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Conserved domains on  [gi|1826689189|ref|NP_001366240|]
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complement factor H-related protein 1 isoform 7 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 72-261 5.72e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 78.16  E-value: 5.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  72 CTEEGWSPTPKCL---------IQNAHIlsrQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGN-----WT-EPPQCKds 136
Cdd:PHA02927   70 CTGTGWTLFNQCIkrrcpsprdIDNGQL---DIGGVDFGSSITYSCNSGYQLIGESKSYCELGStgsmvWNpEAPICE-- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189 137 TGKCGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPP-----KCLHPCVISREIMENYNIA 211
Cdd:PHA02927  145 SVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGFKRS 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1826689189 212 LRWTakqklylrtgESAEFVCKRGYRLSSRShtlRTTCWDGKL---EYPTCAK 261
Cdd:PHA02927  224 YSYN----------DNVDFKCKYGYKLSGSS---SSTCSPGNTwqpELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 72-261 5.72e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 78.16  E-value: 5.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  72 CTEEGWSPTPKCL---------IQNAHIlsrQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGN-----WT-EPPQCKds 136
Cdd:PHA02927   70 CTGTGWTLFNQCIkrrcpsprdIDNGQL---DIGGVDFGSSITYSCNSGYQLIGESKSYCELGStgsmvWNpEAPICE-- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189 137 TGKCGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPP-----KCLHPCVISREIMENYNIA 211
Cdd:PHA02927  145 SVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGFKRS 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1826689189 212 LRWTakqklylrtgESAEFVCKRGYRLSSRShtlRTTCWDGKL---EYPTCAK 261
Cdd:PHA02927  224 YSYN----------DNVDFKCKYGYKLSGSS---SSTCSPGNTwqpELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 140-194 4.77e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 4.77e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689189 140 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 194
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 140-194 5.19e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 5.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689189  140 CGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 194
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
140-194 5.67e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.26  E-value: 5.67e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689189 140 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 194
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 72-261 5.72e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 78.16  E-value: 5.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  72 CTEEGWSPTPKCL---------IQNAHIlsrQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGN-----WT-EPPQCKds 136
Cdd:PHA02927   70 CTGTGWTLFNQCIkrrcpsprdIDNGQL---DIGGVDFGSSITYSCNSGYQLIGESKSYCELGStgsmvWNpEAPICE-- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189 137 TGKCGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPP-----KCLHPCVISREIMENYNIA 211
Cdd:PHA02927  145 SVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGFKRS 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1826689189 212 LRWTakqklylrtgESAEFVCKRGYRLSSRShtlRTTCWDGKL---EYPTCAK 261
Cdd:PHA02927  224 YSYN----------DNVDFKCKYGYKLSGSS---SSTCSPGNTwqpELPKCVR 263
PHA02831 PHA02831
EEV host range protein; Provisional
 4-208 2.09e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 59.62  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189   4 LVSVILISRISSVGGEATFC-DFPKINHGILYDEEKYKpfsqvpTGEVFYYSCEYNFvspSKSFwtrITCTEEGWSPTPK 82
Cdd:PHA02831    4 LTKIIILLFISKTWCICVFNkNDAKYSNVDSYENKVYE------ENENLEYKCNNNF---DKVF---VTCNNGSWSTKNM 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  83 CL----------IQNAHILSRQmSKYPSGERVRYECR----SPYEMFGDEEVMCLNGNWT-EPPQCKDSTGKCgppPPID 147
Cdd:PHA02831   72 CIgkrnckdpvtILNGYIKNKK-DQYSFGDSVTYACKvnklEKYSIVGNETVKCINKQWVpKYPVCKLIRCKY---PALQ 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1826689189 148 NGDITSFPLSVYApASSVEYQCQNLYQLEGNKRITCR-NGQW-SEPPKCLHPCViSREIMENY 208
Cdd:PHA02831  148 NGFLNVFEKKFYY-GDIVNFKCKKGFILLGSSVSTCDiNSIWyPGIPKCVKDKV-HNEIQPNY 208
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 140-194 4.77e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 4.77e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689189 140 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 194
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 88-261 1.84e-09

