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Conserved domains on  [gi|113195688|ref|NP_034941|]
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bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 [Mus musculus]

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase( domain architecture ID 10572471)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 83-514 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 885.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688   83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDHTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  163 EYGVGIIGFFRAREHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLI 242
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  243 ASHRPAELSmPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLVFVDAVAYLTGKRLCLDLDRYILVDIDDIFV 322
Cdd:pfam12062 159 AKVKSGEES-PSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  323 GKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRREFWWFPHMWSHMQPHLFHNRS 402
Cdd:pfam12062 238 GKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  403 VLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHSQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPR 482
Cdd:pfam12062 318 VLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPR 397

                         410       420       430
                  ....*....|....*....|....*....|..
gi 113195688  483 QTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
Cdd:pfam12062 398 QTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
603-852 6.40e-44

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 159.43  E-value: 6.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSpstfEEIQFFNGPNYHKGIDWYMDFFPVPSNASTDFLFEKS-----A 677
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPspriiK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  678 TYFDSEVVPRrgAALLPRAKIITVLINPADRAYSWYQHQRAHGDPIALNYTFYQVisassqaplllRSLQNRCLVPGYYS 757
Cdd:pfam00685  77 THLPLHLLPK--SLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  758 THLQRWLTYYPSGQLLIMDGQELRVNPAASMEIIQKFLGITP----FLNYTRTLRFDEDKGFWCQGL-------EGGKTR 826
Cdd:pfam00685 144 DHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeeLDKIVKHLSFENMKGNPCLNYsklpkevSPFFRK 223

                         250       260
                  ....*....|....*....|....*.
gi 113195688  827 CLGRSKgrrYPDMDMESRLFLTDFFR 852
Cdd:pfam00685 224 GLVGDW---KNYFTPEQAEKFDEIYQ 246
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 83-514 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 885.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688   83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDHTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  163 EYGVGIIGFFRAREHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLI 242
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  243 ASHRPAELSmPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLVFVDAVAYLTGKRLCLDLDRYILVDIDDIFV 322
Cdd:pfam12062 159 AKVKSGEES-PSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  323 GKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRREFWWFPHMWSHMQPHLFHNRS 402
Cdd:pfam12062 238 GKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  403 VLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHSQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPR 482
Cdd:pfam12062 318 VLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPR 397

                         410       420       430
                  ....*....|....*....|....*....|..
gi 113195688  483 QTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
Cdd:pfam12062 398 QTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
603-852 6.40e-44

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 159.43  E-value: 6.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSpstfEEIQFFNGPNYHKGIDWYMDFFPVPSNASTDFLFEKS-----A 677
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPspriiK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  678 TYFDSEVVPRrgAALLPRAKIITVLINPADRAYSWYQHQRAHGDPIALNYTFYQVisassqaplllRSLQNRCLVPGYYS 757
Cdd:pfam00685  77 THLPLHLLPK--SLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  758 THLQRWLTYYPSGQLLIMDGQELRVNPAASMEIIQKFLGITP----FLNYTRTLRFDEDKGFWCQGL-------EGGKTR 826
Cdd:pfam00685 144 DHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeeLDKIVKHLSFENMKGNPCLNYsklpkevSPFFRK 223

                         250       260
                  ....*....|....*....|....*.
gi 113195688  827 CLGRSKgrrYPDMDMESRLFLTDFFR 852
Cdd:pfam00685 224 GLVGDW---KNYFTPEQAEKFDEIYQ 246
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 83-514 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 885.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688   83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDHTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  163 EYGVGIIGFFRAREHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLI 242
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  243 ASHRPAELSmPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLVFVDAVAYLTGKRLCLDLDRYILVDIDDIFV 322
Cdd:pfam12062 159 AKVKSGEES-PSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  323 GKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRREFWWFPHMWSHMQPHLFHNRS 402
Cdd:pfam12062 238 GKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  403 VLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHSQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPR 482
Cdd:pfam12062 318 VLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPR 397

                         410       420       430
                  ....*....|....*....|....*....|..
gi 113195688  483 QTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
Cdd:pfam12062 398 QTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
603-852 6.40e-44

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 159.43  E-value: 6.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSpstfEEIQFFNGPNYHKGIDWYMDFFPVPSNASTDFLFEKS-----A 677
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPspriiK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  678 TYFDSEVVPRrgAALLPRAKIITVLINPADRAYSWYQHQRAHGDPIALNYTFYQVisassqaplllRSLQNRCLVPGYYS 757
Cdd:pfam00685  77 THLPLHLLPK--SLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  758 THLQRWLTYYPSGQLLIMDGQELRVNPAASMEIIQKFLGITP----FLNYTRTLRFDEDKGFWCQGL-------EGGKTR 826
Cdd:pfam00685 144 DHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeeLDKIVKHLSFENMKGNPCLNYsklpkevSPFFRK 223

                         250       260
                  ....*....|....*....|....*.
gi 113195688  827 CLGRSKgrrYPDMDMESRLFLTDFFR 852
Cdd:pfam00685 224 GLVGDW---KNYFTPEQAEKFDEIYQ 246
Sulfotransfer_3 pfam13469
Sulfotransferase family;
608-798 4.56e-11

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 62.31  E-value: 4.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  608 IVGPQKTGTTAIHFFLSLHPAVTSsfpspstFEEIQFFNGPNYHKGIDWYMDF---FPVPSNAstDFLFEKSATYFDS-E 683
Cdd:pfam13469   3 IVGLPRSGTTLLHRLLAAHPDVRP-------PEETWFVIPRILALLQAWGKSLealARVPSYA--RWLCDKSPSHLFHlD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195688  684 VVprrgAALLPRAKIITVLINPADRAYSWYQHqrahgdpialnytfyqvISASSQAPLLLRSLQNRCLVPGYYSTHLQRW 763
Cdd:pfam13469  74 LL----LKAFPDAKFIHLHRDPVDTVISSYCS-----------------LFGFTLSSYSTAFLRDIGLALARWSRAYERL 132

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 113195688  764 LT---YYPSGQLLIMDGQELRVNPAASMEIIQKFLGIT 798
Cdd:pfam13469 133 MAaraRVPPGRFLDVRYEDLVADPEGTLRRILEFLGLP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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