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Conserved domains on  [gi|1915609117|ref|NP_001374502|]
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zinc finger protein 320 isoform 1 [Homo sapiens]

Protein Classification

KRAB_A-box and COG5048 domain-containing protein( domain architecture ID 12017008)

protein containing domains KRAB_A-box, SFP1, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 2.49e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 2.49e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1915609117   7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-483 6.97e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 147 HLRRHRRIHTGEKPYKC--EECEKVFSCKSHLEIHRIIHTGEKPYKCK-----------------------VCDKAFKHD 201
Cdd:COG5048    48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsnDNNLLSSHS 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 202 SHLAKHTRIH---------RGDKHYTCNECGKVFDQKA-------------------TLACHHRSHTGEKPYKCNECGKT 253
Cdd:COG5048   128 LPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 254 FSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGE------- 326
Cdd:COG5048   208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 327 KPYRCEECDKVFSRKSHLERHRR--IHTGE--KPYKCKV--CDKAFRSDSRLAEHQRVHTGERPYTC--NECGKVFSTKA 398
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 399 Y-----LACHQKLHTGEKLYECE--ECDKVYIRKSHLERHRRIHTGEKPH--KCGDCGKAFNSPSHLIRHQRIHTGQKSY 469
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         410
                  ....*....|....
gi 1915609117 470 KCHQCGKVFSLRSL 483
Cdd:COG5048   448 LCSILKSFRRDLDL 461
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 25-216 8.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117  25 LDPAQRTLYRDVMLENyRNLVSLDISSKC---MMNTLSSTGQGNTEVIHTGTLqrqasyhigAFCSQEIEKDIHDFvfQW 101
Cdd:COG5189   234 IDIGHMMDTHQFYLED-VDLMDDDILGPSneeMLYKYISPSQGSAELFEESSL---------GFDYEFIHKSVGNK--EI 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 102 QEDETNDHeapMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRfhlhlrrhRRIHTGEKPYKCE--ECEKVFSCKSHLEIH 179
Cdd:COG5189   302 RGGISTGE---MIDVRKLPCTNSSSNGKLAHGGERNIDTPSR--------MLKVKDGKPYKCPveGCNKKYKNQNGLKYH 370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915609117 180 R-------------------IIHTGEKPYKCKVCDKAFKHDSHLakhtRIHRGDKH 216
Cdd:COG5189   371 MlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGL----KYHRKHSH 422
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 2.49e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 2.49e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1915609117   7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 8.34e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 8.34e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1915609117    8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 5.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 5.31e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1915609117   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-483 6.97e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 147 HLRRHRRIHTGEKPYKC--EECEKVFSCKSHLEIHRIIHTGEKPYKCK-----------------------VCDKAFKHD 201
Cdd:COG5048    48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsnDNNLLSSHS 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 202 SHLAKHTRIH---------RGDKHYTCNECGKVFDQKA-------------------TLACHHRSHTGEKPYKCNECGKT 253
Cdd:COG5048   128 LPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 254 FSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGE------- 326
Cdd:COG5048   208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 327 KPYRCEECDKVFSRKSHLERHRR--IHTGE--KPYKCKV--CDKAFRSDSRLAEHQRVHTGERPYTC--NECGKVFSTKA 398
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 399 Y-----LACHQKLHTGEKLYECE--ECDKVYIRKSHLERHRRIHTGEKPH--KCGDCGKAFNSPSHLIRHQRIHTGQKSY 469
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         410
                  ....*....|....
gi 1915609117 470 KCHQCGKVFSLRSL 483
Cdd:COG5048   448 LCSILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 25-216 8.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117  25 LDPAQRTLYRDVMLENyRNLVSLDISSKC---MMNTLSSTGQGNTEVIHTGTLqrqasyhigAFCSQEIEKDIHDFvfQW 101
Cdd:COG5189   234 IDIGHMMDTHQFYLED-VDLMDDDILGPSneeMLYKYISPSQGSAELFEESSL---------GFDYEFIHKSVGNK--EI 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 102 QEDETNDHeapMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRfhlhlrrhRRIHTGEKPYKCE--ECEKVFSCKSHLEIH 179
Cdd:COG5189   302 RGGISTGE---MIDVRKLPCTNSSSNGKLAHGGERNIDTPSR--------MLKVKDGKPYKCPveGCNKKYKNQNGLKYH 370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915609117 180 R-------------------IIHTGEKPYKCKVCDKAFKHDSHLakhtRIHRGDKH 216
Cdd:COG5189   371 MlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGL----KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 1.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 1915609117 343 HLERHRRIHTGEKPYKCKVCDKAFRS 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 2.49e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 2.49e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1915609117   7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 8.34e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 8.34e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1915609117    8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 5.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 5.31e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1915609117   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-483 6.97e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 147 HLRRHRRIHTGEKPYKC--EECEKVFSCKSHLEIHRIIHTGEKPYKCK-----------------------VCDKAFKHD 201
Cdd:COG5048    48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsnDNNLLSSHS 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 202 SHLAKHTRIH---------RGDKHYTCNECGKVFDQKA-------------------TLACHHRSHTGEKPYKCNECGKT 253
Cdd:COG5048   128 LPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 254 FSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGE------- 326
Cdd:COG5048   208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 327 KPYRCEECDKVFSRKSHLERHRR--IHTGE--KPYKCKV--CDKAFRSDSRLAEHQRVHTGERPYTC--NECGKVFSTKA 398
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 399 Y-----LACHQKLHTGEKLYECE--ECDKVYIRKSHLERHRRIHTGEKPH--KCGDCGKAFNSPSHLIRHQRIHTGQKSY 469
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         410
                  ....*....|....
gi 1915609117 470 KCHQCGKVFSLRSL 483
Cdd:COG5048   448 LCSILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 25-216 8.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117  25 LDPAQRTLYRDVMLENyRNLVSLDISSKC---MMNTLSSTGQGNTEVIHTGTLqrqasyhigAFCSQEIEKDIHDFvfQW 101
Cdd:COG5189   234 IDIGHMMDTHQFYLED-VDLMDDDILGPSneeMLYKYISPSQGSAELFEESSL---------GFDYEFIHKSVGNK--EI 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 102 QEDETNDHeapMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRfhlhlrrhRRIHTGEKPYKCE--ECEKVFSCKSHLEIH 179
Cdd:COG5189   302 RGGISTGE---MIDVRKLPCTNSSSNGKLAHGGERNIDTPSR--------MLKVKDGKPYKCPveGCNKKYKNQNGLKYH 370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915609117 180 R-------------------IIHTGEKPYKCKVCDKAFKHDSHLakhtRIHRGDKH 216
Cdd:COG5189   371 MlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGL----KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 1.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 1915609117 343 HLERHRRIHTGEKPYKCKVCDKAFRS 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 185-263 1.87e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 185 GEKPYKCKV--CDKAFKHDSHLAKHTrihrgdKHYTCNecgkvfdQKATLACHHRSHTG----EKPYKCNECGKTFSQTS 258
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM------LHGHQN-------QKLHENPSPEKMNIfsakDKPYRCEVCDKRYKNLN 412


