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Conserved domains on  [gi|1862354198|ref|NP_001371694|]
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putative solute carrier family 22 member 31 isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-187 6.16e-42

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17443:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 343  Bit Score: 149.16  E-value: 6.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180
                  ....*....|....*....|....*..
gi 1862354198 161 AAALVFLLLTADCCGRRPVLLLGTMVT 187
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVT 242
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-115 2.64e-10

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 61.57  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1862354198  84 LeenslatELTMLSARSPQPRYHSPLGLLRTR 115
Cdd:TIGR00898 299 L-------SLSLEKDLSSSKKQYSFLDLFRTP 323
 
Name Accession Description Interval E-value
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-187 6.16e-42

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 149.16  E-value: 6.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180
                  ....*....|....*....|....*..
gi 1862354198 161 AAALVFLLLTADCCGRRPVLLLGTMVT 187
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVT 242
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-115 2.64e-10

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 61.57  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1862354198  84 LeenslatELTMLSARSPQPRYHSPLGLLRTR 115
Cdd:TIGR00898 299 L-------SLSLEKDLSSSKKQYSFLDLFRTP 323
Sugar_tr pfam00083
Sugar (and other) transporter;
24-183 6.03e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 47.65  E-value: 6.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  24 WRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPgdssleenSLATELTMLsARSPQP 103
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLF---LPESPRWLVEKGRLEEAREVLAKLRGVPDVDR--------ELDEIKDSL-EAGQEA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198 104 RYHSPLGLLRTRvTWRNGLILGFSSLVGG---GIRASFrrslapqvptFYLPYFLE-AGLE-------------AAALVF 166
Cdd:pfam00083 238 EKASWKELFSTK-TRRQRLLIGVMLQIFQqltGINAIF----------YYSTTIFEnLGLSdsflvtiivgvvnFVFTFI 306

                         170
                  ....*....|....*..
gi 1862354198 167 LLLTADCCGRRPVLLLG 183
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLG 323
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 5-186 1.27e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 40.40  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   5 LFSVVGTLLLPG------LAALVQDWRLLQGLgALMSGLLLLFWGFpaLFPESPCWLLATGQVARARKILWRFAEASGVG 78
Cdd:TIGR00879 170 LAITFGILVAYGfgsgkvSLNNTLGWRIPLGL-QLIPAGLLFLGLF--FLPESPRWLVGKGRVEEARKSLARLRGTSGED 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  79 PGdsSLEENSLATELTMLSARSPQPRYHSPLGLLRtRVTWR--NGLILGFsSLVGGGIRASFrrslapqvptFYLPYFLE 156
Cdd:TIGR00879 247 KE--LLDELELIDIKRSIEKRSVQPSWGSLFSSTR-RIRRRlfLGVVLQW-FQQFTGINAIM----------YYSPTIFE 312

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1862354198 157 -AGLE---------------AAALVFLLLTADCCGRRPVLLLGTMV 186
Cdd:TIGR00879 313 nAGVStdhaflvsiivgavnFAFTFVAIFLVDRFGRRPLLLIGAAG 358
 
Name Accession Description Interval E-value
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-187 6.16e-42

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 149.16  E-value: 6.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180
                  ....*....|....*....|....*..
gi 1862354198 161 AAALVFLLLTADCCGRRPVLLLGTMVT 187
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVT 242
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 1-206 8.91e-36

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 133.03  E-value: 8.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17373   117 MVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFP---------------------------------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVP-TFYLPYFLEAGL 159
Cdd:cd17373   163 --------------------------------------KNILILGFNSLTGYGIRHCFARSMMGHEPeNFYLDYYLTAGI 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1862354198 160 EAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQCELGAPQ 206
Cdd:cd17373   205 AAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLLNLIGKYSQ 251
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-115 2.64e-10

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 61.57  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1862354198  84 LeenslatELTMLSARSPQPRYHSPLGLLRTR 115
Cdd:TIGR00898 299 L-------SLSLEKDLSSSKKQYSFLDLFRTP 323
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 1-187 2.06e-08

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 55.17  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLlFWGFPALfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17445   128 MAGGLTMVGGHFLLLGLALGCGSWRVLQGTITAPLSLFL-CYGCPGV--------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIR---ASFRRSLAPQVPTFYLPYFLEA 157
Cdd:cd17445   174 --------------------------------------KNLLILGFTTFIAHAIShcyQSFSDDVRGTPSTFYLSYLLST 215

                         170       180       190
                  ....*....|....*....|....*....|
gi 1862354198 158 GLEAAALVFLLLTADCCGRRPVLLLGTMVT 187
Cdd:cd17445   216 GTAGLACLFLCATVDRFGRRGILLLAMTLT 245
Sugar_tr pfam00083
Sugar (and other) transporter;
24-183 6.03e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 47.65  E-value: 6.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  24 WRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPgdssleenSLATELTMLsARSPQP 103
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLF---LPESPRWLVEKGRLEEAREVLAKLRGVPDVDR--------ELDEIKDSL-EAGQEA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198 104 RYHSPLGLLRTRvTWRNGLILGFSSLVGG---GIRASFrrslapqvptFYLPYFLE-AGLE-------------AAALVF 166
Cdd:pfam00083 238 EKASWKELFSTK-TRRQRLLIGVMLQIFQqltGINAIF----------YYSTTIFEnLGLSdsflvtiivgvvnFVFTFI 306

                         170
                  ....*....|....*..
gi 1862354198 167 LLLTADCCGRRPVLLLG 183
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLG 323
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 5-186 1.27e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 40.40  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198   5 LFSVVGTLLLPG------LAALVQDWRLLQGLgALMSGLLLLFWGFpaLFPESPCWLLATGQVARARKILWRFAEASGVG 78
Cdd:TIGR00879 170 LAITFGILVAYGfgsgkvSLNNTLGWRIPLGL-QLIPAGLLFLGLF--FLPESPRWLVGKGRVEEARKSLARLRGTSGED 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862354198  79 PGdsSLEENSLATELTMLSARSPQPRYHSPLGLLRtRVTWR--NGLILGFsSLVGGGIRASFrrslapqvptFYLPYFLE 156
Cdd:TIGR00879 247 KE--LLDELELIDIKRSIEKRSVQPSWGSLFSSTR-RIRRRlfLGVVLQW-FQQFTGINAIM----------YYSPTIFE 312

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1862354198 157 -AGLE---------------AAALVFLLLTADCCGRRPVLLLGTMV 186
Cdd:TIGR00879 313 nAGVStdhaflvsiivgavnFAFTFVAIFLVDRFGRRPLLLIGAAG 358
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 1-50 6.78e-03

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 37.91  E-value: 6.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1862354198   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPE 50
Cdd:cd17444   128 MVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCI---FPK 174
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 5-71 7.76e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 37.94  E-value: 7.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1862354198   5 LFSVVGTLLLPGLAALVqDWRLLQGLGALMSGLLLLfwGFPaLFPESPCWLLATGQVARARKILWRF 71
Cdd:cd17358   137 LLVNIGILLGYVLGSFL-PWRTLALIGAIPPVVFLI--LLF-FIPESPRWLAKKGREEEAEKSLQFL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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