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Conserved domains on  [gi|21361444|ref|NP_038471|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-332 3.96e-176

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467706  Cd Length: 229  Bit Score: 487.05  E-value: 3.96e-176
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 185 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978  81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21361444 264 MVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23978 161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-332 3.96e-176

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 487.05  E-value: 3.96e-176
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 185 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978  81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21361444 264 MVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23978 161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-285 6.41e-25

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 101.14  E-value: 6.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444   102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 180
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444   181 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 247
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 21361444   248 TMVIAVELCDHVHVYGMVPPNYcsqrprLQRMPYHYYE 285
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFLD------SRGNSHHYYD 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-332 3.96e-176

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 487.05  E-value: 3.96e-176
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 185 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978  81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21361444 264 MVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23978 161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 105-330 5.11e-127

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 362.33  E-value: 5.11e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP-QEFVNRTPETVFIFW 183
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAiLLLAGTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 184 GPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23965  81 GPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21361444 264 MVPPNYCSQRPRlQRMPYHYYEPKGPDECVTYIQNEHSRKGnHHRFITEKRVFSSWAQLYGITFSHP 330
Cdd:cd23965 161 MVPENYCREHPN-SKVPYHYYEPGGLKECTYYNYHENALKG-GHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 91-332 2.72e-107

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 313.34  E-value: 2.72e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  91 GYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQE 170
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 171 FVNRTPETVFIFWGPPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTM 249
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 250 VIAVELCDHVHVYGMVPPNYCsQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSH 329
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFC-RDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQ 239


                ...
gi 21361444 330 PSW 332
Cdd:cd23976 240 PDW 242
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 105-333 1.24e-83

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 252.48  E-value: 1.24e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 185 PPSKM-QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23977  81 PERNMdRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 264 MVPPNYCSQRPRlQRMPYHYYEPKGPDECVTYIQNEHSRKGNhHRFITEKRVFSSWAQLYGITFSHPSWT 333
Cdd:cd23977 161 MVSDSYCRNKNH-SSVPYHYYEKGRLDECRMYLVHERAPRGG-HRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 105-332 1.51e-78

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 239.45  E-value: 1.51e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 185 PPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23975  81 PFRNMRKDgKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21361444 264 MVPPNYCSQRPrLQRMPYHYYEPkGPDECVTYIQNEHSRKGNhHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23975 161 MINDTYCKTEG-YRKVPYHYYEP-GRDECDEYFLHENAPYGG-HRFITEKKVFAKWAKKHPITFTHPNW 226
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 108-319 5.42e-35

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 125.94  E-value: 5.42e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 108 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTP---ETVFIFWG 184
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPleeEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 185 PPSKMQKpqgslvRVIQRAGLvfPNMEAYAVSPGR---MRQFDDLFRGETGKDrEKSHSWLSTGWFTMVIAVELCDHVHV 261
Cdd:cd19952  81 AAAADFK------RLKRRKKR--HDNAVLLLTDPApdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21361444 262 YGMVPPNYCSqrprlQRMPYHYYEPKGPdecvtyiqnehSRKGNHHRFITEKRVFSSW 319
Cdd:cd19952 152 YGFGVDSGHA-----PKVPYHYYDLVEA-----------EEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-285 6.41e-25

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 101.14  E-value: 6.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444   102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 180
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444   181 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 247
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 21361444   248 TMVIAVELCDHVHVYGMVPPNYcsqrprLQRMPYHYYE 285
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFLD------SRGNSHHYYD 226
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 104-287 4.01e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 97.75  E-value: 4.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 104 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFrvlRRPQEFvnrTPETVFIF- 182
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAF---RDPEEY---DSDWLLVLv 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 183 --------WGPPSKMQKPQGSLVRVIQRAGLVFPnmeayaVSPGRMRQFDDLFRGETG-------KDREKSHSWLSTGWF 247
Cdd:cd23967  75 pfksmdllWLQAVIKGKKPNGKGGFWKKIATSVP------KPPKKIRILNPYILQEAAfdliglpMNGKQGKNVPTTGII 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 21361444 248 TMVIAVELCDHVHV----YGMVPPNycsqrprlqrMPYHYYEPK 287
Cdd:cd23967 149 AIVMALHYCDEVDIagfgYDPSDPN----------APLHYYDSL 182
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 70-312 2.84e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 91.55  E-value: 2.84e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  70 YGSLRGRSRRPVNLKKWSITDGYVPIlGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGN 149
Cdd:cd23963  33 YYSYFKKKTFKITKSLYELLPKTSPF-SHKRYKT----CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGR 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 150 KTTYRVVAHSSVFRVL------RRPQEFVNRTPETV-FIFWGPPSKMQKPQGSLVRVIQRAGLVFPNME-AYAvSPGRMR 221
Cdd:cd23963 108 KTNLTTLNPSILKRRYnslkknRDRDKFLNRLKEYNgSILWYPKFSFKSSTNLLLKAARALKKNGLNLTvVYS-NPEHFL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 222 QFDDlFRGETGKDRekshsWLSTGWFTMVIAVELCDHVHVYGMVPpnYcSQRPRLQRMPYHYYEPkgpdecvtyiqNEHS 301
Cdd:cd23963 187 AVQK-FWKRRGLEK-----RPSTGLYLVSLALTFCDEIHLYGFWP--F-PTDPNGRPVPYHYYDD-----------LSPS 246

                       250
                ....*....|.
gi 21361444 302 RKGNHHRFITE 312
Cdd:cd23963 247 TKNKVHNMPEE 257
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 72-286 7.06e-21

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 90.41  E-value: 7.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  72 SLRGRSRRPVNLKKWSitdgYVPILGNKTLPSRCHQ-CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 150
Cdd:cd23968  15 STLRKTTSPFKDLLSL----RYPFPESSLENTKRYNtCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSK 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 151 TTYRVVAH----SSVFRVLRRPqEFVNrtpETVFIfWGPPS-------KMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGR 219
Cdd:cd23968  91 TTLRLINSqilsKPEFNFLTDP-LYRN---VTLLV-WDPSSynvnlekWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPRF 165

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21361444 220 M-RQFDDLFRGETGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRprlqrmpYHYYEP 286
Cdd:cd23968 166 LwRLWDILQEYTPEKIKPNPP---SSGFIGIVLMLHLCDWVDVYEYVPSVRQTDR-------CHYYDV 223
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 80-285 9.37e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 81.68  E-value: 9.37e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  80 PVNLKKWsitDGYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVaHS 159
Cdd:cd23985  23 PFNTSEW---EGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI-NS 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 160 SVfrVLRRPQEFVNRT--PETVFIFWGP-------PSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGE 230
Cdd:cd23985  99 QL--VTTEKHKFLKDSlyNEGILIVWDPapyhsdiPEWYKNPDYNFFENYKTYRRLNPNQPFYILHPQMQWELWDIIQEN 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21361444 231 TGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVPpnycSQRprlQRMPYHYYE 285
Cdd:cd23985 177 SPEEIQPNPP--SSGMLGIILMMTLCDQVDVYEFLP----SKR---KTDVCHYYQ 222
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 92-285 1.23e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 78.34  E-value: 1.23e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  92 YVP-ILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHssvfRVLRRPQE 170
Cdd:cd23986  35 YVPkIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINS----QILTNPNH 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 171 FVNRTP---ETVFIFWGP-PSKM------QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHS 240
Cdd:cd23986 111 HFIDSSlykDVILVAWDPaPYSAnlhkwyKKPDYNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP 190

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 21361444 241 wlSTGWFTMVIAVELCDHVHVYGMVPpnycSQRprlQRMPYHYYE 285
Cdd:cd23986 191 --SSGFIGILIMMSMCREVHVYEYIP----SVR---QTDLCHYHE 226
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 104-285 3.42e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 70.46  E-value: 3.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 104 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFrvlrRPQEfvNRTPETVF-- 180
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFyPESAQF----DPGI--ENDPDTLLvl 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 181 -----------------------IFWGPPSKMQKPQGSLVRVIqraglvfpnmeayavSPGRMRQFDDLFRGETGKDREK 237
Cdd:cd23982  75 vpfkpldfywlyeilsnekrvrkGFWKQPPRIWDANPKQIRIL---------------NPYYTYVAATKLLQVPGQRKKK 139

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 21361444 238 SHSwlSTGWFTMVIAVELCDHVHVYGMVPPNycsqrPRLQRMPYHYYE 285
Cdd:cd23982 140 QKP--TTGLLAITLALHLCDEVHIAGFGYPD-----NGNSNQPIHYYN 180
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 102-264 2.85e-13

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 68.85  E-value: 2.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVahssvfrvlrRPQEFVNRTPETVFI 181
Cdd:cd23966  74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM----------YPESAVDLDPGVHLV 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 182 FWgpPSKMQKPQ--------GSLVRviqraglvfpnmeayavSPGRMRQFDDLfrgetgkDREK-----------SH-SW 241
Cdd:cd23966 144 LV--PFKVLDLQwlisalttGEITR-----------------TYTPVKRFIKA-------DKDKvlvinpafikyVHdNW 197