                  ....*
gi 1915609117 259 HLVYH 263
Cdd:COG5189   413 GLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-172 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 1915609117 147 HLRRHRRIHTGEKPYKCEECEKVFSC 172
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
243-509 2.94e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 243 KPYKCNECGKTFSQTSHLVYHHRLHTGEKPYKCN--ECGKTFARNSVLVIH---------------------KAVHTAE- 298
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHlrthhnnpsdlnskslplsnsKASSSSLs 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 299 -------KPYKCNECGKVFKQRATLAGHRRVHTGEKPYRCEEC----------------------DKVFSRKSHLERHRR 349
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 350 IHTGEKPYKCKVCDKAFRSDSRLAEHQRVHTGERPYTCNECGKVFSTKAYLA------CHQKLHTGEKLYECEECDKVYI 423
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 424 RKSHLERHRRIHTG-EKPHKCGDCGKAFNSPSHLIRHQR--IHTGQ--KSYKC--HQCGKVFSLRSLLAEHQKIPFGDNC 496
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330
                  ....*....|...
gi 1915609117 497 FKCNEYSKPSSIN 509
Cdd:COG5048   352 AKEKLLNSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-452 4.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 1915609117 427 HLERHRRIHTGEKPHKCGDCGKAFNS 452
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-200 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 1915609117 175 HLEIHRIIHTGEKPYKCKVCDKAFKH 200
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 348-432 1.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 348 RRIHT-GEKPYKCKV--CDKAFRSDSRLAEHqRVHTGERPYTCNECGKVfstkaylaCHQKLHTGEKLYECEECDKVYIR 424
Cdd:COG5189   340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 1915609117 425 KSHLERHR 432
Cdd:COG5189   411 LNGLKYHR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 329-351 1.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|...
gi 1915609117 329 YRCEECDKVFSRKSHLERHRRIH 351
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 318-380 3.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915609117 318 GHRRVHTGEKPYRCE--ECDKVFSRKSHLERHRR-------------------IHTGEKPYKCKVCDKAFRSDSRLAEHq 376
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                  ....
gi 1915609117 377 RVHT 380
Cdd:COG5189   418 RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 1915609117 259 HLVYHHRLHTGEKPYKCNECGKTFAR 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-479 4.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*
gi 1915609117 455 HLIRHQRIHTGQKSYKCHQCGKVFS 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 441-463 9.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.57e-03
                          10        20
                  ....*....|....*....|...
gi 1915609117 441 HKCGDCGKAFNSPSHLIRHQRIH 463
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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