NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1952076990|ref|NP_001376511|]
View 

DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2 [Homo sapiens]

Protein Classification

RPOL8c domain-containing protein( domain architecture ID 10652794)

RPOL8c domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
2-147 1.93e-77

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


:

Pssm-ID: 197821  Cd Length: 143  Bit Score: 226.13  E-value: 1.93e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990    2 AGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDR 81
Cdd:smart00658   1 AIILFEDIFKVKSVDPDGKKFDKVSRIFAESEYLQMELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALI 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952076990   82 PSRADQFEYVMYGKVYRIEGDETSTeaaTRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 147
Cdd:smart00658  81 KSLADKYEYVMYGKVYRIEEDKTET---SKLSAYVSFGGLLMRLKGDANNLKGFELDSNLYLLMRK 143
 
Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
2-147 1.93e-77

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


Pssm-ID: 197821  Cd Length: 143  Bit Score: 226.13  E-value: 1.93e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990    2 AGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDR 81
Cdd:smart00658   1 AIILFEDIFKVKSVDPDGKKFDKVSRIFAESEYLQMELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALI 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952076990   82 PSRADQFEYVMYGKVYRIEGDETSTeaaTRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 147
Cdd:smart00658  81 KSLADKYEYVMYGKVYRIEEDKTET---SKLSAYVSFGGLLMRLKGDANNLKGFELDSNLYLLMRK 143
RNA_pol_Rpb8 pfam03870
RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II ...
10-146 3.01e-75

RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.


Pssm-ID: 461079  Cd Length: 136  Bit Score: 220.44  E-value: 3.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990  10 FDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPT---DDRPSRAD 86
Cdd:pfam03870   1 FTVTDVDPDGKKFDRVSRIEATSESFDMDLTLDINTELYPVKVGDKFTLVLASTLSLDGTPDDGEYDQSwrpPGEPSLAD 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990  87 QFEYVMYGKVYRIEGDETSteaaTRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMK 146
Cdd:pfam03870  81 DYDYVMYGKVYKFEEEESG----DKVAVYASFGGLLMRLEGDPRKLSDLEVDQNVYLLIR 136
PTZ00167 PTZ00167
RNA polymerase subunit 8c; Provisional
2-147 1.55e-26

RNA polymerase subunit 8c; Provisional


Pssm-ID: 185493  Cd Length: 144  Bit Score: 97.15  E-value: 1.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990   2 AGILFEDIFDVKDIDpeGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNptdDR 81
Cdd:PTZ00167    4 PSCLFEDRFVVRSVD--NSKFERVSRIKAKSTGFDAELILDINSDLFPVREKQSLYIGLTNQLSSGPDDNVWESS---EP 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952076990  82 PSRADQFEYVMYGKVYRIEgdETSTEaatRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 147
Cdd:PTZ00167   79 QSLMDQYEYVMYGKIFKFE--EKSSE---RRTLYASFGGLLMALTADKQVVGDLELDMRIYLLVRR 139
 
Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
2-147 1.93e-77

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


Pssm-ID: 197821  Cd Length: 143  Bit Score: 226.13  E-value: 1.93e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990    2 AGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDR 81
Cdd:smart00658   1 AIILFEDIFKVKSVDPDGKKFDKVSRIFAESEYLQMELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALI 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952076990   82 PSRADQFEYVMYGKVYRIEGDETSTeaaTRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 147
Cdd:smart00658  81 KSLADKYEYVMYGKVYRIEEDKTET---SKLSAYVSFGGLLMRLKGDANNLKGFELDSNLYLLMRK 143
RNA_pol_Rpb8 pfam03870
RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II ...
10-146 3.01e-75

RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.


Pssm-ID: 461079  Cd Length: 136  Bit Score: 220.44  E-value: 3.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990  10 FDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPT---DDRPSRAD 86
Cdd:pfam03870   1 FTVTDVDPDGKKFDRVSRIEATSESFDMDLTLDINTELYPVKVGDKFTLVLASTLSLDGTPDDGEYDQSwrpPGEPSLAD 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990  87 QFEYVMYGKVYRIEGDETSteaaTRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMK 146
Cdd:pfam03870  81 DYDYVMYGKVYKFEEEESG----DKVAVYASFGGLLMRLEGDPRKLSDLEVDQNVYLLIR 136
PTZ00167 PTZ00167
RNA polymerase subunit 8c; Provisional
2-147 1.55e-26

RNA polymerase subunit 8c; Provisional


Pssm-ID: 185493  Cd Length: 144  Bit Score: 97.15  E-value: 1.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076990   2 AGILFEDIFDVKDIDpeGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNptdDR 81
Cdd:PTZ00167    4 PSCLFEDRFVVRSVD--NSKFERVSRIKAKSTGFDAELILDINSDLFPVREKQSLYIGLTNQLSSGPDDNVWESS---EP 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1952076990  82 PSRADQFEYVMYGKVYRIEgdETSTEaatRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 147
Cdd:PTZ00167   79 QSLMDQYEYVMYGKIFKFE--EKSSE---RRTLYASFGGLLMALTADKQVVGDLELDMRIYLLVRR 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH