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Conserved domains on  [gi|256418948|ref|NP_009084|]
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zinc finger protein 208 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.71e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.92  E-value: 1.71e-29
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256418948      4 LTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAFKPDLIIFLEEGKESWN 64
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
691-1133 1.28e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 84.36  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  691 KPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKC--EECGKSFSTFSVLTKHKVIHTGEKPYKCEECGKAYK-WSSTLSYH 767
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNsKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  768 KKIHTVEKPYKCEECGKAFnrSAILIKHKRIHTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKEcgkAFSKFSI 847
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPP--SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  848 LTKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKKihtgekpykceecgkgFSMFSILTKHEVIHTGEKPYKCEecgkafS 927
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ------S 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  928 WLSVFSKHKKTHAGEkfykceaCGKAYKSSSTLSYHKKIHTEE-------KPYKYEECGKGFSTFSILTKHK--VIHTGE 998
Cdd:COG5048   245 PSSLSSSDSSSSASE-------SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  999 --KPYKCEE--CGKAFNWSSNLMEHKKIHTGETPYKC--EECDKAFS-----WPSSLTEHKATHAGEKPYKCE--ECGKA 1065
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLsnSCIRN 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1066 FSWPSRLTEHKATHAGEEP--YKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKV 1133
Cdd:COG5048   398 FKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-619 2.76e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  227 KPYRCKECGKAFSKFSILTKHKVIHTGEKSYKC--EECGKAFNQSAILTKHKIIHTGEKPNKCE-ECGKAFSKVSTLTTH 303
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  304 KAIHAGEKPYKCKECGKAFSK-VSTLITHKAI-HAGEKPYK---------------------CKECGKAFSKFSILTKHK 360
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSrDPQLPDLLSIsNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  361 VIHTGEKPYKCEECGKAYKWPSTLSYHKKIHTgEKPYKCEECGKGFSMFSILTKHEVIHTGEKPYKCEECGKAFNWSSNL 440
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  441 MEHKKIHTGE-------TPYKCEECGKGFSMFSILTKHK--VIHNGEkpykceecdkathaGEKPYKCEE--CGKAFNWS 509
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE--------------SLKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  510 SNLMEHKRIHTGEKPYKC--EECGKSFSTFSI------LTKHKVIHTGEKPYKCEECGKAYKWS-STLSYHKKIHTVEKP 580
Cdd:COG5048   337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRP 416

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 256418948  581 --YKCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFS 619
Cdd:COG5048   417 ynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1137-1217 2.54e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1137 GEKPYKCE--ECGKAYKWSSTLSYHKKiHTVEKPYKCEECGKgfvmfsilAKHKVIHTGEKLYKCEECGKAYKWPSTLRY 1214
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1215 HKK 1217
Cdd:COG5189   417 HRK 419
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1193-1273 1.42e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1193 GEKLYKCE--ECGKAYKWPSTLRYHKKiHTGEKPYKCEECGKafstfsilTKHKVIHTGEKPYKCEECGKAFSWLSVFSK 1270
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1271 HKK 1273
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.71e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.92  E-value: 1.71e-29
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256418948      4 LTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAFKPDLIIFLEEGKESWN 64
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 5.31e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 5.31e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 256418948     3 SLTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 9.68e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 9.68e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 256418948    4 LTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
691-1133 1.28e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 84.36  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  691 KPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKC--EECGKSFSTFSVLTKHKVIHTGEKPYKCEECGKAYK-WSSTLSYH 767
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNsKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  768 KKIHTVEKPYKCEECGKAFnrSAILIKHKRIHTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKEcgkAFSKFSI 847
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPP--SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  848 LTKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKKihtgekpykceecgkgFSMFSILTKHEVIHTGEKPYKCEecgkafS 927
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ------S 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  928 WLSVFSKHKKTHAGEkfykceaCGKAYKSSSTLSYHKKIHTEE-------KPYKYEECGKGFSTFSILTKHK--VIHTGE 998
