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Conserved domains on  [gi|5453712|ref|NP_006140|]
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galectin-4 [Homo sapiens]

Protein Classification

galectin family protein( domain architecture ID 10049251)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 18-147 1.33e-52

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 168.97  E-value: 1.33e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712   18 PYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDpgsDVAFHFNPRFDGwDKVVFNTLQGGKWGSEERKRSMPFKK 97
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDE-NVIVRNSFLNGNWGPEERSGGFPFQP 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 5453712   98 GAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSI 147
Cdd:cd00070  77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 199-322 2.50e-51

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 165.84  E-value: 2.50e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712     199 QGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQFFDLSI 278
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFELEI 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 5453712     279 RCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:smart00908  80 LVEEDEFKVAVNGQHFLEFPHRLP-LESIDTLEISGDVQLTSVQ 122
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 18-147 1.33e-52

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 168.97  E-value: 1.33e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712   18 PYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDpgsDVAFHFNPRFDGwDKVVFNTLQGGKWGSEERKRSMPFKK 97
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDE-NVIVRNSFLNGNWGPEERSGGFPFQP 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 5453712   98 GAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSI 147
Cdd:cd00070  77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-148 1.97e-51

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 165.84  E-value: 1.97e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712      24 PGGLNVGMSVYIQGVASEHMKRFFVNFvvGQDPGSDVAFHFNPRFDGWdKVVFNTLQGGKWGSEERKRSMPFKKGAAFEL 103
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINL--QCGPNADIALHFNPRFDEG-TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 5453712     104 VFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSIN 148
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 199-322 2.50e-51

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 165.84  E-value: 2.50e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712     199 QGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQFFDLSI 278
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFELEI 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 5453712     279 RCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:smart00908  80 LVEEDEFKVAVNGQHFLEFPHRLP-LESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 193-322 4.55e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 162.80  E-value: 4.55e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712  193 PYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSgDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQ 272
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-DIALHFNPRFDENVIVRNSFLNGNWGPEERS-GGFPFQPGQ 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 5453712  273 FFDLSIRCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:cd00070  79 PFELTILVEEDKFQIFVNGQHFFSFPHRLP-LESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-148 1.74e-48

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 158.57  E-value: 1.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712     24 PGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDVAFHFNPRFDGwDKVVFNTLQGGKWGSEERKRSMPFKKGAAFEL 103
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDE-NVIVRNSRQNGQWGQEEREGGFPFQPGQPFEL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 5453712    104 VFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSIN 148
Cdd:pfam00337  80 TILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 199-322 6.52e-46

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 151.64  E-value: 6.52e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712    199 QGGLTARRTIIIKGYVPPTGKSFAINF--KVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQFFDL 276
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLqtGVGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEERE-GGFPFQPGQPFEL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 5453712    277 SIRCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:pfam00337  80 TILVGDDHFKIYVNGQHFTTFKHRLP-PEDIDALQVRGDVKLTSVL 124
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 18-147 1.33e-52

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 168.97  E-value: 1.33e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712   18 PYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDpgsDVAFHFNPRFDGwDKVVFNTLQGGKWGSEERKRSMPFKK 97
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDE-NVIVRNSFLNGNWGPEERSGGFPFQP 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 5453712   98 GAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSI 147
Cdd:cd00070  77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 24-148 1.97e-51

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 165.84  E-value: 1.97e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712      24 PGGLNVGMSVYIQGVASEHMKRFFVNFvvGQDPGSDVAFHFNPRFDGWdKVVFNTLQGGKWGSEERKRSMPFKKGAAFEL 103
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINL--QCGPNADIALHFNPRFDEG-TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 5453712     104 VFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSIN 148
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 199-322 2.50e-51

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 165.84  E-value: 2.50e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712     199 QGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQFFDLSI 278
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGPNADIALHFNPRFDEGTIVRNSKQNGKWGKEERS-GGFPFQPGQPFELEI 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 5453712     279 RCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:smart00908  80 LVEEDEFKVAVNGQHFLEFPHRLP-LESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 193-322 4.55e-50

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 162.80  E-value: 4.55e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712  193 PYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSgDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQ 272
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS-DIALHFNPRFDENVIVRNSFLNGNWGPEERS-GGFPFQPGQ 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 5453712  273 FFDLSIRCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:cd00070  79 PFELTILVEEDKFQIFVNGQHFFSFPHRLP-LESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 24-148 1.74e-48

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 158.57  E-value: 1.74e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712     24 PGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDVAFHFNPRFDGwDKVVFNTLQGGKWGSEERKRSMPFKKGAAFEL 103
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDE-NVIVRNSRQNGQWGQEEREGGFPFQPGQPFEL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 5453712    104 VFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSIN 148
Cdd:pfam00337  80 TILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 197-323 1.86e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 153.54  E-value: 1.86e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712     197 RLQGGLTARRTIIIKGYVPPTGKSFAINFkVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQFFDL 276
Cdd:smart00276   4 PIPGGLKPGQTLTVRGIVLPDAKRFSINL-LTGGDDIALHFNPRFNENKIVCNSKLNGSWGSEERE-GGFPFQPGQPFDL 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 5453712     277 SIRCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQI 323
Cdd:smart00276  82 TIIVQPDHFQIFVNGVHITTFPHRLP-LESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 199-322 6.52e-46

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 151.64  E-value: 6.52e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712    199 QGGLTARRTIIIKGYVPPTGKSFAINF--KVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKiTHNPFGPGQFFDL 276
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLqtGVGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEERE-GGFPFQPGQPFEL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 5453712    277 SIRCGLDRFKVYANGQHLFDFAHRLSaFQRVDTLEIQGDVTLSYVQ 322
Cdd:pfam00337  80 TILVGDDHFKIYVNGQHFTTFKHRLP-PEDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 19-149 1.23e-45

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 151.23  E-value: 1.23e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453712      19 YYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGqdpGSDVAFHFNPRFDGwDKVVFNTLQGGKWGSEERKRSMPFKKG 98
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTG---GDDIALHFNPRFNE-NKIVCNSKLNGSWGSEEREGGFPFQPG 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 5453712      99 AAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSINF 149
Cdd:smart00276  77 QPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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