                       170       180       190
                ....*....|....*....|....*....|
gi 21361444 242 L-------STGWFTMVIAVELCDHVHVYGM 264
Cdd:cd23966 198 TehhgrypSTGFLALIFALHICDEVSVFGF 227
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 105-285 8.11e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 66.69  E-value: 8.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV------------AHSSVF-RVLRRPQEF 171
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegapkseqeyDPTSLFvAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 172 ------VNRTPETV---FIFWGppskmqkpqgslvRVIQRAGLvfpnmeayavSPGRMRQFDDLFRGETGKD----REKS 238
Cdd:cd23983  82 awlkamVKKEPLSFwsrLFFWK-------------EVADSIPL----------KPSQFRILNPLIIKETALDilqyPEPQ 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 21361444 239 HSWLS-------TGWFTMVIAVELCDHVHVYGMvppNYCSQRPRLqrmPYHYYE 285
Cdd:cd23983 139 SRLWGwdknvptLGVTAVVLATHLCDEVSLAGF---GYDLSQPHA---PLHYYD 186
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 76-263 1.72e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 63.75  E-value: 1.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  76 RSRRPVNLKK-----WSITDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 150
Cdd:cd23980  48 REKKPKNLNDtirelFQVVPGNVDPLLEKR-LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 151 TTYRVVAHSSvFRVLRRPQEFVNRTPETVFIFW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQF 223
Cdd:cd23980 127 TTHHFVYPES-FRELAQNVSMILVPFKTLDLEWvisatttGTISHTYVPVPRKIKVKKEKILIY--------HPAFIKYV 197

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 21361444 224 DDLFRGETGKdrekshsWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23980 198 FDRWLQGHGR-------YPSTGILSVIFSLHVCDEVDLYG 230
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 108-288 6.02e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 62.03  E-value: 6.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 108 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVA-------HSSVFRVLRRPQEFVNRTPETVF 180
Cdd:cd23970  71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyYNNLLTIQDRNNFFLSLKKLDGA 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 181 IFWGPPSKMQKpqgslVRVIQRAGLVF-------PNME-AYavsPGR-MRQFDDLFRGETGKDREkshswLSTGWFTMVI 251
Cdd:cd23970 151 ILWIPAFFFHT-----SATVTRTLVDFfvehrgqLKVQlAW---PGNiMQHVNRYWKTKHLSPKR-----LSTGILMYTL 217

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21361444 252 AVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKG 288
Cdd:cd23970 218 ASAICEEIHLYGFWP---FGFDPTGTPLPYHYYDKKG 251
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 108-288 6.03e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 62.05  E-value: 6.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 108 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRTPETVF------- 180
Cdd:cd23969  67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-TTMNPSV--IPHAYGDLVNATDKEKFverlrql 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 181 ---IFWgPPSKMQKPQGSLVRVIQRAGL--VFPNMEAYAvsPGRMRQfddLFRG--ETGKDREKSHswlSTGWFTMVIAV 253
Cdd:cd23969 144 gdsILW-IPAFVSKGGEEHVQWTNEIILkhKLNVKTAYP--PLRLNH---AIRGywLTTKFRIKRP---STGLLMYTLAT 214

                       170       180       190
                ....*....|....*....|....*....|....*
gi 21361444 254 ELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKG 288
Cdd:cd23969 215 RFCDEIHLYGFYP---FSEDGNGRAVKYHYYDNRK 246
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 105-285 1.25e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 60.15  E-value: 1.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVF-------------------RVL 165
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFsdpshydpnttvvlipfkpHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 166 RRPQEFVNRTPETVFIFW-GPPSKMQ-KPqgSLVRVIqraglvfpnmeayavSPGRMRQFD-DLFRGETGKDREKSHSWL 242
Cdd:cd23984  82 RWLLDLLMGKKVSAKGFWkKPALNLIyKP--NQIRIL---------------NPFILRIAAyELLHFPKRFPKEKKPKHP 144