Cdd:COG5048   245 PSSLSSSDSSSSASE-------SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  999 --KPYKCEE--CGKAFNWSSNLMEHKKIHTGETPYKC--EECDKAFS-----WPSSLTEHKATHAGEKPYKCE--ECGKA 1065
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLsnSCIRN 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1066 FSWPSRLTEHKATHAGEEP--YKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKV 1133
Cdd:COG5048   398 FKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-619 2.76e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  227 KPYRCKECGKAFSKFSILTKHKVIHTGEKSYKC--EECGKAFNQSAILTKHKIIHTGEKPNKCE-ECGKAFSKVSTLTTH 303
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  304 KAIHAGEKPYKCKECGKAFSK-VSTLITHKAI-HAGEKPYK---------------------CKECGKAFSKFSILTKHK 360
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSrDPQLPDLLSIsNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  361 VIHTGEKPYKCEECGKAYKWPSTLSYHKKIHTgEKPYKCEECGKGFSMFSILTKHEVIHTGEKPYKCEECGKAFNWSSNL 440
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  441 MEHKKIHTGE-------TPYKCEECGKGFSMFSILTKHK--VIHNGEkpykceecdkathaGEKPYKCEE--CGKAFNWS 509
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE--------------SLKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  510 SNLMEHKRIHTGEKPYKC--EECGKSFSTFSI------LTKHKVIHTGEKPYKCEECGKAYKWS-STLSYHKKIHTVEKP 580
Cdd:COG5048   337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRP 416

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 256418948  581 --YKCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFS 619
Cdd:COG5048   417 ynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1137-1217 2.54e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1137 GEKPYKCE--ECGKAYKWSSTLSYHKKiHTVEKPYKCEECGKgfvmfsilAKHKVIHTGEKLYKCEECGKAYKWPSTLRY 1214
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1215 HKK 1217
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1099-1124 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 256418948  1099 NLMEHKRIHTGEKPYKCEECGKSFST 1124
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-536 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 256418948   511 NLMEHKRIHTGEKPYKCEECGKSFST 536
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1193-1273 1.42e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1193 GEKLYKCE--ECGKAYKWPSTLRYHKKiHTGEKPYKCEECGKafstfsilTKHKVIHTGEKPYKCEECGKAFSWLSVFSK 1270
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1271 HKK 1273
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1212-1236 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.00e-04
                           10        20
                   ....*....|....*....|....*
gi 256418948  1212 LRYHKKIHTGEKPYKCEECGKAFST 1236
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.71e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.92  E-value: 1.71e-29
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256418948      4 LTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAFKPDLIIFLEEGKESWN 64
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 5.31e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 5.31e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 256418948     3 SLTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 9.68e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 9.68e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 256418948    4 LTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
691-1133 1.28e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 84.36  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  691 KPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKC--EECGKSFSTFSVLTKHKVIHTGEKPYKCEECGKAYK-WSSTLSYH 767
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNsKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  768 KKIHTVEKPYKCEECGKAFnrSAILIKHKRIHTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKEcgkAFSKFSI 847
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPP--SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  848 LTKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKKihtgekpykceecgkgFSMFSILTKHEVIHTGEKPYKCEecgkafS 927
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ------S 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  928 WLSVFSKHKKTHAGEkfykceaCGKAYKSSSTLSYHKKIHTEE-------KPYKYEECGKGFSTFSILTKHK--VIHTGE 998
Cdd:COG5048   245 PSSLSSSDSSSSASE-------SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  999 --KPYKCEE--CGKAFNWSSNLMEHKKIHTGETPYKC--EECDKAFS-----WPSSLTEHKATHAGEKPYKCE--ECGKA 1065
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETLsnSCIRN 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1066 FSWPSRLTEHKATHAGEEP--YKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKV 1133
Cdd:COG5048   398 FKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
579-993 2.27e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.59  E-value: 2.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  579 KPYKCEECGKAFNQSAILIKHKRIHTGEKPYKC--EECGKTFSKVSTLTTHKAIHAGEKPYKC-KECGKTFIKVSTLTTH 655
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  656 KAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECgkaFNWSSNLMEHKRIHtGEKPYKCeECGKSFSTFSV 735
