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Conserved domains on  [gi|7110675|ref|NP_032737|]
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noggin precursor [Mus musculus]

Protein Classification

Noggin domain-containing protein( domain architecture ID 10530716)

Noggin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Noggin pfam05806
Noggin; This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that ...
12-232 1.49e-140

Noggin; This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation.


:

Pssm-ID: 399070  Cd Length: 215  Bit Score: 392.17  E-value: 1.49e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110675     12 YALVVVLGLRAAPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGG 91
Cdd:pfam05806   1 YLLVLSLGLRIHEGICQHYLHLRPIPSDNLPVVDLIEHPDPIYDPREQDLNETTLRAKLGSNFDPNFMSVSLPVEDRLSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110675     92 GgpaggaEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLaQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPR 171
Cdd:pfam05806  81 P------DELPELDLLLRLKPTGAMPKEIKKLDFSEFP-YGKRHRLSKKLRRKLQQWLWSYTFCPVLYTWKDLGVRFWPR 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7110675    172 YVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ-RRGGQRCGWIPIQYPIISECKCSC 232
Cdd:pfam05806 154 YVKEGSCFSKRSCSVPEGMVCKPAKSVHLTILRWRCQgRRRQKYCAWIPVQYPIISECKCSC 215
 
Name Accession Description Interval E-value
Noggin pfam05806
Noggin; This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that ...
12-232 1.49e-140

Noggin; This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation.


Pssm-ID: 399070  Cd Length: 215  Bit Score: 392.17  E-value: 1.49e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110675     12 YALVVVLGLRAAPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGG 91
Cdd:pfam05806   1 YLLVLSLGLRIHEGICQHYLHLRPIPSDNLPVVDLIEHPDPIYDPREQDLNETTLRAKLGSNFDPNFMSVSLPVEDRLSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110675     92 GgpaggaEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLaQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPR 171
Cdd:pfam05806  81 P------DELPELDLLLRLKPTGAMPKEIKKLDFSEFP-YGKRHRLSKKLRRKLQQWLWSYTFCPVLYTWKDLGVRFWPR 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7110675    172 YVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ-RRGGQRCGWIPIQYPIISECKCSC 232
Cdd:pfam05806 154 YVKEGSCFSKRSCSVPEGMVCKPAKSVHLTILRWRCQgRRRQKYCAWIPVQYPIISECKCSC 215
 
Name Accession Description Interval E-value
Noggin pfam05806
Noggin; This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that ...
12-232 1.49e-140

Noggin; This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation.


Pssm-ID: 399070  Cd Length: 215  Bit Score: 392.17  E-value: 1.49e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110675     12 YALVVVLGLRAAPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGG 91
Cdd:pfam05806   1 YLLVLSLGLRIHEGICQHYLHLRPIPSDNLPVVDLIEHPDPIYDPREQDLNETTLRAKLGSNFDPNFMSVSLPVEDRLSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110675     92 GgpaggaEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLaQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPR 171
Cdd:pfam05806  81 P------DELPELDLLLRLKPTGAMPKEIKKLDFSEFP-YGKRHRLSKKLRRKLQQWLWSYTFCPVLYTWKDLGVRFWPR 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7110675    172 YVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQ-RRGGQRCGWIPIQYPIISECKCSC 232
Cdd:pfam05806 154 YVKEGSCFSKRSCSVPEGMVCKPAKSVHLTILRWRCQgRRRQKYCAWIPVQYPIISECKCSC 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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