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 56.92  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  88 AHILSRQMSKYPSGERVRYECRSPyemFGDEEVMCLNGNWTEPPQCKDSTgKCGPPPPIDNGDITSfPLSVYAPASSVEY 167
Cdd:PHA02831   30 SNVDSYENKVYEENENLEYKCNNN---FDKVFVTCNNGSWSTKNMCIGKR-NCKDPVTILNGYIKN-KKDQYSFGDSVTY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189 168 QCQ----NLYQLEGNKRITCRNGQW-SEPP-----KCLHPcVISREIMENYnialrwtaKQKLYLrtGESAEFVCKRGYR 237
Cdd:PHA02831  105 ACKvnklEKYSIVGNETVKCINKQWvPKYPvckliRCKYP-ALQNGFLNVF--------EKKFYY--GDIVNFKCKKGFI 173

                         170       180
                  ....*....|....*....|....
gi 1826689189 238 LSSrshTLRTTCWDGKLEYPTCAK 261
Cdd:PHA02831  174 LLG---SSVSTCDINSIWYPGIPK 194
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 140-194 5.19e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 5.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689189  140 CGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 194
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
140-194 5.67e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.26  E-value: 5.67e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689189 140 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 194
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 91-261 1.06e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 48.89  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  91 LSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL----NGNWT-EPPQCKdsTGKCGPPPPIDNGDITSfPLSVYAPASSV 165
Cdd:PHA02639   33 ITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIkdknNAIWSnKAPFCM--LKECNDPPSIINGKIYN-KREMYKVGDEI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189 166 EYQCQN----LYQLEGNKRITC-RNGQWS-EPPKCLHPCVISREIMENYNIALrwTAKQKLYLRTgeSAEFVCKRGYRLS 239
Cdd:PHA02639  110 YYVCNEhkgvQYSLVGNEKITCiQDKSWKpDPPICKMINCRFPALQNGYINGI--PSNKKFYYKT--RVGFSCKSGFDLV 185

                         170       180
                  ....*....|....*....|..
gi 1826689189 240 SRSHTLRTTCWDGKLEYPTCAK 261
Cdd:PHA02639  186 GEKYSTCNINATWFPSIPTCVR 207
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 85-134 3.64e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 3.64e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1826689189  85 IQNAHILSRQmSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCK 134
Cdd:cd00033     7 PENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 85-133 3.00e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.59  E-value: 3.00e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1826689189   85 IQNAHILSRQmSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQC 133
Cdd:smart00032   7 IENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
85-133 3.21e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 40.56  E-value: 3.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1826689189  85 IQNAHIlSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQC 133
Cdd:pfam00084   7 IPNGKV-SATKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 48-189 1.65e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.38  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689189  48 GEVFYYSCEYNfvSPSKSFWTRITCteegwsPTPKCL-IQNAHILSRQM-SKYPSGERVRYECRSPYEMFGDEEVMCLNG 125
Cdd:PHA02954  103 DETKYFRCEEK--NGNTSWNDTVTC------PNAECQpLQLEHGSCQPVkEKYSFGEHITINCDVGYEVIGASYISCTAN 174

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1826689189 126 NWTEPPQCKDstgKCGpPPPIDNGDITSfplSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWS 189
Cdd:PHA02954  175 SWNVIPSCQQ---KCD-IPSLSNGLISG---STFSIGGVIHLSCKSGFTLTGSPSSTCIDGKWN 231
PHA02817 PHA02817
EEV Host range protein; Provisional
 133-194 3.14e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.08  E-value: 3.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1826689189 133 CKDSTGKCGPPPPIDNGDITSfPLSVYAPASSVEYQCQN-----LYQLEGNKRITC-RNGQWS-EPPKC 194
Cdd:PHA02817   17 SLCDLNKCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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