NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1519316332|ref|NP_004415|]
View 

transcription factor E4F1 isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-595 5.79e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 183 KLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRES 260
Cdd:COG5048    25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 261 galTRHLKSLTPCT---------------EKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVT 325
Cdd:COG5048   105 ---ASSSSLSSSSSnsndnnllsshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 326 DAKGTVIHEVHVQM----QELSLGMKALAPEPPVSQELPCSSEGSREnllhqAMQNSGIVLERAAGEEGALEPAPAAGSS 401
Cdd:COG5048   182 SNLSLLISSNVSTSipssSENSPLSSSYSIPSSSSDQNLENSSSSLP-----LTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 402 PQPLaVAAPQLPVLEVQPLETQVASEASAVPRT-HPCPQCSETFPTAATLEAHKRG--HTGP--RPFAC--AQCGKAFPK 474
Cdd:COG5048   257 ASES-PRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 475 AYLLKKHQEVHVRERRFRC--GDCGKLYK---------TIAHVRGHRRVHSDERPYpcPKCGKRYKTKNAQQVHFRTHLE 543
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnneppqSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLS 413

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1519316332 544 EKPHVCQF--CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 595
Cdd:COG5048   414 FRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-595 5.79e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 183 KLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRES 260
Cdd:COG5048    25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 261 galTRHLKSLTPCT---------------EKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVT 325
Cdd:COG5048   105 ---ASSSSLSSSSSnsndnnllsshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 326 DAKGTVIHEVHVQM----QELSLGMKALAPEPPVSQELPCSSEGSREnllhqAMQNSGIVLERAAGEEGALEPAPAAGSS 401
Cdd:COG5048   182 SNLSLLISSNVSTSipssSENSPLSSSYSIPSSSSDQNLENSSSSLP-----LTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 402 PQPLaVAAPQLPVLEVQPLETQVASEASAVPRT-HPCPQCSETFPTAATLEAHKRG--HTGP--RPFAC--AQCGKAFPK 474
Cdd:COG5048   257 ASES-PRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 475 AYLLKKHQEVHVRERRFRC--GDCGKLYK---------TIAHVRGHRRVHSDERPYpcPKCGKRYKTKNAQQVHFRTHLE 543
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnneppqSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLS 413

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1519316332 544 EKPHVCQF--CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 595
Cdd:COG5048   414 FRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-585 2.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.01e-05
                          10        20
                  ....*....|....*....|....*
gi 1519316332 561 SLVRHVRHHTGEKPFKCYKCGRGFA 585
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-595 5.79e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 5.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 183 KLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRES 260
Cdd:COG5048    25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 261 galTRHLKSLTPCT---------------EKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVT 325
Cdd:COG5048   105 ---ASSSSLSSSSSnsndnnllsshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 326 DAKGTVIHEVHVQM----QELSLGMKALAPEPPVSQELPCSSEGSREnllhqAMQNSGIVLERAAGEEGALEPAPAAGSS 401
Cdd:COG5048   182 SNLSLLISSNVSTSipssSENSPLSSSYSIPSSSSDQNLENSSSSLP-----LTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 402 PQPLaVAAPQLPVLEVQPLETQVASEASAVPRT-HPCPQCSETFPTAATLEAHKRG--HTGP--RPFAC--AQCGKAFPK 474
Cdd:COG5048   257 ASES-PRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 475 AYLLKKHQEVHVRERRFRC--GDCGKLYK---------TIAHVRGHRRVHSDERPYpcPKCGKRYKTKNAQQVHFRTHLE 543
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnneppqSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLS 413

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1519316332 544 EKPHVCQF--CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 595
Cdd:COG5048   414 FRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-585 2.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.01e-05
                          10        20
                  ....*....|....*....|....*
gi 1519316332 561 SLVRHVRHHTGEKPFKCYKCGRGFA 585
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 508-570 4.86e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 508 GHRRVHSDERPYPCP--KCGKRYKTKNAQQVHfRTH--------------------LEEKPHVCQFCSRGFREKGSLVRH 565
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 1519316332 566 VRHHT 570
Cdd:COG5189   418 RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-257 7.69e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.69e-05
                          10        20
                  ....*....|....*....|....
gi 1519316332 234 SLIRHHRRHTDERPYKCSKCGKSF 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 459-541 1.78e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 459 GPRPFACA--QCGKAFPKAYLLKKHQeVHvrerrfrcGDCGKLYKTIAHVRGHRRVHSDERPYPCPKCGKRYKTKNAQQV 536
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1519316332 537 HfRTH 541
Cdd:COG5189   417 H-RKH 420
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 436-522 4.61e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 40.10  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519316332 436 PC--PQCSETFPTAATLEAHKRGHTGP------RPFACA--QCGKAFPKAYLLKKHQEVHVRERR-FRCGDCGKLYKTIA 504
Cdd:pfam15909   1 PCssPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSalSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHR 80

                          90
                  ....*....|....*...
gi 1519316332 505 HVRGHRRVHSDERPYPCP 522
Cdd:pfam15909  81 SLFKHLHVCAEHAQSPAP 98
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 5.30e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.30e-04
                          10        20
                  ....*....|....*....|...
gi 1519316332 220 HECKLCGASFRTKGSLIRHHRRH 242
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
450-472 6.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.47e-04
                          10        20
                  ....*....|....*....|...
gi 1519316332 450 LEAHKRGHTGPRPFACAQCGKAF 472
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 1519316332 505 HVRGHRRVHSDERPYPCPKCGKRYKT 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 248-269 4.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.37e-03
                          10        20
                  ....*....|....*....|..
gi 1519316332 248 YKCSKCGKSFRESGALTRHLKS 269
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRT 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH