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Conserved domains on  [gi|4505887|ref|NP_002658|]
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cardiac phospholamban [Homo sapiens]

Protein Classification

P_lamban family protein( domain architecture ID 10018779)

P_lamban family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P_lamban TIGR01294
phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein ...
 1-52 3.48e-15

phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein phospholamban. Phospholamban, in its unphosphorylated form, inhibits SERCA2, the cardiac sarcoplasmic reticulum Ca-ATPase.


:

Pssm-ID: 273541  Cd Length: 52  Bit Score: 61.47  E-value: 3.48e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505887     1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:TIGR01294  1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
 
Name Accession Description Interval E-value
P_lamban TIGR01294
phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein ...
 1-52 3.48e-15

phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein phospholamban. Phospholamban, in its unphosphorylated form, inhibits SERCA2, the cardiac sarcoplasmic reticulum Ca-ATPase.


Pssm-ID: 273541  Cd Length: 52  Bit Score: 61.47  E-value: 3.48e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505887     1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:TIGR01294  1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Phospholamban cd20250
Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs ...
 1-52 1.20e-11

Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs to a family of bioactive peptides which includes vertebrate sarcolipin (SLN), and the invertebrate sarcolamban (SCLA, and SCLB). SCLA and SCLB are encoded within a single putative noncoding transcript, pncr003:2L; PLN and SLN are each encoded within a single exon of a spliced transcript. PLN is chiefly expressed in the cardiac muscle, while SLN is expressed in the atria of the heart and embryonic slow-type skeletal muscle; SCL is found in cardiac and somatic muscle of Drosophila melanogaster. PLN and SLN are each a single-pass transmembrane alpha-helix that interacts directly with the sarcoplasmic reticulum (SR) calcium pump (SERCA), lower its affinity for Ca2+, thereby decreasing the rate of Ca2+ reuptake into the SR from the sarcoplasm. In the heart, PLN and SLN inhibit the activity of SERCA2a isoform and function as important regulators of cardiac contractibility and disease. SCLA and SCLB are each predicted to form a single-pass transmembrane helix, localize to the SR with the SR calcium pump (Ca-P60A), and dampen its activity. PLN and SLN differ in their interaction with SERCA; PLN is an affinity modulator of SERCA. It is thought to form a pentamer in the membrane.


Pssm-ID: 380750  Cd Length: 52  Bit Score: 52.83  E-value: 1.20e-11
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|..
gi 4505887   1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:cd20250  1 MEKVQHLTRSAIRRASTIEVNPQARQNLQELFINFCLILICLLLICIIVMLL 52
Phospholamban pfam04272
Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic ...
 1-52 2.81e-08

Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation. Phospholamban is thought to form a pentamer in the membrane.


Pssm-ID: 367891  Cd Length: 52  Bit Score: 44.20  E-value: 2.81e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505887     1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:pfam04272  1 MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL 52
 
Name Accession Description Interval E-value
P_lamban TIGR01294
phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein ...
 1-52 3.48e-15

phospholamban; This model represents the short (52 residue) transmembrane phosphoprotein phospholamban. Phospholamban, in its unphosphorylated form, inhibits SERCA2, the cardiac sarcoplasmic reticulum Ca-ATPase.


Pssm-ID: 273541  Cd Length: 52  Bit Score: 61.47  E-value: 3.48e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505887     1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:TIGR01294  1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Phospholamban cd20250
Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs ...
 1-52 1.20e-11

Phospholamban bioactive peptide and similar proteins; Vertebrate phospholamban (PLN) belongs to a family of bioactive peptides which includes vertebrate sarcolipin (SLN), and the invertebrate sarcolamban (SCLA, and SCLB). SCLA and SCLB are encoded within a single putative noncoding transcript, pncr003:2L; PLN and SLN are each encoded within a single exon of a spliced transcript. PLN is chiefly expressed in the cardiac muscle, while SLN is expressed in the atria of the heart and embryonic slow-type skeletal muscle; SCL is found in cardiac and somatic muscle of Drosophila melanogaster. PLN and SLN are each a single-pass transmembrane alpha-helix that interacts directly with the sarcoplasmic reticulum (SR) calcium pump (SERCA), lower its affinity for Ca2+, thereby decreasing the rate of Ca2+ reuptake into the SR from the sarcoplasm. In the heart, PLN and SLN inhibit the activity of SERCA2a isoform and function as important regulators of cardiac contractibility and disease. SCLA and SCLB are each predicted to form a single-pass transmembrane helix, localize to the SR with the SR calcium pump (Ca-P60A), and dampen its activity. PLN and SLN differ in their interaction with SERCA; PLN is an affinity modulator of SERCA. It is thought to form a pentamer in the membrane.


Pssm-ID: 380750  Cd Length: 52  Bit Score: 52.83  E-value: 1.20e-11
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|..
gi 4505887   1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:cd20250  1 MEKVQHLTRSAIRRASTIEVNPQARQNLQELFINFCLILICLLLICIIVMLL 52
Phospholamban pfam04272
Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic ...
 1-52 2.81e-08

Phospholamban; The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation. Phospholamban is thought to form a pentamer in the membrane.


Pssm-ID: 367891  Cd Length: 52  Bit Score: 44.20  E-value: 2.81e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505887     1 MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL 52
Cdd:pfam04272  1 MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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