgavrsvAFSPDGKTLASGSDDGTVrLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 222080092 701 LEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL 739
Cdd:COG2319  366 RT----LTGHTGAVTSVAFSP--DGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-739 3.73e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 3.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNL 486
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 487 CEININDNMprILSLACSPNGaSFVCSaaapsltSQVDfsapdigskgmnqvpGRLLLWDTKTMKQQlqFSLDPEPIAIN 566
Cdd:cd00200   87 RTLTGHTSY--VSSVAFSPDG-RILSS-------SSRD---------------KTIKVWDVETGKCL--TTLRGHTDWVN 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 567 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLP 646
Cdd:cd00200  140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGH 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 647 SDatgpFVLSGysgykqvqvprgrlfAFDSEGNYMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDC 725
Cdd:cd00200  219 EN----GVNSV---------------AFSPDGYLLASGSEDGTIrVWDLRTGECVQT----LSGHTNSVTSLAWSP--DG 273

                        330
                 ....*....|....
gi 222080092 726 GTCLTASMDGKIKL 739
Cdd:cd00200  274 KRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
407-633 1.41e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 1.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 407 HHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKrDRLLLLGSGVGTVRLYDTEAKKNL 486
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 487 CEININDNmpRILSLACSPNGASFVCsaaapsltsqvdfsapdiGSKGmnqvpGRLLLWDTKTmkQQLQFSLDPEPIAIN 566
Cdd:COG2319  282 RTLTGHSG--GVNSVAFSPDGKLLAS------------------GSDD-----GTVRLWDLAT--GKLLRTLTGHTGAVR 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222080092 567 CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNI 633
Cdd:COG2319  335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 403-632 7.52e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 7.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 403 EYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKA--------SSISKSPllslewatkrDRLLLLGSGV-G 473
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrghtdwvNSVAFSP----------DGTFVASSSQdG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 474 TVRLYDTEAKKnlCEININDNMPRILSLACSPNGASFVCSAAapsltsqvdfsapDigskgmnqvpGRLLLWDTKTMKQQ 553
Cdd:cd00200  158 TIKLWDLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSS-------------D----------GTIKLWDLSTGKCL 212

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222080092 554 LQFSLDPEPIaiNCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 632
Cdd:cd00200  213 GTLRGHENGV--NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
512-739 1.92e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 512 CSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDM 591
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 592 QQHECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhKSGLKVSEYSLPSDA--------TGPFVLSGySGYKQ 663
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAvtsvafspDGKLLASG-SDDGT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 664 VQV---PRGRLF-------------AFDSEGNYMLTCSATGGV-IYKLGGDEKVlescLSLGGHRAPVVTVDWSTamDCG 726
Cdd:COG2319  186 VRLwdlATGKLLrtltghtgavrsvAFSPDGKLLASGSADGTVrLWDLATGKLL----RTLTGHSGSVRSVAFSP--DGR 259

                        250
                 ....*....|...
gi 222080092 727 TCLTASMDGKIKL 739
Cdd:COG2319  260 LLASGSADGTVRL 272
WD40 COG2319
WD40 repeat [General function prediction only];
420-592 3.33e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 3.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 420 GRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWaTKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNmpRIL 499
Cdd:COG2319  258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVR 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 500 SLACSPNGaSFVCSAAApsltsqvdfsapDigskgmnqvpGRLLLWDTKTMKQQLQFSLDPEPIaiNCTAFNHNGNLLVT 579
Cdd:COG2319  335 SVAFSPDG-KTLASGSD------------D----------GTVRLWDLATGELLRTLTGHTGAV--TSVAFSPDGRTLAS 389

                        170
                 ....*....|...
gi 222080092 580 GAADGVIRLFDMQ 592
Cdd:COG2319  390 GSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 600-747 1.30e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222080092 600 WRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWNIhksglkvseyslpsdATGPFVLSGYSGYKQVQVprgrlFAFDSEGN 679
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL---------------ETGELLRTLKGHTGPVRD-----VAASADGT 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222080092 680 YMLTCSATGGV-IYKLGGDEKVLEsclsLGGHRAPVVTVDWSTamDCGTCLTASMDGKIKL---------TTLLAHKA 747
Cdd:cd00200   65 YLASGSSDKTIrLWDLETGECVRT----LTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvetgkclTTLRGHTD 136
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 564-590 7.95e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 7.95e-05
                           10        20
                   ....*....|....*....|....*..
gi 222080092   564 AINCTAFNHNGNLLVTGAADGVIRLFD 590
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 555-615 4.69e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 4.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222080092  555 QFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYD 615
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
564-590 8.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.21e-04
                          10        20
                  ....*....|....*....|....*..
gi 222080092  564 AINCTAFNHNGNLLVTGAADGVIRLFD 590
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 595-632 3.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 222080092   595 ECAMSWRAHYGEVYSVEFSYDENTVYSIGEDGKFIQWN 632
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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