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH-PPLPANS-LSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  736 LTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKKIHTVEkPYKCEECGKAFNRSAILIKHKRIHTDEKPYKCEECGKTFS 815
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  816 KVSTLTTHKAIHAGE-------KPYKCKECGKAFSKFSILTKHK--VIHTGE--KPYKCEE--CGKAYKWPSTLSYHKKI 882
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  883 HTGEKPYKCEECGKGFSMFSILTK-------HEVIHTGEKPYKCE--ECGKAFSWLSVFSKHKKTHAGEKF--YKCEACG 951
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 256418948  952 KAYKSSSTLSYHKKIHTEEKPYKYEECGKGFSTFSILTKHKV 993
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
495-903 2.62e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 2.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  495 KPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKC--EECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYK-WSSTLSYH 571
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNsKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  572 KKIHTVEKPYKCeeCGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGKTFIkvst 651
Cdd:COG5048   112 SSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLS---- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  652 LTTHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFS 731
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  732 TFSVLTKHKVIHTGE-------KPYKCEECGKAYKWSSTLSYHK--KIHTVE--KPYKCEE--CGKAFNRSAILIKHKRI 798
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  799 HTDEKPYKC--EECGKTFSKVSTLTTHKAIHA--GEKPYKCKE-----CGKAFSKFSILTKHKVIHTGEKP--YKCEECG 867
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 256418948  868 KAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMFSI 903
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
801-1189 3.40e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 3.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  801 DEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKC--KECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAYK-WPSTLS 877
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNsKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  878 YHKKIHTGEKPYKCEECGKGFSMFSILTKHEVIHTGEKPYKCEEC-----------------------GKAFSWLSVFSK 934
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  935 HKKTHAGEKFYKCEACGKAYKSSSTLSYHKKIHTEEkPYKYEECGKGF-------STFSILTKHKVIHTGEKPYKCeECG 1007
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSS-LPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1008 KAFNWSSNLMEHKKIHTGET-PYKCEECDKAFSWPSSLTEHKAT--HAGE--KPYKCEE--CGKAFSWPSRLTEHKATHA 1080
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1081 GEEPYKC--EECGKAFNWSSN-----LMEHKRIHTGEKPYKCE--ECGKSFSTFSILTKHKVIHTGEKP--YKCEECGKA 1149
Cdd:COG5048   348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 256418948 1150 YKWSSTLSYHKKIHTVEKPYKCEECGKGFVMFSILAKHKV 1189
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-619 2.76e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  227 KPYRCKECGKAFSKFSILTKHKVIHTGEKSYKC--EECGKAFNQSAILTKHKIIHTGEKPNKCE-ECGKAFSKVSTLTTH 303
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  304 KAIHAGEKPYKCKECGKAFSK-VSTLITHKAI-HAGEKPYK---------------------CKECGKAFSKFSILTKHK 360
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSrDPQLPDLLSIsNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  361 VIHTGEKPYKCEECGKAYKWPSTLSYHKKIHTgEKPYKCEECGKGFSMFSILTKHEVIHTGEKPYKCEECGKAFNWSSNL 440
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  441 MEHKKIHTGE-------TPYKCEECGKGFSMFSILTKHK--VIHNGEkpykceecdkathaGEKPYKCEE--CGKAFNWS 509
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE--------------SLKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  510 SNLMEHKRIHTGEKPYKC--EECGKSFSTFSI------LTKHKVIHTGEKPYKCEECGKAYKWS-STLSYHKKIHTVEKP 580
Cdd:COG5048   337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRP 416

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 256418948  581 --YKCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFS 619
Cdd:COG5048   417 ynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-631 1.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 1.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  255 KSYKCEECGKAFNQSAILTKHKIIHTGEKPNKC--EECGKAFSKVSTLTTHKAIHAGEKPYKC-KECGKAFSKVSTLITH 331
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  332 KAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAYkwPSTLSYHKKIHTGEKPykcEECGKGFSMFSI 411
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS--VNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  412 LTKHEVIHTGEKPYKCEECGKA-FNWSSNLMEHKKihTGETPYKCEECGKGFSM-------FSILTKHKVIHNGEKPYKC 483
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSySIPSSSSDQNLE--NSSSSLPLTTNSQLSPKsllsqspSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  484 ---EECDKATH---------AGEKPYKCEECGKAFNWSSNLMEHKR--IHTGE--KPYKCEE--CGKSFSTFSILTKHKV 545
Cdd:COG5048   265 lptASSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  546 IHTGEKPYKCEEC-------GKAYKWSSTLSYHKKIHTVEKPYKCE--ECGKAFNQSAILIKHKRIHTGEKP--YKCEEC 614
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410
                  ....*....|....*..
