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Conserved domains on  [gi|2071063209|ref|NP_001382554|]
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dysbindin domain-containing protein 1 isoform 4 [Mus musculus]

Protein Classification

Dysbindin domain-containing protein( domain architecture ID 10517140)

Dysbindin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 46-182 3.58e-51

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


:

Pssm-ID: 461312  Cd Length: 143  Bit Score: 161.18  E-value: 3.58e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063209  46 VKVPQAALNVSAH-----ETGDMCRTPVAEEEEEVGIpipAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQEL 120
Cdd:pfam04440   1 AEHAQKVLEMEHTqqlklKERQKFFEEAFQQDMEQYL---STGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2071063209 121 AEVFADSDDENLATESPAGlhpLSRASC-----LRSPSWTKTRAEQNREKQPPSDPER--QGTIVDTFL 182
Cdd:pfam04440  78 LDVFADSDGEENALESPAG---LPRSSCqneisLRVPSWTETRAEQPSESSPCTDPETenSDGGDDPLV 143
 
Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 46-182 3.58e-51

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


Pssm-ID: 461312  Cd Length: 143  Bit Score: 161.18  E-value: 3.58e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063209  46 VKVPQAALNVSAH-----ETGDMCRTPVAEEEEEVGIpipAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQEL 120
Cdd:pfam04440   1 AEHAQKVLEMEHTqqlklKERQKFFEEAFQQDMEQYL---STGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2071063209 121 AEVFADSDDENLATESPAGlhpLSRASC-----LRSPSWTKTRAEQNREKQPPSDPER--QGTIVDTFL 182
Cdd:pfam04440  78 LDVFADSDGEENALESPAG---LPRSSCqneisLRVPSWTETRAEQPSESSPCTDPETenSDGGDDPLV 143
 
Name Accession Description Interval E-value
Dysbindin pfam04440
Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa ...
 46-182 3.58e-51

Dysbindin (Dystrobrevin binding protein 1); Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.


Pssm-ID: 461312  Cd Length: 143  Bit Score: 161.18  E-value: 3.58e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063209  46 VKVPQAALNVSAH-----ETGDMCRTPVAEEEEEVGIpipAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQEL 120
Cdd:pfam04440   1 AEHAQKVLEMEHTqqlklKERQKFFEEAFQQDMEQYL---STGYLQITERRQPLGSVSSMEVNVDLLDQMELTDMSDQEA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2071063209 121 AEVFADSDDENLATESPAGlhpLSRASC-----LRSPSWTKTRAEQNREKQPPSDPER--QGTIVDTFL 182
Cdd:pfam04440  78 LDVFADSDGEENALESPAG---LPRSSCqneisLRVPSWTETRAEQPSESSPCTDPETenSDGGDDPLV 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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