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Conserved domains on  [gi|171543875|ref|NP_032708|]
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protein NEDD1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-299 1.73e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.53  E-value: 1.73e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  24 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLnSTSMYLASGGLNNTVNI 103
Cdd:cd00200    1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 104 WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF-GHgsKQPIRHIKYSLFRKSLLGSvS 182
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 183 DNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 261
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 171543875 262 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 299
Cdd:cd00200  233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-299 1.73e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.53  E-value: 1.73e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  24 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLnSTSMYLASGGLNNTVNI 103
Cdd:cd00200    1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 104 WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF-GHgsKQPIRHIKYSLFRKSLLGSvS 182
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 183 DNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 261
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 171543875 262 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 299
Cdd:cd00200  233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 3.62e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 3.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875   5 LRFASSGDDVKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIVVssckckpvpLLELAEGQKQ---- 80
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA--DGTVR---------LWDLATGKLLrtlt 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  81 ------TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSS 154
Cdd:COG2319  160 ghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 155 TPFGHGSkQPIRHIKYSLFRKSLLgSVSDNGVVTLWDVNSQSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILY 234
Cdd:COG2319  240 RTLTGHS-GSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLW 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 171543875 235 DTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 299
Cdd:COG2319  316 DLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 160-309 1.64e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 160 GSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVnSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSK 239
Cdd:PLN00181 530 ASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 171543875 240 KLVKTLVADTPLTAVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKAS 309
Cdd:PLN00181 609 VSIGTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-147 3.70e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 171543875   108 SKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHS 147
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-299 1.73e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.53  E-value: 1.73e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  24 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLnSTSMYLASGGLNNTVNI 103
Cdd:cd00200    1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 104 WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF-GHgsKQPIRHIKYSLFRKSLLGSvS 182
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 183 DNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 261
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 171543875 262 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 299
Cdd:cd00200  233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 3.62e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 3.62e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875   5 LRFASSGDDVKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIVVssckckpvpLLELAEGQKQ---- 80
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA--DGTVR---------LWDLATGKLLrtlt 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  81 ------TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSS 154
Cdd:COG2319  160 ghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 155 TPFGHGSkQPIRHIKYSLFRKSLLgSVSDNGVVTLWDVNSQSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILY 234
Cdd:COG2319  240 RTLTGHS-GSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLW 315

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 171543875 235 DTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 299
Cdd:COG2319  316 DLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
6-278 2.18e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 2.18e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875   6 RFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIV----VSSCKCkpvpLLELAEGQK 79
Cdd:COG2319  134 TLASGSADgtVRLWDLATGKLLRTLTGHSGA--VTSVAFSPDGKLLASGSD--DGTVrlwdLATGKL----LRTLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  80 Q-TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFG 158
Cdd:COG2319  206 AvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 159 HGSkQPIRHIKYSLFRKSLLgSVSDNGVVTLWDVNSQSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILYDTSS 238
Cdd:COG2319  286 GHS-GGVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 171543875 239 KKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLR 278
Cdd:COG2319  362 GELLRTLTGHTgAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
91-299 2.09e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 2.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  91 YLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFgHGSKQPIRHIKY 170
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 171 SLFRKSLLgSVSDNGVVTLWDVNSQSSYHTFDStHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 249
Cdd:COG2319  171 SPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLATGKLLRTLTGHSg 247

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 171543875 250 PLTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 299
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
92-299 1.22e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  92 LASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFgHGSKQPIRHIKYS 171
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 172 LFRKSLLgSVSDNGVVTLWDVNSQSSYHTFdSTHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT-P 250
Cdd:COG2319  130 PDGKTLA-SGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTgA 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 171543875 251 LTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 299
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF 254
WD40 COG2319
WD40 repeat [General function prediction only];
6-194 6.06e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 6.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875   6 RFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLvtASSSGDKIV----VSSCKCkpvplLELAEGQK 79
Cdd:COG2319  218 LLASGSADgtVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL--ASGSADGTVrlwdLATGEL-----LRTLTGHS 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875  80 Q--TCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPF 157
Cdd:COG2319  289 GgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 171543875 158 -GHGSkqPIRHIKYSLfRKSLLGSVSDNGVVTLWDVNS 194
Cdd:COG2319  369 tGHTG--AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-145 8.90e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 8.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875   8 ASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIV--VSSCKCkpvplLELAEGQKQ--T 81
Cdd:cd00200  151 ASSSQDgtIKLWDLRTGKCVATLTGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLwdLSTGKC-----LGTLRGHENgvN 223

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 171543875  82 CVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIIL 145
Cdd:cd00200  224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 160-309 1.64e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 160 GSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVnSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSK 239
Cdd:PLN00181 530 ASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 171543875 240 KLVKTLVADTPLTAVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKAS 309
Cdd:PLN00181 609 VSIGTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-105 4.06e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 4.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875   4 NLRFASSGDD--VKIWDASFLTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGdKIVV-SSCKCKPVplLELAEGQKQ 80
Cdd:cd00200  189 GEKLLSSSSDgtIKLWDLSTGKCLGTLRGHENG--VNSVAFSPDGYLLASGSEDG-TIRVwDLRTGECV--QTLSGHTNS 263

                         90       100
                 ....*....|....*....|....*.
gi 171543875  81 -TCVDLNSTSMYLASGGLNNTVNIWD 105
Cdd:cd00200  264 vTSLAWSPDGKRLASGSADGTIRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
125-288 2.98e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 125 VAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDsT 204
Cdd:COG3391   30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIP-V 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171543875 205 HKAPaSGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGK-----IYQYDLRM 279
Cdd:COG3391  109 GGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187


                 ....*....
gi 171543875 280 LKsPVKTIS 288
Cdd:COG3391  188 GK-VVATIP 195
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-147 3.70e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 171543875   108 SKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHS 147
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 210-279 1.11e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.44  E-value: 1.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 171543875 210 SGICF-SPVNELLFVTIGLDKRIILYDTSSKK--LVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRM 279
Cdd:cd22857  182 TDLTFlSKDDHRKIVTGTGYHQVRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRT 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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