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Conserved domains on  [gi|161016843|ref|NP_031909|]
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desmoglein-2 preproprotein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-273 1.51e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 1.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  168 VFVGSIEELSAAHTLVMKITATDADDPEtlNAKVSYRIVSQEPanSHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEAR 247
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE--DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 161016843  248 DGNGQitdKPVQQAQVQIRILDVNDN 273
Cdd:cd11304    76 DGGGP---PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-387 1.60e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  282 YEGTVEENQ-VNVEVMRIKVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVT 360
Cdd:cd11304     2 YEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSIDPST----GEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*..
gi 161016843  361 NKAAFHKSilskykaTPIPITVKVKNV 387
Cdd:cd11304    76 DGGGPPLS-------STATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 414-500 3.98e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  414 SIGNFQVFDEDTGQAAKVTYVKV-QDTDNWVSVDSVTSEIKLVKIPDFEsryvQNGTYTAKVVAISKEHPQKTITGTIVI 492
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGGGPPLSSTATVTI 90


                  ....*...
gi 161016843  493 TVEDVNDN 500
Cdd:cd11304    91 TVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 67-160 5.01e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 5.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   67 EDLSRKNPIAKIH-SDLAEEKGIKITYKYTGkgitEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLE 145
Cdd:cd11304     8 ENAPPGTVVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 161016843  146 KPLELRIKVLDINDN 160
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 489-545 3.27e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


:

Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 37.16  E-value: 3.27e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161016843   489 TIVITVEDVNDNcPVLVDSVRSVCEDEPYV---NVTAEDLDGaqNSAPFSFSIIDQPP--GT 545
Cdd:pfam17803    2 TVTITVTGVNDA-PVAVDDTATVDEDTPVTitgNVLANDTDV--DGDTLTVTSVTGAPayGT 60
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-273 1.51e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 1.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  168 VFVGSIEELSAAHTLVMKITATDADDPEtlNAKVSYRIVSQEPanSHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEAR 247
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE--DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 161016843  248 DGNGQitdKPVQQAQVQIRILDVNDN 273
Cdd:cd11304    76 DGGGP---PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 187-275 8.11e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 8.11e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    187 TATDADDPEtlNAKVSYRIVSQEPAnsHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEARDGNGQItdkPVQQAQVQIR 266
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGNDD--GLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPP---LSSTATVTIT 72


                    ....*....
gi 161016843    267 ILDVNDNIP 275
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
169-268 1.24e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   169 FVGSIEELSAAHTLVMKITATDADDPetLNAKVSYRIVSQEPanSHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEARD 248
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP--GGNFRIDPDTGDISTTK-PLDRESIGEYELTVEATD 75

                           90       100
                   ....*....|....*....|
gi 161016843   249 GNGQItdkPVQQAQVQIRIL 268
Cdd:pfam00028   76 SGGPP---LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-387 1.60e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  282 YEGTVEENQ-VNVEVMRIKVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVT 360
Cdd:cd11304     2 YEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSIDPST----GEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*..
gi 161016843  361 NKAAFHKSilskykaTPIPITVKVKNV 387
Cdd:cd11304    76 DGGGPPLS-------STATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 414-500 3.98e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  414 SIGNFQVFDEDTGQAAKVTYVKV-QDTDNWVSVDSVTSEIKLVKIPDFEsryvQNGTYTAKVVAISKEHPQKTITGTIVI 492
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGGGPPLSSTATVTI 90


                  ....*...
gi 161016843  493 TVEDVNDN 500
Cdd:cd11304    91 TVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 419-502 9.46e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 9.46e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    419 QVFDEDTGQAAKVTYVKVQDTD-NWVSVDSVTSEIKLVKIPDFESRyvqnGTYTAKVVAISKEHPQKTITGTIVITVEDV 497
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 161016843    498 NDNCP 502
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 67-160 5.01e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 5.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   67 EDLSRKNPIAKIH-SDLAEEKGIKITYKYTGkgitEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLE 145
Cdd:cd11304     8 ENAPPGTVVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 161016843  146 KPLELRIKVLDINDN 160
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
282-384 1.19e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 1.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   282 YEGTVEENQ-VNVEVMRIKVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVT 360
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....
gi 161016843   361 NKAAFHKSilskykaTPIPITVKV 384
Cdd:pfam00028   75 DSGGPPLS-------STATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-162 1.30e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.30e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843     80 SDLAEEKGIKITYKytgkGITEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKVLDIND 159
Cdd:smart00112    3 TDADSGENGKVTYS----ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 161016843    160 NEP 162
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 299-387 4.94e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 4.94e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    299 KVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVTNKAAFHKSilskykaTPI 378
Cdd:smart00112    1 SATDADS--GENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67


                    ....*....
gi 161016843    379 PITVKVKNV 387
Cdd:smart00112   68 TVTITVLDV 76
Cadherin pfam00028
Cadherin domain;
414-495 3.53e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 3.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   414 SIGNFQVFDEDTGQAAKVTYVKVQD-TDNWVSVDSVTSEIKLVKIPDFESRyvqnGTYTAKVVAISKEHPQKTITGTIVI 492
Cdd:pfam00028   14 EVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGPPLSSTATVTI 89


