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Conserved domains on  [gi|28882053|ref|NP_005533|]
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insulin-induced gene 1 protein isoform 1 [Homo sapiens]

Protein Classification

INSIG family protein( domain architecture ID 10538083)

INSIG (insulin-induced gene) family protein similar to insulin-induced gene 1 protein and 1nsulin-induced gene 2 protein, which are oxysterol-binding proteins that mediate feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INSIG pfam07281
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ...
 87-267 6.84e-61

Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.


:

Pssm-ID: 462131  Cd Length: 189  Bit Score: 190.91  E-value: 6.84e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882053    87 RSLVLFSVGVVLALVLNLLQIQRNVTLFPEeviATIFSSAWWVPPCCGTAAAVVGLLYPCIDS------------HLGEP 154
Cdd:pfam07281   2 RSLVLFVLGVGYGLLVTHLHDERNIAPKLE---PTVSSSSWWYLVFWGLAGVALGLLLPWLDRlweeffaaeeeeNLGEP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882053   155 HKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLItqFLVYNGVY 234
Cdd:pfam07281  79 TSFSTEWSLVVRSIGAFVGIAFAIRKLPWQSTLQLSLTLALVNPGLWYLIDRSKPGFLLSTAVGLLGTVV--LLGLNPDL 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 28882053   235 QYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLA 267
Cdd:pfam07281 157 MPSAQESLEVRSWLPSVLFCSCVCFGNIGRRLA 189
 
Name Accession Description Interval E-value
INSIG pfam07281
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ...
 87-267 6.84e-61

Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.


Pssm-ID: 462131  Cd Length: 189  Bit Score: 190.91  E-value: 6.84e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882053    87 RSLVLFSVGVVLALVLNLLQIQRNVTLFPEeviATIFSSAWWVPPCCGTAAAVVGLLYPCIDS------------HLGEP 154
Cdd:pfam07281   2 RSLVLFVLGVGYGLLVTHLHDERNIAPKLE---PTVSSSSWWYLVFWGLAGVALGLLLPWLDRlweeffaaeeeeNLGEP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882053   155 HKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLItqFLVYNGVY 234
Cdd:pfam07281  79 TSFSTEWSLVVRSIGAFVGIAFAIRKLPWQSTLQLSLTLALVNPGLWYLIDRSKPGFLLSTAVGLLGTVV--LLGLNPDL 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 28882053   235 QYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLA 267
Cdd:pfam07281 157 MPSAQESLEVRSWLPSVLFCSCVCFGNIGRRLA 189
 
Name Accession Description Interval E-value
INSIG pfam07281
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ...
 87-267 6.84e-61

Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.


Pssm-ID: 462131  Cd Length: 189  Bit Score: 190.91  E-value: 6.84e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882053    87 RSLVLFSVGVVLALVLNLLQIQRNVTLFPEeviATIFSSAWWVPPCCGTAAAVVGLLYPCIDS------------HLGEP 154
Cdd:pfam07281   2 RSLVLFVLGVGYGLLVTHLHDERNIAPKLE---PTVSSSSWWYLVFWGLAGVALGLLLPWLDRlweeffaaeeeeNLGEP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28882053   155 HKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLItqFLVYNGVY 234
Cdd:pfam07281  79 TSFSTEWSLVVRSIGAFVGIAFAIRKLPWQSTLQLSLTLALVNPGLWYLIDRSKPGFLLSTAVGLLGTVV--LLGLNPDL 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 28882053   235 QYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLA 267
Cdd:pfam07281 157 MPSAQESLEVRSWLPSVLFCSCVCFGNIGRRLA 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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