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Conserved domains on  [gi|15812178|ref|NP_008818|]
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mRNA decay activator protein ZFP36L2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 1-131 1.07e-34

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


:

Pssm-ID: 461350  Cd Length: 114  Bit Score: 125.75  E-value: 1.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812178     1 MSTTLLSAFYDVDFLCKTEKSLANLNLNNML-DKKAVGTPVAAAPSsgfapgFLRRHSASNLHALAHPApspgscspKFp 79
Cdd:pfam04553   1 MSTTLVSAFFDFDVLCKNNKSLNSNPTGLNLlDRKAVGTPVTGSGV------FQRRHSVSNLSAKFNQN--------QF- 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15812178    80 gaANGSSCGSAAAGGptsygtlkepSGGGGTALLNKENKFRDRSFSENGDRS 131
Cdd:pfam04553  66 --LKELKAEPSSLIS----------GSGGTTALLNKENKFRDRSFSENGERL 105
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
154-216 2.32e-12

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 68.16  E-value: 2.32e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15812178 154 YKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 216
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
 
Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 1-131 1.07e-34

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


Pssm-ID: 461350  Cd Length: 114  Bit Score: 125.75  E-value: 1.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812178     1 MSTTLLSAFYDVDFLCKTEKSLANLNLNNML-DKKAVGTPVAAAPSsgfapgFLRRHSASNLHALAHPApspgscspKFp 79
Cdd:pfam04553   1 MSTTLVSAFFDFDVLCKNNKSLNSNPTGLNLlDRKAVGTPVTGSGV------FQRRHSVSNLSAKFNQN--------QF- 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15812178    80 gaANGSSCGSAAAGGptsygtlkepSGGGGTALLNKENKFRDRSFSENGDRS 131
Cdd:pfam04553  66 --LKELKAEPSSLIS----------GSGGTTALLNKENKFRDRSFSENGERL 105
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
154-216 2.32e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 68.16  E-value: 2.32e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15812178 154 YKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 216
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
154-180 4.20e-08

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 48.73  E-value: 4.20e-08
                          10        20
                  ....*....|....*....|....*..
gi 15812178   154 YKTELCRPFEESGTCKYGEKCQFAHGF 180
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
ZnF_C3H1 smart00356
zinc finger;
191-217 3.52e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.39  E-value: 3.52e-06
                           10        20
                   ....*....|....*....|....*..
gi 15812178    191 KYKTELCRTFHTiGFCPYGPRCHFIHN 217
Cdd:smart00356   1 KYKTELCKFFKR-GYCPRGDRCKFAHP 26
 
Name Accession Description Interval E-value
Tis11B_N pfam04553
Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH ...
 1-131 1.07e-34

Tis11B like protein, N terminus; Members of this family always contain a tandem repeat of CCCH zinc fingers pfam00642. Tis11B, Tis11D and their homologs are thought to be regulatory proteins involved in the response to growth factors. The function of the N terminus is unknown.


Pssm-ID: 461350  Cd Length: 114  Bit Score: 125.75  E-value: 1.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15812178     1 MSTTLLSAFYDVDFLCKTEKSLANLNLNNML-DKKAVGTPVAAAPSsgfapgFLRRHSASNLHALAHPApspgscspKFp 79
Cdd:pfam04553   1 MSTTLVSAFFDFDVLCKNNKSLNSNPTGLNLlDRKAVGTPVTGSGV------FQRRHSVSNLSAKFNQN--------QF- 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15812178    80 gaANGSSCGSAAAGGptsygtlkepSGGGGTALLNKENKFRDRSFSENGDRS 131
Cdd:pfam04553  66 --LKELKAEPSSLIS----------GSGGTTALLNKENKFRDRSFSENGERL 105
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
154-216 2.32e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 68.16  E-value: 2.32e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15812178 154 YKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIH 216
Cdd:COG5063 113 YKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFIS 175
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
154-216 6.84e-11

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 63.53  E-value: 6.84e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15812178 154 YKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHP--KYKTELCRTFHTIGFCPYGPRCHFIH 216
Cdd:COG5063 272 FRTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEAslGYLDGPCRTRAKGGAFPSGGAVCKSF 336
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
150-220 4.76e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 61.22  E-value: 4.76e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15812178 150 NSTRYKT--ELCRPFEESGTCKY---GEKCQFA---HGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADE 220
Cdd:COG5063 222 NKPLYKTnpELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHGDDS 300
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
154-180 4.20e-08

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 48.73  E-value: 4.20e-08
                          10        20
                  ....*....|....*....|....*..
gi 15812178   154 YKTELCRPFEESGTCKYGEKCQFAHGF 180
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAHGQ 27
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
192-216 1.23e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 47.57  E-value: 1.23e-07
                          10        20
                  ....*....|....*....|....*
gi 15812178   192 YKTELCRTFHTIGFCPYGPRCHFIH 216
Cdd:pfam00642   1 YKTELCRFFLRTGYCKYGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
191-217 3.52e-06

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 43.39  E-value: 3.52e-06
                           10        20
                   ....*....|....*....|....*..
gi 15812178    191 KYKTELCRTFHTiGFCPYGPRCHFIHN 217
Cdd:smart00356   1 KYKTELCKFFKR-GYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
153-179 1.32e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 41.85  E-value: 1.32e-05
                           10        20
                   ....*....|....*....|....*..
gi 15812178    153 RYKTELCRPFEeSGTCKYGEKCQFAHG 179
Cdd:smart00356   1 KYKTELCKFFK-RGYCPRGDRCKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 159-178 8.31e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 33.93  E-value: 8.31e-03
                          10        20
                  ....*....|....*....|
gi 15812178   159 CRPFEEsGTCKYGEKCQFAH 178
Cdd:pfam18345   1 CKFFLK-GRCRYGDKCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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