gi 256418948  615 GKTFSKVSTLTTHKAIH 631
Cdd:COG5048   425 SKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
859-1272 2.84e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 2.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  859 KPYKCEECGKAYKWPSTLSYHKKIHTGEKPYKC--EECGKGFSMFSILTKHEVIHTGEKPYKCE-ECGKAFSWLSVFSKH 935
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  936 KKTHAGEKFYKCEACGKA----YKSSSTLSYHKKIHTEEKPYKYEECGKGFSTFSILTKHKVIHTGEKPYKceecgkafn 1011
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS--------- 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1012 WSSNLMEHKKIHTGETPYKCEECDKAFSWPSSLTEHKATHAgEKPYKCEECGKAF------SWPSRLTEHKATHAGEEPY 1085
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1086 KCEECGKAFNWSSNLMEHKRIHTG-EKPYKCEECGKSFSTFSILTKHK--VIHTGE--KPYKCEE--CGKAYKWSSTLSY 1158
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1159 HKKIHTVEKPYKC--EECGKGFVMFSI------LAKHKVIHTGEKLYKCEECGKAYKW-PSTLRYHKKIHTGEKP--YKC 1227
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKrDSNLSLHIITHLSFRPynCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 256418948 1228 EECGKAFSTFSILTKHKVIHTGEKPYKCEECGKAFSWLSVFSKHK 1272
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
887-1276 8.99e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 8.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  887 KPYKCEECGKGFSMFSILTKHEVIHTGEKPYKC--EECGKAFSWLSVFSKHKKTHAGEKFYKCEACGKAYKSS-STLSYH 963
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  964 KKIHTEEKPYKYEECGKGFSTFSILTKHKVIHTGEKPYKCEECgkaFNWSSNLMEHKKIHtGETPYKCEeCDKAFSWPSS 1043
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH-PPLPANSL-SKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1044 LTEHKATHAGEKPYKCEECGKAFSWPSRLTEHKATHAgEEPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFS 1123
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1124 TFSILTKHKVIHTGE-------KPYKCEECGKAYKWSSTLSYHK--KIHTVE--KPYKCEE--CGKGFVMFSILAKHKVI 1190
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1191 HTGEKLYKCEEC-------GKAYKWPSTLRYHKKIHTGEKPYKCE--ECGKAFSTFSILTKHKVIHTGEKP--YKCEECG 1259
Cdd:COG5048   346 HTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410
                  ....*....|....*..
gi 256418948 1260 KAFSWLSVFSKHKKIHT 1276
Cdd:COG5048   426 KSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-545 1.17e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  154 FHKCSNSNRHKIRHTGKKHLQCKEY--VRSFCMLSHLSQHKRIYTRENSYKCE-EGGKAFNWSSTLTYYKSAHTGEKPYR 230
Cdd:COG5048    43 FSRLEHLTRHIRSHTGEKPSQCSYSgcDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  231 CKECGKAFSKFSILTKHKVIHTGEKSYKCEECGKAFNQSAILTKHKIIHTGEKPNKCEecgkafSKVSTLTTHKAIHAGE 310
Cdd:COG5048   123 LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP------SSNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  311 KPYKCKECGKAFSKVSTLITHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKKI 390
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  391 HTGE-------KPYKCEECGKGFSMFSILTKH--EVIHTGE--KPYKCEE--CGKAFNWSSNLMEHKKIHTGETPYKCEE 457
Cdd:COG5048   277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  458 CGKGFSMFSILTK-------HKVIHNGEKPY--------------KCEECDKATHAGEKP--YKCEECGKAFNWSSNLME 514
Cdd:COG5048   357 LNSSSKFSPLLNNeppqslqQYKDLKNDKKSetlsnscirnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420       430
                  ....*....|....*....|....*....|.
gi 256418948  515 HKRIHTGEKPYKCEECGKSFSTFSILTKHKV 545
Cdd:COG5048   437 HKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
955-1277 5.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 5.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  955 KSSSTLSYHKKIHTEEKPYKYEECGKGFSTFSILTKHKVIHTGEKPYKC--EECGKAFNWSSNLMEHKKIHTGETPYKCE 1032
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1033 -ECDKAFSWPSSLTEHKATHAGEKPYKCEECGKAFSWPSRLT--EHKATHAGEEPYKceecgKAFNWSSNLMEHKRIHtG 1109
Cdd:COG5048    96 kSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLP-----GNNSSSVNTPQSNSLH-P 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1110 EKPYKCeECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKKIHTVEkPYKCEECGKGFVMFSILAKHKV 1189
Cdd:COG5048   170 PLPANS-LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1190 IHTGEKLYKCEECGKAYKWPSTLRYHKKIHTGE-------KPYKCEECGKAFSTFSILTKHK--VIHTGE--KPYKCEE- 1257
Cdd:COG5048   248 LSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYs 327

                         330       340
                  ....*....|....*....|.
