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Conserved domains on  [gi|261823995|ref|NP_035264|]
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serum paraoxonase/arylesterase 1 isoform 1 precursor [Mus musculus]

Protein Classification

Arylesterase domain-containing protein( domain architecture ID 10484254)

Arylesterase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 3.27e-45

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 149.54  E-value: 3.27e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995  168 NDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAEGFDFANGIGISLDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 261823995  248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 3.27e-45

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 149.54  E-value: 3.27e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995  168 NDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAEGFDFANGIGISLDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 261823995  248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 166-308 2.03e-14

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 72.23  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995 166 SINDIAaIGPE-SFYATNdhyfadpylrsweMYLGLSWSNVVYYSPD-KVQVVAEGFDFANGIGISLDGKYVYIAELLAH 243
Cdd:COG3386   94 RPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAG 159

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261823995 244 KIHVYEKHANWTLTPLKVL----NFDTLVDNISVDpVTGDLWVgCHPNGMRIFFYDaenPPGSEVLRIQ 308
Cdd:COG3386  160 RIYRFDLDADGTLGNRRVFadlpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFD---PDGELLGRIE 223
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 168-253 3.27e-45

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 149.54  E-value: 3.27e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995  168 NDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAEGFDFANGIGISLDGKYVYIAELLAHKIHV 247
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 261823995  248 YEKHAN 253
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 166-308 2.03e-14

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 72.23  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995 166 SINDIAaIGPE-SFYATNdhyfadpylrsweMYLGLSWSNVVYYSPD-KVQVVAEGFDFANGIGISLDGKYVYIAELLAH 243
Cdd:COG3386   94 RPNDGV-VDPDgRLYFTD-------------MGEYLPTGALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAG 159

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261823995 244 KIHVYEKHANWTLTPLKVL----NFDTLVDNISVDpVTGDLWVgCHPNGMRIFFYDaenPPGSEVLRIQ 308
Cdd:COG3386  160 RIYRFDLDADGTLGNRRVFadlpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFD---PDGELLGRIE 223
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 137-308 6.18e-07

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 49.95  E-value: 6.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995  137 SSSTVEVFKFQEEERSLLHLKTITHELLPSINDiAAIGPE-SFYATNDHYFADPylrswemylGLSWSNVVYYSPD-KVQ 214
Cdd:pfam08450  58 LKDGVALLDLATGELTPLADPEDDDWPLNRFND-GKVDPDgRFWFGTMGDDEAP---------GGDPGALYRLDPDgKLT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823995  215 VVAEGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHA-NWTLTPLKVL----NFDTLVDNISVDPvTGDLWVgCHPNGM 289
Cdd:pfam08450 128 RVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYDYDLdGGLISNRRVFadfkPGLGRPDGMAVDA-EGNVWV-ARWGGG 205

                         170
                  ....*....|....*....
gi 261823995  290 RIFFYDaenPPGSEVLRIQ 308
Cdd:pfam08450 206 KVVRFD---PDGKLLREIE 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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