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 21361444 243 STGWFTMVIAVELCDHVHVYGMvppnycsqRPRLQRM--PYHYYE 285
Cdd:cd23984 145 TTGIIAITLALHICNEVHIAGF--------KYDFSNLnsTLHYYG 181
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 107-289 2.82e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 59.96  E-value: 2.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 107 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTgYSADVGNKTTYrVVAHSSVFR-----VLRRPQEFVNRtpetvfi 181
Cdd:cd23971  66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL-VTANPSILRekfhnLKKRRRPFVER------- 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 182 fwgppskMQKPQGSLV------------------RVIQRAGlvfPNMEAYAVSPGRMRQFDDLFRGETGKDREkshswLS 243
Cdd:cd23971 137 -------MKVYGNALLllpafsytsntepslralYTLEDFG---SPQKVLFFNPEYLRNLSRYWKSKGLKARR-----LS 201

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 21361444 244 TGwFTMV-IAVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKGP 289
Cdd:cd23971 202 TG-LMLVsAALELCENVHLYGFWP---FSTDLDGNPISHHYYDNVLP 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 103-323 7.52e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 58.99  E-value: 7.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 103 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF----VNRTPET 178
Cdd:cd23973  81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRgfknIPQDKDI 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 179 VFIF---------WGPPSKMQK--PQGSLVRVIQRA--GLVFpNMEAYAVS-PGRMRQFDDLFRgeTGKDREKSHSWL-- 242
Cdd:cd23973 161 KYILfpegprdyqWLEALLKNKtiPSGAYYGRRPRSyfSGDF-TEDKYLVLhPDFLRYVKNRFL--RSKTLKGKYWAIyr 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 243 -STGWFTMVIAVELCDHVHVYGMVPPNYcsqrprlQRMPYHYYEpKGPDECVTYIqnehsrkgnHHRFITEKRVfssWAQ 321
Cdd:cd23973 238 pTTGAFLLLTALHLCDTVSAYGFITEDY-------RKYPDHYYD-KKKTKLVFYI---------NHDFRLEKKL---WKR 297


                ..
gi 21361444 322 LY 323
Cdd:cd23973 298 LH 299
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 96-285 1.00e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 58.41  E-value: 1.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  96 LGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRT 175
Cdd:cd23987  59 LKNKHFKT----CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSV--VQRAFEDLVNET 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 176 PETVFIfwgppSKMQKPQGSLVRViqraglvfpnmEAYAVSPG--RMRQFDDLFRGETGKDREKSHS----------WL- 242
Cdd:cd23987 132 WKEKFL-----QRLQSLNGSILWI-----------PAFMAKGGeeRVEWVNDLILKHHINVRTAYPSlrllhavrgyWLt 195

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 21361444 243 --------STGWFTMVIAVELCDHVHVYGMVP-PNYCSQRPrlqrMPYHYYE 285
Cdd:cd23987 196 nkvhikrpTTGLLMYTLATRFCNRIHLYGFWPfPRDQNQNP----VKYHYYD 243
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 102-263 1.01e-09

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 58.34  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVfRVLRRPQEFVNRTPETVFI 181
Cdd:cd23979  77 PSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA-KNLPANVSFVLVPFKTLDL 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 182 FW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQFDDLFRGETGKdrekshsWLSTGWFTMVIAVE 254
Cdd:cd23979 156 LWitsalstGQIRFTYAPVKQFLRVDKDKVQIY--------NPAFFKYIHDRWTEHHGR-------YPSTGMLVLFFALH 220


                ....*....
gi 21361444 255 LCDHVHVYG 263
Cdd:cd23979 221 VCDEVNVYG 229
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 89-325 1.04e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 55.73  E-value: 1.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  89 TDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP 168
Cdd:cd23964  67 TSSRYMFVLRGG-RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKH 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 169 qefVNRTPETVFIF----------------WGPPSKMQKPQGSlvrviqraglvFPNMEAYAVSPGRMRQFD-DLFRget 231
Cdd:cd23964 146 ---VPQDKDTKYLFipfkirdydyldavlsGKPVPDGCDKGKR-----------PPPLFGPKLNATNVRLLHpDFIR--- 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 232 gkdreksH---SWL--------STGWFTMVIAVELCDHVHVYGM-VPPNYcsqrprlqrmPYHYYEPKgpdecvtyIQNE 299
Cdd:cd23964 209 -------YlfnRWLnsstsyrpTTGALMLLTALHTCDQVSVYGFgYDPRF----------SLHYYDKT--------FVKF 263