                   ...
gi 161016843   493 TVE 495
Cdd:pfam00028   90 TVL 92
Cadherin pfam00028
Cadherin domain;
75-155 1.17e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    75 IAKIHSDLAEekGIKITYKYTGkgitEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKV 154
Cdd:pfam00028   18 VTATDPDLGP--NGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                   .
gi 161016843   155 L 155
Cdd:pfam00028   92 L 92
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 489-545 3.27e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 37.16  E-value: 3.27e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161016843   489 TIVITVEDVNDNcPVLVDSVRSVCEDEPYV---NVTAEDLDGaqNSAPFSFSIIDQPP--GT 545
Cdd:pfam17803    2 TVTITVTGVNDA-PVAVDDTATVDEDTPVTitgNVLANDTDV--DGDTLTVTSVTGAPayGT 60
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 168-273 1.51e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 1.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  168 VFVGSIEELSAAHTLVMKITATDADDPEtlNAKVSYRIVSQEPanSHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEAR 247
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE--DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 161016843  248 DGNGQitdKPVQQAQVQIRILDVNDN 273
Cdd:cd11304    76 DGGGP---PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 187-275 8.11e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 8.11e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    187 TATDADDPEtlNAKVSYRIVSQEPAnsHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEARDGNGQItdkPVQQAQVQIR 266
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGNDD--GLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPP---LSSTATVTIT 72


                    ....*....
gi 161016843    267 ILDVNDNIP 275
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
169-268 1.24e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   169 FVGSIEELSAAHTLVMKITATDADDPetLNAKVSYRIVSQEPanSHMFYLNKDTGEIYTTSfTLDREEHSSYSLTVEARD 248
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP--GGNFRIDPDTGDISTTK-PLDRESIGEYELTVEATD 75

                           90       100
                   ....*....|....*....|
gi 161016843   249 GNGQItdkPVQQAQVQIRIL 268
Cdd:pfam00028   76 SGGPP---LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-387 1.60e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  282 YEGTVEENQ-VNVEVMRIKVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVT 360
Cdd:cd11304     2 YEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSIDPST----GEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*..
gi 161016843  361 NKAAFHKSilskykaTPIPITVKVKNV 387
Cdd:cd11304    76 DGGGPPLS-------STATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 414-500 3.98e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.26  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843  414 SIGNFQVFDEDTGQAAKVTYVKV-QDTDNWVSVDSVTSEIKLVKIPDFEsryvQNGTYTAKVVAISKEHPQKTITGTIVI 492
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGGGPPLSSTATVTI 90


                  ....*...
gi 161016843  493 TVEDVNDN 500
Cdd:cd11304    91 TVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 419-502 9.46e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 9.46e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    419 QVFDEDTGQAAKVTYVKVQDTD-NWVSVDSVTSEIKLVKIPDFESRyvqnGTYTAKVVAISKEHPQKTITGTIVITVEDV 497
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 161016843    498 NDNCP 502
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 67-160 5.01e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 5.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   67 EDLSRKNPIAKIH-SDLAEEKGIKITYKYTGkgitEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLE 145
Cdd:cd11304     8 ENAPPGTVVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 161016843  146 KPLELRIKVLDINDN 160
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
282-384 1.19e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 1.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   282 YEGTVEENQ-VNVEVMRIKVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVT 360
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....
gi 161016843   361 NKAAFHKSilskykaTPIPITVKV 384
Cdd:pfam00028   75 DSGGPPLS-------STATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-162 1.30e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.30e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843     80 SDLAEEKGIKITYKytgkGITEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKVLDIND 159
Cdd:smart00112    3 TDADSGENGKVTYS----ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 161016843    160 NEP 162
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 299-387 4.94e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 4.94e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    299 KVTDADEvgSDNWLANFTFASGNEGGYFHIETDTqtneGIVTLVKEVDYEEMKKLDLSIIVTNKAAFHKSilskykaTPI 378
Cdd:smart00112    1 SATDADS--GENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67


                    ....*....
gi 161016843    379 PITVKVKNV 387
Cdd:smart00112   68 TVTITVLDV 76
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 67-160 6.42e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.58  E-value: 6.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   67 EDLSRKNPIAKIHSDLAEEkgIKITYKYTGKGiTEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEK 146
Cdd:cd00031     8 EGRSRGSFRVSIPTDLIAS--SGEIIKISAAG-KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQT 84

                          90
                  ....*....|....
gi 161016843  147 PLELRIKVLDINDN 160
Cdd:cd00031    85 SSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
414-495 3.53e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 3.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843   414 SIGNFQVFDEDTGQAAKVTYVKVQD-TDNWVSVDSVTSEIKLVKIPDFESRyvqnGTYTAKVVAISKEHPQKTITGTIVI 492
Cdd:pfam00028   14 EVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGPPLSSTATVTI 89


                   ...
gi 161016843   493 TVE 495
Cdd:pfam00028   90 TVL 92
Cadherin pfam00028
Cadherin domain;
75-155 1.17e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161016843    75 IAKIHSDLAEekGIKITYKYTGkgitEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKV 154
Cdd:pfam00028   18 VTATDPDLGP--NGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                   .
gi 161016843   155 L 155
Cdd:pfam00028   92 L 92
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 489-545 3.27e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 37.16  E-value: 3.27e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161016843   489 TIVITVEDVNDNcPVLVDSVRSVCEDEPYV---NVTAEDLDGaqNSAPFSFSIIDQPP--GT 545
Cdd:pfam17803    2 TVTITVTGVNDA-PVAVDDTATVDEDTPVTitgNVLANDTDV--DGDTLTVTSVTGAPayGT 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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