gi 256418948 1258 -CGKAFSWLSVFSKHKKIHTG 1277
Cdd:COG5048   328 lCGKLFSRNDALKRHILLHTS 348
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1137-1217 2.54e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 2.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1137 GEKPYKCE--ECGKAYKWSSTLSYHKKiHTVEKPYKCEECGKgfvmfsilAKHKVIHTGEKLYKCEECGKAYKWPSTLRY 1214
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1215 HKK 1217
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 745-824 1.82e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.03  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  745 GEKPYKCE--ECGKAYKWSSTLSYHKKiHTVEKPYKCEECGKafnrsailIKHKRIHTDEKPYKCEECGKTFSKVSTLTT 822
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 256418948  823 HK 824
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 549-628 2.02e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.64  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  549 GEKPYKCE--ECGKAYKWSSTLSYHKKiHTvekpykceECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFSKVSTLTT 626
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 256418948  627 HK 628
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 941-1021 2.73e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  941 GEKFYKCE--ACGKAYKSSSTLSYHKKiHTEEKPYKYEECGKgfstfsilTKHKVIHTGEKPYKCEECGKAFNWSSNLME 1018
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1019 HKK 1021
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 689-769 3.11e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  689 GEKPYKCE--ECGKAFNwSSNLMEHKRIHTGEKPYKCEECGKSfstfsvltKHKVIHTGEKPYKCEECGKAYKWSSTLSY 766
Cdd:COG5189   346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948  767 HKK 769
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 493-573 3.11e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.26  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  493 GEKPYKCE--ECGKAFNwSSNLMEHKRIHTGEKPYKCEECGKSfstfsiltKHKVIHTGEKPYKCEECGKAYKWSSTLSY 570
Cdd:COG5189   346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948  571 HKK 573
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 801-881 1.12e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  801 DEKPYKCE--ECGKTFSKVSTLTTHKaihagekpyKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAYKWPSTLSY 878
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948  879 HKK 881
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1081-1161 1.30e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1081 GEEPYKCE--ECGKAFNwSSNLMEHKRIHTGEKPYKCEECGKSfstfsiltKHKVIHTGEKPYKCEECGKAYKWSSTLSY 1158
Cdd:COG5189   346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1159 HKK 1161
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-445 1.38e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.95  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  365 GEKPYKCE--ECGKAYKWPSTLSYHKKiHTGEKPYKCEECGKgfsmfsilTKHEVIHTGEKPYKCEECGKAFNWSSNLME 442
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948  443 HKK 445
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 857-937 2.02e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.56  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  857 GEKPYKCE--ECGKAYKWPSTLSYHKKiHTGEKPYKCEECGKgfsmfsilTKHEVIHTGEKPYKCEECGKAFSWLSVFSK 934
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948  935 HKK 937
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1099-1124 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 256418948  1099 NLMEHKRIHTGEKPYKCEECGKSFST 1124
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
707-732 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 256418948   707 NLMEHKRIHTGEKPYKCEECGKSFST 732
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-536 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*.
gi 256418948   511 NLMEHKRIHTGEKPYKCEECGKSFST 536
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1193-1273 1.42e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948 1193 GEKLYKCE--ECGKAYKWPSTLRYHKKiHTGEKPYKCEECGKafstfsilTKHKVIHTGEKPYKCEECGKAFSWLSVFSK 1270
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948 1271 HKK 1273
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 309-389 1.43e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256418948  309 GEKPYKCK--ECGKAFSKVSTLITHKaihagekpyKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAYKWPSTLSY 386
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 256418948  387 HKK 389
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1212-1236 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 6.00e-04
                           10        20
                   ....*....|....*....|....*
gi 256418948  1212 LRYHKKIHTGEKPYKCEECGKAFST 1236
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1015-1039 1.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.38e-03
                           10        20
                   ....*....|....*....|....*
gi 256418948  1015 NLMEHKKIHTGETPYKCEECDKAFS 1039
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
596-620 2.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.83e-03
                           10        20
                   ....*....|....*....|....*
gi 256418948   596 LIKHKRIHTGEKPYKCEECGKTFSK 620
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
568-592 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.91e-03
                           10        20
                   ....*....|....*....|....*
gi 256418948   568 LSYHKKIHTVEKPYKCEECGKAFNQ 592
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
764-788 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.09e-03
                           10        20
                   ....*....|....*....|....*
gi 256418948   764 LSYHKKIHTVEKPYKCEECGKAFNR 788
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-463 4.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.03e-03
                           10        20
                   ....*....|....*....|....*
gi 256418948   439 NLMEHKKIHTGETPYKCEECGKGFS 463
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-407 7.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.56e-03
                           10        20
                   ....*....|....*....|....
gi 256418948   384 LSYHKKIHTGEKPYKCEECGKGFS 407
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
876-899 7.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 7.56e-03
                           10        20
                   ....*....|....*....|....
gi 256418948   876 LSYHKKIHTGEKPYKCEECGKGFS 899
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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