                       250       260
                ....*....|....*....|....*...
gi 21361444 300 HSRKGNHHrFITEKRVfssWAQL--YGI 325
Cdd:cd23964 264 TVFYANHD-FTNERKL---WRKLheEGI 287
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 40-285 1.06e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 55.35  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444  40 EQRSAVFVILFALITILILYSSNSANEVFHYGSLRgrsRRPVNLKK--WSITDGYVPiLGNKTLPSrchqCVIVSSSSHL 117
Cdd:cd23988   5 EIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDR---RRTLNISQnlHSLLPEVSP-MKNRRFKT----CAVVGNSGIL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 118 LGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRV---LRRP---QEFVNRTPE-TVFIFWgPPSKMQ 190
Cdd:cd23988  77 LDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNEsdrEKFVHRLSMlNDSVLW-IPAFMV 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 191 KpqGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLfRGE--TGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVP-P 267
Cdd:cd23988 156 K--GGEKHVEWVNALILKNKLKVRTAYPSLRLIHAV-RGYwlTNKVNIKRP---STGLLMYTLATRFCDEIHLYGFWPfP 229

                       250
                ....*....|....*...
gi 21361444 268 NYCSQRPrlqrMPYHYYE 285
Cdd:cd23988 230 KDANGNP----VKYHYYD 243
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 104-184 1.48e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.16  E-value: 1.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 104 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSvfrVLRRPQEFvnrTPETVFIFW 183
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEG---AIQKPEQY---EKDSLFVLA 74


                .
gi 21361444 184 G 184
Cdd:cd23981  75 G 75
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 107-302 3.09e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.99  E-value: 3.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 107 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTG-YSADVGNKTTYrVVAHSSVFrvLRRPQEFVNRtpetvfifwgp 185
Cdd:cd23991  66 QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSII--SIKYAKLNER----------- 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 186 pskmQKPQGSLVRVIQRAGLVFPnmeAYAVSPGRMRQFDDLFRGETGKDREK------------SHSW---------LST 244
Cdd:cd23991 132 ----RKPFLETVSVYGDAFLLLP---AFSYRSNTALSFKVYYTLEDFKAKQKviffhpiylkhlAQFWrskgvqvyrLST 204

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21361444 245 GWFTMVIAVELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSR 302
Cdd:cd23991 205 GLMITSAALELCEEVKLYGFWP---FSKNTEGKPISHHYYDNQLPKPGFHSMPKEFYQ 259
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 101-287 5.57e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 50.59  E-value: 5.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 101 LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF-VNRTPET- 178
Cdd:cd23972  78 TPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLgFTRTPQGq 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 179 ----VFIfwgpPSKMQK-------------PQGsLVRVIQRAGLVFPNMEAYA---VSPGRMRQFDDLFRGETGKDREKS 238
Cdd:cd23972 158 dlqyIFI----PSDIRDyvmlrsailgvpvPEG-LDKGDRPHKYFGPEASAKKfklLHPDFISYLTDRFLKSKLLNTHYG 232

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 21361444 239 HSWL-STGWFTMVIAVELCDHVHVYGMVPPNYcsqrprlQRMPYHYYEPK 287
Cdd:cd23972 233 HLYMpSTGALMLLTALHTCDQVSAYGFITSNY-------WKFSDHYYERK 275
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 101-290 5.84e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 50.21  E-value: 5.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 101 LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAP-TTGYSADVGNKTtYRVVAHSSVFR-----VLRRPQEFVN- 173
Cdd:cd23989  59 LQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT-QLVTANPSIIDkrfqnLLWSRKSFVEs 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 174 -RTPETVFIFWgPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFddlfrGETGKDREKSHSWLSTGWFTMVIA 252
Cdd:cd23989 138 mKVYGRSYIYM-PAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRNV-----GKFWKSKGVHAKRLSTGLFLVSAA 211

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 21361444 253 VELCDHVHVYGMVPpnyCSQRPRLQRMPYHYYEPKGPD 290
Cdd:cd23989 212 LGLCEEVTIYGFWP---FSVDLDERTISHHYYDNVLPD 246
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 103-287 2.55e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 45.13  E-value: 2.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 103 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRR---------PQefvn 173
Cdd:cd23974  82 SPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngpPQ---- 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 174 rTPETVFIFWgP---------------------PSKMQKPQ---GSLVRViqraglvfpnmEAYAV-SPGRMRQFDDLF- 227
Cdd:cd23974 158 -SKETRYIFL-PdhdrdyllvkaalthtpidrgRDKSKRPSkyfGKDVTA-----------EKFKIyHPDFIRYLRNRFl 224

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361444 228 RGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNYcsqrprlQRMPYHYYEPK 287
Cdd:cd23974 225 WSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFMTPDY-------GKYSDHYYDKT 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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